-
1
-
-
0021957656
-
Immunopharmacological profile of a novel isoxazol derivative, HWA 486, with potential antirheumatic activity. I. Disease modifying action on adjuvant arthritis of the rat
-
BARTLETT RR, SCHLEYERBACH R: Immunopharmacological profile of a novel isoxazol derivative, HWA 486, with potential antirheumatic activity. I. Disease modifying action on adjuvant arthritis of the rat. Int J Immunopharmacol 1985; 7: 7-18.
-
(1985)
Int. J. Immunopharmacol.
, vol.7
, pp. 7-18
-
-
Bartlett, R.R.1
Schleyerbach, R.2
-
2
-
-
0026060988
-
Prevention of kidney and skin graft rejection in rats by leflunomide, a new immunomodulating agent
-
KUCHLE CC, THOENES GH, LANGER KH et al.: Prevention of kidney and skin graft rejection in rats by leflunomide, a new immunomodulating agent. Transplant Proc 1991; 23: 1083-6.
-
(1991)
Transplant. Proc.
, vol.23
, pp. 1083-1086
-
-
Kuchle, C.C.1
Thoenes, G.H.2
Langer, K.H.3
-
3
-
-
0028235690
-
An evaluation of leflunomide in the canine renal transplantation model
-
McCHESNEY LP, XIAO F, SANKARY HN et al.: An evaluation of leflunomide in the canine renal transplantation model. Transplantation 1994; 57: 1717-22.
-
(1994)
Transplantation
, vol.57
, pp. 1717-1722
-
-
McChesney, L.P.1
Xiao, F.2
Sankary, H.N.3
-
4
-
-
0028606053
-
Effects of leflunomide and cyclosporine on aortic allograft chronic rejection in the rat
-
MacDONALD AS, SABR K, MacAULEY MA et al.: Effects of leflunomide and cyclosporine on aortic allograft chronic rejection in the rat. Transplant Proc 1994; 26: 3244-5.
-
(1994)
Transplant. Proc.
, vol.26
, pp. 3244-3245
-
-
MacDonald, A.S.1
Sabr, K.2
Macauley, M.A.3
-
5
-
-
0029563361
-
Leflunomide prolongs pulmonary allograft and xenograft survival
-
YUH DD, GANDY KL, MORRIS RE et al.: Leflunomide prolongs pulmonary allograft and xenograft survival. J Heart Lung Transplant 1995; 14: 1136-44.
-
(1995)
J. Heart Lung Transplant.
, vol.14
, pp. 1136-1144
-
-
Yuh, D.D.1
Gandy, K.L.2
Morris, R.E.3
-
6
-
-
0025980747
-
Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection
-
BARTLETT RR, DIMITRIJEVIC M, MATTAR T et al.: Leflunomide (HWA 486), a novel immunomodulating compound for the treatment of autoimmune disorders and reactions leading to transplantation rejection. Agents Actions 1991; 32: 10-21.
-
(1991)
Agents Actions
, vol.32
, pp. 10-21
-
-
Bartlett, R.R.1
Dimitrijevic, M.2
Mattar, T.3
-
7
-
-
0027238470
-
Effects of leflunomide on immune responses and models of inflammation
-
BARTLETT RR, ANAGNOSTOPULOS H, ZIELINSKI T et al.: Effects of leflunomide on immune responses and models of inflammation. Semin Immunopathol 1993; 14: 381-94.
-
(1993)
Semin. Immunopathol.
, vol.14
, pp. 381-394
-
-
Bartlett, R.R.1
Anagnostopulos, H.2
Zielinski, T.3
-
8
-
-
0030020362
-
Immunomodulution of rat antigen-induced arthritis by leflunomide alone and in combination with cyclosporin A
-
THOSS K, HENZGEN S, PETROW PK et al.: Immunomodulution of rat antigen-induced arthritis by leflunomide alone and in combination with cyclosporin A. Inflamm Res 1996; 45: 103-7.
-
(1996)
Inflamm. Res.
