Pharmacovigilance of antimalarial treatment in Uganda: Community perceptions and suggestions for reporting adverse events

Tropical Medicine and International Health

Volumn 13, Issue 9, 2008, Pages 1143-1152

  Bukirwa, Hasifa ^a   Nayiga, Susan ^a   Lubanga, Rosalind ^b   Mwebaza, Norah ^b   Chandler, Clare ^c   Hopkins, Heidi ^d   Talisuna, Ambrose O ^e   Staedke, Sarah G ^c,f  

^a Uganda Malaria Surveillance Project   (Uganda)

^b MAKERERE UNIVERSITY   (Uganda)

^c LONDON SCHOOL OF HYGIENE AND TROPICAL MEDICINE   (United Kingdom)

^d UNIVERSITY OF CALIFORNIA   (United States)

^e MINISTRY OF HEALTH   (Uganda)

^f MULAGO HOSPITAL   (Uganda)

Author keywords

Adverse event reporting; Antimalarials; Focus group discussion; Pharmacovigilance; Uganda

Indexed keywords

AMODIAQUINE; ANTIMALARIAL AGENT; ARTEMETHER PLUS BENFLUMETOL; CHLOROQUINE; DIHYDROARTEMISININ PLUS PIPERAQUINE; DUOCOTECXIN; FANSIDAR; HERBACEOUS AGENT; METAKELFIN; PRIMAQUINE; QUALAQUIN; QUININE; UNCLASSIFIED DRUG;

ANTIMALARIAL AGENT; DISEASE TREATMENT; HEALTH CARE; HEALTH WORKER; MALARIA; PERCEPTION;

ARTICLE; BLURRED VISION; CHILD; COMMUNITY CARE; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; DATA ANALYSIS; DECREASED APPETITE; DIARRHEA; DIZZINESS; DRUG SURVEILLANCE PROGRAM; EXPECTATION; FEMALE; FEVER; HEALTH CARE PERSONNEL; HUMAN; INFORMATION PROCESSING; INJECTION SITE SWELLING; MAJOR CLINICAL STUDY; MALARIA; MALE; MEDICAL DOCUMENTATION; MENTAL DISEASE; OTOTOXICITY; PARALYSIS; PATIENT INFORMATION; PERCEPTION; PRURITUS; RETROSPECTIVE STUDY; RURAL AREA; SELF MEDICATION; SENSORY DYSFUNCTION; SKIN BURNING SENSATION; STEVENS JOHNSON SYNDROME; TINNITUS; TREATMENT OUTCOME; UGANDA; URBAN AREA; VOMITING; WEAKNESS;

ADVERSE DRUG REACTION REPORTING SYSTEMS; ANTIMALARIALS; CROSS-SECTIONAL STUDIES; FEMALE; FEVER; FOCUS GROUPS; HEALTH KNOWLEDGE, ATTITUDES, PRACTICE; HUMANS; MALARIA; MALE; PATIENT ACCEPTANCE OF HEALTH CARE; RETROSPECTIVE STUDIES; RURAL HEALTH; UGANDA; URBAN HEALTH;

AFRICA; EAST AFRICA; SUB-SAHARAN AFRICA; UGANDA;

EID: 50049095766     PISSN: 13602276     EISSN: 13653156     Source Type: Journal    
DOI: 10.1111/j.1365-3156.2008.02119.x     Document Type: Article

References (33)

