Shoot-and-trap: Use of specific x-ray damage to study structural protein dynamics by temperature-controlled cryo-crystallography

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 33, 2008, Pages 11742-11747

  Colletier, Jacques Philippe ^a,e   Bourgeois, Dominique ^a,d   Sanson, Benoît ^a   Fournier, Didier ^b   Sussman, Joel L ^c   Silman, Israel ^c   Weik, Martin ^a  

^a INSTITUT DE BIOLOGIE STRUCTURALE   (France)

^b INSTITUT DE PHARMACOLOGIE ET DE BIOLOGIE STRUCTURALE   (France)

^c WEIZMANN INSTITUTE OF SCIENCE   (Israel)

^d EUROPEAN SYNCHROTRON RADIATION FACILITY   (France)

^e UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Acetylcholinesterase; Energy landscape; Kinetic crystallography; Structure dynamics function relationships; Synchrotron radiation

Indexed keywords

ACETYLCHOLINESTERASE;

ARTICLE; CHOLINERGIC SYNAPSE; ENZYME ACTIVE SITE; ENZYME STRUCTURE; PRIORITY JOURNAL; PROTEIN FUNCTION; SYNCHROTRON; TEMPERATURE; X RAY CRYSTALLOGRAPHY;

ACETYLCHOLINE; ACETYLCHOLINESTERASE; ANIMALS; BINDING SITES; CRYSTALLOGRAPHY, X-RAY; MODELS, MOLECULAR; PROTEIN STRUCTURE, TERTIARY; RADIOCHEMISTRY; SUBSTRATE SPECIFICITY; TEMPERATURE; TORPEDO;

EID: 50149111314     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0804828105     Document Type: Article

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