Functional (neurologic) recovery following transient focal cerebral ischemia in the rat requires at least 80% of ipsilateral cortical and subcortical integrity

Experimental Neurology

Volumn 213, Issue 1, 2008, Pages 238-240

  Haelewyn, Benoit ^a   Rouillon, Christophe ^b   Risso, Jean Jacques ^c   Abraini, Jacques H ^b  

^a NNOXe Pharmaceuticals Inc   (Canada)

^b UNIVERSITÉ DE CAEN   (France)

^c IMNSSA   (France)

Author keywords

Cortical outcome; Ischemic stroke; Neurologic outcome; Subcortical outcome

Indexed keywords

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BRAIN CORTEX; BRAIN PROTECTION; CONTROLLED STUDY; CONVALESCENCE; HEMIPARESIS; MALE; MIDDLE CEREBRAL ARTERY OCCLUSION; MOTOR PERFORMANCE; NONHUMAN; PRIORITY JOURNAL; RAT; TRANSIENT ISCHEMIC ATTACK;

ANIMALS; BRAIN; CEREBRAL CORTEX; CEREBRAL INFARCTION; CYTOPROTECTION; DISABILITY EVALUATION; DISEASE PROGRESSION; FUNCTIONAL LATERALITY; INFARCTION, MIDDLE CEREBRAL ARTERY; ISCHEMIC ATTACK, TRANSIENT; MALE; NEUROPROTECTIVE AGENTS; NITROUS OXIDE; RATS; RATS, SPRAGUE-DAWLEY; RECOVERY OF FUNCTION; REPERFUSION INJURY; SEVERITY OF ILLNESS INDEX; XENON;

EID: 49549114026     PISSN: 00144886     EISSN: 10902430     Source Type: Journal    
DOI: 10.1016/j.expneurol.2008.05.012     Document Type: Article

References (20)

1. Abraini J.H., Rostain J.C., and Kriem B. Sigmoidal compression rate-dependence of the narcotic potency of inert gases in rats: implications for lipid vs protein theories of inert gas action in the central nervous system. Brain Res. 808 (1998) 300-304
2. Colloc'h N., Sopkoya-de Oliveira Santos J., Retailleau P., et al. Protein crystallography under xenon and nitrous oxide pressure: comparison with in vivo pharmacology studies and implications for the mechanism of inhaled anesthetic action. Biophys. J. 92 (2007) 217-224
3. David H.N., Leveillé F., Chazalviel L., et al. Reduction of ischemic brain damage by nitrous oxide and xenon. J. Cereb. Blood Flow Metab. 23 (2003) 1168-1173
4. David H.N., Ansseau M., Lemaire M., et al. Nitrous oxide and xenon prevent amphetamine-induced carrier-mediated dopamine release in a memantine-like fashion and protect against behavioral sensitization. Biol. Psychiatry 60 (2006) 49-57
5. David H.N., Haelewyn B., Rouillon C., et al. Neuroprotective effects of xenon: a therapeutic window of opportunity in rats subjected to transient focal cerebral ischemia. FASEB J 22 (2008) 1275-1286
6. DeVries A.C., Nelson R.J., Traystman R.J., et al. Cognitive and behavioral assessment in experimental stroke research: will it prove useful?. Neurosci. Biobehav. Rev. 25 (2001) 325-342
7. Franks N.P., Dickinson R., de Sousa S.L., Hall A.C., and Lieb W.R. How does xenon produce anaesthesia?. Nature (1998) 396:324
8. Fisher, C.M., Lacunes: small, deep cerebral infarcts. 1965. Neurology 1998; 50: 841-852.
9. Goto T., Nakata Y., Ishiguro Y., et al. Minimum alveolar concentration-awake of xenon alone and in combination with isoflurane or sevoflurane. Anesthesiology 93 (2000) 1188-1193
10. Grabowski M., Nordborg C., Brundin P., et al. Middle cerebral artery occlusion in the hypertensive and normotensive rat: a study of histopathology and behaviour. J. Hypertens. 6 (1988) 405-411
11. Gruss M., Bushell T.J., Bright D.P., et al. Two-pore-domain K+ channels are a novel target for the anesthetic gases xenon, nitrous oxide, and cyclopropane. Mol. Pharmacol. 65 (2004) 443-452
12. Hattori K., Lee H., Hurn P.D., Crain B.J., et al. Cognitive deficits after focal cerebral ischemia in mice. Stroke 31 (2000) 1939-1944
13. Haelewyn B., David H.N., Rouillon C. et al. Neuroprotection by nitrous oxide: facts and evidence. Critical Care Med 2008, in press.
14. Jevtovic-Todorovic V., Todorovic S.M., Mennerick S., et al. Nitrous oxide is an NMDA antagonist, neuroprotectant and neurotoxin. Nat. Med. 4 (1998) 460-463
15. Nedelmann M., Wilhelm-Schwenkmezger T., Alessandri B., et al. Cerebral embolic ischemia in rats: correlation of stroke severity and functional deficit as important outcome parameter. Brain Res. 1130 (2007) 188-196
16. Reglodi D., Tamás A., and Lengvári I. Examination of sensorimotor performance following middle cerebral artery occlusion in rats. Brain Res. Bull. 59 (2003) 459-466
17. Rogers D.C., Campbell C.A., Stretton J.L., et al. Correlation between motor impairment and infarct volume after permanent and transient middle cerebral artery occlusion in the rat. Stroke 28 (1997) 2060-2065
18. Yamakura T., and Harris R.A. Effects of gaseous anesthetics nitrous oxide and xenon on ligand-gated ion channels. Comparison with isoflurane and ethanol. Anesthesiology 93 (2000;) 1095-1101
19. Zausinger S., Hungerhuber E., Baethmann A., et al. Neurological impairment in rats after transient middle cerebral artery occlusion: a comparative study under various treatment paradigms. Brain Res. 863 (2000) 94-105
20. Zhang L., Chen J., Li Y., et al. Quantitative measurement of motor and somatosensory impairments after mild (30 min) and severe (2 h) transient middle cerebral artery occlusion in rats. J. Neurol. Sci. 174 (2000) 141-146