Does the RET variant G691S influence the features of sporadic medullary thyroid carcinoma?

Clinical Endocrinology

Volumn 69, Issue 3, 2008, Pages 506-510

  Cardot Bauters, C ^a   Leteurtre, E ^b   Leclerc, L ^a   Vantyghem, M C ^a   Do Cao, C ^a   Wemeau, J L ^a   D'Herbomez, M ^b   Carnaille, B ^a   Barbu, V ^c   Pinson, S ^d   Pigny, P ^a  

^a LILLE UNIVERSITY HOSPITAL   (France)

^b Centre de Biologie Pathologie   (France)

^c HÔPITAL SAINT ANTOINE   (France)

^d EDOUARD HERRIOT HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

CALCITONIN;

ADOLESCENT; ADULT; AGED; ARTICLE; CELL HYPERPLASIA; CLINICAL TRIAL; CONTROLLED STUDY; GENE REARRANGEMENT; GENETIC ANALYSIS; GENETIC VARIABILITY; HETEROZYGOSITY; HUMAN; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MEDICAL RECORD; MULTICENTER STUDY; PREVALENCE; PRIORITY JOURNAL; PROTO ONCOGENE; SCHOOL CHILD; THYROID CARCINOMA; THYROID MEDULLARY CARCINOMA;

ADOLESCENT; ADULT; AGE OF ONSET; AGED; CARCINOMA, MEDULLARY; CASE-CONTROL STUDIES; FEMALE; GENETIC VARIATION; GLYCINE; HUMANS; MALE; MIDDLE AGED; NEOPLASM METASTASIS; PROTO-ONCOGENE PROTEINS C-RET; RETROSPECTIVE STUDIES; SERINE; THYROID NEOPLASMS; YOUNG ADULT;

EID: 49649083859     PISSN: 03000664     EISSN: 13652265     Source Type: Journal    
DOI: 10.1111/j.1365-2265.2008.03230.x     Document Type: Article

References (11)

1. Taraviras, S., Marcos-Gutierrez, C.V., Durbec, P., Jani, H., Grigoriou, M., Sukumaran, M., Wang, L.C., Hynes, M., Raisman, G. Pachnis, V. (1999) Signalling by the RET receptor tyrosine kinase and its role in the development of the mammalian enteric nervous system. Development, 126, 2785 2797.
2. Robledo, M., Gil, L., Pollan, M., Cebrian, A., Ruiz, S., Azanedo, M., Benitez, J., Menarguez, J. Rojas, J.M. (2003) Polymorphism G691S/S904S of RET as genetic modifiers of MEN2A. Cancer Research, 63, 1814 1817.
3. Elisei, R., Cosci, B., Romei, C., Bottici, V., Sculli, M., Lari, R., Barale, R., Pacini, F. Pinchera, A. (2004) RET exon 11 (G691S) polymorphism is significantly more frequent in sporadic medullary thyroid carcinoma than in the general population. Journal of Clinical Endocrinology and Metabolism, 89, 3579 3584.
4. Cebrian, A., Lesueur, F., Martin, S., Leyland, J., Ahmed, S., Luccarini, C., Smith, P.L., Luben, R., Whittaker, J., Pharoah, P.D., Dunning, A.M. Ponder, B.A.J. (2005) Polymorphisms in the initiators of RET (Rearranged during Transfection) signalling pathway and susceptibility to sporadic medullary thyroid carcinoma. Journal of Clinical Endocrinology and Metabolism, 90, 6268 6274.
5. Sobin, L.H. (2002) Head and neck tumours. In : L.H. Sobin, Ch. Wittekind eds. UICC: TNM Classification of Malignant Tumors, 6th edn. Wiley-Liss, New York, 52 56.
6. Vantyghem, M.-C., Pigny, P., Leteurtre, E., Leclerc, E., Bauters, C., Douillard, C., d'Herbomez, M., Carnaille, B., Proye, C., Wemeau, J.L. Lecomte-Houcke, M. (2004) Thyroid carcinomas involving follicular and parafollicular C cells: seventeen cases with characterization of RET oncogenic mutation. Thyroid, 14, 847 852.
7. Guyetant, S., Rousselet, M.C., Durigon, M., Chappard, D., Franc, B., Guerin, O. Saint André, J.P. (1997) Sex-related C-cell hyperplasia in the normal human thyroid: a quantitative autopsy study. Journal of Clinical Endocrinology and Metabolism, 82, 42 47.
8. Bounacer, A., Du Villard, J.A., Wicker, R., Caillou, B., Schlumberger, M., Sarasin, A. Suarez, H.G. (2002) Association of RET codon 691 polymorphism in radiation-induced human thyroid tumours with C-cell hyperplasia in peritumoural tissue. British Journal of Cancer, 86, 1929 1936.
9. Sawai, H., Okada, Y., Kazanjian, K., Kim, J., Hasan, S., Hines, O.J., Reber, H.A., Hoon, D.S.B. Eibl, G. (2005) The G691S RET polymorphism increases GDNF-induced pancreatic cancer cell invasion by amplifying MAPK signaling. Cancer Research, 65, 11536 11544.
10. Lindahl, M., Timmusk, T., Rossi, J., Saarma, M. Airaksinen, M.S. (2000) Expression and alternative splicing of mouse Gfra4 suggest roles in endocrine cell development. Molecular and Cellular Neurosciences, 15, 522 533.
11. Cuccuru, G., Lanzi, C., Cassinelli, G., Pratesi, G., Tortoreto, M., Petrangolini, G., Seregni, E., Martinetti, A., Laccabue, D., Zanchi, C. Zunino, F. (2004) Cellular effects and antitumor activity of RET inhibitor RPI-1 on MEN2A associated medullary thyroid carcinoma. Journal of the National Cancer Institute, 96, 1006 1014.