Gonadotropin-releasing hormone agonist blocks anxiogenic-like and depressant-like effect of corticotrophin-releasing hormone in mice

Neuropeptides

Volumn 42, Issue 4, 2008, Pages 399-410

  Umathe, S N ^a   Bhutada, P S ^a   Jain, N S ^b   Shukla, N R ^a   Mundhada, Y R ^a   Dixit, P V ^a  

^a RTM NAGPUR UNIVERSITY   (India)

^b JL Chaturvedi College of Pharmacy   (India)

Author keywords

Anxiety; Castration; Corticotrophin releasing factor; d Trp 6 LHRH; Depression; HPA axis; HPG axis; Leuprolide; Luteinizing hormone releasing hormone; Stress

Indexed keywords

CORTICOTROPIN RELEASING FACTOR; CORTICOTROPIN RELEASING FACTOR[9-41]; GONADORELIN AGONIST; GONADORELIN ANTAGONIST; LEUPRORELIN; TRIPTORELIN;

ALPHA HELIX; ANIMAL EXPERIMENT; ANXIETY DISORDER; ARTICLE; CONTROLLED STUDY; DEPRESSION; DOSE RESPONSE; DRUG EFFECT; FORCED SWIMMING TEST; HORMONE RELEASE; IMMOBILIZATION; MALE; MOUSE; NONHUMAN; PRIORITY JOURNAL; SOCIAL INTERACTION;

ANIMALS; ANTINEOPLASTIC AGENTS, HORMONAL; ANXIETY; BEHAVIOR, ANIMAL; CASTRATION; CORTICOTROPIN-RELEASING HORMONE; DEPRESSION; DOSE-RESPONSE RELATIONSHIP, DRUG; GONADOTROPIN-RELEASING HORMONE; HUMANS; LEUPROLIDE; MALE; MICE; MOTOR ACTIVITY;

MUS;

EID: 49549085962     PISSN: 01434179     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.npep.2008.04.005     Document Type: Article

References (68)

