Methylenetetrahydrofolate reductase 677CT polymorphism and cobalamin, folate, and homocysteine status in Spanish adolescents

Annals of Nutrition and Metabolism

Volumn 52, Issue 4, 2008, Pages 315-321

  Al Tahan, Jasmin ^a   Sola, Ricardo ^b   Ruiz, Jonatan R ^b   Breidenassel, Christina ^a   García Fuentes, Miguel ^c   Moreno, Luis A ^d   Castillo, Manuel ^b   Pietrzik, Klaus ^a   González Gross, Marcela ^a,b,e  

^a UNIVERSITY OF BONN   (Germany)

^b UNIVERSITY OF GRANADA   (Spain)

^c UNIVERSITY OF CANTABRIA   (Spain)

^d UNIVERSITY OF ZARAGOZA   (Spain)

^e UNIVERSIDAD POLITÉCNICA DE MADRID   (Spain)

Author keywords

Adolescents, Spanish; B vitamins; Cobalamin; Folate; Homocysteine

Indexed keywords

5,10 METHYLENETETRAHYDROFOLATE REDUCTASE (FADH2); COBALAMIN; FOLIC ACID; HOMOCYSTEINE; METHYLENETETRAHYDROFOLATE REDUCTASE 677CT; UNCLASSIFIED DRUG;

ADOLESCENT; ADULT; ARTICLE; BODY MASS; DEVELOPMENTAL STAGE; FEMALE; FOLIC ACID BLOOD LEVEL; GENETIC POLYMORPHISM; GROUPS BY AGE; HUMAN; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; SEX DIFFERENCE; SMOKING HABIT; SOCIAL STATUS; SPAIN;

ADOLESCENT; ADOLESCENT NUTRITIONAL PHYSIOLOGICAL PHENOMENA; ANALYSIS OF VARIANCE; BODY MASS INDEX; FEMALE; FOLIC ACID; FOLIC ACID DEFICIENCY; HOMOCYSTEINE; HUMANS; MALE; METHYLENETETRAHYDROFOLATE REDUCTASE (NADPH2); NUTRITION ASSESSMENT; NUTRITIONAL STATUS; POLYMORPHISM, GENETIC; SEX FACTORS; SMOKING; SPAIN; VITAMIN B 12; VITAMIN B COMPLEX;

EID: 49549118927     PISSN: 02506807     EISSN: None     Source Type: Journal    
DOI: 10.1159/000151485     Document Type: Article

References (39)

