메뉴 건너뛰기




Volumn 86, Issue 1, 2008, Pages 10-15

Promises and obstacles for the blockade of CD40-CD40L interactions in allotransplantation

Author keywords

CD154; CD40; CD8+ Treg; Costimulation; Tolerance; Transplantation

Indexed keywords

ANTIBODY; BELATACEPT; CALCINEURIN INHIBITOR; CD40 ANTIGEN; CD40 LIGAND; CD40 LIGAND MONOCLONAL ANTIBODY; CD45RB ANTIBODY; CYCLOSPORIN A; CYTOTOXIC T LYMPHOCYTE ANTIGEN 4 ANTIBODY; IMMUNOSUPPRESSIVE AGENT; INTERLEUKIN ANTIBODY; LYMPHOCYTE FUNCTION ASSOCIATED ANTIGEN 1 ANTIBODY; RAPAMYCIN; THYMOCYTE ANTIBODY; UNCLASSIFIED DRUG; MONOCLONAL ANTIBODY;

EID: 49849101512     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31817c4b97     Document Type: Short Survey
Times cited : (29)

References (82)
  • 1
    • 2942589284 scopus 로고    scopus 로고
    • The CD154-CD40 costimulation pathway in organ transplantation
    • Zhai Y, Kupiec-Weglinski JW. The CD154-CD40 costimulation pathway in organ transplantation. Transplant Reviews 2004; 18: 10.
    • (2004) Transplant Reviews , vol.18 , pp. 10
    • Zhai, Y.1    Kupiec-Weglinski, J.W.2
  • 2
    • 33846234751 scopus 로고    scopus 로고
    • A costimulatory function for T cell CD40
    • Munroe ME, Bishop GA. A costimulatory function for T cell CD40. J Immunol 2007; 178: 671.
    • (2007) J Immunol , vol.178 , pp. 671
    • Munroe, M.E.1    Bishop, G.A.2
  • 4
    • 0030744132 scopus 로고    scopus 로고
    • Functions of CD40 on B cells, dendritic cells and other cells
    • Van Kooten C, Banchereau J. Functions of CD40 on B cells, dendritic cells and other cells. Curr Opin Immunol 1997; 9: 330.
    • (1997) Curr Opin Immunol , vol.9 , pp. 330
    • Van Kooten, C.1    Banchereau, J.2
  • 5
    • 33746069706 scopus 로고    scopus 로고
    • Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival
    • Lesley R, Kelly LM, Xu Y, et al. Naive CD4 T cells constitutively express CD40L and augment autoreactive B cell survival. Proc Natl Acad Sci USA 2006; 103: 10717.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 10717
    • Lesley, R.1    Kelly, L.M.2    Xu, Y.3
  • 6
    • 0033980596 scopus 로고    scopus 로고
    • + T cells and prolonged graft survival in a CTLA4-dependent manner
    • + T cells and prolonged graft survival in a CTLA4-dependent manner. J Immunol 2000; 164: 512.
    • (2000) J Immunol , vol.164 , pp. 512
    • Iwakoshi, N.N.1    Mordes, J.P.2    Markees, T.G.3
  • 7
    • 0034695882 scopus 로고    scopus 로고
    • CD40 ligand (CD154) triggers a short-term CD4( + ) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis
    • Blair PJ, Riley JL, Harlan DM, et al. CD40 ligand (CD154) triggers a short-term CD4( + ) T cell activation response that results in secretion of immunomodulatory cytokines and apoptosis. J Exp Med 2000; 191: 651.
    • (2000) J Exp Med , vol.191 , pp. 651
    • Blair, P.J.1    Riley, J.L.2    Harlan, D.M.3
  • 8
    • 0142105503 scopus 로고    scopus 로고
    • Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade
    • Monk NJ, Hargreaves RE, Marsh JE, et al. Fc-dependent depletion of activated T cells occurs through CD40L-specific antibody rather than costimulation blockade. Nat Med 2003; 9: 1275.
    • (2003) Nat Med , vol.9 , pp. 1275
    • Monk, N.J.1    Hargreaves, R.E.2    Marsh, J.E.3
  • 9
    • 23244459502 scopus 로고    scopus 로고
    • Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance: The interplay of clonal anergy and immune regulation
    • Quezada SA, Bennett K, Blazar BR, et al. Analysis of the underlying cellular mechanisms of anti-CD154-induced graft tolerance: The interplay of clonal anergy and immune regulation. J Immunol 2005; 175: 771.
    • (2005) J Immunol , vol.175 , pp. 771
    • Quezada, S.A.1    Bennett, K.2    Blazar, B.R.3
  • 10
    • 0037111521 scopus 로고    scopus 로고
    • + alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: Implications for anti-CD154 immunotherapy
    • + alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: Implications for anti-CD154 immunotherapy. J Immunol 2002; 169:5401.
