Pediatric injuries from needles discarded in the community: Epidemiology and risk of seroconversion

Pediatrics

Volumn 122, Issue 2, 2008, Pages

  Papenburg, Jesse ^a,b   Blais, Denis ^c   Moore, Dorothy ^a   Al Hosni, Mohammed ^a   Laferriere, Celine ^c   Tapiero, Bruce ^a   Quach, Caroline ^a,b  

^a Division of Infectious Diseases   (Canada)

^b MONTREAL CHILDREN S HOSPITAL   (Canada)

^c UNIVERSITY OF MONTREAL   (Canada)

Author keywords

Accident prevention; Antiretroviral agents; Bloodborne pathogens; Needlestick injuries; Nonoccupational exposure; Pediatrics

Indexed keywords

ANTIRETROVIRUS AGENT; HEPATITIS B ANTIBODY; HEPATITIS B VACCINE; INDINAVIR; LAMIVUDINE; LOPINAVIR PLUS RITONAVIR; NELFINAVIR; PROTEINASE INHIBITOR; ZIDOVUDINE;

ARTICLE; CHEMOPROPHYLAXIS; CHILD; CHILDHOOD INJURY; FATIGUE; FEMALE; GASTROINTESTINAL TOXICITY; HALLUCINATION; HEADACHE; HEPATITIS B VIRUS; HEPATITIS C VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; LEUKOPENIA; MAJOR CLINICAL STUDY; MALE; NEEDLESTICK INJURY; NEUTROPENIA; PRIORITY JOURNAL; SEROCONVERSION; SIDE EFFECT; VIRUS TRANSMISSION; ACQUIRED IMMUNE DEFICIENCY SYNDROME; ADOLESCENT; AGE DISTRIBUTION; ANALYSIS OF VARIANCE; BLOODBORNE BACTERIUM; CANADA; COHORT ANALYSIS; COMMUNICABLE DISEASE; DISEASE TRANSMISSION; HEPATITIS C; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; INCIDENCE; ISOLATION AND PURIFICATION; NEEDLE; PRESCHOOL CHILD; PROBABILITY; RETROSPECTIVE STUDY; RISK ASSESSMENT; SEX RATIO; URBAN POPULATION; VIROLOGY;

ACQUIRED IMMUNODEFICIENCY SYNDROME; ADOLESCENT; AGE DISTRIBUTION; ANALYSIS OF VARIANCE; BLOOD-BORNE PATHOGENS; CHILD; CHILD, PRESCHOOL; COHORT STUDIES; COMMUNITY-ACQUIRED INFECTIONS; DISEASE TRANSMISSION; FEMALE; HEPATITIS C; HIV INFECTIONS; HUMANS; INCIDENCE; MALE; NEEDLES; NEEDLESTICK INJURIES; PROBABILITY; QUEBEC; RETROSPECTIVE STUDIES; RISK ASSESSMENT; SEX DISTRIBUTION; URBAN POPULATION;

EID: 49849083208     PISSN: 00314005     EISSN: 10984275     Source Type: Journal    
DOI: 10.1542/peds.2008-0290     Document Type: Article

References (39)

