Targeting small airways in asthma: The new challenge of inhaled corticosteroid treatment

European Respiratory Journal

Volumn 31, Issue 6, 2008, Pages 1145-1147

  Lahzami, S ^a,b   King, G G ^a,b,c,d  

^a ROYAL NORTH SHORE HOSPITAL   (Australia)

^b WOOLCOCK INSTITUTE OF MEDICAL RESEARCH   (Australia)

^c Cooperative Research Centre for Asthma ^*  (Australia)

^d UNIVERSITY OF SYDNEY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

BECLOMETASONE; CICLESONIDE; PLACEBO; ANTIINFLAMMATORY AGENT; CORTICOSTEROID;

ASTHMA; CLINICAL ASSESSMENT; DRUG EFFICACY; DRUG FORMULATION; EDITORIAL; HIGH RESOLUTION COMPUTER TOMOGRAPHY; HUMAN; PRIORITY JOURNAL; TREATMENT OUTCOME; AEROSOL; BRONCHUS; CHEMISTRY; DRUG EFFECT; INFLAMMATION; INHALATIONAL DRUG ADMINISTRATION; NOTE; PARTICLE SIZE; PATHOPHYSIOLOGY;

ADMINISTRATION, INHALATION; ADRENAL CORTEX HORMONES; AEROSOLS; ANTI-INFLAMMATORY AGENTS; ASTHMA; BRONCHI; HUMANS; INFLAMMATION; PARTICLE SIZE;

EID: 49649103807     PISSN: 09031936     EISSN: 13993003     Source Type: Journal    
DOI: 10.1183/09031936.00045608     Document Type: Editorial

References (21)

1. Carroll N, Elliot J, Morton A, James A. The structure of large and small airways in nonfatal and fatal asthma. Am Rev Respir Dis 1993; 147: 405-410.
2. Balzar S, Wenzel SE, Chu HW. Transbronchial biopsy as a tool to evaluate small airways in asthma. Eur Respir J 2002; 20: 254-259.
3. Cohen J, Douma WR, ten Hacken NHT, Vonk JM, Oudkerk M, Postma DS. Ciclesonide improves measures of small airway involvement in asthma. Eur Respir J 2008; 31: 1213-1220.
4. in 't Veen JC, Beekman AJ, Bel EH, Sterk PJ. Recurrent exacerbations in severe asthma are associated with enhanced airway closure during stable episodes. Am J Respir Crit Care Med 2000; 161: 1902-1906.
5. Downie S, Salome C, Verbanck S, Thompson B, Berend N, King G. Ventilation heterogeneity is a major determinant of airway hyperresponsiveness in asthma, independent of airway inflammation. Thorax 2007; 62: 684-689.
6. Kaminsky DA, Irvin CG, Lundblad L, et al. Oscillation mechanics of the human lung periphery in asthma. J Appl Physiol 2004; 97: 1849-1858.
7. Tgavalekos NT, Musch G, Harris RS, et al. Relationship between airway narrowing, patchy ventilation and lung mechanics in asthmatics. Eur Respir J 2007; 29: 1174-1181.
8. Zeidler MR, Kleerup EC, Goldin JG, et al. Montelukast improves regional air-trapping due to small airways obstruction in asthma. Eur Respir J 2006; 27: 307-315.
9. Kaminsky DA, Irvin CG, Lundblad LKA, et al. Heterogeneity of bronchoconstriction does not distinguish mild asthmatic subjects from healthy controls when supine. J Appl Physiol 2008; 104: 10-19.
10. Brown R, Woolcock AJ, Vincent NJ, Macklem PT. Physiological effects of experimental airway obstruction with beads. J Appl Physiol 1969; 27: 328-335.
11. Brown NJ, Salome CM, Berend N, Thorpe CW, King GG. Airway distensibility in asthmatic and healthy adults measured by forced oscillation technique. Am J Respir Crit Care Med 2007; 176: 129-137.
12. Lutchen KR, Jensen A, Atileh H, et al. Airway constriction pattern is a central component of asthma severity. The role of deep inspirations. Am J Respir Crit Care Med 2001; 164: 207-215.
13. Sont JK, Willems LNA, Bel EH, van Krieken JHJM, Vandenbroucke JP, Sterk PJ. Clinical control and histopathological outcome of asthma when using airway hyperresponsiveness as an additional guide to long-term treatment. Am J Respir Crit Care Med 1999; 159: 1043-1051.
14. ten Brinke A, Zwinderman AH, Sterk PJ, Rabe KF, Bel EH. Factors associated with persistent airflow limitation in severe asthma. Am J Respir Crit Care Med 2001; 164: 744-748.
15. Rasmussen F, Taylor DR, Flannery EM, et al. Risk factors for hospital admission for asthma from childhood to young adulthood: a longitudinal population study. J Allergy Clin Immunol 2002; 110: 220-227.
16. Newman S, Salmon A, Nave R, Drollmann A. High lung deposition of 99mTc-labeled ciclesonide administered via HFA-MDI to patients with asthma. Respir Med 2006; 100: 375-384.
17. Goldin JG, Tashkin DP, Kleerup EC, et al. Comparative effects of hydrofluoroalkane and chlorofluorocarbon beclomethasone dipropionate inhalation on small airways: assessment with functional helical thin-section computed tomography. J Allergy Clin Immunol 1999; 104: S258-S267.
18. Tunon-de-Lara JM, Laurent F, Giraud V, et al. Air trapping in mild and moderate asthma: effect of inhaled corticosteroids. J Allergy Clin Immunol 2007; 119: 583-590.
19. Thongngarm T, Silkoff P, Kossack W, Nelson H. Hydrofluoroalkane-134A beclomethasone or chlorofluorocarbon fluticasone: effect on small airways in poorly controlled asthma. J Asthma 2005; 42: 257-263.
20. Verbanck S, Schuermans D, Paiva M, Vincken W. The functional benefit of anti-inflammatory aerosols in the lung periphery. J Allergy Clin Immunol 2006; 118: 340-346.
21. King GG, Carroll JD, Müller NL, et al. Heterogeneity of narrowing in normal and asthmatic airways measured by HRCT. Eur Respir J 2004; 24: 211-218.