CXCR4 antagonism increases T cell trafficking in the central nervous system and improves survival from West Nile virus encephalitis

Proceedings of the National Academy of Sciences of the United States of America

Volumn 105, Issue 32, 2008, Pages 11270-11275

  McCandless, Erin E ^a   Zhang, Bo ^a   Diamond, Michael S ^a   Klein, Robyn S ^a  

^a WASHINGTON UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

CD8 T cell; Chemokine; CNS; CXCL12; Neuropathology

Indexed keywords

CHEMOKINE RECEPTOR CXCR4; PLERIXAFOR; STROMAL CELL DERIVED FACTOR 1;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CD8+ T LYMPHOCYTE; CELL ACTIVATION; CELL INFILTRATION; CELL MIGRATION; CELLULAR DISTRIBUTION; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DRUG MECHANISM; DRUG RECEPTOR BINDING; ENCEPHALITIS; GLIA CELL; HUMAN; MALE; MOUSE; NONHUMAN; PARENCHYMA; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN FUNCTION; PROTEIN LOCALIZATION; RNA TRANSLATION; SURVIVAL RATE; T LYMPHOCYTE; TIME TO MAXIMUM PLASMA CONCENTRATION; VIRUS LOAD; WEST NILE FLAVIVIRUS;

ACUTE DISEASE; ANIMALS; ANTI-HIV AGENTS; BLOOD-BRAIN BARRIER; CD8-POSITIVE T-LYMPHOCYTES; CELL MOVEMENT; CHEMOKINE CXCL12; DISEASE MODELS, ANIMAL; HETEROCYCLIC COMPOUNDS; HUMANS; MALE; MICE; RECEPTORS, CXCR4; WEST NILE FEVER; WEST NILE VIRUS;

MURINAE; WEST NILE VIRUS;

EID: 49649103837     PISSN: 00278424     EISSN: 10916490     Source Type: Journal    
DOI: 10.1073/pnas.0800898105     Document Type: Article

References (36)

