Serum neopterin, nitric oxide, inducible nitric oxide synthase and tumor necrosis factor-α levels in patients with ischemic heart disease

Clinical Chemistry and Laboratory Medicine

Volumn 46, Issue 8, 2008, Pages 1149-1155

  Djordjevic, Vidosava B ^a,b   Stojanovic, Ivana ^b   Cosic, Vladan ^a   Zvezdanovic, Lilika ^a   Deljanin Ilic, Marina ^c   Dimic, Senada ^b   Kundalic, Braca ^b   Cvetkovic, Tatjana ^b   Jevtovic Stoimenov, Tatjana ^b  

^a Clinical Center   (Serbia)

^b Faculty of Medicine   (Serbia)

^c Institute for Cardiovascular and Rheumatic Diseases   (Serbia)

Author keywords

Inducible nitric oxide synthase (iNOS); Ischemic heart diseases; Neopterin; Nitric oxide; Tumor necrosis factor (TNF )

Indexed keywords

ACETYLSALICYLIC ACID; ADRENALIN; AMIODARONE; BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CALCIUM ANTAGONIST; CHOLESTEROL; CLOPIDOGREL; DIPEPTIDYL CARBOXYPEPTIDASE INHIBITOR; DIURETIC AGENT; FIBRINOLYTIC AGENT; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; INDUCIBLE NITRIC OXIDE SYNTHASE; LIDOCAINE; LOW MOLECULAR WEIGHT HEPARIN; NEOPTERIN; NITRATE; TRIACYLGLYCEROL; TUMOR NECROSIS FACTOR ALPHA;

ADULT; AGED; ARTICLE; ATHEROSCLEROSIS; BLOOD LEVEL; CARDIOVASCULAR DISEASE; CIGARETTE SMOKING; CONTROLLED STUDY; CORONARY RISK; DIAGNOSTIC KIT; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HEART DEATH; HEART REINFARCTION; HUMAN; HYPERCHOLESTEROLEMIA; HYPERTENSION; INFLAMMATION; ISCHEMIC HEART DISEASE; LABORATORY TEST; MAJOR CLINICAL STUDY; MALE; OBESITY; PRIORITY JOURNAL; RISK FACTOR; SERUM; ST SEGMENT ELEVATION; STABLE ANGINA PECTORIS; THROMBOEMBOLISM; TRIACYLGLYCEROL BLOOD LEVEL; UNSTABLE ANGINA PECTORIS;

AGED; BIOLOGICAL MARKERS; FEMALE; HUMANS; MALE; MIDDLE AGED; MYOCARDIAL ISCHEMIA; NEOPTERIN; NITRIC OXIDE; NITRIC OXIDE SYNTHASE TYPE II; RISK FACTORS; TUMOR NECROSIS FACTOR-ALPHA;

ANGINA;

EID: 50249102875     PISSN: 14346621     EISSN: 14374331     Source Type: Journal    
DOI: 10.1515/CCLM.2008.213     Document Type: Article

References (37)