    • (2002) J Immunol , vol.169 , pp. 5401
    • Van Maurik, A.1    Herber, M.2    Wood, K.J.3
  • 12
    • 33646472267 scopus 로고    scopus 로고
    • + T regulatory cell induction and function in transplant recipients after CD154 blockade is TLR4 independent
    • + T regulatory cell induction and function in transplant recipients after CD154 blockade is TLR4 independent. J Immunol 2006; 176: 5988.
    • (2006) J Immunol , vol.176 , pp. 5988
    • Zhai, Y.1    Meng, L.2    Gao, F.3
  • 13
    • 29344468651 scopus 로고    scopus 로고
    • Dimeric but not mono-meric soluble CD40 prolongs allograft survival and generates regulatory T cells that inhibit CTL function
    • Masunaga T, Yamashita K, Sakihama H, et al. Dimeric but not mono-meric soluble CD40 prolongs allograft survival and generates regulatory T cells that inhibit CTL function. Transplantation 2005; 80: 1614.
    • (2005) Transplantation , vol.80 , pp. 1614
    • Masunaga, T.1    Yamashita, K.2    Sakihama, H.3
  • 15
    • 33748320914 scopus 로고    scopus 로고
    • Mast cells are essential intermediaries in regulatory T-cell tolerance
    • Lu LF, Lind EF, Gondek DC, et al. Mast cells are essential intermediaries in regulatory T-cell tolerance. Nature 2006; 442: 997.
    • (2006) Nature , vol.442 , pp. 997
    • Lu, L.F.1    Lind, E.F.2    Gondek, D.C.3
  • 16
    • 0037083278 scopus 로고    scopus 로고
    • Prolonged blockade of CD40-CD40 ligand interactions by gene transfer of CD40Ig results in long-term heart allograft survival and donor-specific hyporesponsive-ness, but does not prevent chronic rejection
    • Guillot C, Guillonneau C, Mathieu P. et al. Prolonged blockade of CD40-CD40 ligand interactions by gene transfer of CD40Ig results in long-term heart allograft survival and donor-specific hyporesponsive-ness, but does not prevent chronic rejection. J Immunol 2002; 168: 1600.
    • (2002) J Immunol , vol.168 , pp. 1600
    • Guillot, C.1    Guillonneau, C.2    Mathieu, P.3
  • 17
    • 0032103285 scopus 로고    scopus 로고
    • Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4( +) T cells, interferon-gamma, and CTLA4
    • Markees TG, Phillips NE, Gordon EJ, et al. Long-term survival of skin allografts induced by donor splenocytes and anti-CD154 antibody in thymectomized mice requires CD4( +) T cells, interferon-gamma, and CTLA4. J Clin Invest 1998; 101: 2446.
    • (1998) J Clin Invest , vol.101 , pp. 2446
    • Markees, T.G.1    Phillips, N.E.2    Gordon, E.J.3
  • 18
    • 33646238468 scopus 로고    scopus 로고
    • Heme oxygenase-1 is essential for and promotes tolerance to transplanted organs
    • Yamashita K, Ollinger R, McDaid J, et al. Heme oxygenase-1 is essential for and promotes tolerance to transplanted organs. Faseb J 2006; 20: 776.
    • (2006) Faseb J , vol.20 , pp. 776
    • Yamashita, K.1    Ollinger, R.2    McDaid, J.3
  • 19
    • 15844404353 scopus 로고    scopus 로고
    • Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways
    • Larsen CP, Elwood ET, Alexander DZ, et al. Long-term acceptance of skin and cardiac allografts after blocking CD40 and CD28 pathways. Nature 1996; 381: 434.
    • (1996) Nature , vol.381 , pp. 434
    • Larsen, C.P.1    Elwood, E.T.2    Alexander, D.Z.3
  • 20
    • 0042532322 scopus 로고    scopus 로고
    • Heterologous immunity provides a potent barrier to transplantation tolerance
    • Adams AB, Williams MA, Jones TR, et al. Heterologous immunity provides a potent barrier to transplantation tolerance. J Clin Invest 2003; 111: 1887.
    • (2003) J Clin Invest , vol.111 , pp. 1887
    • Adams, A.B.1    Williams, M.A.2    Jones, T.R.3
  • 21
    • 0031846313 scopus 로고    scopus 로고
    • CD40 ligand-mediated interactions are involved in the generation of memory CD8( + ) cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection
    • Borrow P, Tough DF, Eto D, et al. CD40 ligand-mediated interactions are involved in the generation of memory CD8( + ) cytotoxic T lymphocytes (CTL) but are not required for the maintenance of CTL memory following virus infection. J Virol 1998; 72: 7440.