1. Ransohoff RM, Kivisakk P, Kidd G (2003) Three ormoreroutes for leukocyte migration into the central nervous system. Nat Rev Immunol 3:569-581.
2. McGavern DB, Truong P (2004) Rebuilding an immune-mediated central nervous system disease: Weighing the pathogenicity of antigen-specific versus bystander T cells. J Immunol 173:4779-4790.
3. Hausmann J, et al. (2005) CD8 T cells require gamma interferon to clear borna disease virus from the brain and prevent immune system-mediated neuronal damage. J Virol 79:13509-13518.
4. Bouffard JP, Riudavets MA, Holman R, Rushing EJ (2004) Neuropathology of the brain and spinal cord in human West Nile virus infection. Clin Neuropathol 23:59-61.
5. McCandless EE, Wang Q, Woerner BM, Harper JM, Klein RS (2006) CXCL12 limits inflammation by localizing mononuclear infiltrates to the perivascular space during experimental autoimmune encephalomyelitis. J Immunol 177:8053-8064.
6. Bleul CC, Schultze JL, Springer TA (1998) B lymphocyte chemotaxis regulated in association with microanatomic localization, differentiation state, and B cell receptor engagement. J Exp Med 187:753-762.
7. Dheen ST, Kaur C, Ling EA (2007) Microglial activation and its implications in the brain diseases. Curr Med Chem 14:1189-1197.
8. McCandless EE, et al. (2008) Pathologic expression of CXCL12 at the blood brain barrier correlates with severity of Multiple Sclerosis. Am J Pathol 172:799-808.
9. Rempel JD, Murray SJ, Meisner J, Buchmeier MJ (2004) Mouse hepatitis virus neurovirulence: Evidence of a linkage between S glycoprotein expression and immunopathology. Virology 318:45-54.
10. King NJ, et al. (2007) Immunopathology of flavivirus infections. Immunol Cell Biol 85:33-42.
11. + T cells mediate recovery and immunopathology in West Nile virus encephalitis. J Virol 77:13323-13334.
12. Shrestha B, Gottlieb D, Diamond MS (2003) Infection and injury of neurons by West Nile encephalitis virus. J Virol 77:13203-13213.
13. Kleinschmidt-DeMasters BK, et al. (2004) Naturally acquired West Nile virus encephalomyelitis in transplant recipients: Clinical, laboratory, diagnostic, and neuropathological features. Arch Neurol 61:1210-1220.
14. + T cells require perforin to clear West Nile virus from infected neurons. J Virol 80:119-129.
15. Engle MJ, Diamond MS (2003) Antibody prophylaxis and therapy against West Nile virus infection in wild-type and immunodeficient mice. J Virol 77:12941-12949.
16. Stumm RK, et al. (2002) A dual role for the SDF-1/CXCR4 chemokine receptor system in adult brain: Isoform-selective regulation of SDF-1 expression modulates CXCR4-dependent neuronal plasticity and cerebral leukocyte recruitment after focal ischemia. J Neurosci 22:5865-5878.
17. + T cells in control of West Nile virus infection. J Virol 78:8312-8321.
18. Woerner BM, Warrington NM, Kung AL, Perry A, Rubin JB (2005) Widespread CXCR4 activation in astrocytomas revealed by phospho-CXCR4-specific antibodies. Cancer Res 65:11392-11399.
19. Hatse S, Princen K, Bridger G, De Clercq E, Schols D (2002) Chemokine receptor inhibition by AMD3100 is strictly confined to CXCR4. FEBS Lett 527:255-262.
20. Datema R, et al. (1996) Antiviral efficacy in vivo of the anti-human immunodeficiency virus bicyclam SDZ SID 791 (JM 3100), an inhibitor of infectious cell entry. Antimicrob Agents Chemother 40:750-754.
21. Ben-Nathan D, et al. (1992) Dehydroepiandrosterone protects mice inoculated with West Nile virus and exposed to cold stress. J Med Virol 38:159-166.
22. Purtha WE, et al. (2007) Antigen-specific cytotoxic T lymphocytes protect against lethal West Nile virus encephalitis. Eur J Immunol 37:1845-1854.
23. Glass WG, Chen BP, Liu MT, Lane TE (2002) Mouse hepatitis virus infection of the central nervous system: Chemokine-mediated regulation of host defense and disease. Viral Immunol 15:261-272.
24. Lauterbach H, Zuniga EI, Truong P, Oldstone MB, McGavern DB (2006) Adoptive immunotherapy induces CNS dendritic cell recruitment and antigen presentation during clearance of a persistent viral infection. J Exp Med 203:1963-1975.
25. + T cells. J Gen Virol 77(4):705-714.
26. Tishon A, et al. (2006) CD4 T cell control primary measles virus infection of the CNS: Regulation is dependent on combined activity with either CD8 T cells or with B cells: CD4, CD8, or B cells alone are ineffective. Virology 347:234-245.
27. Wang T, et al. (2003) IFN-gamma-producing gamma delta T cells help control murine West Nile virus infection. J Immunol 171:2524-2531.
28. Schabath R, et al. (1999) The murine chemokine receptor CXCR4 is tightly regulated during T cell development and activation. J Leukoc Biol 66:996-1004.
29. Wehrli N, et al. (2001) Changing responsiveness to chemokines allows medullary plasma-blasts to leave lymph nodes. Eur J Immunol 31:609-616.
30. Chiba K, Matsuyuki H, Maeda Y, Sugahara K (2006) Role of sphingosine 1-phosphate receptor type 1 in lymphocyte egress from secondary lymphoid tissues and thymus. Cell Mol Immunol 3:11-19.
31. + T cells during peripheral differentiation. Eur J Immunol 34:3370-3378.
32. Aboumrad E, Madec AM, Thivolet C (2007) The CXCR4/CXCL12 (SDF-1) signalling pathway protects non-obese diabetic mouse from autoimmune diabetes. Clin Exp Immunol 148:432-439.
33. Roy A, Hooper DC (2007) Lethal silver-haired bat rabies virus infection can be prevented by opening the blood-brain barrier. J Virol 81:7993-7998.
34. Morrey JD, et al. (2006) Humanized monoclonal antibody against West Nile virus envelope protein administered after neuronal infection protects against lethal encephalitis in hamsters. J Infect Dis 194:1300-1308.
35. Ebel GD, et al. (2001) Partial genetic characterization of West Nile virus strains, New York State, 2000. Emerg Infect Dis 7:650-653.
36. + T-cell recruitment and control of West Nile virus encephalitis. J Virol 79:11457-11466.