Beta2-adrenergic receptor haplotype and bronchodilator response to salbutamol in patients with acute exacerbations of COPD

Medical Science Monitor

Volumn 14, Issue 8, 2008, Pages

  Mokry, Michal ^a   Joppa, Pavol ^a   Slaba, Eva ^b   Zidzik, Jozef ^b   Habalova, Viera ^b   Kluchova, Zuzana ^a   Micietova, Lydia ^c   Rozborilova, Eva ^c   Salagovic, Jan ^b   Tkacova, Ruzena ^a  

^a L PASTEUR UNIVERSITY HOSPITAL   (Slovakia)

^b P J AFÁRIK UNIVERSITY   (Slovakia)

^c University Teaching Hospital in Martin   (Slovakia)

Author keywords

2 adrenoreceptor; COPD; Haplotype; Salbutamol

Indexed keywords

AMINO ACID; ARGININE; BETA 2 ADRENERGIC RECEPTOR; BETA 2 ADRENERGIC RECEPTOR STIMULATING AGENT; CORTICOSTEROID; GLUTAMIC ACID; GLUTAMINE; GLYCINE; IPRATROPIUM BROMIDE; OXYGEN; SALBUTAMOL; THEOPHYLLINE; BRONCHODILATING AGENT;

ADULT; AGED; ALLELE; ARTICLE; BODY PLETHYSMOGRAPHY; BRONCHODILATATION; CHRONIC OBSTRUCTIVE LUNG DISEASE; COMPARATIVE STUDY; CONTROLLED STUDY; DISEASE EXACERBATION; DISEASE SEVERITY; FEMALE; FORCED EXPIRATORY VOLUME; GENETIC POLYMORPHISM; HAPLOTYPE; HUMAN; LUNG FUNCTION; MAJOR CLINICAL STUDY; MALE; PEAK EXPIRATORY FLOW; POLYMERASE CHAIN REACTION; PREDICTION; STATISTICAL SIGNIFICANCE; CODON; DEMOGRAPHY; GENETICS; LUNG FUNCTION TEST; MIDDLE AGED; PATHOPHYSIOLOGY;

ADULT; AGED; ALBUTEROL; BRONCHODILATOR AGENTS; CODON; DEMOGRAPHY; FEMALE; GLUTAMIC ACID; GLYCINE; HAPLOTYPES; HUMANS; MALE; MIDDLE AGED; PULMONARY DISEASE, CHRONIC OBSTRUCTIVE; RECEPTORS, ADRENERGIC, BETA-2; RESPIRATORY FUNCTION TESTS;

EID: 50249109629     PISSN: 12341010     EISSN: 16433750     Source Type: Journal    
DOI: None     Document Type: Article

References (41)