    • (1998) J Virol , vol.72 , pp. 7440
    • Borrow, P.1    Tough, D.F.2    Eto, D.3
  • 22
    • 12644262358 scopus 로고    scopus 로고
    • CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates
    • Kirk AD, Harlan DM, Armstrong NN, et al. CTLA4-Ig and anti-CD40 ligand prevent renal allograft rejection in primates. Proc Natl Acad Sci USA 1997; 94: 8789.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 8789
    • Kirk, A.D.1    Harlan, D.M.2    Armstrong, N.N.3
  • 23
    • 0032996025 scopus 로고    scopus 로고
    • Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates
    • Kirk AD, BurklyLC, Batty DS, etal. Treatment with humanized monoclonal antibody against CD154 prevents acute renal allograft rejection in nonhuman primates. Nat Med 1999; 5: 686.
    • (1999) Nat Med , vol.5 , pp. 686
    • Kirk, A.D.1    Burkly, L.C.2    Batty, D.S.3
  • 24
    • 0037443913 scopus 로고    scopus 로고
    • Prevention of kidney allograft rejection using anti-CD40 and anti-CD86 in primates
    • Haanstra KG, Ringers J, Sick EA, et al. Prevention of kidney allograft rejection using anti-CD40 and anti-CD86 in primates. Transplantation 2003; 75: 637.
    • (2003) Transplantation , vol.75 , pp. 637
    • Haanstra, K.G.1    Ringers, J.2    Sick, E.A.3
  • 25
    • 19944412462 scopus 로고    scopus 로고
    • Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival
    • Adams AB, Shirasugi N, Jones TR, et al. Development of a chimeric anti-CD40 monoclonal antibody that synergizes with LEA29Y to prolong islet allograft survival. J Immunol 2005; 174: 542.
    • (2005) J Immunol , vol.174 , pp. 542
    • Adams, A.B.1    Shirasugi, N.2    Jones, T.R.3
  • 26
    • 1642484436 scopus 로고    scopus 로고
    • The role of B7 ligands (CD80 and CD86) in CD152-mediated allograft tolerance: A crosscheck hypothesis
    • Tsai MK, Ho HN, Chien HF, et al. The role of B7 ligands (CD80 and CD86) in CD152-mediated allograft tolerance: A crosscheck hypothesis. Transplantation 2004; 77: 48.
    • (2004) Transplantation , vol.77 , pp. 48
    • Tsai, M.K.1    Ho, H.N.2    Chien, H.F.3
  • 28
    • 0032490629 scopus 로고    scopus 로고
    • B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28
    • Fallarino F, Fields PE, Gajewski TF. B7-1 engagement of cytotoxic T lymphocyte antigen 4 inhibits T cell activation in the absence of CD28. J Exp Med 1998; 188: 205.
    • (1998) J Exp Med , vol.188 , pp. 205
    • Fallarino, F.1    Fields, P.E.2    Gajewski, T.F.3
  • 29
    • 0036852170 scopus 로고    scopus 로고
    • CTLA-4-Ig regulates tryptophan catabolism in vivo
    • Grohmann U, Orabona C, Fallarino F, et al. CTLA-4-Ig regulates tryptophan catabolism in vivo. Nat Immunol 2002; 3: 1097.
    • (2002) Nat Immunol , vol.3 , pp. 1097
    • Grohmann, U.1    Orabona, C.2    Fallarino, F.3
  • 30
    • 0038156291 scopus 로고    scopus 로고
    • Selective blockade of CD28 and not CTLA-4 with a single-chain Fv-alpha1-antitrypsin fusion antibody
    • Vanhove B, Laflamme G, Coulon F, et al. Selective blockade of CD28 and not CTLA-4 with a single-chain Fv-alpha1-antitrypsin fusion antibody. Blood 2003; 102: 564.
    • (2003) Blood , vol.102 , pp. 564
    • Vanhove, B.1    Laflamme, G.2    Coulon, F.3
  • 31
    • 40049105939 scopus 로고    scopus 로고
    • Anti-CD28 antibodies modify regulatory mechanisms and reinforce tolerance in CD40Ig-treated heart allograft recipients
    • Guillonneau C, Seveno C, DugastAS, etal. Anti-CD28 antibodies modify regulatory mechanisms and reinforce tolerance in CD40Ig-treated heart allograft recipients. J Immunol 2007; 179: 8164.
    • (2007) J Immunol , vol.179 , pp. 8164
    • Guillonneau, C.1    Seveno, C.2    Dugast, A.S.3
  • 32
    • 0027451441 scopus 로고
    • Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion
    • Lin H, Bolling SF, Linsley PS, et al. Long-term acceptance of major histocompatibility complex mismatched cardiac allografts induced by CTLA4Ig plus donor-specific transfusion. J Exp Med 1993; 178: 1801.
