Raman mapping of low-content active-ingredient pharmaceutical formulations. Part II: Statistically optimized sampling for detection of less than 1% of an active pharmaceutical ingredient

Applied Spectroscopy

Volumn 62, Issue 8, 2008, Pages 916-921

  Šašić, Slobodan ^a   Whitlock, Mark ^b  

^a PFIZER INC   (United States)

^b PFIZER GLOBAL RESEARCH AND DEVELOPMENT   (United Kingdom)

Author keywords

Active pharmaceutical ingredient; API: Low concentration; Chemical mapping; Raman spectroscopy; Sampling

Indexed keywords

MAPPING; RAMAN SPECTROSCOPY; SAMPLING;

ACTIVE INGREDIENTS; ACTIVE PHARMACEUTICAL INGREDIENTS; ANALYTICAL ANALYSIS; API: LOW CONCENTRATION; CHEMICAL MAPPING; LOW CONCENTRATIONS; OPTIMIZED SAMPLING; PHARMACEUTICAL FORMULATION;

DRUG PRODUCTS;

EID: 50149104150     PISSN: 00037028     EISSN: None     Source Type: Journal    
DOI: 10.1366/000370208785284376     Document Type: Article

References (17)

1. S. Šašić, Ed., Pharmaceutical Applications of Raman Spectroscopy (John Wiley and Sons, Hoboken, NJ, 2007).
2. D. E. Pivonka, J. M. Chalmers, and P. R. Griffiths, Eds., Applications of Vibrational Spectroscopy in Pharmaceutical Research and Environment (John Wiley and Sons, Chichester, UK, 2007).
3. J. M. Chalmers and P. R. Griffiths, Eds., Handbook of Vibrational Spectroscopy (John Wiley and Sons, New York, 2001).
4. T. R. M. De Beer, W. R. G. Baeyens, J. Ouyang, C. Vervaet, and J. P. Remon, Analyst (Cambridge, U.K.) 131, 1137 (2006).
5. G. Finni, J. Raman Spectrosc. 35, 335 (2004).
6. G. Fevotte, Chem. Eng. Res. Design 85, 906 (2007).
7. R. B. Shah, M. A. Tawakkul, and M. A. Khan, J. Pharm. Sci. 96, 1356 (2007).
8. D. S. Hausman, R. T. Cambron, and A. Sakr, Intl. J. Pharm. 80, 298 (2005).
9. S. Šašić, Pharm. Res. 24, 58 (2007).
10. M. Henson and L. Zhang, Appl. Spectrosc. 60, 1247 (2006).
11. L. Zhang, M. L. Henson, and S. S. Sekulic, Anal. Chim. Acta 545, 262 (2005).
12. J. F. Kauffman, K. Dellibovi, and C. R. Cunningham, J. Pharm. Biomed. Anal. 43, 39 (2007).
13. S. E. J. Bell, J. R. Beattie, J. J. McGarvey, K. Laota Peters, N. M. S. Sirimuthu, and S. J. Speers, J. Raman Spectrosc. 35, 409 (2004).
14. S. E. J. Bell, L. J. Barrett, D. T. Burns, A. C. Dennis, and S. J. Speers, Analyst (Cambridge, U.K.) 128, 1331 (2003).
15. M. Dyrby, S. B. Engelsen, L. Norgaard, M. Bruhn, and L. Lundsberg-Nielsen, Appl. Spectrosc. 56, 579 (2002).
16. R. Szostak and S. Mazurek, Analyst (Cambridge, U.K.) 127, 144 (2002).
17. M. Kim, H. Chung, Y. Woo, and M. S. Kemper, Anal. Chim. Acta 587, 200 (2007).