Higher homologous and lower cross-reactive gag-specific T-cell responses in human immunodeficiency virus type 2 (HIV-2) than in HIV-1 infection

Journal of Virology

Volumn 82, Issue 17, 2008, Pages 8619-8628

  Jennes, Wim ^a   Camara, Makhtar ^b   Dièye, Tandakha ^b   Mboup, Souleymane ^b   Kestens, Luc ^a  

^a INSTITUTE OF TROPICAL MEDICINE   (Belgium)

^b Centre Hospitalier Universitaire Dakar   (Senegal)

Author keywords

[No Author keywords available]

Indexed keywords

GAG PROTEIN; VIRUS PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CD4+ T LYMPHOCYTE; CELLULAR IMMUNITY; CLINICAL ARTICLE; CONTROLLED STUDY; CORRELATION ANALYSIS; CROSS REACTION; ENZYME LINKED IMMUNOSORBENT ASSAY; ENZYME LINKED IMMUNOSPOT ASSAY; GENE REPLICATION; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1 INFECTION; HUMAN IMMUNODEFICIENCY VIRUS 2 INFECTION; IMMUNE RESPONSE; MICROBIAL DIVERSITY; PRIORITY JOURNAL; SEQUENCE HOMOLOGY; VIRUS REPLICATION;

ADULT; AMINO ACID SEQUENCE; BELGIUM; CASE-CONTROL STUDIES; CD8-POSITIVE T-LYMPHOCYTES; CELLS, CULTURED; COHORT STUDIES; CROSS REACTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; EPITOPES; FEMALE; GENE PRODUCTS, GAG; HIV INFECTIONS; HIV SERONEGATIVITY; HIV-1; HIV-2; HUMANS; INTERFERON TYPE II; LEUKOCYTES, MONONUCLEAR; MALE; MIDDLE AGED; MOLECULAR SEQUENCE DATA; SENEGAL; SENSITIVITY AND SPECIFICITY; T-LYMPHOCYTES;

HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN IMMUNODEFICIENCY VIRUS 2;

EID: 50149098559     PISSN: 0022538X     EISSN: None     Source Type: Journal    
DOI: 10.1128/JVI.00027-08     Document Type: Article

References (33)