    • (1993) J Exp Med , vol.178 , pp. 1801
    • Lin, H.1    Bolling, S.F.2    Linsley, P.S.3
  • 33
    • 0030474264 scopus 로고    scopus 로고
    • Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection
    • Hancock WW, Sayegh MH, Zheng XG, et al. Costimulatory function and expression of CD40 ligand, CD80, and CD86 in vascularized murine cardiac allograft rejection. Proc Natl Acad Sci USA 1996; 93:13967.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 13967
    • Hancock, W.W.1    Sayegh, M.H.2    Zheng, X.G.3
  • 34
    • 9144227393 scopus 로고    scopus 로고
    • The role of TNF-related activation-induced cytokine-receptor activating NF-kappa B interaction in acute allograft rejection and CD40L-independent chronic allograft rejection
    • Guillonneau C, Louvet C, Renaudin K, et al. The role of TNF-related activation-induced cytokine-receptor activating NF-kappa B interaction in acute allograft rejection and CD40L-independent chronic allograft rejection. J Immunol 2004; 172: 1619.
    • (2004) J Immunol , vol.172 , pp. 1619
    • Guillonneau, C.1    Louvet, C.2    Renaudin, K.3
  • 35
    • 0036721620 scopus 로고    scopus 로고
    • Prevention of chronic rejection in murine cardiac allografts: A comparison of chimerism- and nonchimerism-inducing costimulation blockade-based tolerance induction regimens
    • Shirasugi N, Adams AB, Durham MM, et al. Prevention of chronic rejection in murine cardiac allografts: A comparison of chimerism- and nonchimerism-inducing costimulation blockade-based tolerance induction regimens. J Immunol 2002; 169: 2677.
    • (2002) J Immunol , vol.169 , pp. 2677
    • Shirasugi, N.1    Adams, A.B.2    Durham, M.M.3
  • 36
    • 0032934054 scopus 로고    scopus 로고
    • Mixed allogeneic chimerism to induce tolerance to solid organ and cellular grafts
    • Exner BG, Acholonu IN, Bergheim M, et al. Mixed allogeneic chimerism to induce tolerance to solid organ and cellular grafts. Acta Hematol 1999; 101: 78.
    • (1999) Acta Hematol , vol.101 , pp. 78
    • Exner, B.G.1    Acholonu, I.N.2    Bergheim, M.3
  • 37
    • 23044471742 scopus 로고    scopus 로고
    • Inhibition of chronic rejection and development of tolerogenic T cells after ICOS-ICOSL and CD40-CD40L co-stimulation blockade
    • Guillonneau C, Aubry V, Renaudin K, et al. Inhibition of chronic rejection and development of tolerogenic T cells after ICOS-ICOSL and CD40-CD40L co-stimulation blockade. Transplantation 2005; 80:255.
    • (2005) Transplantation , vol.80 , pp. 255
    • Guillonneau, C.1    Aubry, V.2    Renaudin, K.3
  • 38
    • 0028216858 scopus 로고
    • Cyclosporin A inhibits CD40 ligand expression in T lymphocytes
    • Fuleihan R, Ramesh N, Horner A, et al. Cyclosporin A inhibits CD40 ligand expression in T lymphocytes. J Clin Invest 1994; 93: 1315.
    • (1994) J Clin Invest , vol.93 , pp. 1315
    • Fuleihan, R.1    Ramesh, N.2    Horner, A.3
  • 39
    • 0344613988 scopus 로고    scopus 로고
    • Blocking both signal 1 and signal 2 ofT-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance
    • Li Y, LiXC, Zheng XX, etal. Blocking both signal 1 and signal 2 ofT-cell activation prevents apoptosis of alloreactive T cells and induction of peripheral allograft tolerance. Nat Med 1999; 5: 1298.
    • (1999) Nat Med , vol.5 , pp. 1298
    • Li, Y.1    Li, X.C.2    Zheng, X.X.3
  • 40
    • 33745257254 scopus 로고    scopus 로고
    • A new look at blockade of T-cell costimulation: A therapeutic strategy for long-term maintenance immunosuppression
    • Larsen CP, Knechtle SJ, Adams A, et al. A new look at blockade of T-cell costimulation: A therapeutic strategy for long-term maintenance immunosuppression. Am J Transplant 2006; 6 (5 Pt 1): 876.
    • (2006) Am J Transplant , vol.6 , Issue.5 PART 1 , pp. 876
    • Larsen, C.P.1    Knechtle, S.J.2    Adams, A.3
  • 41
    • 0142186823 scopus 로고    scopus 로고
    • Intragraft gene and protein expression in rat liver allografts treated with costimulatory blockade alone or in combination with CyA
    • Bartlett AS, McCall JL, Ameratunga R, et al. Intragraft gene and protein expression in rat liver allografts treated with costimulatory blockade alone or in combination with CyA. J SurgRes 2003; 115: 1.