, vol.45
, pp. 103-107
-
-
Thoss, K.1
Henzgen, S.2
Petrow, P.K.3
-
9
-
-
0025234002
-
Drug actions on delayed-type hypersensitivity in rats with developing and established adjuvant arthritis
-
HAMBLETON P, McMAHON S: Drug actions on delayed-type hypersensitivity in rats with developing and established adjuvant arthritis. Agents Actions 1990; 29: 328-32.
-
(1990)
Agents Actions
, vol.29
, pp. 328-332
-
-
Hambleton, P.1
McMahon, S.2
-
10
-
-
0023553077
-
Disease modifying activity of HWA 486 in rat adjuvant-induced arthritis
-
PASTERNAK RD, WADOPIAN NS, WRIGHT RN et al.: Disease modifying activity of HWA 486 in rat adjuvant-induced arthritis. Agents Actions 1987; 21: 241-3.
-
(1987)
Agents Actions
, vol.21
, pp. 241-243
-
-
Pasternak, R.D.1
Wadopian, N.S.2
Wright, R.N.3
-
11
-
-
0026589680
-
Immunomodulation of proteoglycan-induced progressive polyarthritis by leflunomide
-
GLANT TT, MIKECZ K, BARTLETT RR et al.: Immunomodulation of proteoglycan-induced progressive polyarthritis by leflunomide. Immunopharmacology 1992; 23: 105-16.
-
(1992)
Immunopharmacology
, vol.23
, pp. 105-116
-
-
Glant, T.T.1
Mikecz, K.2
Bartlett, R.R.3
-
12
-
-
0027965998
-
Suppression of autoimmune responses and inflammatory events by leflunomide in an animal model for rheumatoid arthritis
-
GLANT TT, MIKECZ K, BRENNAN F et al.: Suppression of autoimmune responses and inflammatory events by leflunomide in an animal model for rheumatoid arthritis. Agents Actions 1994; 41: C267-C270.
-
(1994)
Agents Actions
, vol.41
-
-
Glant, T.T.1
Mikecz, K.2
Brennan, F.3
-
13
-
-
0024787777
-
Leflunomide (HWA 486) inhibits experimental autoimmune tubulointerstitial nephritis in rats
-
THOENES GH, SITTER T, LANGER KH et al.: Leflunomide (HWA 486) inhibits experimental autoimmune tubulointerstitial nephritis in rats. Int J Immunopharmacol 1989; 11: 921-9.
-
(1989)
Int. J. Immunopharmacol.
, vol.11
, pp. 921-929
-
-
Thoenes, G.H.1
Sitter, T.2
Langer, K.H.3
-
14
-
-
0029022748
-
Leflunomide prevents the development of experimentally induced myasthenia gravis
-
VIDIC-DANKOVIC B, KOSEC D, DAMJANOVIC M et al.: Leflunomide prevents the development of experimentally induced myasthenia gravis. Int J Immunopharmacol 1995; 17: 273-81.
-
(1995)
Int. J. Immunopharmacol.
, vol.17
, pp. 273-281
-
-
Vidic-Dankovic, B.1
Kosec, D.2
Damjanovic, M.3
-
15
-
-
0023025053
-
Disease modifying activity of HWA 486 on the development of SLE in MRL/1-mice
-
Popovic S, BARTLETT RR: Disease modifying activity of HWA 486 on the development of SLE in MRL/1-mice. Agents Actions 1986; 19: 313-4.
-
(1986)
Agents Actions
, vol.19
, pp. 313-314
-
-
Popovic, S.1
Bartlett, R.R.2
-
16
-
-
0023554171
-
The use of the murine chronic graft vs host (CGVH) disease, a model for systemic lupus erythematosus (SLE), for drug discovery
-
POPOVIC S, BARTLETT RR: The use of the murine chronic graft vs host (CGVH) disease, a model for systemic lupus erythematosus (SLE), for drug discovery. Agents Actions 1987; 21: 284-6.
-
(1987)
Agents Actions
, vol.21
, pp. 284-286
-
-
Popovic, S.1
Bartlett, R.R.2
-
17
-
-
0028792355
-
Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis. Results of a randomized, placebo-controlled, phase II study
-
MLADENOVIC V, DOMLJAN Z, ROZMA B et al.: Safety and effectiveness of leflunomide in the treatment of patients with active rheumatoid arthritis. Results of a randomized, placebo-controlled, phase II study. Arthritis Rheum 1995; 38: 1595-603.
