Preparation, characterization and in vitro cytotoxicity of indomethacin-loaded PLLA/PLGA microparticles using supercritical CO2 technique

European Journal of Pharmaceutics and Biopharmaceutics

Volumn 70, Issue 1, 2008, Pages 85-97

  Kang, Yunqing ^a   Wu, Jiang ^a   Yin, Guangfu ^a   Huang, Zhongbing ^a   Yao, Yadong ^a   Liao, Xiaoming ^a   Chen, Aizheng ^a   Pu, Ximing ^a   Liao, Li ^a  

^a SICHUAN UNIVERSITY   (China)

Author keywords

Drug delivery system; Indomethacin; Microparticles; Poly(l lactic acid); Poly(lactide co glycolide); Supercritical CO2

Indexed keywords

CARBON DIOXIDE; INDOMETACIN; ORGANIC SOLVENT; POLYGLACTIN; POLYLACTIC ACID;

APOPTOSIS; ARTICLE; CANCER CELL CULTURE; CELL PROLIFERATION; CHROMATIN CONDENSATION; CONTROLLED DRUG RELEASE; CONTROLLED STUDY; DRUG CYTOTOXICITY; DRUG DELIVERY SYSTEM; DRUG DOSAGE FORM; DRUG FORMULATION; DRUG UPTAKE; ENCAPSULATION; FLUORESCENCE MICROSCOPY; HUMAN; HUMAN CELL; IN VITRO STUDY; MEMBRANE DAMAGE; MITOCHONDRION; MORPHOLOGY; PARTICLE SIZE; SUPERCRITICAL FLUID; SURFACE PROPERTY; TECHNIQUE; TRANSMISSION ELECTRON MICROSCOPY;

ANTINEOPLASTIC AGENTS; APOPTOSIS; CALORIMETRY, DIFFERENTIAL SCANNING; CARBON DIOXIDE; CELL LINE, TUMOR; CELL PROLIFERATION; CELL SURVIVAL; CHEMISTRY, PHARMACEUTICAL; CHROMATOGRAPHY, SUPERCRITICAL FLUID; CRYSTALLOGRAPHY, X-RAY; DELAYED-ACTION PREPARATIONS; DRUG CARRIERS; HUMANS; INDOMETHACIN; KINETICS; LACTIC ACID; MICROSCOPY, ELECTRON, TRANSMISSION; MICROSCOPY, FLUORESCENCE; PARTICLE SIZE; PHAGOCYTOSIS; POLYGLYCOLIC ACID; POLYMERS; POWDER DIFFRACTION; SOLUBILITY; SOLVENTS; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; SURFACE PROPERTIES; TECHNOLOGY, PHARMACEUTICAL;

EID: 50149107561     PISSN: 09396411     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejpb.2008.03.011     Document Type: Article

References (45)

