The complexity of genotype-phenotype relations associated with loss-of-function sodium channel mutations and the role of in silico studies

American Journal of Physiology - Heart and Circulatory Physiology

Volumn 295, Issue 1, 2008, Pages

  Wilde, Arthur A M ^a   Coronel, Ruben ^a  

^a ACADEMIC MEDICAL CENTER   (Netherlands)

Author keywords

[No Author keywords available]

Indexed keywords

SODIUM CHANNEL; MUSCLE PROTEIN; SCN5A PROTEIN, HUMAN; SODIUM;

BRUGADA SYNDROME; COMPUTER MODEL; EDITORIAL; ELECTROCARDIOGRAPHY; GENE EXPRESSION; GENE MUTATION; GENOTYPE; HEART ARRHYTHMIA; HEART MUSCLE CELL; HEART TRANSPLANTATION; HEREDITY; HUMAN; PATHOPHYSIOLOGY; PHENOTYPE; PRIORITY JOURNAL; ST SEGMENT ELEVATION; ACTION POTENTIAL; ANIMAL; BIOLOGICAL MODEL; CHO CELL; COMPUTER SIMULATION; CRICETULUS; GENETIC PREDISPOSITION; GENETIC TRANSFECTION; GENETICS; HAMSTER; METABOLISM; MISSENSE MUTATION; NOTE; PERICARDIUM; REPRODUCIBILITY; SITE DIRECTED MUTAGENESIS;

ACTION POTENTIALS; ANIMALS; BRUGADA SYNDROME; CHO CELLS; COMPUTER SIMULATION; CRICETINAE; CRICETULUS; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HUMANS; MODELS, CARDIOVASCULAR; MUSCLE PROTEINS; MUTAGENESIS, SITE-DIRECTED; MUTATION, MISSENSE; PERICARDIUM; PHENOTYPE; REPRODUCIBILITY OF RESULTS; SODIUM; SODIUM CHANNELS; TRANSFECTION;

EID: 49849089950     PISSN: 03636135     EISSN: 15221539     Source Type: Journal    
DOI: 10.1152/ajpheart.00494.2008     Document Type: Editorial

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