    • (2003) J SurgRes , vol.115 , pp. 1
    • Bartlett, A.S.1    McCall, J.L.2    Ameratunga, R.3
  • 42
    • 20544436235 scopus 로고    scopus 로고
    • Costimulation blockade followed by a 12-week period of cyclosporine A facilitates prolonged drug-free survival of rhesus monkey kidney allografts
    • Haanstra KG, Sick EA, Ringers J, et al. Costimulation blockade followed by a 12-week period of cyclosporine A facilitates prolonged drug-free survival of rhesus monkey kidney allografts. Transplantation 2005; 79: 1623.
    • (2005) Transplantation , vol.79 , pp. 1623
    • Haanstra, K.G.1    Sick, E.A.2    Ringers, J.3
  • 43
    • 23944475023 scopus 로고    scopus 로고
    • Cyclosporine preserves the anergic state of human T cells induced by costimulation blockade in vitro
    • Koenen HJ, Fasse E, Joosten I. Cyclosporine preserves the anergic state of human T cells induced by costimulation blockade in vitro. Transplantation 2005; 80: 522.
    • (2005) Transplantation , vol.80 , pp. 522
    • Koenen, H.J.1    Fasse, E.2    Joosten, I.3
  • 44
    • 17644410067 scopus 로고    scopus 로고
    • IDEC-131 (anti-CD154), sirolimus and donor-specific transfusion facilitate operational tolerance in non-human primates
    • Preston EH, Xu H, Dhanireddy KK, et al. IDEC-131 (anti-CD154), sirolimus and donor-specific transfusion facilitate operational tolerance in non-human primates. Am J Transplant 2005; 5: 1032.
    • (2005) Am J Transplant , vol.5 , pp. 1032
    • Preston, E.H.1    Xu, H.2    Dhanireddy, K.K.3
  • 45
    • 9144272645 scopus 로고    scopus 로고
    • Combinations of anti-LFA-1, everolimus, anti-CD40 ligand, and allogeneic bone marrow induce central transplantation tolerance through hemopoietic chimerism, including protection from chronic heart allograft rejection
    • Metzler B, Gfeller P, Bigaud M, et al. Combinations of anti-LFA-1, everolimus, anti-CD40 ligand, and allogeneic bone marrow induce central transplantation tolerance through hemopoietic chimerism, including protection from chronic heart allograft rejection. J Immunol 2004; 173: 7025.
    • (2004) J Immunol , vol.173 , pp. 7025
    • Metzler, B.1    Gfeller, P.2    Bigaud, M.3
  • 46
    • 27744577762 scopus 로고    scopus 로고
    • Inhibition of Src kinases combined with CD40 ligand blockade prolongs murine cardiac allograft survival
    • Zhang Q, Fairchild RL, Reich MB, et al. Inhibition of Src kinases combined with CD40 ligand blockade prolongs murine cardiac allograft survival. Transplantation 2005; 80: 1112.
    • (2005) Transplantation , vol.80 , pp. 1112
    • Zhang, Q.1    Fairchild, R.L.2    Reich, M.B.3
  • 47
    • 0035159495 scopus 로고    scopus 로고
    • Targeting signal 1 through CD45RB synergizes with CD40 ligand blockade and promotes long term engraftment and tolerance in stringent transplant models
    • Rothstein DM, Livak MF, Kishimoto K, et al. Targeting signal 1 through CD45RB synergizes with CD40 ligand blockade and promotes long term engraftment and tolerance in stringent transplant models. J Immunol 2001; 166: 322.
    • (2001) J Immunol , vol.166 , pp. 322
    • Rothstein, D.M.1    Livak, M.F.2    Kishimoto, K.3
  • 48
    • 33751191378 scopus 로고    scopus 로고
    • Neutralizing IL-7 promotes long-term allograft survival induced by CD40/CD40L costimulatory blockade
    • Wang Y, Dai H, Liu Z, et al. Neutralizing IL-7 promotes long-term allograft survival induced by CD40/CD40L costimulatory blockade. Am J Transplant 2006; 6: 2851.
    • (2006) Am J Transplant , vol.6 , pp. 2851
    • Wang, Y.1    Dai, H.2    Liu, Z.3
  • 49
    • 33644872830 scopus 로고    scopus 로고
    • Alloimmunity in primate heart recipients with CD154 blockade: Evidence for alternative costimulation mechanisms
    • Azimzadeh AM, Pfeiffer S, Wu G, et al. Alloimmunity in primate heart recipients with CD154 blockade: Evidence for alternative costimulation mechanisms. Transplantation 2006; 81: 255.
    • (2006) Transplantation , vol.81 , pp. 255
    • Azimzadeh, A.M.1    Pfeiffer, S.2    Wu, G.3
  • 50
    • 33751017966 scopus 로고    scopus 로고
    • No synergy between ATG induction and costimulation blockade induced kidney allograft survival in rhesus monkeys
    • Haanstra KG, Sick EA, Ringers J, et al. No synergy between ATG induction and costimulation blockade induced kidney allograft survival in rhesus monkeys. Transplantation 2006; 82: 1194.