1. Perez C., Castellanos I.J., Costantino H.R., Al-Azzam W., and Griebenow K. Recent trends in stabilizing protein structure upon encapsulation and release from bioerodible polymers. J. Pharm. Pharmacol. 54 (2002) 301-313
2. Bhatia S.R., Khattak S.F., and Roberts S.C. Polyelectrolytes for cell encapsulation. Curr. Opin. Colloid. Interface Sci. 10 (2005) 45-51
3. Langer R. Drug delivery and targeting. Nature 392 (1998) 5-10
4. Tom J.W., and Debendetti P.G. Formation of bioerodible polymeric microspheres and microparticles by rapid expansion of supercritical solution. Biotechnol. Prog. 7 (1991) 403-411
5. 2. J. Control. Release 66 (2000) 77-185
6. Rodrigues M., Peirico N., Matos H., Gomes de Azevedo E., Lobato M.R., and Almeida A.J. Microcomposites theophylline/hydrogenated palm oil from a PGSS process for controlled drug delivery systems. J. Supercrit. Fluids 29 (2004) 175-184
7. Falk R.F., and Randolph T.W. Process variable implications for residual solvent removal and polymer morphology in the formation of gentamycin-loaded poly (l-lactide) microparticles. Pharm. Res. 15 (1998) 1233-1237
8. Foster N., Mammucari R., and Deghani F. Processing pharmaceutical compounds using dense gas technology. Ind. Eng. Chem. Res. 42 (2003) 6476-6493
9. Kazarian S.G. Polymer processing with supercritical fluids. Polym. Sci. Ser. C 42 (2000) 78-101
10. M. Hanna, P. York, Patent WO 95/01221, 1994.
11. M. Hanna, P. York, Patent WO 96/00610, 1995.
12. Jung J., and Perrut M. Particle design using supercritical fluids: literature and patent survey. J. Supercrit. Fluid 20 (2001) 179-219
13. Yeo S.D., and Kiran E. Formation of polymer particles with supercritical fluids: a review. J. Supercrit. Fluid 34 (2005) 287-308
14. 2 as antisolvent with enhanced mass transfer. Ind. Eng. Chem. Res. 40 (2001) 3530-3539
15. 2 in a mixed solvent. Ind. Eng. Chem. Res. 40 (2001) 795-800
16. Sarkari M., Brown J., Chen X.X., Swinnea S., Williams III R.O., and Johnston K.P. Enhanced drug dissolution using evaporative precipitation into aqueous solution. Int. J. Pharm. 243 (2002) 17-31
17. Rogers T.L., Nelsen A.C., Hu J.H., Brown J.N., Sarkari M., Young T.J., et al. A novel particle engineering technology to enhance dissolution of poorly water soluble drugs: spray-freezing into liquid. Eur. J. Pharm. Biopharm. 54 (2002) 271-280
18. Hu J.H., Johnston K.P., and Williams III R.O. Spray freezing into liquid (SFL) particle engineering technology to enhance dissolution of poorly water soluble drugs: organic solvent versus organic/aqueous co-solvent systems. Eur. J. Pharm. Sci. 20 (2003) 295-303
19. 2. Macromol. Rapid. Commun. 27 (2006) 1254-1259
20. Anil K.S., and Hardeep W. Zinc-indomethacin complex: synthesis, physicochemical and biological evaluation in the rat. Int. J. Pharm. 120 (1995) 145-155
21. Chandrasekar D., Sistla R., Ahmad F.J., Khar R.K., and Diwan P.V. The development of folate-PAMAM dendrimer conjugates for targeted delivery of anti-arthritic drugs and their pharmacokinetics and biodistribution in arthritic rats. Biomaterials 28 (2007) 504-512
22. Coogan P.F., Rosenberg L., Palmer J.R., Strom B.L., Zauber A.G., Stolley P.D., and Shapiro S. Nonsteroidal anti-inflammatory drugs and risk of digestive cancers at sites other than the large bowel. Cancer Epidemiol. Biomark. Prev. 9 (2000) 119-123
23. Hsu A.L., Ching T.T., Wang D.S., Song X., Rangnekar V.M., and Chen C.S. The cyclooxygenase-2 inhibitor celecoxib induces apoptosis by blocking Akt activation in human prostate cancer cells independently of Bcl-2. J. Biol. Chem. 275 (2000) 11397-11403
24. Maca R.D. Enhancement of etoposide and methotrexate sensitivity by indomethacin in vitro. Anticancer Drug Des. 6 (1991) 453-466