1. Dellicour S, Hall S, Chandramohan D Greenwood B (2007) The safety of artemisinins during pregnancy: a pressing question. Malaria Journal 6, 15.
2. Deressa W, Ali A Enqusellassie F (2003) Self-treatment of malaria in rural communities Butajira southern Ethiopia. Bulletin of the World Health Organization 81, 261 268.
3. Figueiras A, Tato F, Fontainas J, Takkouche B Gestal-Otero JJ (2001) Physicians' attitudes towards voluntary reporting of adverse drug events. Journal of Evaluation in Clinical Practice 7, 347 354.
4. Hazell L Shakir SA (2006) Under-reporting of adverse drug reactions: a systematic review. Drug Safety 29, 385 396.
5. Herdeiro MT, Figueiras A, Polonia J Gestal-Otero JJ (2005) Physicians' attitudes and adverse drug reaction reporting: a case-control study in Portugal. Drug Safety 28, 825 833.
6. Kamat VR (2006) "I thought it was only ordinary fever!" Cultural knowledge and the micropolitics of therapy seeking for childhood febrile illness in Tanzania. Social Science and Medicine 62, 2945 2959.
7. Kengeya-Kayondo JF, Seeley JA, Kajura-Bajenja E et al. (1994) Recognition, treatment seeking, behaviour and perception of cause of malaria among rural women in Uganda. Acta Tropica 58, 267 273.
8. Khoza S, Madungwe I, Nyambayo P, Mthethwa J Chikuni O (2004) Adverse drug reactions reporting at a referral hospital in Zimbabwe. Central African Journal of Medicine 50, 104 107.
9. Li Q, Zhang SM, Chen HT et al. (2004) Awareness and attitudes of healthcare professionals in Wuhan China to the reporting of adverse drug reactions. Chinese Medical Journal 117, 856 861.
10. Lubanga RG, Norman S, Ewbank D Karamagi C (1997) Maternal diagnosis and treatment of children's fever in an endemic malaria zone of Uganda: implications for the malaria control programme. Acta Tropica 68, 53 64.
11. Marsh VM, Mutemi WM, Muturi J et al. (1999) Changing home treatment of childhood fevers by training shop keepers in rural Kenya. Tropical Medicine and International Health 4, 383 389.
12. Mbonye AK (2003) Prevalence of childhood illnesses and care-seeking practices in rural Uganda. Scientific World Journal 3, 721 730.
13. Mccombie SC (1996) Treatment seeking for malaria: a review of recent research. Social Science and Medicine 43, 933 945.
14. Mccombie SC (2002) Self-treatment for malaria: the evidence and methodological issues. Health Policy Plan 17, 333 344.
15. Mehta U, Durrheim D, Mabuza A, Blumberg L, Allen E Barnes KI (2007) Malaria pharmacovigilance in Africa: lessons from a pilot project in Mpumalanga Province, South Africa. Drug Safety 30, 899 910.
16. Montgomery CM, Mwengee W, Kong'ong'o M Pool R (2006) 'To help them is to educate them': power and pedagogy in the prevention and treatment of malaria in Tanzania. Tropical Medicine and International Health 11, 1661 1669.
17. Morgan D (1997) Focus Groups as Qualitative Research. Sage, London.
18. Mwenesi HA (1994) The role of drug delivery systems in health care: the case of self-medication. African Journal of Health Science 1, 42 48.
19. Nsungwa-Sabiiti J, Kallander K, Nsabagasani X et al. (2004) Local fever illness classifications: implications for home management of malaria strategies. Tropical Medicine and International Health 9, 1191 1199.
20. Nyamongo IK (1999) Home case management of malaria: an ethnographic study of lay people's classification of drugs in Suneka division Kenya. Tropical Medicine and International Health 4, 736 743.
21. Okello P, Byaruhanga AM, Correwyn A et al. (2006) Variation in malaria transmission intensity in seven sites throughout Uganda. American Journal of Tropical Medicine and Hygiene 75, 219 225.
22. Pilkington H, Mayombo J, Aubouy N Deloron P (2004) Malaria from natural to supernatural: a qualitative study of mothers' reactions to fever (Dienga Gabon). Journal of Epidemiology and Community Health 58, 826 830.
23. Pirmohamed M, Atuah KN, Dodoo AN Winstanley P (2007) Pharmacovigilance in developing countries. BMJ 335, 462.
24. Ruebush TK, Kern MK, Campbell CC Oloo AJ (1995) Self-treatment of malaria in a rural area of western Kenya. Bulletin of the World Health Organization 73, 229 236.
25. Simooya O (2005) The WHO 'Roll Back Malaria Project': planning for adverse event monitoring in Africa. Drug Safety 28, 277 286.
26. Strauss A (1987) Qualitative Analysis for Social Scientists. Cambridge University Press, Cambridge.
27. Talisuna AO, Staedke SG D'alessandro U (2006) Pharmacovigilance of antimalarial treatment in Africa: is it possible? Malaria Journal 5, 50.
28. UNICEF (2008) Uganda Statistics. Available at : http://wwwuniceforg/ infobycountry/uganda_statisticshtml (accessed on 17 March 2008).
29. Uppsala Monitoring Centre (2000) Safety Monitoring of Medicinal Products: Guidelines for Setting up and Running a Pharmacovigilance Centre. WHO Collaborating Centre for International Drug Monitoring, Uppsala.
30. Ward SA, Sevene EJ, Hastings IM, Nosten F Mcgready R (2007) Antimalarial drugs and pregnancy: safety pharmacokinetics and pharmacovigilance. Lancet Infectious Disease 7, 136 144.
31. Williams HA Jones CO (2004) A critical review of behavioral issues related to malaria control in sub-Saharan Africa: what contributions have social scientists made? Social Science and Medicine 59, 501 523.
32. Williams HA, Kachur SP, Nalwamba NC, Hightower A, Simoonga C Mphande PC (1999) A community perspective on the efficacy of malaria treatment options for children in Lundazi district, Zambia. Tropical Medicine and International Health 4, 641 652.
33. World Health Organization (2006) The Safety of Medicines in Public Health Programmes: Pharmacovigilance an Essential Tool. World Health Organization, Geneva.