IL-6 as a regulatory factor of the humoral response during pregnancy

American Journal of Reproductive Immunology

Volumn 60, Issue 3, 2008, Pages 197-203

  Dubinsky, Valeria ^a   Junovich, Gisela ^a   Gentile, Teresa ^a   Gutiérrez, Gabriela ^a  

^a CONICET/UBA ^*  (Argentina)

Author keywords

Abortion; Asymmetric antibodies; Cytokines; Parity status

Indexed keywords

IMMUNOGLOBULIN G; INTERLEUKIN 6; RECOMBINANT INTERLEUKIN 6;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIBODY PRODUCTION; ANTIGEN EXPRESSION; ANTIGEN FUNCTION; ARTICLE; BAGG ALBINO MOUSE; CBA MOUSE; CONCENTRATION RESPONSE; CONTROLLED STUDY; FEMALE; HUMORAL IMMUNITY; IMMUNOREGULATION; MOUSE; MULTIPARA; NONHUMAN; PLACENTA; PREGNANCY; PRIORITY JOURNAL; RECURRENT ABORTION;

ABORTION, INDUCED; ANIMALS; HUMANS; IMMUNOGLOBULIN G; INTERLEUKIN-6; MICE; MICE, INBRED BALB C; MICE, INBRED CBA; MICE, INBRED DBA; MICE, KNOCKOUT; RECOMBINANT PROTEINS;

EID: 50149085320     PISSN: 10467408     EISSN: 16000897     Source Type: Journal    
DOI: 10.1111/j.1600-0897.2008.00614.x     Document Type: Article

References (34)

