HCCS1 overexpression induces apoptosis via cathepsin D and intracellular calcium, and HCCS1 disruption in mice causes placental abnormality

Cell Death and Differentiation

Volumn 15, Issue 9, 2008, Pages 1481-1490

  Gan, Y ^a   Zhao, X ^b   Hu, J ^a   Wang, Z G ^b   Zhao, X T ^a  

^a SHANGHAI CANCER INSTITUTE   (China)

^b Shanghai Research Center for Model Organisms   (China)

Author keywords

[No Author keywords available]

Indexed keywords

ADENOVIRUS VECTOR; CALCIUM ION; CASPASE; CATHEPSIN D; CYTOCHROME C; HEPATOCELLULAR CARCINOMA SUPPRESSOR 1 PROTEIN; PROTEIN BAX; TUMOR SUPPRESSOR PROTEIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; APOPTOSIS; ARTICLE; CALCIUM CELL LEVEL; CELL PROLIFERATION; CONTROLLED STUDY; CYTOSOL; ENZYME ACTIVATION; ENZYME RELEASE; FEMALE; GENE DISRUPTION; GENE INSERTION; GENE OVEREXPRESSION; HUMAN; HUMAN CELL; LETHALITY; LIVER CARCINOGENESIS; LIVER CELL CARCINOMA; MITOCHONDRIAL MEMBRANE; MOUSE; NONHUMAN; PATHOGENESIS; PLACENTA DISORDER; PRIORITY JOURNAL; TROPHOBLAST;

ANIMALS; APOPTOSIS; BCL-2-ASSOCIATED X PROTEIN; BH3 INTERACTING DOMAIN DEATH AGONIST PROTEIN; CALCIUM; CARCINOMA, HEPATOCELLULAR; CASPASES; CATHEPSIN D; CELL LINE, TUMOR; CYTOCHROMES C; FEMALE; GENES, LETHAL; HUMANS; LIVER NEOPLASMS; LYSOSOMES; MICE; MICE, KNOCKOUT; PLACENTA; PREGNANCY; TUMOR SUPPRESSOR PROTEINS;

ADENOVIRIDAE; MUS;

EID: 49949091264     PISSN: 13509047     EISSN: 14765403     Source Type: Journal    
DOI: 10.1038/cdd.2008.73     Document Type: Article

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