1. Adjorlolo-Johnson, G., K. M. De Cock, E. Ekpini, K. M. Vetter, T. Sibailly, K. Brattegaard, D. Yavo, R. Doorly, J. P. Whitaker, L. Kestens, C. Y. Ou, J. R. George, and H. D. Gayle. 1994. Prospective comparison of mother-to-child transmission of HIV-1 and HIV-2 in Abidjan, Ivory Coast. JAMA 272:462-466.
2. Alatrakchi, N., F. Damond, S. Matheron, S. Beretta-Tempelhoff, P. Campa, G. Carcelain, F. Brun-Vezinet, and B. Autran. 2006. Proliferative, IFNγ and IL-2-producing T-cell responses to HIV-2 in untreated HIV-2 infection. AIDS 20:29-34.
3. Ariyoshi, K., N. Berry, A. Wilkins, D. Ricard, P. Aaby, A. Naucler, P. T. Ngom, O. Jobe, S. Jaffar, F. Dias, R. S. Tedder, and H. Whittle. 1996. A community-based study of human immunodeficiency virus type 2 provirus load in rural village in West Africa. J. Infect. Dis. 173:245-248.
4. Currier, J. R., W. E. Dowling, K. M. Wasunna, U. Alam, C. J. Mason, M. L. Robb, J. K. Carr, F. E. McCutchan, D. L. Birx, and J. H. Cox. 2003. Detection of high frequencies of HIV-1 cross-subtype reactive CD8 T lymphocytes in the peripheral blood of HIV-1-infected Kenyans. AIDS 17:2149-2157.
5. Dorrell, L., T. Dong, G. S. Ogg, S. Lister, S. McAdam, T. Rostron, C. Conlon, A. J. McMichael, and S. L. Rowland-Jones. 1999. Distinct recognition of non-clade B human immunodeficiency virus type 1 epitopes by cytotoxic T lymphocytes generated from donors infected in Africa. J. Virol. 73:1708-1714.
6. Dorrell, L., B. E. Willcox, E. Y. Jones, G. Gillespie, H. Njai, S. Sabally, A. Jaye, K. DeGleria, T. Rostron, E. Lepin, A. McMichael, H. Whittle, and S. Rowland-Jones. 2001. Cytotoxic T lymphocytes recognize structurally diverse, clade-specific and cross-reactive peptides in human immunodeficiency virus type-1 gag through HLA-B53. Eur. J. Immunol. 31:1747-1756.
7. + T-cell help distinguishes HIV-2 from HIV-1 infection. J. Immunol. 176:6973-6981.
8. Geels, M. J., S. A. Dubey, K. Anderson, E. Baan, M. Bakker, G. Pollakis, W. A. Paxton, J. W. Shiver, and J. Goudsmit. 2005. Broad cross-clade T-cell responses to gag in individuals infected with human immunodeficiency virus type 1 non-B clades (A to G): importance of HLA anchor residue conservation. J. Virol. 79:11247-11258.
9. + T-cell responses to human immunodeficiency viruses type 2 (HIV-2) and type 1 (HIV-1) gag proteins are distinguishable by magnitude and breadth but not cellular phenotype. Eur. J. Immunol. 35:1445-1453.
10. Gotch, F., S. N. McAdam, C. E. Allsopp, A. Gallimore, J. Elvin, M. P. Kieny, A. V. Hill, A. J. McMichael, and H. C. Whittle. 1993. Cytotoxic T cells in HIV2 seropositive Gambians: identification of a virus-specific MHC-restricted peptide epitope. J. Immunol. 151:3361-3369.
11. + T-cell decline in human immunodeficiency virus (HIV) type 1- and HIV-2-infected individuals from Senegal, West Africa. J. Infect. Dis. 185:905-914.
12. + T-cell anergy. PLoS ONE 2:e300.
13. Gueudin, M., F. Damond, J. Braun, A. Taieb, V. Lemee, J. C. Plantier, G. Chene, S. Matheron, F. Brun-Vezinet, and F. Simon. 2008. Differences in proviral DNA load between HIV-1- and HIV-2-infected patients. AIDS 22:211-215.
14. Hamel, D. J., J. L. Sankale, G. Eisen, S. T. Meloni, C. Mullins, A. Gueye- Ndiaye, S. Mboup, and P. J. Kanki. 2007. Twenty years of prospective molecular epidemiology in Senegal: changes in HIV diversity. AIDS Res. Hum. Retrovir. 23:1189-1196.
15. + cells is faster in HIV-1 than in HIV-2 infection. J. Acquir. Immune. Defic. Syndr. Hum. Retrovirol. 16:327-332.
16. Jaye, A., R. Sarge-Njie, M. F. Schim van der Loeff, J. Todd, A. Alabi, S. Sabally, T. Corrah, and H. Whittle. 2004. No differences in cellular immune responses between asymptomatic HIV type 1- and type 2-infected Gambian patients. J. Infect. Dis. 189:498-505.
17. Jennes, W., L. Kestens, D. F. Nixon, and B. L. Shacklett. 2002. Enhanced ELISPOT detection of antigen-specific T-cell responses from cryopreserved specimens with addition of both IL-7 and IL-15: the Amplispot assay. J. Immunol. Methods 270:99-108.
