Preoperative serum thrombopoietin levels are higher in patients with ovarian cancer than with benign cysts

European Journal of Obstetrics and Gynecology and Reproductive Biology

Volumn 140, Issue 1, 2008, Pages 67-70

  Tsukishiro, Sami ^a   Suzumori, Nobuhiro ^a   Nishikawa, Hiroshi ^a   Arakawa, Atsushi ^a   Suzumori, Kaoru ^a  

^a NAGOYA CITY UNIVERSITY GRADUATE SCHOOL OF MEDICAL SCIENCES   (Japan)

Author keywords

CA125; Ovarian tumor; Platelet; TPO

Indexed keywords

CA 125 ANTIGEN; THROMBOPOIETIN;

ADULT; ARTICLE; CANCER GRADING; CANCER STAGING; CONTROLLED STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; MAJOR CLINICAL STUDY; OVARY CANCER; OVARY CYST; PREOPERATIVE EVALUATION; PRIORITY JOURNAL; THROMBOCYTE COUNT;

EID: 49649116568     PISSN: 03012115     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejogrb.2005.10.037     Document Type: Article

References (18)

1. de Sauvage F.J., Hass P.E., Spencer S.D., et al. Stimulation of megakaryocytopoiesis and thrombopoiesis by the c-Mpl ligand. Nature 369 (1994) 533-538
2. Kaser A., Brandacher G., Steurer W., et al. Interleukin-6 stimulates thrombopoiesis through thrombopoietin: role in inflammatory thrombocytosis. Blood 98 (2001) 2720-2725
3. Feese M.D., Tamada T., Kato Y., et al. Structure of the receptor-binding domain of human thrombopoietin determined by complexation with a neutralizing antibody fragment. Proc Natl Acad Sci USA 101 (2004) 1816-1821
4. Kaushansky K. Thrombopoietin. N Engl J Med 339 (1998) 746-754
5. Frenkel E.P. Southwestern Internal Medicine Conference: the clinical spectrum of thrombocytosis and thrombocythemia. Am J Med Sci 301 (1991) 69-80
6. Cerutti A., Custodi P., Duranti M., Noris P., and Balduini C.L. Thrombopoietin levels in patients with primary and reactive thrombocytosis. Br J Haematol 99 (1997) 281-284
7. Hsu H.C., Tsai W.H., Jiang M.L., et al. Circulating levels of thrombopoietic and inflammatory cytokines in patients with clonal and reactive thrombocytosis. J Lab Clin Med 134 (1997) 392-397
8. Hernandez E., Donohue K.A., Anderson L.L., Heller P.B., and Stehman F.B. The significance of thrombocytosis in patients with locally advanced cervical carcinoma: a Gynecologic Oncology Group study. Gynecol Oncol 78 (2000) 137-142
9. Scholz H.S., Petru E., Gucer F., Haas J., Tamussino K., and Winter R. Preoperative thrombocytosis is an independent prognostic factor in stage III and IV endometrial cancer. Anticancer Res 20 (2000) 3983-3985
10. Gucer F., Moser F., Tamussino K., et al. Thrombocytosis as a prognostic factor in endometrial carcinoma. Gynecol Oncol 70 (1998) 210-214
11. Lavie O., Comerci G., Daras V., Bolger B.S., Lopes A., and Monaghan J.M. Thrombocytosis in women with vulvar carcinoma. Gynecol Oncol 72 (1999) 82-86
12. Zeimet A.G., Marth C., Muller-Holzner E., Daxenbichler G., and Dapunt O. Significance of thrombocytosis in patients with epithelial ovarian cancer. Am J Obstet Gynecol 170 (1994) 549-554
13. Li A.J., Madden A.C., Cass I., Leuchter R.S., Lagasse L.D., and Karlan B.Y. The prognostic significance of thrombocytosis in epithelial ovarian carcinoma. Gynecol Oncol 92 (2004) 211-214
14. Jacobs I., and Bast R.C. The CA-125 tumour associated antigen: a review of the literature. Hum Reprod 4 (1989) 1-12
15. Obermair A., Tempfer C., Hefler L., et al. Concentration of vascular endothelial growth factor (VEGF) in the serum of patients with suspected ovarian cancer. Br J Cancer 77 (1998) 1870-1874
16. Gastl G., Plante M., Finstad C.L., et al. High IL-6 levels in ascitic fluid correlate with reactive thrombocytosis in patients with ovarian cancer. Br J Haematol 83 (1993) 433-441
17. Werynska B., Ramlau R., Podolak-Dawidziak M., et al. Serum thrombopoietin levels in patients with reactive thrombocytosis due to lung cancer and in patients with essential thrombocythemia. Neoplasma 50 (2003) 447-451
18. Furuhashi M., Miyabe Y., and Oda H. A case of thrombopoietin-producing ovarian carcinoma confirmed by immunohistochemistry. Gynecol Oncol 74 (1999) 278-281