Cathepsin H and napsin A are active in the alveoli and increased in alveolar proteinosis

European Respiratory Journal

Volumn 31, Issue 6, 2008, Pages 1197-1204

  Woischnik, M ^a   Bauer, A ^a   Aboutaam, R ^c   Pamir, A ^a   Stanzel, F ^b   De Blic, J ^c   Griese, M ^a  

^a UNIVERSITY OF MUNICH   (Germany)

^b ASKLEPIOS FACHKLINIKEN MÜNCHEN GAUTING   (Germany)

^c HÔPITAL NECKER ENFANTS MALADES   (France)

Author keywords

Alveolar proteinosis; Cathepsin H; Napsin A; Surfactant protein B; Surfactant protein C

Indexed keywords

ASPARTIC PROTEINASE; CATHEPSIN H; CYSTATIN C; LACTATE DEHYDROGENASE; NAPSIN A ENZYME; UNCLASSIFIED DRUG; CATHEPSIN; CYSTATIN; CYSTEINE PROTEINASE; NAPSA PROTEIN, HUMAN;

ADULT; ARTICLE; CHILD; CLINICAL ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME DEGRADATION; HUMAN; IMMUNOBLOTTING; LUNG ALVEOLUS; LUNG ALVEOLUS PROTEINOSIS; LUNG LAVAGE; PRIORITY JOURNAL; CASE CONTROL STUDY; CHEMISTRY; ENZYMOLOGY; INFANT; METABOLISM; PRESCHOOL CHILD;

ADULT; ASPARTIC ENDOPEPTIDASES; BRONCHOALVEOLAR LAVAGE FLUID; CASE-CONTROL STUDIES; CATHEPSINS; CHILD, PRESCHOOL; CYSTATINS; CYSTEINE ENDOPEPTIDASES; HUMANS; INFANT; PULMONARY ALVEOLAR PROTEINOSIS;

EID: 49649108852     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00081207     Document Type: Article

References (42)

