Modeling glutamatergic synapses: Insights into mechanisms regulating synaptic efficacy

Journal of Integrative Neuroscience

Volumn 7, Issue 2, 2008, Pages 185-197

  Bouteiller, Jean Marie C ^a,b   Baudry, Michel ^a,b   Allam, Sushmita L ^a,b   Greget, Renaud J ^a,b   Bischoff, Serge ^a,b   Berger, Theodore W ^a,b  

^a UNIVERSITY OF SOUTHERN CALIFORNIA   (United States)

^b Rhenovia Pharma   (France)

Author keywords

Glutamate; Hippocampus; Modeling; Plasticity; Receptor; Simulation; Synaptic

Indexed keywords

AMPA RECEPTOR; GLUTAMIC ACID; N METHYL DEXTRO ASPARTIC ACID RECEPTOR;

ARTICLE; BRAIN FUNCTION; COMPUTER SIMULATION; CONTROLLED STUDY; FACILITATION; GLUTAMATERGIC TRANSMISSION; HIPPOCAMPUS; LEARNING; LONG TERM POTENTIATION; MATHEMATICAL MODEL; MEMORY; MEMORY CONSOLIDATION; NEUROTRANSMISSION; SYNAPSE; SYNAPTIC TRANSMISSION;

ANIMALS; COMPUTER SIMULATION; ELECTRIC STIMULATION; GLUTAMIC ACID; HIPPOCAMPUS; MODELS, BIOLOGICAL; NERVE NET; NEURONS; PATCH-CLAMP TECHNIQUES; RECEPTORS, AMPA; SYNAPSES; SYNAPTIC TRANSMISSION;

EID: 49549112677     PISSN: 02196352     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0219635208001770     Document Type: Article

References (22)

1. Alger BE, Not too excited? Thank your endocannabinoids, Neuron 51(4):393-395, 2006.
2. Beierlein M, Regehr WG, Local interneurons regulate synaptic strength by retrograde release of endocannabinoids, J Neurosci 26 39):9935-9943, 2006.
3. Dai WM, Egebjerg J, Lambert JD, Characteristics of AMPA receptor-mediated responses of cultured cortical and spinal cord neurones and their correlation to the expression of glutamate receptor subunits, GluR1-4, Br J Pharmacol 132(8):1859-1875, 2001.
4. Earnshaw BA, Bressloff PC, Biophysical model of AMPA receptor trafficking and its regulation during long-term potentiation/long-term depression, J Neurosci 26(47):12362-12373, 2006.
5. Hayer A, Bhalla US, Molecular switches at the synapse emerge from receptor and kinase traffic, PLoS Comput Biol 1(2):137-154, 2005.
6. Holmes WR, Grover LM, Quantifying the magnitude of changes in synaptic level parameters with long-term potentiation, J Neurophysiol 96 3):1478-1491, 2006.
7. Lin B, Brucher FA, Colgin LL, Lynch G, Long-term potentiation alters the modulator pharmacology of AMPA-type glutamate receptors, J Neurophysiol 87(6):2790-2800, 2002.
8. Lisman J, Raghavachari S, A unified model of the presynaptic and postsynaptic changes during LTP at CA1 synapses, Sci STKE 2006 356):11, 2006.
9. Meyer T, Stryer L, Molecular model for receptor-stimulated calcium spiking, Proc Natl Acad Sci USA 85(14):5051-5055, 1988.
10. Mitani A, Namba S, Ikemune K, Yanase H, Arai T, Kataoka K, Postischemic enhancements of N-methyl-D-aspartic acid (NMDA) and Non-NMDA receptor-mediated responses in hippocampal CA1 pyramidal neurons, J Cereb Blood Flow Metab 18(10): 1088-1098, 1998.
11. Muller D, Arai A, Lynch G, Factors governing the potentiation of NMDA receptor-mediated responses in hippocampus, Hippocampus 2 1):29-38, 1992.
12. Oertner TG, Sabatini BL, Nimchinsky EA, Svoboda K, Facilitation at single synapses probed with optical quantal analysis, Nat Neurosci 5(7):657-664, 2002.
13. Schikorski T, Stevens CF, Quantitative ultrastructural analysis of hippocampal excitatory synapses, J Neurosci 17 15):5858-5867, 1997.
14. Shouval HZ, Bear MF, Cooper LN, A unified model of NMDA receptor-dependent bidirectional synaptic plasticity, Proc Natl Acad Sci USA 99(16):10831-10836. 2002.
15. Shouval HZ, Clusters of interacting receptors can stabilize synaptic efficacies, Proc Natl Acad Sci USA 102(40):14440-14445, 2005.
16. Sneyd J, Dufour JF, A dynamic model of the type-2 inositol trisphosphate receptor, Proc Natl Acad Sci USA 99(4):2398-2403, 2002.
17. Steuber V, Willshaw D, Van Ooyen A, Generation of time delays: Simplified models of intracellular signalling in cerebellar Purkinje cells, Network 17(2):173-191, 2006.
18. Takumi Y, Ramirez-Leon V, Laake P, Rinvik E, Ottersen OP, Different modes of expression of AMPA and NMDA receptors in hippocampal synapses, Nat Neurosci 2(7):618-624, 1999.
19. Tang C, Shi Q, Katchman A, Lynch G, Modulation of the time course of fast EPSCs and glutamate channel kinetics by aniracetam, Science 254(509):288-290, 1991.
20. Wang Z, Song D, Berger TW, Contribution of NMDA receptor channels to the expression of LTP in the hippocampal dentate gyrus, Hippocampus 12(5):680-688, 2002.
21. Xie X, Liaw JS, Baudry M, Berger TW, Novel expression mechanism for synaptic potentiation: Alignment of presynaptic release site and postsynaptic receptor, Proc Natl Acad Sci USA 94 13):6983-6988, 1997.
22. Zucker RS, Regehr WG, Short-term synaptic plasticity, Annu Rev Physiol 64:355-405, 2002.