1. Badr M., and Pelletier G. Characterization and autoradiographic localization of LHRH receptors in the rat brain. Synapse 1 (1987) 567-571
2. Bernardi M., Sandrini M., Vergoni A.V., Marrama D., Tagliavini S., and Bertolini A. Influence of gonadotropin-releasing hormone on castration-induced 'depression' in mice a behavioral and binding study. Eur. J. Pharmacol. 187 (1990) 501-506
3. Bingaman E.W., Magnuson D.J., Gray T.S., and Handa R.J. Androgen inhibits the increases in hypothalamic corticotropin-releasing hormone (CRH) and CRH-immunoreactivity following gonadectomy. Neuroendocrinology 59 (1994) 228-234
4. Bixo M., Allard P., Backstrom T., Mjorndal T., Nyberg S., Spigset O., and Sundstrom-Poromaa I. Binding of [3H] paroxetine to serotonin uptake sites and of [3H] lysergic acid diethylamide to 5-HT2A receptors in platelets from women with premenstrual dysphoric disorder during gonadotropin releasing hormone treatment. Psychoneuroendocrinology 26 (2001) 551-564
5. Bobyntsev I.I., and Sever'yanova L.A. Immunotropic effects of gonadotropin-releasing hormone analog under conditions of emotional painful stress. Bull. Exp. Biol. Med. 133 (2002) 436-438
6. Breckwoldt M., and Keck C.H. Premenstrual syndrome. Ther. Umsch. 59 (2002) 183-187
7. Britton K.T., Morgan J., Rivier J., and Koob G.F. Chlordiazepoxide attenuates CRF-induced response suppression in the conflict test. Psychopharmacology 86 (1985) 170-174
8. Britton K.T., Lee G., and Koob G.F. Corticotropin releasing factor and amphetamine exaggerate partial agonist properties of benzodiazepine antagonist Ro 15-1788 in the conflict test. Psychopharmacology 94 (1988) 306-311
9. Chen M.D., O'Byrne K.T., Chiappini S.E., Hotchkiss J., and Knobil E. Hypoglycemic "stress" and gonadotropin-releasing hormone pulse generator activity in the rhesus monkey: role of the ovary. Neuroendocrinology 56 (1992) 666-673
10. Chrousos G.P., Torpy D.J., and Gold P.W. Interactions between the hypothalamic-pituitary-adrenal axis and the female reproductive system: clinical implications. Ann. Intern. Med. 129 (1998) 229-240
11. De Souza E.B. Corticotropin-releasing factor receptors in the rat central nervous system: characterization and regional distribution. J. Neurosci. 7 (1987) 88-100
12. De Souza E.B., Insel T.R., Perrin M.H., Rivier J., Vale W.W., and Kuhar M.J. Corticotropin-releasing factor receptors are widely distributed within the rat central nervous system: an autoradiographic study. J. Neurosci. 5 (1985) 3189-3203
13. Egashira N., Tanoue A., Matsuda T., Koushi E., Harada S., Takano Y., Tsujimoto G., Mishima K., Iwasaki K., and Fujiwara M. Impaired social interaction and reduced anxiety-related behavior in vasopressin V1a receptor knockout mice. Behav. Brain Res. 178 (2007) 123-127
14. Emanuele N.V., Jurgens J., La Paglia N., Williams D.W., and Kelley M.R. The effect of castration on steady state levels of luteinizing hormone-releasing hormone (LHRH) mRNA and proLHRH processing: time course study utilizing semi-quantitative reverse transcription/polymerase chain reaction. J. Endocrinol. 148 (1996) 509-515
15. Eriksson T. Antiandrogenic treatment for obsessive-compulsive disorder. Am. J. Psychiat. 157 (2000) 483
16. German G.A., and Stampfer H.G. Hypothalamic releasing factor for reactive depression. Lancet 13 (1979) 789
17. Hermans E.J., Putmanc P., Baasa J.M., Gecksa N.M., Kenemansa J.L., and Honka J.V. Exogenous testosterone attenuates the integrated central stress response in healthy young women. Psychoneuroendocrinology 32 (2007) 1052-1061
18. Hodgson R.A., Higgins G.A., Guthrie D.H., Lu S.X., Pond A.J., Mullins D.E., Guzzi M.F., Parker E.M., and Varty G.B. Comparison of the V1b antagonist, SSR149415, and the CRF1 antagonist, CP-154,526, in rodent models of anxiety and depression. Pharmacol. Biochem. Behav. 86 (2007) 431-440
19. Holsboer F. The rationale for corticotropin-releasing hormone receptor (CRH-R) antagonists to treat depression and anxiety. J. Psychiat. Res. 33 (1999) 181-214
20. Irwin M. Stress-induced immune suppression. Role of the autonomic nervous system. Ann. NY Acad. Sci. 697 (1993) 203-218
21. Jain M.R., and Subhedar N.K. Increase in number of LHRH neurones in septal-preoptic area of rats following chronic amitriptyline treatment: implication in antidepressant effect. Brain Res. 604 (1993) 7-15
22. Jennes L., Dalati B., and Conn P.M. Distribution of gonadotropin releasing hormone agonist binding sites in the rat central nervous system. Brain Res. 452 (1988) 156-164
23. Kadar T., Telegdy G., and Schally A.V. Behavioral effects of centrally administered LHRH agonist in rats. Physiol. Behav. 51 (1992) 601-605
24. Kalra P.S. Stimulation of hypothalamic LHRH levels and release by gonadal steroids. J. Steroid Biochem. 23 (1985) 725-731
