Detrimental effects of high levels of antioxidant vitamins C and E on placental function: Considerations for the Vitamins in Preeclampsia (VIP) trial

Journal of Obstetrics and Gynaecology Research

Volumn 34, Issue 4, 2008, Pages 504-511

  Aris, Aziz ^a   Leblanc, Samuel ^a   Ouellet, Annie ^a   Moutquin, Jean Marie ^a  

^a CENTRE HOSPITALIER UNIVERSITAIRE DE SHERBROOKE   (Canada)

Author keywords

Antioxidant vitamins C and E in pregnancy; Birthweight; Fetal growth restriction; hCG; Placenta; Preeclampsia; TNF

Indexed keywords

ALPHA TOCOPHEROL; ANTIOXIDANT; ASCORBIC ACID; CHORIONIC GONADOTROPIN; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; CYTOKINE PRODUCTION; CYTOTROPHOBLAST; ENDOTHELIAL DYSFUNCTION; FEMALE; HUMAN; HUMAN TISSUE; IN VITRO STUDY; LOW BIRTH WEIGHT; PLACENTA FUNCTION; PREECLAMPSIA; PREGNANCY OUTCOME; RISK FACTOR; VITAMIN SUPPLEMENTATION;

ADULT; ANTIOXIDANTS; ASCORBIC ACID; CHORIONIC GONADOTROPIN; DOSE-RESPONSE RELATIONSHIP, DRUG; FEMALE; HUMANS; INFANT, NEWBORN; PLACENTA; PREGNANCY; TROPHOBLASTS; TUMOR NECROSIS FACTOR-ALPHA; VITAMIN E;

EID: 50049098584     PISSN: 13418076     EISSN: 14470756     Source Type: Journal    
DOI: 10.1111/j.1447-0756.2008.00722.x     Document Type: Article

References (34)

