Pulmonary pharmacokinetics and safety of nebulized duramycin in healthy male volunteers

Naunyn-Schmiedeberg's Archives of Pharmacology

Volumn 378, Issue 3, 2008, Pages 323-333

  Steiner, Ilka ^a   Errhalt, Peter ^b   Kubesch, Klaus ^c   Hubner, Marianne ^b   Holy, Marion ^a   Bauer, Martin ^a   Müller, Markus ^a   Hinterberger, Sabine ^d   Widmann, Rudolf ^d   Mascher, Daniel ^c   Freissmuth, Michael ^a   Kneussl, Meinhard ^b  

^a MEDICAL UNIVERSITY OF VIENNA   (Austria)

^b Wilhelminenspital der Stadt Wien ^*  (Austria)

^c Pharm Analyt Laboratory GmbH   (Austria)

^d AOP Orphan Pharmaceuticals AG   (Austria)

Author keywords

Broncheoalveloar lavage; Brush biopsy; Cystic fibrosis; Duramycin; Moli1901; Pulmonary pharmacokinetics

Indexed keywords

BACITRACIN; DURAMYCIN; GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 13; INTERLEUKIN 17; INTERLEUKIN 2; SALBUTAMOL;

ACCURACY; ADULT; AEROSOL; ARTICLE; BLOOD SAMPLING; BRONCHOSCOPY; CELL FRACTIONATION; CLINICAL TRIAL; CYSTIC FIBROSIS; CYTOKINE PRODUCTION; DOSE TIME EFFECT RELATION; DRUG BLOOD LEVEL; DRUG HALF LIFE; DRUG SAFETY; ELECTROCARDIOGRAPHY; EPITHELIUM CELL; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HUMAN; HUMAN EXPERIMENT; INFLAMMATION; LUNG ALVEOLUS MACROPHAGE; LUNG BIOPSY; LUNG LAVAGE; LUNG PARENCHYMA; MALE; MAXIMUM PLASMA CONCENTRATION; NEBULIZATION; NORMAL HUMAN; OPEN STUDY; PHASE 1 CLINICAL TRIAL; PILOT STUDY; PULSE OXIMETRY; QUALITY CONTROL; SINGLE DRUG DOSE;

ADMINISTRATION, INHALATION; ADULT; ANTI-BACTERIAL AGENTS; BACTERIOCINS; BRONCHOALVEOLAR LAVAGE FLUID; BRONCHOSCOPY; CHEMOKINES; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CYTOKINES; HALF-LIFE; HUMANS; LUNG; LYMPHOCYTES; MALE; NEBULIZERS AND VAPORIZERS; PEPTIDES; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION;

EID: 49749091667     PISSN: 00281298     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00210-008-0293-8     Document Type: Article

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