1. 2-adrenoreceptor polymorphisms and asthma: A HuGE review. Am J Epidemiol, 2005; 162: 201-11
2. Joos L: COPD and genetics - what's new? Swiss Med Wkly, 2004; 134: 437-39
3. Bousquet J, Clark TJH, Hurd S et al: GINA guidelines on asthma and beyond. Allergy, 2007; 62: 102-12
4. Celli ER, MacNee W, and the ATS/ERS Task Force. Standards for the diagnosis and treatment of patients with COPD: a summary of the ATS/ERS position paper. Eur Respr J, 2004; 23: 932-46
5. Barnes PJ: β-adrenergic receptors and their regulation. Am J Respir Crit Care Med, 1995; 152: 838-60
6. 2-adrenergic receptor impart distinct agonist-promoted regulatory properties. Biochemistry, 1994; 33: 9414-19
7. 2- adrenergic receptor genotypes on signal transduction in human airway smooth muscle cells. Am J Respir Cell Mol Biol, 1995; 13: 25-33
8. Martinez FD, Graves PE, Baldini M et al: Association between genetic polymorphisms of the β2-adrenoreceptor and response to albuterol in children with and without a history of wheezing. J Clin Invest, 1997; 100: 3184-88
9. 2-agonist therapy in asthma. Eur Respir J, 1998; 11: 589-93
10. Joos L, Pare PD, Sandford AJ: Beta(2)-Adrenergic receptor polymorphisms and asthma. Curr Opin Pulm Med, 2001; 7: 69-74
11. 2 adrenoceptor polymorphism. Thorax, 2000; 55: 762-67
12. 2-adrenoceptor haplotype in patients with asthma. Am J Respir Crit Care Med, 2005; 172: 700-3
13. 2-adrenergic receptor genotype in subjects with persistent asthma. J Allergy Clin Immunol, 2006; 118: 809-16
14. 2-adrenergic receptor on the response to regular use of albuterol in asthma. Am J Respir Crit Care Med, 2000; 162: 75-80
15. 2-adrenoceptor in COPD in Chinese subjects. Chest, 2001; 120: 1493-99
16. Hegab AE, Sakamoto T, Saitoh W et al: Polymorphisms of IL4, IL13, and ADRB2 genes in COPD. Chest, 2004; 126: 1832-39
17. Brogger J, Steen VM, Eiken HG et al: Genetic association between COPD and polymorphisms in TNF, ADRB2 and EPHX1. Eur Respir J, 2006; 27: 682-88
18. 2 adrenergic receptor and bronchodilator response, bronchial hyperresponsiveness, and rate of decline in lung function in smokers. Thorax, 2003; 58: 703-7
19. Hizawa N, Makita H, Nasuhara Y et al: β2-adrenergic receptor genetic polymorphisms and short-term bronchodilator responses in patients with COPD. Chest, 2007; 132: 1485-92
20. Celli BR, Barnes PJ: Exacerbations of chronic obstructive pulmonary disease. Eur Respir J, 2007; 29: 1224-38
21. Rodriguez-Roisin R: Towards a consensus definition for COPD exacerbations. Chest, 2000; 117(Suppl.2): 398S-401S
22. Burge S, Wedzicha JA: COPD exacerbations: definitions and classifications. Eur Respir J, 2003; 21(Suppl.41): 46s-53s
23. Perera WR, Hurst JR, Wilkinson TMA et al: Inflammatory changes, recovery and recurrence at COPD exacerbation. Eur Respir J, 2007; 29: 527-34
24. Hurst JR, Perera WR, Wilkinson TMA et al: Systemic and upper and lower airway inflammation at exacerbation of chronic obstructive pulmonary disease. Am J Respir Crit Care Med, 2006; 173: 71-78
25. Miller MR, Hankinson J, Brusasco V et al: Standardisation of spirometry. Eur Respir J, 2005; 26: 319-38
26. Lehmann S, Bakke PS, Eide GE et al: Bronchodilator reversibility testing in an adult general population; the importance of smoking and anthropometrical variables on the response to a beta2-agonist. Pulm Pharmacol Ther, 2006; 19: 272-80
27. Littlejohn MD, Taylor DR, Miller AL, Kennedy MA: Determination of beta2-adrenergic receptor (ADRB2) haplotypes by a multiplexed polymerase chain reaction assay. Hum Mutat, 2002; 20: 479
28. 2- adrenoreceptor variants with bronchial hyperresponsiveness. Am J Respir Crit Care Med, 2000; 161: 469-74
29. 2-adrenergic receptor polymorphisms are associated with asthma and COPD in adults. J Hum Genet, 2006; 51: 943-51
30. Fujita M, Nakanishi Y: The pathogenesis of COPD: lessons learned from in vivo animal models. Med Sci Monit, 2007; 13(2): RA19-24
31. 2-adrenoreceptor (ADRB2) haplotypes. A population study. Am J Respir Crit CareMed, 1998; 158: 1968-73
32. 2- adrenoceptor polymorphisms at codons 16 and 27 to persistence of asthma symptoms after the onset of puberty. Chest, 2005; 128: 609-17
33. 2-adrenergic receptor gene polymorphism and cigarette smoking. Am J Respir Crit Care Med, 2001; 163: 1404-9
34. Contopoulos-Ioannidis DG, Manoli EN, Ioannidis JP: Meta-analysis of the association of beta2-adrenergic receptor polymorphisms with asthma phenotypes. J Alergy Clin Immunol, 2005; 115: 963-72
35. Litonjua AA, Silverman EK, Tantisira KG et al: β2-adrenergic receptor polymorphisms and haplotypes are associated with airways hyperresponsiveness among nonsmoking men. Chest, 2004; 126: 66-74
36. Small KM, McGraw DW, Liggett SB: Pharmacology and physiology of human adrenergic receptor polymorphisms. Annu Rev Pharmacol Toxicol, 2003; 43: 381-411
37. Lee DK, Bates CE, Lipworth BJ: Acute systemic effects of inhaled salbutamol in asthmatic subjects expressing common homozygous beta2-adrenoceptor haplotypes at positions 16 and 27. Br J Clin Pharmacol, 2004; 57: 100-4
38. Lima JJ, Thomason DB, Mohamed MH et al: Impact of genetic polymorphisms of the beta2-adrenergic receptor on albuterol bronchodilator pharmacodynamics. Clin Pharmacol Ther, 1999; 65: 519-25
39. 2-adrenergic receptor haplotypes alter receptor expression and predict in vivo responsiveness. Proc Natl Acad Sci USA, 2000; 97: 10483-88
40. Bleecker ER, Postma DS, Lawrence RM et al: Effect of ADRB2 polymorphisms on response to longacting beta2-agonist therapy: a pharmacogenetics analysis of two randomised studies. Lancet, 2007; 370: 2118-25
41. Tattersfield AE, Hall IP: Are beta2-adrenoceptor polymorphisms important in asthma: an unravelling story. Lancet, 2004; 364: 1464-66