1. Roberts JM, Lain KY. Recent insights into the pathogenesis of pre-eclampsia. Placenta 2002 23 : 359 372.
2. Sibai BM. Diagnosis and management of gestational hypertension and preeclampsia. Obstet Gynecol 2003 102 : 181 192.
3. Kharfi A, Giguere Y, Sapin V, Masse J, Dastugue B, Forest JC. Trophoblastic remodeling in normal and preeclamptic pregnancies: Implication of cytokines. Clin Biochem 2003 36 : 323 331.
4. Wickens D, Wilkins MH, Lunec J, Ball G, Dormandy TL. Free radical oxidation (peroxidation) products in plasma in normal and abnormal pregnancy. Ann Clin Biochem 1981 18 : 158 162.
5. Hubel CA, McLaughlin MK, Evans RW, Hauth BA, Sims CJ, Roberts JM. Fasting serum triglycerides, free fatty acids, and malondialdehyde are increased in preeclampsia, are positively correlated, and decrease within 48 hours post partum. Am J Obstet Gynecol 1996 174 : 975 982.
6. Mikhail MS, Anyaegbunam A, Garfinkel D, Palan PR, Basu J, Romney SL. Preeclampsia and antioxidant nutrients: Decreased plasma levels of reduced ascorbic acid, alpha-tocopherol, and beta-carotene in women with preeclampsia. Am J Obstet Gynecol 1994 171 : 150 157.
7. Kharfi A, Giguere Y, De Grandpre P, Moutquin JM, Forest JC. Human chorionic gonadotropin (hCG) may be a marker of systemic oxidative stress in normotensive and preeclamptic term pregnancies. Clin Biochem 2005 38 : 717 721.
8. Kharfi Aris A, Leblanc S, Ouellet A, Moutquin JM. Dual action of H2O2 on placental hCG secretion: Implications for oxidative stress in preeclampsia. Clin Biochem 2007 40 : 94 97.
9. Saugstad OD. Hypoxanthine as an indicator of hypoxia: Its role in health and disease through free radical production. Pediatr Res 1988 23 : 143 150.
10. Saugstad OD. Update on oxygen radical disease in neonatology. Curr Opin Obstet Gynecol 2001 13 : 147 153.
11. Poston L, Briley AL, Seed PT, Kelly FJ, Shennan AH. Vitamin C and vitamin E in pregnant women at risk for pre-eclampsia (VIP trial): Randomised placebo-controlled trial. Lancet 2006 367 : 1145 1154.
12. Chappell LC, Seed PT, Briley AL et al. Effect of antioxidants on the occurrence of pre-eclampsia in women at increased risk: A randomised trial. Lancet 1999 354 : 810 816.
13. Rumbold AR, Crowther CA, Haslam RR, Dekker GA, Robinson JS. Vitamins C and E and the risks of preeclampsia and perinatal complications. N Engl J Med 2006 354 : 1796 1806.
14. Polyzos NP, Mauri D, Tsappi M et al. E supplementation during pregnancy for preeclampsia prevention: A systematic review. Obstet Gynecol Surv 2007 62 : 202 206.
15. Mayhew TM, Burton GJ. Methodological problems in placental morphometry: Apologia for the use of stereology based on sound sampling practice. Placenta 1988 9 : 565 581.
16. Guilbert LJ, Winkler-Lowen B. Placental alkaline phosphatase (PLAP) staining and human chorionic gonadotropin (hCG) production in cultures of fresh and cryopreserved cytotrophoblasts isolated by CD9/MHC class I/MHC class II immunoelimination. Placenta 2007 28 : 348 349.
17. Kharb S. Vitamin E and C in preeclampsia. Eur J Obstet Gynecol Reprod Biol 2000 93 : 37 39.
18. Pfaffl MW. A new mathematical model for relative quantification in real-time RT-PCR. Nucleic Acids Res 2001 29 : e45.
19. Tao YX, Lei ZM, Hofmann GE, Rao CV. Human intermediate trophoblasts express chorionic gonadotropin/luteinizing hormone receptor gene. Biol Reprod 1995 53 : 899 904.
20. Han SW, Lei ZM, Rao CV. Treatment of human endometrial stromal cells with chorionic gonadotropin promotes their morphological and functional differentiation into decidua. Mol Cell Endocrinol 1999 147 : 7 16.
21. Chaouat G, Menu E, Delage G et al. Immuno-endocrine interactions in early pregnancy. Hum Reprod 1995 10 : 55 59.
22. Toth P, Lukacs H, Gimes G et al. Clinical importance of vascular LH/hCG receptors - a review. Reprod Biol 2001 1 : 5 11.
23. Hunt JS, Chen HL, Miller L. Tumor necrosis factors: Pivotal components of pregnancy? Biol Reprod 1996 54 : 554 562.
24. Kharfi A, Bureau M, Giguere Y, Moutquin JM, Forest JC. Dissociation between increased apoptosis and expression of the tumor necrosis factor-alpha system in term placental villi with preeclampsia. Clin Biochem 2006 39 : 646 651.
25. Li Y, Matsuzaki N, Masuhiro K et al. Trophoblast-derived tumor necrosis factor-alpha induces release of human chorionic gonadotropin using interleukin-6 (IL-6) and IL-6-receptor-dependent system in the normal human trophoblasts. J Clin Endocrinol Metab 1992 74 : 184 191.
26. Yui J, Garcia-Lloret M, Wegmann TG, Guilbert LJ. Cytotoxicity of tumour necrosis factor-alpha and gamma-interferon against primary human placental trophoblasts. Placenta 1994 15 : 819 835.
27. White LR, Juul R, Skaanes KO, Aasly J. Cytokine enhancement of endothelin ET(B) receptor-mediated contraction in human temporal artery. Eur J Pharmacol 2000 406 : 117 122.
28. Nakamura M, Yoshida H, Arakawa N, Saitoh S, Satoh M, Hiramori K. Effects of tumor necrosis factor-alpha on basal and stimulated endothelium-dependent vasomotion in human resistance vessel. J Cardiovasc Pharmacol 2000 36 : 487 492.
29. Rask-Madsen C, Dominguez H, Ihlemann N, Hermann T, Kober L, Torp-Pedersen C. Tumor necrosis factor-alpha inhibits insulin's stimulating effect on glucose uptake and endothelium-dependent vasodilation in humans. Circulation 2003 108 : 1815 1821.
30. Knackstedt M, Ding JW, Arck PC et al. Activation of the novel prothrombinase, fg12, as a basis for the pregnancy complications spontaneous abortion and pre-eclampsia. Am J Reprod Immunol 2001 46 : 196 210.
31. Cederberg J, Siman CM, Eriksson UJ. Combined treatment with vitamin E and vitamin C decreases oxidative stress and improves fetal outcome in experimental diabetic pregnancy. Pediatr Res 2001 49 : 755 762.
32. Leisser C, Saleh L, Haider S, Husslein H, Sonderegger S, Knofler M. Tumour necrosis factor-alpha impairs chorionic gonadotrophin beta-subunit expression and cell fusion of human villous cytotrophoblast. Mol Hum Reprod 2006 12 : 601 609.
33. Yui J, Hemmings D, Garcia-Lloret M, Guilbert LJ. Expression of the human p55 and p75 tumor necrosis factor receptors in primary villous trophoblasts and their role in cytotoxic signal transduction. Biol Reprod 1996 55 : 400 409.
34. Manna SK, Mukhopadhyay A, Aggarwal BB. Human chorionic gonadotropin suppresses activation of nuclear transcription factor-kappa B and activator protein-1 induced by tumor necrosis factor. J Biol Chem 2000 275 : 13307 13314.