Are the current attempts at standardization of antiphospholipid antibodies still useful? Emerging technologies signal a shift in direction

Seminars in Thrombosis and Hemostasis

Volumn 34, Issue 4, 2008, Pages 356-360

  Andreoli, Laura ^a   Rizzini, Silvia ^b   Allegri, Flavio ^a   Meroni, Pierluigi ^b   Tincani, Angela ^a  

^a UNIVERSITY OF BRESCIA   (Italy)

^b UNIVERSITY OF MILAN   (Italy)

Author keywords

Antiphospholipid antibodies; Antiphospholipid syndrome; Automation; Immunoassays

Indexed keywords

CARDIOLIPIN ANTIBODY; PHOSPHOLIPID ANTIBODY;

ANTIBODY DETECTION; IMMUNOASSAY; LIFE; PRIORITY JOURNAL; REVIEW; SAMPLE; STANDARDIZATION; TECHNOLOGY;

ANTIBODIES, ANTIPHOSPHOLIPID; AUTOIMMUNE DISEASES; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEMATOLOGIC TESTS; HUMANS;

EID: 50249135024     PISSN: 00946176     EISSN: 10989064     Source Type: Journal    
DOI: 10.1055/s-0028-1085478     Document Type: Review

References (15)

1. Laurell AB, Nilsson IM. Hypergamma-globulinemia, circulating anticoagulant and biologic false positive Wassermann reaction: a study of 2 cases. J Lab Clin Med 1957;49:694-707
2. Loizou S, Mc Crea JD, Rudge AC, et al. Measurement of anticardiolipin antibodies by an enzyme linked immunosorbent assay (ELISA): standardization and quantitation of results. Clin Exp Immunol 1985;62:738-745
3. Miyakis S, Lockshin MD, Atsumi T, et al. International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemost 2006;4:295-306
4. Tincani A, Allegri F, Balestrieri G, et al. Minimal requirements for antiphospholipid antibodies ELISAs proposed by the European Forum on antiphospholipid antibodies. Thromb Res 2004;114:553-558
5. Reber G, Tincani A, Sanmarco M, de Moerloose P, Boffa MC. Proposals for the measurement of anti-beta2-glycoprotein I antibodies. Standardization group of the European Forum on Antiphospholipid Antibodies. J Thromb Haemost 2004;2:1860-1862
6. Tincani A, Allegri F, Sanmarco M, et al. Anticardiolipin antibody assay: a methodological analysis for a better consensus in routine determination - an operative project of the European Antiphospholipid Forum. Thromb Haemost 2001;86:575-583
7. Balestrieri G, Tincani A, Spatola L, et al. Anti-beta2glycoprotein I antibodies. A marker of antiphospholipid syndrome? Lupus 1995;4:122-130
8. Capuano F, Grasso V, Belforte L, et al. Development of automated assays for anticardiolipin antibodies determination: addressing antigen and standardization issues. Ann N Y Acad Sci 2007;1109:493-502
9. Iverson GM, von Mühlen CA, Staub HL, Lassen AJ, Binder W, Norman GL. Patients with atherosclerotic syndrome, negative in anti-cardiolipin assays, make IgA autoantibodies that preferentially target domain 4 of beta2-GPI. J Autoimmun 2006;27:266-271
10. de Laat B, Derksen RH, Urbanus RT, de Groot PG. IgG antibodies that recognize epitope Gly40-Arg43 in domain I of beta2-glycoprotein I cause LAC, and their presence correlates strongly with thrombosis. Blood 2005;105:1540-1545
11. de Laat B, Wu XX, van Lummel M, Derksen RH, de Groot PG, Rand JH. Correlation between antiphospholipid antibodies that recognize domain I of beta2-glycoprotein I and a reduction in the anticoagulant activity of annexin A5. Blood 2007;109:1490-1494
12. Favaloro EJ, Wong RC, Silvestrini R, McEvoy R, Jovanovich S, Roberts-Thomson P. A multilaboratory peer assessment quality assurance program-based evaluation of anticardiolipin antibody, and beta2-glycoprotein I antibody testing. Semin Thromb Hemost 2005;31:73-84
13. Sanmarco M, Bardin N, Blank M, et al. Heterogenity for anti-beta2-glycoprotein I antibodies. A factor of variability in test results. Thromb Haemost 2005;93:80-87
14. Reber G, Tincani A, Sanmarco M, de Moerloose P, Boffa MC; European Forum on Antiphospholipid Antibodies Standardization Group. Variability of anti-beta2 glycoprotein I antibodies measurement by commercial assays. Thromb Haemost 2005;94:665-672
15. Cavazzana A, Ruffatti A, Tonello M, Bortolati M, De Moerloose P, Reber G. An analysis of experimental conditions influencing the anti-beta2-glycoprotein I ELISA assay results. Ann N Y Acad Sci 2007;1109:484-492 361-377