Clear cell adenocarcinoma arising from a giant cystic adenomyosis: A case report with immunohistochemical analysis of laminin-5 gamma2 chain and p53 overexpression

Pathology Research and Practice

Volumn 204, Issue 9, 2008, Pages 677-682

  Ohta, Yoshiki ^a   Hamatani, Shigeharu ^a   Suzuki, Takao ^b   Ikeda, Katsuhide ^b   Kiyokawa, Kaoru ^c   Shiokawa, Akira ^a   Kushima, Miki ^d   Ota, Hidekazu ^e  

^a SHOWA UNIVERSITY NORTHERN YOKOHAMA HOSPITAL   (Japan)

^b SHOWA UNIVERSITY FUJIGAOKA HOSPITAL   (Japan)

^c Yokohama Shin Midori General Hospital   (Japan)

^d SHOWA UNIVERSITY HOSPITAL   (Japan)

^e SHOWA UNIVERSITY   (Japan)

Author keywords

Adenomyosis; Clear cell adenocarcinoma; Laminin 5 gamma2 chain; p53

Indexed keywords

ANTINEOPLASTIC AGENT; CYTOKERATIN; KALININ; LAMININ 5 GAMMA2; PROTEIN P53;

ABDOMINAL HYSTERECTOMY; ADENOMYOSIS; ADULT; ARTICLE; CANCER GROWTH; CANCER INVASION; CANCER STAGING; CASE REPORT; CELL PROLIFERATION; CLEAR CELL CARCINOMA; COMPUTER ASSISTED TOMOGRAPHY; DIFFERENTIAL DIAGNOSIS; ECHOGRAPHY; FEMALE; GENE EXPRESSION; HISTOPATHOLOGY; HUMAN; HUMAN CELL; HUMAN TISSUE; HYPERMENORRHEA; IMMUNOHISTOCHEMISTRY; LIVER METASTASIS; MALIGNANT TRANSFORMATION; METASTASIS; MICROSCOPY; NUCLEAR MAGNETIC RESONANCE IMAGING; OVARY TUMOR; POSTOPERATIVE PERIOD; SALPINGOOOPHORECTOMY; TUMOR CELL; UTERUS MYOMA;

ADENOCARCINOMA, CLEAR CELL; CYSTS; ENDOMETRIAL NEOPLASMS; ENDOMETRIOSIS; FEMALE; HUMANS; IMMUNOHISTOCHEMISTRY; LAMININ; MIDDLE AGED; TUMOR MARKERS, BIOLOGICAL; TUMOR SUPPRESSOR PROTEIN P53; UP-REGULATION;

EID: 49749153422     PISSN: 03440338     EISSN: 16180631     Source Type: Journal    
DOI: 10.1016/j.prp.2008.02.005     Document Type: Article

References (18)

1. Andersson S., Hellstrom A.C., Angstrom T., Stendahl U., Auer G., and Wallin K.L. The clinicopathologic significance of laminin-5 γ2 chain expression in cervical squamous carcinoma and adenocarcinoma. Int. J. Gynecol. Cancer 15 (2005) 1065-1072
2. Chu P., Wu E., and Weiss L.M. Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases. Mod. Pathol. 13 (2000) 962-972
3. Czernobilsky B., and Morris W.J. A histologic study of ovarian endometriosis with emphasis on hyperplastic and atypical changes. Obstet. Gynecol. 53 (1979) 318-323
4. de la Cuesta R.S., Eichhorn J.H., Rice L.W., Fuller Jr. A.F., Nikrui N., and Goff B.A. Histologic transformation of benign endometriosis to early ovarian cancer. Gynecol. Oncol. 60 (1996) 238-244
5. Ejeckman G.C., Zeinab O.A., Salman M., and Bobeck H.E. Giant adenomyotic cyst of the uterus. Br. J. Obstet. Gynaecol. 100 (1993) 596-598
6. Fukunaga M., Nomura K., Ishikawa E., and Ushigome S. Ovarian atypical endometriosis: its close association with malignant epithelial tumours. Histopathology 30 (1997) 249-255
7. Irvin W., Pelkey T., Rice L., and Anderson W. Endometrial stromal sarcoma of the vulva arising in extraovarian endometriosis: a case report and literature review. Gynecol. Oncol. 71 (1998) 313-316
8. Koshikawa N., Moriyama K., Takamura H., Mizushima H., Nagashima Y., Yamano S., and Miyazaki K. Overexpression of laminin gamma2 chain monomer in invading gastric carcinoma cells. Cancer Res. 59 (1999) 5596-5601
9. Negri G., Romano F., Vittadello F., Kasal A., Mazzoleni G., Colombetti V., and Egarter-Vigl E. Laminin-5 γ2 chain immunohistochemistry facilitates the assessment of invasiveness and improves the diagnostic reproducibility of glandular lesions of the cervix uteri. Hum. Pathol. 37 (2006) 704-710
10. Okuda T., Otsuka J., Sekizawa A., Saito H., Makino R., Kushima M., Farina A., Kuwano Y., and Okai T. p53 mutations and overexpression affect prognosis of ovarian endometrioid cancer but not clear cell cancer. Gynecol. Oncol. 88 (2003) 318-325
11. Ordi J., Romagosa C., Tavassoli F.A., Nogales F., Palacin A., Condom E., Torne A., and Cardesa A. CD10 expression in epithelial tissues and tumors of the gynecologic tract. Am. J. Surg. Pathol. 27 (2003) 178-186
12. Puppa G., Shoze M., Perin T., Nomura K., Gloghini A., Campagnutta E., and Canzonieri V. Small primary adenocarcinoma in adenomyosis with nodal metastasis: a case report. BMC Cancer 20 (2007) 103-108
13. Pyke C., Salo S., Ralfkiaer E., Rømer J., Danø K., and Tryqqvason K. Laminin-5 is a marker of invading cancer cells in some human carcinomas and is coexpressed with the receptor for urokinase plasminogen activator in budding cancer cells in colon adenocarcinomas. Cancer Res. 55 (1995) 4132-4139
14. Robboy S.J., Anderson M.C., and Russell P. Epithelial/Stromal Ovarian Tumors, Pathology of the Female Reproductive Tract (2002), Churchill Livingstone, London p. 584
15. Shimizu M., Nikaido T., Toki T., Shiozawa T., and Fujii S. Clear cell carcinoma has an expression pattern of cell cycle regulatory molecules that is unique among ovarian adenocarcinomas. Cancer 85 (1999) 669-677
16. Stoltzfus P., Salo S., Eriksson E., Aspenblad U., Tryggvason K., Auer G., and Avall-Lundqvist E. Laminin-5 γ2 chain expression facilitates detection of invasive squamous cell carcinoma of the uterine cervix. Int J. Gynecol. Pathol. 23 (2004) 215-222
17. Tavassoli F.A., and Devilee P. World Health Organization Classification of Tumours, Pathology and Genetics of Tumours of the Breast and Female Genital Organs (2003), IARC Press, Lyon p. 139
18. Timple R. Structure and biological activity of basement membrane proteins. Eur. J. Biochem. 180 (1989) 487-502