    • (2006) Transplantation , vol.82 , pp. 1194
    • Haanstra, K.G.1    Sick, E.A.2    Ringers, J.3
  • 51
    • 2942711587 scopus 로고    scopus 로고
    • Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patients
    • Sidiropoulos PI, Boumpas DT. Lessons learned from anti-CD40L treatment in systemic lupus erythematosus patients. Lupus 2004; 13: 391.
    • (2004) Lupus , vol.13 , pp. 391
    • Sidiropoulos, P.I.1    Boumpas, D.T.2
  • 52
    • 0032484987 scopus 로고    scopus 로고
    • CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells
    • Henn V, Slupsky JR, Grafe M, et al. CD40 ligand on activated platelets triggers an inflammatory reaction of endothelial cells. Nature 1998; 391: 591.
    • (1998) Nature , vol.391 , pp. 591
    • Henn, V.1    Slupsky, J.R.2    Grafe, M.3
  • 53
    • 0036130828 scopus 로고    scopus 로고
    • CD40L stabilizes arterial thrombi by a beta3 integrin-dependent mechanism
    • Andre P, Prasad KS, Denis CV, et al. CD40L stabilizes arterial thrombi by a beta3 integrin-dependent mechanism. Nat Med 2002; 8: 247.
    • (2002) Nat Med , vol.8 , pp. 247
    • Andre, P.1    Prasad, K.S.2    Denis, C.V.3
  • 54
    • 0037877918 scopus 로고    scopus 로고
    • CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation
    • Inwald DP, McDowall A, Peters MJ, et al. CD40 is constitutively expressed on platelets and provides a novel mechanism for platelet activation. Circ Res 2003; 92: 1041.
    • (2003) Circ Res , vol.92 , pp. 1041
    • Inwald, D.P.1    McDowall, A.2    Peters, M.J.3
  • 55
    • 0033965079 scopus 로고    scopus 로고
    • Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand
    • Kawai T, Andrews D, Colvin RB, et al. Thromboembolic complications after treatment with monoclonal antibody against CD40 ligand. Nat Med 2000; 6: 114.
    • (2000) Nat Med , vol.6 , pp. 114
    • Kawai, T.1    Andrews, D.2    Colvin, R.B.3
  • 56
    • 10744220010 scopus 로고    scopus 로고
    • Thrombophilia associated with anti-CD154 monoclonal antibody treatment and its prophylaxis in nonhuman primates
    • Koyama I, Kawai T, Andrews D, et al. Thrombophilia associated with anti-CD154 monoclonal antibody treatment and its prophylaxis in nonhuman primates. Transplantation 2004; 77: 460.
    • (2004) Transplantation , vol.77 , pp. 460
    • Koyama, I.1    Kawai, T.2    Andrews, D.3
  • 57
    • 33644649772 scopus 로고    scopus 로고
    • Platelet-derived or soluble CD154 induces vascularized allograft rejection independent of cell-bound CD154
    • Xu H, Zhang X, Mannon RB, et al. Platelet-derived or soluble CD154 induces vascularized allograft rejection independent of cell-bound CD154. J Clin Invest 2006; 116:769.
    • (2006) J Clin Invest , vol.116 , pp. 769
    • Xu, H.1    Zhang, X.2    Mannon, R.B.3
  • 58
    • 0037108717 scopus 로고    scopus 로고
    • Anti-CD40 therapy extends renal allograft survival in rhesus macaques
    • Pearson TC, Trambley J, Odom K, et al. Anti-CD40 therapy extends renal allograft survival in rhesus macaques. Transplantation 2002; 74:933.
    • (2002) Transplantation , vol.74 , pp. 933
    • Pearson, T.C.1    Trambley, J.2    Odom, K.3
  • 59
    • 37349029002 scopus 로고    scopus 로고
    • A novel fully human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys
    • Imai A, Suzuki T, Sugitani A, et al. A novel fully human anti-CD40 monoclonal antibody, 4D11, for kidney transplantation in cynomolgus monkeys. Transplantation 2007; 84: 1020.
    • (2007) Transplantation , vol.84 , pp. 1020
    • Imai, A.1    Suzuki, T.2    Sugitani, A.3
  • 60
    • 66049137672 scopus 로고    scopus 로고
    • Immunosuppression by a novel anti-CD40 mAb, 4D11, is not abrogated by combined treatment with tacrolimus for renal transplantation in cynomolgus monkeys
    • Uno M ST, Aoyagi T. Immunosuppression by a novel anti-CD40 mAb, 4D11, is not abrogated by combined treatment with tacrolimus for renal transplantation in cynomolgus monkeys. Am J Transplant 2007; 7(Suppl): 202.
    • (2007) Am J Transplant , vol.7 , Issue.SUPPL. , pp. 202
    • Uno, M.S.1    Aoyagi, T.2
  • 61
    • 0035164360 scopus 로고    scopus 로고
    • Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: A role of CD40 in regulatory T cell development
    • Kumanogoh A, Wang X, Lee I, et al. Increased T cell autoreactivity in the absence of CD40-CD40 ligand interactions: A role of CD40 in regulatory T cell development. J Immunol 2001; 166: 353.
