A facile solid phase synthesis of 2-alkylthio-4(1H)-quinolones

Chinese Journal of Chemistry

Volumn 21, Issue 5, 2003, Pages 585-587

  Tang, Jing ^a   Wu, Ming Guang ^a   Huang, Xian ^a,b  

^a ZHEJIANG UNIVERSITY   (China)

^b SHANGHAI INSTITUTE OF ORGANIC CHEMISTRY   (China)

Author keywords

2 alkylthio 4(1H) quinolones; Resin bound cyclic malonic acid ester; Solid phase synthesis

Indexed keywords

EID: 4944240867     PISSN: 1001604X     EISSN: None     Source Type: Journal    
DOI: 10.1002/cjoc.20030210522     Document Type: Article

References (15)

1. Reviews on SPOS, see: (a) Guillier, F.; Orain, D.; Bradley, M. Chem. Rev. 2000, 100, 2091.
2. (b) Sammekon, R. E.; Kurth, M. J. Chem. Rev. 2001, 101, 137.
3. (a) Reitsema, R. H. Chem. Rev. 1948, 43, 43.
4. (b) Delfourne, E.; Roubin, C.; Bastide, J. J. Org. Chem. 2000, 65, 5476.
5. (a) Andersag, H.; Breitner, S.; Jung, H. US 2 233 970, 1941 [Chem. Abstr. 1941, 35, 3771].
6. (b) Delfourne, E.; Roubin, C.; Bastide, J. J. Org. Chem. 2000, 65, 5476.
7. (a) McNab, H. Chem. Soc. Rev. 1978, 7, 345.
8. (b) Gaberm, A. M.; McNab, H. Synthesis 2001, 2059.
9. (c) Chen, B. C.; Huang, X.; Ma, S. M. Synth. Commun. 1987, 17, 1519.
10. (d) Huang, X.; Chen, B. C.; Wu, G. Y.; Chen, H. B. Synth. Commun. 1991, 21, 1213.
11. (e) Chen, B. C.; Huang, X.; Wang, J. Synthesis 1987, 482.
12. Augustin, M.; Guenther, E. Wiss. Z. Martin-Luther-Univ. Halle-Wittenberg, Math-Naturwiss. Reihe. 1989, 38(3), 27.
13. (a) Huang, X.; Liu, Z. X. Tetrahedron Lett. 2001, 42, 7655.
14. (b) Huang, X.; Liu, Z. X. J. Org. Chem. 2002, 67, 6731.
15. The loading of resin 2 was determined by reversed titration with hydrochloride acid after saponification with excess NaOH in EtOH (loading = 1.11 mmol/g).