25. Kanayama G., Amiaz R., Seidman S., and Pope Jr. H.G. Testosterone supplementation for depressed men: current research and suggested treatment guidelines. Exp. Clin. Psychopharmacol. 15 (2007) 529-538
26. Kim J.H., Kim H.J., Noh H.S., Roh G.S., Kang S.S., Cho G.J., Park S.K., Lee B.J., and Choi W.S. Suppression by ethanol of male reproductive activity. Brain Res. 989 (2003) 91-98
27. Kinsey-Jones J.S., Li X.F., Bowe J.E., Lightman S.L., and O'Byrne K.T. Corticotrophin-releasing factor type 2 receptor-mediated suppression of gonadotrophin-releasing hormone mRNA expression in GT1-7 cells. Stress 4 (2006) 215-222
28. Leblanc P., Crumeyrolle M., Latouche J., Jordan D., Fillion G., L'Heritier A., Kordon C., Dussaillant M., Rostene W., and Haour F. Characterization and distribution of receptors for gonadotropin releasing hormone in the rat hippocampus. Neuroendocrinology 48 (1988) 482-488
29. Lomniczi A., Mastronardi C.A., Faletti A.G., Seilicovich A., De Laurentiis A., McCann S.M., and Rettori V. Inhibitory pathways and the inhibition of luteinizing hormone-releasing hormone release by alcohol. Proc. Natl. Acad. Sci. USA 97 (2000) 2337-2342
30. Maayan R., Touati-Werner D., Ram E., Strous R., Keren O., and Weizman A. The protective effect of frontal cortex dehydroepiandrosterone in anxiety and depressive models in mice. Pharmacol. Biochem. Behav. 85 (2006) 415-421
31. MacLusky N.J., Naftolin F., and Leranth C. Immunocytochemical evidence for direct synaptic connections between corticotrophin-releasing factor (CRF) and gonadotrophin-releasing hormone (GnRH)-containing neurons in the preoptic area of the rat. Brain Res. 439 (1988) 391-395
32. Massol J., Martin P., Adessi G., and Peuch A.J. Gonadotropin-releasing hormone (GnRH) as antidepressant: a psychopharmacological animal study. Eur. J. Pharmacol. 160 (1989) 395-399
33. Matsumoto K., Ojima K., and Watanabe H. Central corticotropin-releasing factor and benzodiazepine receptor systems are involved in the social isolation stress-induced decrease in ethanol sleep in mice. Brain Res. 753 (1997) 318-321
34. McAdoo B.C., Doering C.H., Kraemer H.C., Dessert N., Brodie H.K., and Hamburg D.A. A study of the effects of gonadotropin-releasing hormone on human mood and behavior. Psychosom. Med. 40 (1978) 199-209
35. Merchenthaler I., Gorcs T., Setalo G., Petrusz P., and Flerko B. Gonadotropin-releasing hormone (GnRH) neurons and pathways in the rat brain. Cell Tissue Res. 237 (1984) 15-29
36. Ogilvie K.M., and Rivier C. Gender difference in hypothalamic-pituitary-adrenal axis response to alcohol in the rat: activational role of gonadal steroids. Brain Res. 766 (1997) 19-28
37. Pan J.T., Kow L.M., and Pfaff D.W. Modulatory actions of luteinizing hormone-releasing hormone on electrical activity of preoptic neurons in brain slices. Neuroscience 27 (1988) 623-628
38. Papakostas G.I., Trivedi M.H., Alpert J.E., Seifert C.A., Krishen A., Goodale E.P., and Tucker V.L. Efficacy of bupropion and the selective serotonin reuptake inhibitors in the treatment of anxiety symptoms in major depressive disorder: a meta-analysis of individual patient data from 10 double-blind, randomized clinical trials. J. Psychiat. Res. 42 (2008) 134-140
39. Park Y., Park S.D., Cho W.K., and Kim K. Testosterone stimulates LHRH-like mRNA level in the rat hypothalamus. Brain Res. 451 (1988) 255-261
40. Pasha K.V., and Vijayan E. Acute and short-term effects of intraventricular injection of somatostatin and LHRH on glutamate and GABA levels in rat brain. Biochem. Int. 26 (1992) 7-15
41. Pelleymounter M.A., Joppa M., Ling N., and Foster A.C. Behavioral and neuroendocrine effects of the selective CRF2 receptor agonists urocortin II and urocortin III. Peptides 25 (2004) 659-666
42. Petraglia F., Sutton S., Vale W., and Plotsky P. Corticotropin-releasing factor decreases plasma luteinizing hormone levels in female rats by inhibiting gonadotropin-releasing hormone release into hypophysial-portal circulation. Endocrinology 120 (1987) 1083-1088
43. Ponnusamy R., Nissim H.A., and Barad M. Systemic blockade of D2-like dopamine receptors facilitates extinction of conditioned fear in mice. Learn. Mem. 12 (2005) 399-406
44. Porsolt R.D., Le Pichon M., and Jalfre M. Depression: a new animal model sensitive to antidepressant treatments. Nature 266 (1977) 730-732
45. Rance N.E., Young III W.S., and McMullen N.T. Topography of neurons expressing luteinizing hormone releasing hormone gene transcripts in the human hypothalamus and basal forebrain. J. Comp. Neurol. 339 (1994) 573-586
46. Rettori V., and McCann S.M. The mechanism of action of alcohol to suppress gonadotropin secretion. Mol. Psychiat. 2 (1997) 350-354