1. Weaver TE. Synthesis, processing and secretion of surfactant proteins B and C. Biochim Biophys Acta 1998; 1408: 173-179.
2. Phelps DS, Floros J. Localization of surfactant protein synthesis in human lung by in situ hybridization. Am Rev Respir Dis 1988; 137: 939-942.
3. Beers MF, Kim CY, Dodia C, Fisher AB. Localization, synthesis, and processing of surfactant protein SP-C in rat lung analyzed by epitope-specific antipeptide antibodies. J Biol Chem 1994; 269: 20318-20328.
4. Brasch F, Ochs M, Kahne T, et al. Involvement of napsin A in the C- and N-terminal processing of surfactant protein B in type-II pneumocytes of the human lung. J Biol Chem 2003; 278: 49006-49014.
5. Brasch F, Ten Brinke A, Johnen G, et al. Involvement of cathepsin H in the processing of the hydrophobic surfactant-associated protein C in type II pneumocytes. Am J Respir Cell Mol Biol 2002; 26: 659-670.
6. Ueno T, Linder S, Na CL, Rice WR, Johansson J, Weaver TE. Processing of pulmonary surfactant protein B by napsin and cathepsin H. J Biol Chem 2004; 279: 16178-16184.
7. Guttentag S, Robinson L, Zhang P, Brasch F, Buhling F, Beers M Cysteine protease activity is required for surfactant protein B processing, lamellar body genesis, Am J Respir Cell Mol Biol 2003; 28: 69-79.
8. Chapman HA, Riese RJ, Shi GP. Emerging roles for cysteine proteases in human biology. Annu Rev Physiol 1997; 59: 63-88.
9. Buhling F, Waldburg N, Reisenauer A, Heimburg A, Golpon H, Welte T. Lysosomal cysteine proteases in the lung: role in protein processing and immunoregulation. Eur Respir J 2004; 23: 620-628.
10. Nishimura Y, Kato K. Intracellular transport and processing of lysosomal cathepsin H. Biochem Biophys Res Commun 1987; 148: 329-334.
11. Ishii Y, Hashizume Y, Kominami E, Uchiyama Y. Changes in immunoreactivity for cathepsin H in rat type II alveolar epithelial cells and its proteolytic activity in bronchoalveolar lavage fluid over 24 hours. Anat Rec 1991; 230: 519-523.
12. Ishii Y, Hashizume Y, Watanabe T, et al. Cysteine proteinases in bronchoalveolar epithelial cells and lavage fluid of rat lung. J Histochem Cytochem 1991; 39: 461-468.
13. Serveau-Avesque C, Martino MF, Hervé-Grépinet V, et al. Active cathepsins B, H, K, L and S in human inflammatory bronchoalveolar lavage fluids. Biol Cell 2006; 98: 15-22.
14. Perdereau C, Godat E, Maurel MC, Hazouard E, Diot E, Lalmanach G. Cysteine cathepsins in human silicotic bronchoalveolar lavage fluids. Biochim Biophys Acta 2006; 1762: 351-356.
15. Altiok O, Yasumatsu R, Bingol-Karakoc G, et al. Imbalance between cysteine proteases and inhibitors in a baboon model of bronchopulmonary dysplasia. Am J Respir Crit Care Med 2006; 173: 318-326.
16. Chuman Y, Bergman A, Ueno T, et al. Napsin A, a member of the aspartic protease family, is abundantly expressed in normal lung and kidney tissue and is expressed in lung adenocarcinomas. FEBS Lett 1999; 462: 129-134.
17. Schauer-Vukasinovic V, Langen H, Giller T. Detection of immunoreactive napsin A in human urine. Biochim Biophys Acta 2001; 1524: 51-56.
18. Ratjen F, Bredendiek M, Brendel M, Meltzer J, Costabel U. Differential cytology of bronchoalveolar lavage fluid in normal children. Eur Respir J 1994; 7: 1865-1870.
19. Abrahamson M, Ritonja A, Brown MA, Grubb A, Machleidt W, Barrett AJ. Identification of the probable inhibitory reactive sites of the cysteine proteinase inhibitors human cystatin C and chicken cystatin. J Biol Chem 1987; 262: 9688-9694.
20. Brasch F, Johnen G, Schauer-Vukasinovic V, Ten Brinke A, Kapp N. Napsin A is involved in the processing of proSPC. Am J Respir Crit Care Med 2001; 163: A560.
21. Tatnell PJ, Powell DJ, Hill J, Smith TS, Tew DG, Kay J. Napsins: new human aspartic proteinases. Distinction between two closely related genes. FEBS Lett 1998; 441: 43-48.
22. Doyle IR, Bersten AD, Nicholas TE. Surfactant proteins-A and -B are elevated in plasma of patients with acute respiratory failure. Am J Respir Crit Care Med 1997; 156: 1217-1229.
23. Griese M, Schumacher S, Tredano M, et al. Expression profiles of hydrophobic surfactant proteins in children with diffuse chronic lung disease. Respir Res 2005; 6: 80.
24. Weaver TE, Whitsett JA. Processing of hydrophobic pulmonary surfactant protein B in rat type II cells. Am J Physiol 1989; 257: 100-108.
25. Kitamura T, Tanaka N, Watanabe J, et al. Idiopathic pulmonary alveolar proteinosis as an autoimmune disease with neutralizing antibody against granulocyte/macrophage colony-stimulating factor. J Exp Med 1999; 190: 875-880.
26. Uchida K, Beck DC, Yamamoto T, et al. GM-CSF autoantibodies and neutrophil dysfunction in pulmonary alveolar proteinosis. N Engl J Med 2007; 356: 567-579.
27. Tanaka N, Watanabe J, Kitamura T, Yamada Y, Kanegasaki S, Nakata K. Lungs of patients with idiopathic pulmonary alveolar proteinosis express a factor which neutralizes granulocyte-macrophage colony stimulating factor. FEBS Lett 1999; 442: 246-250.
28. de Blic J. Pulmonary alveolar proteinosis in children. Paediatr Respir Rev 2004; 5: 316-322.
29. Seymour JF, Presneill JJ. Pulmonary alveolar proteinosis: progress in the first 44 years. Am J Respir Crit Care Med 2002; 166: 215-235.
30. Latzin P, Tredano M, Wust Y, et al. Anti-GM-CSF antibodies in paediatric pulmonary alveolar proteinosis. Thorax 2005; 60: 39-44.
31. Rebello CM, Jobe AH, Eisele JW, Ikegami M. Alveolar and tissue surfactant pool sizes in humans. Am J Respir Crit Care Med 1996; 154: 625-628.
32. Schauer-Vukasinovic V, Bur D, Kling D, Grüninger F, Giller T. Human napsin A: expression, immunochemical detection, and tissue localization. FEBS Lett 1999; 462: 135-139.
33. Schauer-Vukasinovic V, Wright MB, Breu V, Giller T. Cloning, expression and functional characterization of rat napsin. Biochim Biophys Acta 2000; 1492: 207-210.
34. Mori K, Shimizu H, Konno A, Iwanaga T. Immunohistochemical localization of napsin and its potential role in protein catabolism in renal proximal tubules. Arch Histol Cytol 2002; 65: 359-368.
35. Härter L, Keel M, Hentze H, Leist M, Ertel W. Caspase-3 activity is present in cerebrospinal fluid from patients with traumatic brain injury. J Neuroimmunol 2001; 121: 76-78.
36. Hentze H, Schwoebel F, Lund S, et al. In vivo and in vitro evidence for extracellular caspase activity released from apoptotic cells. Biochem Biophys Res Commun 2001; 283: 1111-1117.
37. Cowan KN, Leung WC, Mar C, Bhattacharjee R, Zhu Y, Rabinovitch M. Caspases from apoptotic myocytes degrade extracellular matrix: a novel remodeling paradigm. FASEB J 2005; 19: 1848-1850.
38. Yayoi Y, Ohsawa Y, Koike M, Zhang G, Kominami E, Uchiyama Y. Specific localization of lysosomal aminopeptidases in type II alveolar epithelial cells of the rat lung. Arch Histol Cytol 2001; 64: 89-97.
39. Ng AW, Bidani A, Heming TA. Innate host defense of the lung: effects of lung-lining fluid pH. Lung 2004; 182: 297-317.
40. Turk V, Bode W. The cystatins: protein inhibitors of cysteine proteinases. FEBS Lett 1991; 285: 213-219.
41. Grubb AO. Cystatin C - properties and use as diagnostic marker. Adv Clin Chem 2000; 35: 63-99.
42. Simonsen O, Grubb A, Thysell H. The blood serum concentration of cystatin C (gamma-trace) as a measure of the glomerular filtration rate. Scand J Clin Lab Invest 1985; 45: 97-101.