1. Ministère de la Santé et des Services Sociaux, Gouvernement du Québec. La récupération des seringues et des aiguilles usagées: une responsabilité à partager. Rapport et recommandations du Groupe de travail sur la réicupéiration des seringues usagéies au Quéibec. 2005. Available at: http://publications.msss.gouv.qc.ca/acrobat/f/documentation/2004/04-322-01.pdf. Accessed January15, 2008
2. Nourse CB, Charles CA, McKay M, Keenan P, Butler KM. Childhood needlestick injuries in the Dublin metropolitan area. IrMedJ. 1997;90(2):66-69
3. Blais D. A child is injured with a syringe [in French]. Perspect Infirm. 2005;3(1):27-28
4. Health Canada, Surveillance and Risk Assessment Division, Centre for Infectious Disease Prevention and Control, Public Health Agency of Canada. HIV/AIDS EPI updates. Available at: www. phac-aspc.gc.ca/publicat/epiu-aepi/epi- 06/index.html. Accessed January 16, 2008
5. Minuk G, Uhanova J. Chronic hepatitis B infection in Canada. Can J Infect Dis. 2001;12(6):351-356
6. Zou S, Tepper M, Giulivi A. Current status of hepatitis C in Canada. Can J Public Health. 2000;91(suppl 1):S10-S16
7. Institut National de Santé Publique du Quéibec. Épidéimiologie du VHC: un regard rétrospectif, 1997-2003-Surveillance des Maladies Infectieuses Chez les Utilisateurs de Drogues par Injection. Available at: www.inspq.qc.ca/pdf/publications/478 www.inspq.qc.ca/pdf/publications/478 SurveillanceMaladiesInfectieuses-VHC-1997- 2003.pdf. Accessed January 15, 2008
8. Ministère de la Santé et des Services Sociaux, Gouvernement du Quebec. Unis dans l'action: Plan D'action Interministériel en Toxicomanie 2006-2011. Available at: http://publications.msss. gouv.qc.ca/acrobat/f/documentation/2005/05-804-01.pdf. Accessed January 15, 2008
9. Remis RS, Bruneau J, Hankins CA. Enough sterile syringes to prevent HIV transmission among injection drug users in Montreal? JAcquirImmune Defic Syndr Hum Retrovirol. 1998;18(suppl1):S57-S59
10. Panlilio AL, Cardo DM, Grohskopf LA, Heneine W, Ross CS. Updated U.S. Public Health Service guidelines for the management of occupational exposures to HIV and recommendations for postexposure prophylaxis. MMWR Recomm Rep. 2005; 54(RR-9):1-17
11. Centers for Disease Control and Prevention. Updated U.S. Public Health Service guidelines for the management of occupational exposures to HBV, HCV, and HIV and recommendations for postexposure prophylaxis. MMWR Recomm Rep. 2001; 50(RR-11):1-52
12. Young TN, Arens FJ, Kennedy GE, Laurie JW, Rutherford G. Antiretroviral post-exposure prophylaxis (PEP) for occupational HIV exposure. Cochrane Database Syst Rev. 2007;(1): CD002835
13. Cardo DM, Culver DH, Ciesielski CA, et al. A case-control study of HIV seroconversion in health care workers after percutaneous exposure. Centers for Disease Control and Prevention Needlestick Surveillance Group. N Engl J Med. 1997;337(21):1485-1490
14. Babl FE, Cooper ER, Damon B, Louie T, Kharasch S, Harris JA. HIV postexposure prophylaxis for children and adolescents. Am J Emerg Med. 2000;18(3);282-287
15. Statistics Canada. Population and dwelling counts for census metropolitan areas, 2006 and 2001 censuses-100% data. Population and dwelling counts, 2006 census. 2007. Available at: www12.statcan.ca/english/census06/data/popdwell/ Table.cfm?T=205&RPP=50. Accessed January 15, 2008
16. Agence de la Santé et des Services Sociaux de Montréal. Breakdown of the Montreal population according to certain socio- demographic characteristics, 2001 (number and proportion): population profile, sociodemographic characteristics, 2001. 2007. Available at: www.santemontreal. qc.ca/En/population/ etat.html. Accessed January 15, 2008
17. Montella F, Di Sora F, Recchia O. Can HIV-1 infection be transmitted by a "discarded" syringe? J Acquir Immune Defic Syndr. 1992;5(12):1274-1275
18. Szenborn L, Owoc-Lempach J, Mordak M, Czerniak T, Klinowska J, Kacprzak-Bergman I. Accidentalneedlestick injuries by children-Prophylaxis of HBV and HIV infections in children: own experiences [in Polish]. Pediatr Pol. 2006;81(9):650-655