1. Duyer J: Nutritional requirements of adolescence. Nutr Rev 1981;39:56-72.
2. Deheeger M, Bellisle F, Rolland-Cachera MF: The French longitudinal study of growth and nutrition: data in adolescent males and females. J Hum Nutr Diet 2002;15:429-438.
3. Block G, Patterson B, Subar A: Fruits, vegetables and cancer prevention. A review of epidemiological evidence. Nutr Cancer 1992;18:1-29.
4. Bouchard C, Despres JP: Physical activity and health: atherosclerotic, metabolic, and hypertensive diseases. Res Q Exerc Sport 1995;66:268-275.
5. Diplock AT: Antioxidants and disease prevention. Mol Aspects Med 1993;15:293-376.
6. Ueland PM, Monsen AL: Hyperhomocysteinemia and B-vitamin deficiencies in infants and children. Clin Chem Lab Med 2003;41:1418-1426.
7. 12 and folate levels in long-term vegans. Isr J Med Sci 1990;26:309-312.
8. 12 deficiency due to a strictly vegetarian diet in adolescence. Clin Pediatr (Phila) 1987;26:662-663.
9. Stanger O, Herrmann W, Pietrzik K, Fowler B, Geisel J, Dierkes J, Weger M: Clinical use and rational management of homocysteine, folic acid, and B-vitamins in cardiovascular and thrombotic diseases. Z Kardiol 2004;93:439-453.
10. Frosst P, Blom HJ, Milos R, Goyette P, Sheppard CA, Matthews RG, Boers GJ, den Heijer M, Kluijtmans LA, van den Heuvel LP, et al: A candidate genetic risk factor for vascular disease: A common mutation in methylenetetrahydrofolate reductase. Nat Genet 1995;10:111-113.
11. van der Put NM, Eskes TK, Blom HJ: Is the common 677C>T mutation in the methylenetetrahydrofolate reductase gene a risk factor for neural tube defects? A meta-analysis. QJM 1997;90:111-115.
12. Klerk M, Verhoef P, Clarke R, Blom HJ, Kok FJ, Schouten EG; MTHFR Studies Collaboration Group: MTHFR 677C>T polymorphism and risk of coronary heart disease: a meta-analysis. JAMA 2002;288:2023-2032.
13. Al-Tahan J, González-Gross M, Pietrzik K: B-vitamin status in European adolescents. A review of the literature. Nutr Hosp 2006;21:452-465.
14. Lambert J, Agostoni C, Elmadfa I, Hulshof K, Krause E, Livingstone B, Socha P, Pannemans D, Samartin S: Dietary intake and nutritional status of children and adolescents in Europe. Br J Nutr 2004;92(suppl 2):S147-S211.
15. Kersting M, Alexy U, Sichert-Hellert W: Vitamin intake of 1- to 18-year-old German children and adolescents in the light of various recommendations. Int J Vitam Nutr Res 2000;70:48-53.
16. Gonzalez-Gross M, Castillo MJ, Moreno L, Nova E, Gonzalez-Lamuno D, Perez-Llamas F, Gutierrez A, Garaulet M, Joyanes M, Leiva A, Marcos A: Feeding and assessment of nutritional status of Spanish adolescents (AVENA study). Evaluation of risks and interventional proposal. I. Methodology (In Spanish). Nutr Hosp 2003;18:15-28.
17. Moreno LA, Mesana MI, Fleta J, Ruiz JR, Gonzalez-Gross M, Sarria A, Marcos A, Bueno M: Overweight, obesity and body fat composition in Spanish adolescents. The AVENA study. Ann Nutr Metab 2005;49:71-76.
18. Ruiz JR, Ortega FB, Moreno L, Wärnberg J, Gonzalez-Gross M, Cano MD, Gutierrez A, Castillo MJ; AVENA Study Group: Reference values for serum lipids and lipoproteins in Spanish adolescents: The AVENA study. Soz Präventivmed 2006;51:99-109.
19. Sociedad española de epidemiología: La medición de la clase social en ciencias de la salud. Informe de un grupo de trabajo de la sociedad española de epidemiología. Barcelona, Sociedad española de epidemiología, 1995.
20. Moreno L, Joyanes M, Mesana M, Gonzalez-Gross M, Gil C, Sarria A, Gutierrez A, Garaulet M, Perez-Prieto R, Bueno M, Marcos A; AVENA Study Group: Harmonization of anthropometric measurements for a multicenter nutrition survey in Spanish adolescents. Nutrition 2003;19:481-486.
21. Cole T, Bellizzi M, Flegal M, Dietz W: Establishing a standard definition for child overweight and obesity worldwide: international survey. BMJ 2002;320:1-6.
22. Slaughter MH, Lohman TG, Boileau RA, Horswill CA, Stillman RJ, Van Loan MD, Bemben DA: Skinfold equations for estimation of body fatness in children and youth. Hum Biol 1988;60:709-723.
23. Tanner JM, Whitehouse RH: Clinical longitudinal standards for height, weight, height velocity and stages of puberty. Arch Dis Child 1976;51:170-179.
24. Higuchi R: Simple and rapid preparation of samples for PCR; in Erlich H (ed): PCR Technology: Principles and Applications for DNA Amplification. New York, Stockton Press, 1989, pp 31-38.
25. 12, Pantothenic Acid, Biotin and Choline: a Report of the Standing Committee on the Scientific Evaluation of Dietary Reference Intakes and Its Panel on Folate, Other B-Vitamins, and Choline and Subcommittee on Upper Levels of Nutrients. Washington, National Academy Press, 1998.
26. Osganian SK, Stampfer MJ, Spiegelman D, Rimm E, Cutler JA, Feldman HA, Montgomery DH, Webber LS, Lytle LA, Bausserman L, Nader PR: Distribution of and factors associated with serum homocysteine levels in children: child and adolescent trial for cardiovascular health. JAMA 1999;281:1189-1196.
27. 12 in a Greek school age population. Clin Nutr 2006;25:797-802.
28. Huemer M, Vonblon K, Fodinger M, Krumpholz R, Hubmann M, Ulmer H, Simma B: Total homocysteine, folate, and cobalamin, and their relation to genetic polymorphisms, lifestyle and body mass index in healthy children and adolescents. Pediatr Res 2006;60:764-769.
29. Papoutsakis C, Yiannakouris N, Manios Y, Papaconstantinou E, Magkos F, Schulpis KH, Zampelas A, Matalas AL: The effect of MTHFR 677C>T genotype on plasma homocysteine concentrations in healthy children is influenced by gender. Eur J Clin Nutr 2006;60:155-162.
30. Bjorke Monsen AL, Refsum H, Markestad T, Ueland PM: Cobalamin status and its biochemical markers methylmalonic acid and homocysteine in different age groups from 4 days to 19 years. Clin Chem 2003;49:2067-2075.
31. Reddy MN: Reference ranges for total homocysteine in children. Clin Chim Acta 1997;262:153-155.
32. Jacques PF, Selhub J, Bostom AG, Wilson PW, Rosenberg IH: The effect of folic acid fortification on plasma folate and total homocysteine concentrations. N Engl J Med 1999;340:1449-1454.
33. Bates CJ, Mansoor MA, Gregory J, Pentiev K, Prentice A: Correlates of plasma homocysteine, cysteine and cysteinyl-glycine in respondents in the British National Diet and Nutrition Survey of young people aged 4-18 years, and a comparison with the survey of people aged 65 years and over. Br J Nutr 2002;87:71-79.
34. De Laet C, Wautrecht JC, Brasseur D, Dramaix M, Boeynaems JM, Decuyper J, Kahn A: Plasma homocysteine concentration in a Belgian school-age population. Am J Clin Nutr 1999;69:968-972.
35. Oner N, Vatansever U, Karasalihoglu S, Ekuklu G, Celtik C, Biner B: The prevalence of folic acid deficiency among adolescent girls living in Edirne, Turkey. J Adolesc Health 2006;38:599-606.
36. Vilaseca MA, Moyano D, Ferrer I, Artuch R: Total homocysteine in paediatric patients. Clin Chem 1997;43:690-692.
37. van Beynum IM, Smeitink JA, den Heijer M, te Poele Pothoff MT, Blom HJ: Hyperhomocysteinemia: a risk factor for ischemic stroke in children. Circulation 1999;99:2070-2072.
38. Rauh M, Verwied S, Knerr I, Dorr HG, Sonnichsen A, Koletzko B: Homocysteine concentrations in a German cohort of 500 individuals: reference ranges and determinants of plasma levels in healthy children and their parents. Amino Acids 2001;20:409-418.
39. Raslova K, Bederova A, Gasparovic J, Blazicek P, Smolkova B: Effect of diet and 677C>T 5,10-methylenetetrahydrofolate reductase genotypes on plasma homocyst(e)ine concentrations in Slovak adolescent population. Physiol Res 2000;49:651-658.