47. Reubi J.C., and Maurer R. Visualization of LHRH receptors in the rat brain. Eur. J. Pharmacol. 106 (1984) 453-454
48. Reubi J.C., Palacios J.M., and Maurer R. Specific luteinizing-hormone-releasing hormone receptor binding sites in hippocampus and pituitary: an autoradiographic study. Neuroscience 21 (1987) 847-856
49. Rothfeld J.M., Hejtmancik J.F., Conn P.M., and Pfaff D.W. LHRH messenger RNA in neurons in the intact and castrate male rat forebrain, studied by in situ hybridization. Exp. Brain Res. 67 (1987) 113-118
50. Rubinow D.R., Roca C.A., Schmidt P.J., Danaceau M.A., Putnam K., Cizza G., Chrousos G., and Nieman L. Testosterone suppression of CRH-stimulated cortisol in men. Neuropsychopharmacology 30 (2005) 1906-1912
51. Rudenstein R.S., Bigdeli H., McDonald M.H., and Snyder P.J. Administration of gonadal steroids to the castrated male rat prevents a decrease in the release of gonadotrophin-releasing hormone from the incubated hypothalamus. J. Clin. Invest. 63 (1979) 262-267
52. Simon P., Panissaud C., and Costentin J. Anxiogenic-like effects induced by stimulation of dopamine receptors. Pharmacol. Biochem. Behav. 45 (1993) 685-690
53. Soulairac M.M.A., Lambinet H., Neuman J.C., and Schally A.V. Action de la luteo-liberina (LHRH). Ann. Med. Psychol. 141 (1983) 876
54. Soysal M.E., Soysal S., Vicdan K., and Ozer S. A randomized controlled trial of goserelin and medroxyprogesterone acetate in the treatment of pelvic congestion. Hum. Reprod. 16 (2001) 931-939
55. Studd J. Ovariectomy for menstrual madness and premenstrual syndrome-19th century history and lessons for current practice. Gynecol. Endocrinol. 22 (2006) 411-415
56. Swiergiel A.H., Zhou Y., and Dunn A.J. Effects of chronic footshock, restraint and corticotropin-releasing factor on freezing, ultrasonic vocalization and forced swim behavior in rats. Behav. Brain Res. 183 (2007) 178-187
57. Sutton S.W., Behan D.P., Lahrichi S.L., Kaiser R., Corrigan A., Lowry P., Potter E., Perrin M.H., Rivier J., and Vale W.W. Ligand requirements of the human corticotropin-releasing factor-binding protein. Endocrinology 136 (1995) 1097-1102
58. Tellam D.J., Perone M.J., Dunn I.C., Radovick S., Brennand J., Rivier J.E., Catsro M.G., and Lovejoy D.A. Direct regulation of GnRH transcription by CRF-like peptides in an immortalized neuronal cell line. Neuroreport 9 (1998) 3135-3140
59. Todorovic C., Jahna O., Tezvala H., Hippela C., and Spiessa J. The role of CRF receptors in anxiety and depression: implications of the novel CRF1 agonist cortagine. Neurosci. Biobehav. Rev. 29 (2005) 1323-1333
60. Uday G., Pravinkumar B., Manish W., and Sudhir U. LHRH antagonist attenuates the effect of fluoxetine on marble-burying behavior in mice. Eur. J. Pharmacol. 563 (2007) 155-159
61. Umathe, S.N., Bhutada, P.S., Dixit, P.V., Jain, N.S., 2008a. Leuprolide - a luteinizing hormone releasing hormone agonist attenuates ethanol withdrawal syndrome and ethanol-induced locomotor sensitization in mice. Neuropeptides (Epub ahead of print), doi:10.1016/j.npep.2007.12.006.
62. Umathe, S., Bhutada, P., Dixit, P., Shende V., 2008b. Increased marble-burying behavior in ethanol-withdrawal state: modulation by gonadotropin-releasing hormone agonist. Eur. J. Pharmacol. (Epub ahead of print).
63. Umathe S.N., Dixit P.V., Wanjari M.M., and Ullewar M.P. Leuprolide - a GnRH agonist, prevents restraint stress-induced immunosuppression via sex steroid-independent peripheral mechanism in mice. Int. Immunopharmacol. 8 (2008) 71-79
64. Van Honk J., Peper J.S., and Schutter D.J. Testosterone reduces unconscious fear but not consciously experienced anxiety: implications for the disorders of fear and anxiety. Biol. Psychiat. 58 (2005) 218-225
65. West C.P., and Hillier H. Ovarian suppression with the gonadotrophin-releasing hormone agonist goserelin (Zoladex) in management of the premenstrual tension syndrome. Hum. Reprod. 9 (1994) 1058-1063
66. Westphal N.J., and Seasholtz A.F. Gonadotropin-releasing hormone (GnRH) positively regulates corticotropin-releasing hormone-binding protein expression via multiple intracellular signaling pathways and a multipartite GnRH response element in alpha T3-1 cells. Mol. Endocrinol. 19 (2005) 2780-2797
67. Williams C.L., Nishihara M., Thalabard J.C., Grosser P.M., Hotchkiss J., and Knobil E. Corticotropin-releasing factor and gonadotropin releasing hormone pulse generator activity in the rhesus monkey. Neuroendocrinology 52 (1990) 133-137
68. Yatham L.N., Goldstein J.M., Vieta E., Bowden C.L., Grunze H., Post R.M., Suppes T., and Calabrese J.R. Atypical antipsychotics in bipolar depression: potential mechanisms of action. J. Clin. Psychiat. 66 Suppl. 5 (2005) 40-48