1. Ross R. Atherosclerosis - an inflammatory disease. N Engl J Med 1999;340:115-26.
2. Huber C, Batchelor JR, Fuchs D, Hausen A, Lang A, Niederwieser D, et al. Immune response-associated production of neopterin. Release from macrophages primarily under control of interferon-gamma. J Exp Med 1984;160:310-6.
3. Sorimachi K, Akimoto K, Hattori Y, Leiri T, Niwa A. Secretion of TNF-α, IL-8 and nitric oxide by macrophages activated with polyanions, and involvement of interferon-γ in the regulation of cytokine secretion. Cytokine 1999;11:571-8.
4. Kaski JC, Zouridakis EG. Inflammation, infection and acute coronary plaque events. Eur Heart J 2001;Suppl 3:I10-5.
5. Thurberg BL, Collins T. The nuclear factor kappaB/inhibitor of kappaB autoregulatory system and atherosclerosis. Curr Opin Lipidol 1998;9:387-96.
6. Schobersberger W, Hoffmann G, Grote J, Wachter H, Fuchs D. Induction of inducible nitric oxide synthase expression by neopterin in vascular smooth muscle cells. FEBS Lett 1995;377:461-4.
7. Hoffmann G, Frede S, Kenn S, Smolny M, Wachter H, Fuchs D, et al. Neopterin-induced tumor necrosis factor-α synthesis in vascular smooth muscle cells in vitro. Int Arch Allergy Immunol 1998;116:240-5.
8. Nathan C, Xie QW. Regulation of biosynthesis of nitric oxide. J Biol Chem 1994;269:13725-8.
9. Knowles RG, Moncada S. Nitric oxide synthases in mammals. Biochem J 1994;298:249-58.
10. Cook S. Coronary artery disease, nitric oxide and oxidative stress: the "Yin-Yang" effect - a Chinese concept for a worldwide pandemic. Swiss Med Wkly 2006;136:103-13.
11. Hamm CW, Braunwald E. A classification of unstable angina revisited. Circulation 2000;102:118-22.
12. Van de Werf F, Ardissino D, Betriu A, Cokkinos DV, Falk E, Fox KA, et al. Management of acute myocardial infarction in patients presenting with ST-segment elevation. Eur Heart J 2003;24:28-66.
13. Navaro-Gonzalvez JA, Garcia-Benayas M, Arenas I. Semiautomated measurement of nitrate in biological fluids. Clin Chem 1998;44:679-81.
14. Schumacher M, Halwachs G, Tatzber F, Fruhwald FM, Zweiker R, Watzinger N, et al. Increased neopterin in patients with chronic and acute coronary syndromes. J Am Coll Cardiol 1997;30:703-7.
15. Ilhan F, Akbulut H, Karaca I, Godekmerdan A, Ilkay E, Bulut V. Procalcitonin, C-reactive protein and neopterin levels in patients with coronary atherosclerosis. Acta Cardiol 2005;60:361-5.
16. Avanzas P, Arroyo-Espliguero R, Quiles J, Roy D, Kaski JC. Elevated serum neopterin predicts future adverse cardiac events in patients with chronic stable angina pectoris. Eur Heart J 2005;26:457-63.
17. Garcia-Moll X, Cole D, Zouridakis E, Kaski JC. Increase serum neopterin: a marker of coronary artery disease activity in women. Heart 2000;83:346-50.
18. Smith DA, Zouridakis EG, Mariani M, Fredericks S, Cole D, Kaski JC. Neopterin levels in patients with coronary artery disease are independent of Chlamydia pneumoniae seropositivity. Am Heart J 2003;146:69-74.
19. Mazzone A, De Servi S, Mazzucchelli I, Bossi I, Ottini E, Vezzoli M, et al. Increased concentrations of inflammatory mediators in unstable angina: correlation with serum troponin T. Heart 2001;85:571-5.
20. Zouridakis E, Avanzas P, Arroyo-Espliguero R, Fredericks S, Kaski JC. Markers of inflammation and rapid coronary artery disease progression in patients with stable angina pectoris. Circulation 2004;110:1747-53.
21. Dichtl W, Nilsson L, Goncalves I, Ares MP, Banfi C, Calara F, et al. Very low-density lipoprotein activated nuclear factor-κB in endothelial cells. Circ Res 1999;84:1085-94.
22. Le N-A, Walter MF. The role of hypertriglyceridemia in atherosclerosis. Curr Atheroscler Rep 2007;9:110-5.
23. Satoh T, Brown LM, Blattner WA, Maloney EM, Kurman CC, Nelson DL, et al. Serum neopterin, β2-microglobulin, soluble interleukin-2 receptors, and immunoglobulin levels in healthy adolescents. Clin Immunol Immunopathol 1998;88:176-82.
24. Gottsater A, Anwaar I, Lind P, Mattiasson I, Lindgarde F. Increasing plasma fibrinogen, but unchanged levels of intraplatelet cyclic nucleotides, plasma endothelin-1, factor VII, and neopterin during cholesterol lowering with fluvastatin. Blood Coagul Fibrinolysis 1999;10:133-40.
25. van Haelst PL, van Doormaal JJ, May JF, Gans RO, Crijns HJ, Cohen Tervaert JW. Secondary prevention with fluvastatin decreases levels of adhesion molecules, neopterin and C-reactive protein. Eur J Intern Med 2001;12:503-9.
26. Schumacher M, Halwachs G, Tatzber F, Fruhwald FM, Zweiker R, Watzinger N, et al. Increased neopterin in patients with chronic and acute coronary syndromes. J Am Coll Cardiol 1998;31:1215-6.
27. Gurfinkel EP, Scirica BM, Bozovich G, Macchia A, Manos E, Mautn B. Serum neopterin levels and the angiographic extent of coronary arterial narrowing in unstable angina pectoris and non-Q-wave acute myocardial infarction. Am J Cardiol 1999;83:515-8.
28. Choussat R, Montalescot G, Collet J, Jardel C, Ankri A, Fillet A, et al. Effect of prior exposure to Chlamydia pneumoniae, Helicobacter pylori, or cytomegalovirus on the degree of inflammation and one-year prognosis of patients with unstable angina pectoris or non-Q-wave acute myocardial infarction. Am J Cardiol 2000;86:379-84.
29. Kanai AJ, Mesaros S, Finkel MS, Oddis CV, Birder LA, Malinski T. β-Adrenergic regulation of constitutive nitric oxide synthase in cardiac myocytes. Am J Physiol Cell Physiol 1997;273:C1371-7.
30. Ferdinandy P, Schulz R. Nitric oxide, superoxide, and peroxynitrite in myocardial ischemia-reperfusion injury and preconditioning. Br J Pharmacol 2003;138:532-43.
31. Manukhina EB, Downey HF, Mallet RT. Role of nitric oxide in cardiovascular adaptation to intermittent hypoxia. Exp Biol Med 2006;231:343-65.
32. Akiyama K, Suzuki H, Grant P, Bing RJ. Oxidation products of nitric oxide, NO2 and NO3, in plasma after experimental myocardial infarction. Mol Cell Cardiol 1997;29:1-9.
33. Sanchez de Miguel L, Arriero MM, Farre J, Jimenez P, Garcia-Mendez A, de Frutos T. Nitric oxide production by neutrophils obtained from patients during acute coronary syndromes: expression of the nitric oxide synthase isoforms. J Am Coll Cardiol 2002;39:818-25.
34. Eikelboom JW, Hirsh J, Weitz JI, Johnston M, Yi Q, Yusuf S. Aspirin-resistant thromboxane biosynthesis and the risk of myocardial infarction, stroke, or cardiovascular death in patients at high risk for cardiovascular events. Circulation 2002;105:1650-5.
35. Willoughby SR, Stewart S, Holmes AS, Chirkov YY, Horowitz JD. Platelet nitric oxide responsiveness. A novel prognostic marker in acute coronary syndromes. Arterioscl Thromb Vasc Biol 2005;25:2661-6.
36. Battery LD, Springall DR, Chester AH, Evans TJ, Standfield N, Parums DV, et al. Inducible nitric oxide synthase is present within human atherosclerotic lesions and promotes the formation and activity of peroxinitrite. Lab Invest 1996;75:77-85.
37. Djordjević BV, Stanković T, Ćosić V, Zvezdanović L, Kamenov B, Tasić-Dimov D, et al. Immune system - mediated endothelial damage is associated with NO and antioxidant system disorders. Clin Chem Lab Med 2004;42:1117-21.