19. Thomas HL, Liebeschuetz S, Shingadia D, Addiman S, Mellanby A. Multiple needle-stick injuries with risk of human immunodeficiency virus exposure in a primary school. Pediatr Infect Dis J. 2006;25(10):933-936
20. Makwana N, Riordan FA. Prospective study of community needlestick injuries. Arch Dis Child. 2005;90(5):523-524
21. Aragón Peña AJ, Arrazola Martínez MP, García de Codes A, Dáivila Alvarez FM, de Juanes Pardo JR. Hepatitis B prevention and risk of HIV infection in children injured by discarded needles and/or syringes [in Spanish]. Aten Primaria. 1996;17(2):138 - 40
22. Wyatt JP, Robertson CE, Scobie WG. Out of hospital needle- stick injuries. Arch Dis Child. 1994;70(3):245-246
23. Walsh SS, Pierce AM, Hart CA. Drug abuse: a new problem. Br Med J (Clin Res Ed). 1987;295(6597):526-527
24. O'Leary FM, Green TC. Community acquired needlestick injuries in non-health care workers presenting to an urban emergency department. Emerg Med (Fremantle). 2003;15(5-6): 434-440
25. Russell FM, Nash MC. A prospective study of children with community-acquired needlestick injuries in Melbourne. J Paediatr Child Health. 2002;38(3):322-323
26. de Waal N, Rabie H, Bester R, Cotton MF. Mass needle stick injury in children from the Western cape. J Trop Pediatr. 2006; 52(3):192-196
27. Havens PL; American Academy of Pediatrics Committee on Pediatric AIDS. Postexposure prophylaxis in children and adolescents for nonoccupational exposure to human immunodeficiency virus. Pediatrics. 2003;111(6 pt 1):1475-1489
28. Smith DK, Grohskopf LA, Black RJ, et al. Antiretroviral post- exposure prophylaxis after sexual, injection-drug use, or other nonoccupational exposure to HIV in the United States: recommendations from the U.S. Department of Health and Human Services. MMWR Recomm Rep. 2005;54(RR-2):1-20
29. Almeda J, Casabona J, Simon B, et al. Proposed recommendations for the management of HIV post-exposure prophylaxis after sexual, injecting drug or other exposures in Europe. Euro Surveill. 2004;9(6):35-40
30. Canadian Paediatric Society, Infectious Diseases and Immunization Committee. Needlestick injuries in the community. Pae- diatr Child Health. 2008;13(3):205-210
31. Hanley JA, Lippman-Hand A. If nothing goes wrong, is everything all right? Interpreting zero numerators. JAMA. 1983; 249(13):1743-1745
32. Nyiri P, Leung T, Zuckerman MA. Sharps discarded in inner city parks and playgrounds-risk of bloodborne virus exposure. Commun Dis Public Health. 2004;7(4):287-288
33. Thompson SC, Boughton CR, Dore GJ. Blood-borne viruses and their survival in the environment: is public concern about community needlestick exposures justified? Aust N Z J Public Health. 2003;27(6):602-607
34. Page JB, Shapshak P, Duran EM, Even G, Moleon-Borodowski I, Llanusa-Cestero R. Detection of HIV-1 in injection paraphernalia: risk in an era of heightened awareness. AIDS Patient Care STDS. 2006;20(8):576-585
35. Shapshak P, Fujimura RK, Page JB, et al. HIV-1 RNA load in needles/syringes from shooting galleries in Miami: a preliminary laboratory report. Drug Alcohol Depend. 2000;58(1-2):153-157
36. García-Algar O, Vall O. Hepatitis B virus infection from a needle stick. Pediatr Infect Dis J. 1997;16(11):1099
37. Libois A, Fumero E, Castro P, et al. Transmission of hepatitis C virus by discarded-needle injury. Clin Infect Dis. 2005;41(1): 129-130
38. Bassett IV, Freedberg KA, Walensky RP. Two drugs or three? Balancing efficacy, toxicity, and resistance in postexposure prophylaxis for occupational exposure to HIV. Clin Infect Dis. 2004;39(3):395-401
39. Luque A, Hulse S, Wang D, et al. Assessment of adverse events associated with antiretroviral regimens for postexposure prophylaxis for occupational and nonoccupational exposures to prevent transmission of human immunodeficiency virus. Infect Control Hosp Epidemiol. 2007;28(6):695-701