-
(1995)
Arthritis Rheum.
, vol.38
, pp. 1595-1603
-
-
Mladenovic, V.1
Domljan, Z.2
Rozma, B.3
-
18
-
-
0033596065
-
Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate
-
STRAND V, COHEN S, SCHIFF M et al.: Treatment of active rheumatoid arthritis with leflunomide compared with placebo and methotrexate. Arch Intern Med 1999; 159: 2542-50.
-
(1999)
Arch. Intern. Med.
, vol.159
, pp. 2542-2550
-
-
Strand, V.1
Cohen, S.2
Schiff, M.3
-
19
-
-
18044400396
-
Two-year, blinded, randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate
-
COHEN S, CANNON GW, SCHIFF M et al.: Two-year, blinded, randomized, controlled trial of treatment of active rheumatoid arthritis with leflunomide compared with methotrexate. Arthritis Rheum 2001; 44: 1984-1992.
-
(2001)
Arthritis Rheum.
, vol.44
, pp. 1984-1992
-
-
Cohen, S.1
Cannon, G.W.2
Schiff, M.3
-
20
-
-
0028215036
-
Methotrexate for rheumatoid arthritis: Suggested guidelines for monitoring liver toxicity
-
KREMER JM, ALARCON GS, LIGHTFOOT RW et al.: Methotrexate for rheumatoid arthritis: suggested guidelines for monitoring liver toxicity. Arthritis Rheum 1994; 37: 316-28.
-
(1994)
Arthritis Rheum.
, vol.37
, pp. 316-328
-
-
Kremer, J.M.1
Alarcon, G.S.2
Lightfoot, R.W.3
-
21
-
-
0343169971
-
Treatment with leflunomide shows radiographic progression of rheumatoid arthritis. Results from three randomized controlled trials of leflunomide in patients with active rheumatoid arthritis
-
SHARP JT, STRAND V, LEUNG H, HURLEY F, LOEW-FRIEDRICH I: Treatment with leflunomide shows radiographic progression of rheumatoid arthritis. Results from three randomized controlled trials of leflunomide in patients with active rheumatoid arthritis. Arthritis Rheum 1999; 43: 1345-51.
-
(1999)
Arthritis Rheum.
, vol.43
, pp. 1345-1351
-
-
Sharp, J.T.1
Strand, V.2
Leung, H.3
Hurley, F.4
Loew-Friedrich, I.5
-
22
-
-
4944225130
-
Comparative assessment of leflunomide and methotrexate for the treatment of rheumatoid arthritis: A double-blind, randomized, multicenter trial
-
REECE RJ, KRAAN MC, RADJENOVIC A et al.: Comparative assessment of leflunomide and methotrexate for the treatment of rheumatoid arthritis: a double-blind, randomized, multicenter trial. Lancet 1999; 353: 259-66.
-
(1999)
Lancet
, vol.353
, pp. 259-266
-
-
Reece, R.J.1
Kraan, M.C.2
Radjenovic, A.3
-
23
-
-
2342499810
-
Towards a better understanding of methotrexate
-
KREMER JM: Towards a better understanding of methotrexate. Arthritis Rheum 2004; 50: 1370-82.
-
(2004)
Arthritis Rheum.
, vol.50
, pp. 1370-1382
-
-
Kremer, J.M.1
-
24
-
-
4944257959
-
Pharmacokinetics, safety, and efficacy of combination treatment with methotrexate and leflunomide in patients with active rheumatoid arthritis
-
WEINBLATT ME, KREMER JM, COBLN JS et al.: Pharmacokinetics, safety, and efficacy of combination treatment with methotrexate and leflunomide in patients with active rheumatoid arthritis. Arthritis Rheum 1999; 37: 316-28.
-
(1999)
Arthritis Rheum.
