Current trends in the management of Beta Thalassemia

Indian Journal of Pediatrics

Volumn 75, Issue 7, 2008, Pages 739-743

  Dubey, A P ^a   Parakh, A ^a   Dublish, S ^a  

^a LOK NAYAK HOSPITAL   (India)

Author keywords

Beta Thalassemia; Iron chelation; Iron overload

Indexed keywords

ASCORBIC ACID; CALCIUM; DEFERASIROX; DEFERIPRONE; DEFEROXAMINE; DIGOXIN; GLIBENCLAMIDE; IRON CHELATING AGENT; LEVOTHYROXINE; METFORMIN; VITAMIN D;

ABDOMINAL DISCOMFORT; AGRANULOCYTOSIS; ARTHROPATHY; AUDITORY TOXICITY; BACTERIAL INFECTION; BETA THALASSEMIA; BLOOD TRANSFUSION; BONE; CHELATION THERAPY; CLINICAL TRIAL; CONFERENCE PAPER; CONTINUOUS INFUSION; CREATININE BLOOD LEVEL; DIABETES MELLITUS; DRUG COST; DRUG DOSE INCREASE; DRUG POTENTIATION; ENDOCRINE DISEASE; FERTILITY; GASTROINTESTINAL TOXICITY; GROWTH RETARDATION; HEART ATRIUM FIBRILLATION; HEART DISEASE; HEART FAILURE; HEMOSIDEROSIS; HEPATITIS B; HEPATITIS C; HUMAN; HYPOPARATHYROIDISM; HYPOTHYROIDISM; INJECTION SITE REACTION; IRON OVERLOAD; MENTAL HEALTH; NEUTROPENIA; RASH; REPRODUCTION; RETINAL TOXICITY; SIDE EFFECT; TOXICITY;

ADAPTATION, PSYCHOLOGICAL; BACTERIAL INFECTIONS; BETA-THALASSEMIA; BLOOD TRANSFUSION; CARDIOVASCULAR DISEASES; CHELATION THERAPY; CHILD; COMORBIDITY; DIABETES MELLITUS; FERTILITY; GROWTH DISORDERS; HUMANS; HYPOPARATHYROIDISM; HYPOTHYROIDISM; IRON OVERLOAD;

EID: 50249128697     PISSN: 00195456     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12098-008-0140-4     Document Type: Conference Paper

References (25)