18. Kanki, P. J., K. U. Travers, S. Mboup, C. C. Hsieh, R. G. Marlink, A. Gueye-Ndiaye, T. Siby, I. Thior, M. Hernandez-Avila, J. L. Sankale, I. Ndoye, and M. E. Essex. 1994. Slower heterosexual spread of HIV-2 than HIV-1. Lancet 343:943-946.
19. Karlsson, A. C., A. K. Iversen, J. M. Chapman, T. de Oliviera, G. Spotts, A. J. McMichael, M. P. Davenport, F. M. Hecht, and D. F. Nixon. 2007. Sequential broadening of CTL responses in early HIV-1 infection is associated with viral escape. PLoS ONE 2:e225.
20. Leligdowicz, A., I. M. Yindom, C. Onyango, R. Sarge-Njie, A. Alabi, M. Cotten, T. Vincent, C. da Costa, P. Aaby, A. Jaye, T. Dong, A. McMichael, H. Whittle, and S. Rowland-Jones. 2007. Robust Gag-specific T-cell responses characterize viremia control in HIV-2 infection. J. Clin. Investig. 117:3067-3074.
21. Lemey, P., S. L. Kosakovsky Pond, A. J. Drummond, O. G. Pybus, B. Shapiro, H. Barroso, N. Taveira, and A. Rambaut. 2007. Synonymous substitution rates predict HIV disease progression as a result of underlying replication dynamics. PLoS Comput. Biol. 3:e29.
22. + TCR heterogeneity and functional flexibility in HIV-2 compared to HIV-1 infection. J. Immunol. 171:307-316.
23. MacNeil, A., J. L. Sankale, S. T. Meloni, A. D. Sarr, S. Mboup, and P. Kanki. 2007. Long-term intrapatient viral evolution during HIV-2 infection. J. Infect. Dis. 195:726-733.
24. Marlink, R., P. Kanki, I. Thior, K. Travers, G. Eisen, T. Siby, I. Traore, C. C. Hsieh, M. C. Dia, E. H. Gueye, J. Hellinger, A. Gueyendiaye, J. L. Sankale, I. Ndoye, S. Mboup, and M. Essex. 1994. Reduced rate of disease development after HIV-2 infection as compared to HIV-1. Science 265:1587-1590.
25. Martinez-Steele, E., A. A. Awasana, T. Corrah, S. Sabally, M. van der Sande, A. Jaye, T. Togun, R. Sarge-Njie, S. J. McConkey, H. Whittle, and M. F. Schim van der Loeff. 2007. Is HIV-2-induced AIDS different from HIV-1-associated AIDS? Data from a West African clinic. AIDS 21:317-324.
26. Popper, S. J., A. D. Sarr, A. Gueye-Ndiaye, S. Mboup, M. E. Essex, and P. J. Kanki. 2000. Low plasma human immunodeficiency virus type 2 viral load is independent of proviral load: low virus production in vivo. J. Virol. 74:1554-1557.
27. Popper, S. J., A. D. Sarr, K. U. Travers, A. Gueye-Ndiaye, S. Mboup, M. E. Essex, and P. J. Kanki. 1999. Lower human immunodeficiency virus (HIV) type 2 viral load reflects the difference in pathogenicity of HIV-1 and HIV-2. J. Infect. Dis. 180:1116-1121.
28. Sarr, A. D., J. L. Sankale, A. Gueye-Ndiaye, M. Essex, S. Mboup, and P. J. Kanki. 2000. Genetic analysis of HIV type 2 in monotypic and dual HIV infections. AIDS Res. Hum. Retrovir. 16:295-298.
29. Schramm, B., M. L. Penn, E. H. Palacios, R. M. Grant, F. Kirchhoff, and M. A. Goldsmith. 2000. Cytopathicity of human immunodeficiency virus type 2 (HIV-2) in human lymphoid tissue is coreceptor dependent and comparable to that of HIV-1. J. Virol. 74:9594-9600.
30. Streeck, H., H. Jessen, G. Alter, N. Teigen, M. T. Waring, A. Jessen, I. Stahmer, J. van Lunzen, M. Lichterfeld, X. Gao, T. M. Allen, M. Carrington, B. D. Walker, J. K. Rockstroh, and M. Altfeld. 2006. Immunological and virological impact of highly active antiretroviral therapy initiated during acute HIV-1 infection. J. Infect. Dis. 194:734-739.
31. + T cells with whole soluble gag protein in HIV-infected subjects. J. Acquir. Immune. Defic. Syndr. 41:548-556.
32. van der Loeff, M. F., A. A. Awasana, R. Sarge-Njie, M. van der Sande, A. Jaye, S. Sabally, T. Corrah, S. J. McConkey, and H. C. Whittle. 2006. Sixteen years of HIV surveillance in a West African research clinic reveals divergent epidemic trends of HIV-1 and HIV-2. Int. J. Epidemiol. 35:1322-1328.
33. Zheng, N. N., N. B. Kiviat, P. S. Sow, S. E. Hawes, A. Wilson, H. Diallo-Agne, C. W. Critchlow, G. S. Gottlieb, L. Musey, and M. J. McElrath. 2004. Comparison of human immunodeficiency virus (HIV)-specific T-cell responses in HIV-1- and HIV-2-infected individuals in Senegal. J. Virol. 78:13934-13942.