    • (2001) J Immunol , vol.166 , pp. 353
    • Kumanogoh, A.1    Wang, X.2    Lee, I.3
  • 62
    • 0033682056 scopus 로고    scopus 로고
    • + immunoregulatory T cells that control autoimmune diabetes
    • + immunoregulatory T cells that control autoimmune diabetes. Immunity 2000; 12: 431.
    • (2000) Immunity , vol.12 , pp. 431
    • Salomon, B.1    Lenschow, D.J.2    Rhee, L.3
  • 63
    • 23944502334 scopus 로고    scopus 로고
    • Costimulation blockade with belatacept in renal transplantation
    • Vincenti F, Larsen C, Durrbach A, et al. Costimulation blockade with belatacept in renal transplantation. N Engl J Med 2005; 353: 770.
    • (2005) N Engl J Med , vol.353 , pp. 770
    • Vincenti, F.1    Larsen, C.2    Durrbach, A.3
  • 64
    • 34247580749 scopus 로고    scopus 로고
    • + regulatory T cell expansion in renal transplanted patients treated in vivo with Belatacept mediated CD28-CD80/86 blockade
    • + regulatory T cell expansion in renal transplanted patients treated in vivo with Belatacept mediated CD28-CD80/86 blockade. Transpl Immunol 2007; 17:243.
    • (2007) Transpl Immunol , vol.17 , pp. 243
    • Chavez, H.1    Beaudreuil, S.2    Abbed, K.3
  • 65
    • 0027529650 scopus 로고
    • Human CD40-ligand: Molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production
    • Gauchat JF, Aubry JP, Mazzei G, et al. Human CD40-ligand: Molecular cloning, cellular distribution and regulation of expression by factors controlling IgE production. FEBS Lett 1993; 315: 259.
    • (1993) FEBS Lett , vol.315 , pp. 259
    • Gauchat, J.F.1    Aubry, J.P.2    Mazzei, G.3
  • 66
    • 0027164915 scopus 로고
    • Regulation of expression of the ligand for CD40 on T helper lymphocytes
    • Castle BE, Kishimoto K, Stearns C, et al. Regulation of expression of the ligand for CD40 on T helper lymphocytes. J Immunol 1993; 151: 1777.
    • (1993) J Immunol , vol.151 , pp. 1777
    • Castle, B.E.1    Kishimoto, K.2    Stearns, C.3
  • 68
    • 34948892926 scopus 로고    scopus 로고
    • + T cells and is quickly expressed on the cell surface in an antigen-specific manner
    • + T cells and is quickly expressed on the cell surface in an antigen-specific manner. Blood 2007; 110:2520.
    • (2007) Blood , vol.110 , pp. 2520
    • Koguchi, Y.1    Thauland, T.J.2    Slifka, M.K.3
  • 69
    • 33749007945 scopus 로고    scopus 로고
    • Differential regulation of soluble and membrane CD40L proteins in T cells
    • Matthies KM, Newman JL, Hodzic A, et al. Differential regulation of soluble and membrane CD40L proteins in T cells. Cell Immunol 2006; 241: 47.
    • (2006) Cell Immunol , vol.241 , pp. 47
    • Matthies, K.M.1    Newman, J.L.2    Hodzic, A.3
  • 71
    • 0032845218 scopus 로고    scopus 로고
    • Expression, regulation, and function of B cell-expressed CD154 in germinal centers
    • Grammer AC, McFarland RD, Heaney J, et al. Expression, regulation, and function of B cell-expressed CD154 in germinal centers. J Immunol 1999; 163: 4150.
    • (1999) J Immunol , vol.163 , pp. 4150
    • Grammer, A.C.1    McFarland, R.D.2    Heaney, J.3
  • 72
    • 0029034495 scopus 로고
    • The CD40 ligand expressed by human B cells costimulates B cell responses
    • Grammer AC, Bergman MC, MiuraY,et al. The CD40 ligand expressed by human B cells costimulates B cell responses. J Immunol 1995; 154: 4996.
    • (1995) J Immunol , vol.154 , pp. 4996
    • Grammer, A.C.1    Bergman, M.C.2    MiuraY3
  • 73
    • 0030033308 scopus 로고    scopus 로고
    • Human dendritic cells activate T lymphocytes via a CD40:CD40 ligand-dependent pathway
    • McLellan AD, Sorg RV, Williams LA, et al. Human dendritic cells activate T lymphocytes via a CD40:CD40 ligand-dependent pathway. Eur J Immunol 1996; 26: 1204.