25. Ruegg C., Zaric J., and Stupp R. Non steroidal anti-inflammatory drugs and COX-2 inhibitors as anti-cancer therapeutics: hypes, hopes and reality. Ann. Med. 35 (2003) 476-487
26. Hull M.A., Gardner S.H., and Hawcroft G. Activity of the non-steroidal anti-inflammatory drug indomethacin against colorectal cancer. Cancer Treat. Rev. 29 (2003) 309-320
27. Hixson L.J., Alberts D.S., Krutzsch M., Einsphar J., Brendel K., Gross P.H., et al. Antiproliferative effect of nonsteroidal antiinflammatory drugs against human colon cancer cells. Cancer Epidemiol. Biomarkers. Prev. 3 (1994) 433-438
28. Denbenedetti P.G., Tom J.W., Yeo S.D., and Lim G.B. Application of supercritical fluids for the production of sustained delivery devices. J. Control. Release 24 (1993) 27-44
29. Song K.H., Lee C.H., and Lim J.S. Preparation of L-PLA submicron particles by a continuous supercritical antisolvent precipitation process. Korean J. Chem. Eng. 19 (2002) 139-145
30. Wu T., Sun Y., Li N., de Villiers M.M., and Yu L. Inhibiting surface crystallization of amorphous indomethacin by nanocoating. Langmuir 23 (2007) 5148-5153
31. Chandrashekar G., and Udupa N. Biodegradable injectable implant systems for long term drug delivery using poly(lactic-co-glycolic) acid copolymers. J. Pharm. Pharmacol. 48 (1996) 669-674
32. Witschi C., and Doelker E. Influence of the microencapsulation method and peptide loading on poly(lactic acid) and poly(lactic-co-glycolic acid) degradation during in vitro testing. J. Control. Release 51 (1998) 327-341
33. Loo J.S.C., Ooi C.P., and Boey F.Y.C. Degradation of poly(lactide-co-glycolide) (PLGA) and poly(l-lactide)(PLLA) by electron beam radiation. Biomaterials 26 (2005) 1359-1367
34. Ghaderi R., Artursson P., and Carlfors J. Preparation of biodegradable microparticles using solution-enhanced dispersion by supercritical fluids (SEDS). Pharm. Res. 16 (1999) 676-681
35. Blanco M.D., Sastre R.L., Teijón C., Olmo R., and Teijón J.M. Degradation behaviour of microspheres prepared by spray-drying poly(d,l-lactide) and poly(d,l-lactide-co-glycolide) polymers. Int. J. Pharm. 326 (2006) 139-147
36. Griffith L.G. Polymeric biomaterials. Acta Mater. 48 (2000) 263-277
37. Liu R., Huang S.S., Wan Y.H., Ma G.H., and Su Z.G. Preparation of insulin-loaded PLA/PLGA microcapsules by a novel membrane emulsification method and its release in vitro. Colloid. Surface B 51 (2006) 30-38
38. Raffin R.P., Jornada D.S., Ré M.I., Pohlmann A.R., and Guterres S.S. Sodium pantoprazole-loaded enteric microparticles prepared by spray drying: effect of the scale of production and process validation. Int. J. Pharm. 324 (2006) 10-18
39. Singla A.K., and Wadhwa H. Zinc-indomethacin complex: synthesis, physicochemical and biological evaluation in the rat. Int. J. Pharm. 120 (1995) 145-155
40. Timko M., Koneracká M., Tomašovičová N., Kopčanský P., and Závišova V. Magnetite polymer nanospheres loaded by Indomethacin for anti-inflammatory therapy. J. Magn. Magn. Mater. 300 (2006) e191-e194
41. Rusu D., Cimpoiu C., and Hodisan T. Control over a new preparation of indomethacin. J. Pharm. Biomed. Anal. 17 (1998) 409-413
42. 2-based microencapsulation. Langmuir 21 (2005) 379-385
43. Elvassore N., Bertucco A., and Caliceti P. Production of insulin loaded poly(ethylene glycol)/poly (I-lactide) (PEG/PLA)nanoparticles by gas antisolvent techniques. J. Pharm. Sci. 90 (2001) 1628-1636
44. Sato S., Kwon Y., Kamisuki S., Srivastava N., Mao Q., Kawazoe Y., and Uesugi M. Polyproline-rod approach to isolating protein targets of bioactive small molecules: isolation of a new target of indomethacin. J. Am. Chem. Soc. 129 (2007) 873-880
45. Bernardi A., Jacques-Silva M.C., Delgado-Cañedo A., Lenz G., and Battastini A.M.O. Nonsteroidal anti-inflammatory drugs inhibit the growth of C6 and U138-MG glioma cell lines. Eur. J. Pharmacol. 532 (2006) 214-222