1. Chaouat G, Zourbas S, Ostojic S, Lappree-Delage G, Dubanchet S, Ledee N, Martal J: A brief review of recent data on some cytokine expressions at the materno-foetal interface which might challenge the classical Th1/Th2 dichotomy. Am J Reprod Immunol 2002; 53:241-256.
2. Chaouat G, Ledee-Bataille N, Dubanchet S, Zourbas S, Sandra O, Martal J: TH1/TH2 paradigm in pregnancy: Paradigm lost? Cytokines in pregnancy/ early abortion: Reexamining the TH1/TH2 paradigm. Int Arch Allergy Immunol 2004; 134:93-119.
3. Chaouat G, Ledee-Bataille N, Zourbas S, Ostojic S, Dubanchet S, Martal J, Frydman R: Cytokines, implantation Rnd early abortion: re-examining the Th1/Th2 paradigm leads to question the single pathway, single therapy concept. Am J Reprod Immunol 2003; 50:177-186. Review.
4. Diehl S, Rincon M: The two faces of IL-6 on Th1/Th2 differentiation. Mol Immunol 2002; 39: 531-536. Review. Postepy Biochem. 2006; 52(2):194-203.
5. Augustyniak D, Majkowska-Skrobek G, Basiewicz-Worsztynowicz B, Jankowski A: The role of IL-6/sIL-6R complex and its natural inhibitor sgp130 in modulation of inflammatory process. Postepy Biochem 2006; 52:194-203.
6. Jones SA: Directing transition from innate to acquired immunity: defining a role for IL-6. J Immunol 2005; 175:3463-3468.
7. Jasper MJ, Tremellen KP, Robertson SA: Reduced expression of IL-6 and IL-1alpha mRNAs in secretory phase endometrium of women with recurrent miscarriage. J Reprod Immunol 2007; 73:74-84.
8. Koumantaki Y, Matalliotakis I, Sifakis S, Kyriakou D, Neonaki M, Goymenou A, Koumantakis E: Detection of interleukin-6, interleukin-8, and interleukin-11 in plasma from women with spontaneous abortion. Eur J Obstet Gynecol Reprod Biol 2001; 98: 66-71.
9. Robertson SA, O'Connell A, Pensa K, Ramsay A: Impaired implantation, fetal development and parturition in interleukin-6 deficient mice. Am J Reprod Immunol 2001; 46; IPL-11: 69.
10. Mattsson R: Increase in the number of splenic plaque forming cells with length of gestation in untreated pregnant mice. Dev Comp Immunol 1982; 6:339-348.
11. Carter J, Dresser DW: Pregnancy induces an increase in the number immunoglobulin-secreting cell. Immunology 1983; 49:481-490.
12. Mattsson R: Changes in the spleen cell populations of the mouse during pregnancy the influence of the thymus. Dev Comp Immunol 1983; 7:169-178.
13. Sulila P, Mattsson R: Humoral immune activity in CBA/Ca mice during late pregnancy and the post partum period. J Reprod Immunol 1990; 18:259-269.
14. Bernadotte F, Mattsson R: A fraction of murine placental extract enhancement IgA production in cultured splenocytes. J Reprod Immunol 1991; 21:189-202.
15. Dresser DW: The potentiating effect of pregnancy on humoral immune responses of mice. J Reprod Immunol 1991; 20:253-266.
16. Voisin G, Chaouat G: Demonstration, nature and properties of maternal antibodies fixed on placenta and directed against paternal alloantigens. J Reprod Fertil 1974; 21:89-103.
17. Chaouat G, Voisin G, Escalier D, Robert P: Facilitation reaction (enhancing antibodies and suppressor cells) and rejection reaction (sensitized cells) from the mother to the paternal antigens of the conceptus. Clin Exp Immunol 1979; 35:143-224.
18. Bell S, Billington W: Major antipaternal alloantibody induced by murine pregnancy is non-complement fixing IgG1. Nature 1980; 288:387-388.
19. Malan Borel I, Gentile T, Angelucci J, Pividori J, Guala MC, Binaghi R, Margni R: IgG asymmetric molecules with anti-paternal activity isolated from sera and placenta of pregnant human. J Reprod Immunol 1991; 20:129-140.
20. Margni RA, Binaghi RA: Nonprecipitating asymmetric antibodies. Annu Rev Immunol 1988; 6:535-554.
21. Gutiérrez G, Malan Borel I, Margni RA: The placental regulatory factor involved in the asymmetric IgG antibody synthesis responds to IL-6 features. J Reprod Immunol 2001; 49:21-32.
22. Clark DS, McDermott MR, Szewczuk MR: Impairment of host-versus-graft reaction in pregnant mice II. Selective suppression of cytotoxic T-cell generation correlates with soluble suppressors activity and with successful allogeneic pregnancy. Cell Immunol 1980; 52:106-118.
23. Gutiérrez G, Sarto A, Berod L, Canellada A, Gentile T, Pascualini S, Margni RA: Regulation of interleukin-6 fetoplacental levels could be involved in the protective effects of low-molecular weight heparin treatment on murine spontaneous abortion. Am J Reprod Immunol 2004; 51:160-165.
24. Taylor C, Faulk WP: Prevention of recurrent abortions with leukocyte transfusion. Lancet 1981; 2:68.
25. Taylor C, Faulk WP, McIntyre JA: Prevention of recurrent abortions with leukocyte transfusion. J R Soc Med 1985; 78:623.
26. Chavez DJ, McIntyre JA, Colliver JA, Faulk P: Allogeneic matings and immunization have different effects on nulliparous and multiparous mice. J Immunol 1987; 139:85-88.
27. Kopf M, Baumann H, Freer G, Freudenberg M, Lamers M, Kishimoto T, Zinkernagel R, Bluethmann H, Köhler G: Impaired immune and acute-phase responses in interleukin-6-deficient mice. Nature 1994; 368:339-342.
28. Malan Borel I, Menezes Freire S, Canellada A, Margni RA: Effect of rat placental culture supernatants on cellular and humoral immune responses. Am J Reprod Immunol 1997; 38:366-373.
29. Hammaher A, Ward L, Weinstock J, Treutlein H, Yasukawa K, Simpson R: Structure-function analysis of human IL-6: Identification of two distinct regions that are important for receptor binding. Protein Sci 1994; 3:2280-2293.
30. Junovich G, Dubinsky V, Gentile T, Margni RA, Gutierrez G: La multiparidad incrementa la producción de factores capaces de prevenir el aborto. Medicina 2003; 63:550.
31. Raghupathy R, Makhseed M, Azizieh F, Hassan N, Al-azemi M, Shamali A: Maternal Th1 and Th2 type reactivity to placental antigens in normal human pregnancy and unexplained recurrent spontaneous abortion. Cell Immunol 1999; 196:122-130.
32. Laird SM: Cytokine expression in the endometrium of women with implantation failure and recurrent miscarriage. Reprod Biomed Online 2006; 13:13-23.
33. Miranda S, Malan Borel I., Menezes Freire S, Binaghi R, Margni RA: Influence of mouse placental factors on in vitro antibody synthesis. J Reprod Immunol 1996; 30:151-171.
34. Margni RA, Malan Borel I: Paradoxical behavior of asymmetric IgG antibodies. Immunol Rev 1998; 163:77-78.