1. V. Ladis G. Chouliaras H. Berdousi E. Kanavakis C. Kattamis 2005 Longitudinal study of survival and causes of death in patients with thalassemia major in Greece Ann N Y Acad Sci 1054 445 450
2. C.B. Pignatti S. Rugolotto P. Stefano A. Piga F. Gregorio M. Gamberini 1998 Survival and Disease Complications in Thalassemia Major Ann N Y Acad Sci 850 227 231
3. Guidelines for the Clinical Management of Thalassemia. Thalassemia international federation (TIF) 2007.
4. Roberts DJ, Rees D, Howard J, Hyde C, Alderson P, Brunskill S. Desferrioxamine mesylate for managing transfusional iron overload in people with transfusion-dependent thalassemia. Cochrane Database Syst Rev 2005 19: CD004450.
5. Borgna-Pignatti C, Cappellini MD, De Stefano P, Del Vecchio GC, Forni GL, Gamberini MR et al. Cardiac morbidity and mortality in deferoxamine-or deferiprone-treated patients with thalassemia major. Blood 2005 Dec 22; [Epub ahead of print]
6. J. Porter E. Vichinsky C. Rose A. Piga N. Olivieri N. Gattermann 2004 A Phase II Study with ICL670 (Exjade®), a Once-Daily Oral Iron Chelator, in Patients with Various Transfusion-Dependent Anemias and Iron Overload Blood 104 872A 872A
7. E. Vichinsky R. Fischer E. Fung O. Onyekwere J. Porter P. Swerdlow 2005 A randomized, controlled phase II trial in sickle cell disease patients with chronic iron overload demonstrates that the once-daily oral iron chelator deferasirox (Exjade ((R)) ICL670) is well tolerated and reduces iron Blood 106 95A 95A
8. A. Piga R. Galanello M.D. Cappellini G.L. Forni G. Lupo J.M. Ford 2003 Phase II study of ICL670, an oral chelator, in adult thalassaemia patients with transfusional iron overload: Efficacy, safety, pharmaco kinetics (PK) and pharmacodynamics (PD) after 18 months of therapy Blood 102 121A 121A
9. A. Piga R. Galanello M.L. Foschini A. Zappu E. Bordone F. Longo 2004 Once-daily treatment with the oral iron chelator ICL670 (Exjade (R): Results of a phase II study in pediatric patients with beta thalassernia major Blood 104 983A 983A
10. Cappellini MD, Cohen A, Piga A, Bejaoui M, Perrotta S, Agaoglu L et al. A Phase III study of deferasirox (ICL670), a once-daily oral iron chelator, in patients with ta-thalassemia. Blood 2006; 107: 3455-3462.
11. R. Origa P. Bina A. Agus G. Crobu E. Defraia C. Dessý 2005 Combined therapy with deferiprone and desferrioxamine in thalassemia major Haematologica 90 1309 1314
12. L.J. Anderson B. Wonke E. Prescott S. Holden J.M. Walker D.J. Pennell 2002 Comparison of effects of oral deferiprone and subcutaneous desferrioxamine on myocardial iron concentrations and ventricular function in beta thalassemia Lancet 360 516 520
13. A.A. Shamshirsaz M.R. Bekheirnia M. Kamgar N. Pourzahedgilani N. Bouzari M. Habibzadeh 2003 Endocrine complications of thalassemia. Metabolic and endocrinologic complications in beta-thalassemia major: a multicenter study in Tehran BMC Endocrine Disorders 3 4
14. V. De Sanctis A. Eleftheriou C. Malaventura 2004 Thalassaemia International Federation Study Group on Growth and Endocrine Complications in Thalassaemia. Prevalence of endocrine complications and short stature in patients with thalassaemia major: a multicenter study by the Thalassaemia International Federation (TIF) Pediatr Endocrinol Rev 2 249 255
15. K.H. Wu F.J. Tsai C.T. Peng 2003 Growth hormone (GH) deficiency in patients with beta-thalassemia major and the efficacy of recombinant GH treatment Ann Hematol 82 540 637
16. J. P. S. Chern K. H. Lin M. Y. Lu D. T. Lin K. S. Lin J.D. Chen 2001 Abnormal Glucose Tolerance in Transfusion-Dependent β-Thalassemic Patients Diabetes Care 24 850 854
17. K. Dmochowski D.T. Finegood W. Francombe B. Tyler B. Zinman 1993 Factors determining glucose tolerance in patients with Thalassaemia Major J Clin Endocrinol Metab 77 478 483
18. S. Venti F. Cainelli F. Cesario 2006 Infections and thalassaemia Lancet Infect Dis 6 226 233
19. J. Tsiantis D. Xypolita-Tsantili S. Papadakou-Lagoyianni 1982 Family reactions and their management in a parents group with beta-thalassemia Arch Dis Child 57 860 863
20. D. Shaligram S.C. Girimaji S.K. Chaturvedi 2007 Psychological problems and quality of life in children with thalassemia Indian J Pediatr 74 727 730
21. C. Pafumi M. Farina G. Pernicone 2000 At term pregnancies in transfusion-dependent beta-thalassemic women Clin Exp Obstet Gynecol 27 185 187
22. N. Skordis S. Christou M. Koliou N. Pavlides M. Angastiniotis 1998 Fertility in female patients with thalassemia J Pediatr Endocrinol Metab 11 Suppl3 935 943
23. M. Karagiorga-Lagana 1998 Fertility in thalassemia: the Greek experience J Pediatr Endocrinol Metab 11 Suppl3 945 951
24. M.J. Cunningham E.A. Macklin G. Muraca E.J. Neufeld 2004 Successful pregnancy in thalassemia major women in the Thalassemia Clinical Research Network Pediatr Res 55 294
25. R. Chatterjee M. Katz 2000 Reversible hypogonadotrophic hypogonadism in sexually infantile male thalassaemic patients with transfusional iron overload Clin Endocrinol 53 33 42