    • (1996) Eur J Immunol , vol.26 , pp. 1204
    • McLellan, A.D.1    Sorg, R.V.2    Williams, L.A.3
  • 74
    • 0030588549 scopus 로고    scopus 로고
    • Functional CD40 ligand expressed by human blood dendritic cells is up-regulated by CD40 ligation
    • Pinchuk LM, Klaus SJ, Magaletti DM, et al. Functional CD40 ligand expressed by human blood dendritic cells is up-regulated by CD40 ligation. J Immunol 1996; 157: 4363.
    • (1996) J Immunol , vol.157 , pp. 4363
    • Pinchuk, L.M.1    Klaus, S.J.2    Magaletti, D.M.3
  • 75
    • 0029073133 scopus 로고
    • CD40 on human endothe-lial cells: Inducibility by cytokines and functional regulation of adhesion molecule expression
    • Karmann K, Hughes CC, Schechner J, et al. CD40 on human endothe-lial cells: Inducibility by cytokines and functional regulation of adhesion molecule expression. Proc Natl Acad Sci USA 1995; 92: 4342.
    • (1995) Proc Natl Acad Sci USA , vol.92 , pp. 4342
    • Karmann, K.1    Hughes, C.C.2    Schechner, J.3
  • 76
    • 33746798082 scopus 로고    scopus 로고
    • CD40 ligand increases expression of its receptor CD40 in human coronary artery endothelial cells
    • Chai H, Yan S, Wang H, et al. CD40 ligand increases expression of its receptor CD40 in human coronary artery endothelial cells. Surgery 2006; 140: 236.
    • (2006) Surgery , vol.140 , pp. 236
    • Chai, H.1    Yan, S.2    Wang, H.3
  • 77
    • 0031049711 scopus 로고    scopus 로고
    • Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40-CD40 ligand signaling in atherosclerosis
    • Mach F, Schonbeck U, Sukhova GK, et al. Functional CD40 ligand is expressed on human vascular endothelial cells, smooth muscle cells, and macrophages: Implications for CD40-CD40 ligand signaling in atherosclerosis. Proc Natl Acad Sci USA 1997; 94: 1931.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 1931
    • Mach, F.1    Schonbeck, U.2    Sukhova, G.K.3
  • 78
    • 0035075438 scopus 로고    scopus 로고
    • Platelet CD40 ligand (CD40L) - Subcellular localization, regulationof expression, and inhibition by clopidogrel
    • Hermann A, Rauch BH, Braun M, et al. Platelet CD40 ligand (CD40L) - Subcellular localization, regulationof expression, and inhibition by clopidogrel. Platelets 2001; 12: 74.
    • (2001) Platelets , vol.12 , pp. 74
    • Hermann, A.1    Rauch, B.H.2    Braun, M.3
  • 79
    • 0042703227 scopus 로고    scopus 로고
    • The platelet CD40L/GP IIb-IIIa axis in atherothrombotic disease
    • Prasad KS, AndreP, Yan Y,et al. The platelet CD40L/GP IIb-IIIa axis in atherothrombotic disease. Curr Opin Hematol 2003; 10: 356.
    • (2003) Curr Opin Hematol , vol.10 , pp. 356
    • Prasad, K.S.1    Andre, P.2    Yan, Y.3
  • 80
    • 34547923169 scopus 로고    scopus 로고
    • Immunomodulation by adenoviral-mediated sCD40Ig gene therapy for mouse allogeneic islet transplantation
    • Rehman KK, Bertera S, Trucco M, et al. Immunomodulation by adenoviral-mediated sCD40Ig gene therapy for mouse allogeneic islet transplantation. Transplantation 2007; 84: 301.
    • (2007) Transplantation , vol.84 , pp. 301
    • Rehman, K.K.1    Bertera, S.2    Trucco, M.3
  • 81
    • 33644779799 scopus 로고    scopus 로고
    • Nanji SA, Hancock WW, Luo B, et al. Costimulation blockade of both inducible costimulator and CD40 ligand induces dominant tolerance to islet allografts and prevents spontaneous autoimmune diabetes in the NOD mouse. Diabetes 2006; 55: 27.
    • Nanji SA, Hancock WW, Luo B, et al. Costimulation blockade of both inducible costimulator and CD40 ligand induces dominant tolerance to islet allografts and prevents spontaneous autoimmune diabetes in the NOD mouse. Diabetes 2006; 55: 27.
  • 82
    • 34248385683 scopus 로고    scopus 로고
    • CD154 blockade, sirolimus, and donor-specific transfusion prevents renal allograft rejection in cyno-molgus monkeys despite homeostatic T-cell activation
    • Pearl JP, Xu H, Leopardi F, et al. CD154 blockade, sirolimus, and donor-specific transfusion prevents renal allograft rejection in cyno-molgus monkeys despite homeostatic T-cell activation. Transplantation 2007; 83: 1219.
    • (2007) Transplantation , vol.83 , pp. 1219
    • Pearl, J.P.1    Xu, H.2    Leopardi, F.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.