, vol.37
, pp. 316-328
-
-
Weinblatt, M.E.1
Kremer, J.M.2
Cobln, J.S.3
-
25
-
-
0037027427
-
Concomitant leflunomide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate: A randomized comparison of efficacy, safety, and tolerability compared to methotrexate alone
-
KREMER JM, GENOVESE MC, CANNON GW et al.: Concomitant leflunomide therapy in patients with active rheumatoid arthritis despite stable doses of methotrexate: a randomized comparison of efficacy, safety, and tolerability compared to methotrexate alone. Ann Intern Med 2002: 137; 726-33.
-
(2002)
Ann. Intern. Med.
, vol.137
, pp. 726-733
-
-
Kremer, J.M.1
Genovese, M.C.2
Cannon, G.W.3
-
26
-
-
85018409568
-
Combination of leflunomide and methotrexate in patients with active rheumatoid arthritis failing MTX inonotherapy: An open-label extension study
-
in press
-
KREMER JM, GENOVESE M, CANNON GW et al.: Combination of leflunomide and methotrexate in patients with active rheumatoid arthritis failing MTX inonotherapy: an open-label extension study. J Rheumatol 2004, in press.
-
(2004)
J. Rheumatol.
-
-
Kremer, J.M.1
Genovese, M.2
Cannon, G.W.3
-
27
-
-
0029916174
-
Significant changes in serum AST across hepatic histological biopsy grades: Prospective analysis of 3 cohorts receiving methotrexate therapy for rheumatoid arthritis
-
KREMER JM, FURST DE, WEINBLATT ME, BLOTNER SD: Significant changes in serum AST across hepatic histological biopsy grades: Prospective analysis of 3 cohorts receiving methotrexate therapy for rheumatoid arthritis. J Rheumatol 1996; 23: 459-61.
-
(1996)
J. Rheumatol.
, vol.23
, pp. 459-461
-
-
Kremer, J.M.1
Furst, D.E.2
Weinblatt, M.E.3
Blotner, S.D.4
-
28
-
-
0029097616
-
Light and electron micorscopic analysis of sequential liver biopsy samples from patients with rheumatoid arthritis receiving long term methotrexate therapy: Follow-up over prolonged treatment intervals and correlation with clinical and laboratory variables
-
KREMER JM, KAYE GI, KAYE NW, ISHAK KG, AXIOTIS CA: Light and electron micorscopic analysis of sequential liver biopsy samples from patients with rheumatoid arthritis receiving long term methotrexate therapy: follow-up over prolonged treatment intervals and correlation with clinical and laboratory variables. Arthritis Rheum 1995: 38; 1194-203.
-
(1995)
Arthritis Rheum.
, vol.38
, pp. 1194-1203
-
-
Kremer, J.M.1
Kaye, G.I.2
Kaye, N.W.3
Ishak, K.G.4
Axiotis, C.A.5
-
30
-
-
0018110856
-
Excess risk of lymphomas, leukemia and meloma in patients with rheumatoid arthritis
-
ISOMAKI H, HAKULINEN T, JOUTSENLAHTI U: Excess risk of lymphomas, leukemia and meloma in patients with rheumatoid arthritis. J Chronic Dis 1978; 31: 691-6.
-
(1978)
J. Chronic. Dis.
, vol.31
, pp. 691-696
-
-
Isomaki, H.1
Hakulinen, T.2
Joutsenlahti, U.3
-
31
-
-
0035203725
-
Rheumatoid arthritis, methotrexate, and lymphoma: Risk substitution, or cat and mouse with Epstein-Barr virus ?
-
STARKEBAUM G: Rheumatoid arthritis, methotrexate, and lymphoma: risk substitution, or cat and mouse with Epstein-Barr virus ? J Rheumatol 2001; 28: 2573-5.
-
(2001)
J. Rheumatol.
, vol.28
, pp. 2573-2575
-
-
Starkebaum, G.1
-
32
-
-
15444350253
-
Clinical, laboratory, radiographic, and histopathologic features of methotrexate-associated lung injury in patients with rheumatoid arthritis: A multicenter study with literature review
-
KREMER JM, ALARCON GS, WEINBLATT ME et al.: Clinical, laboratory, radiographic, and histopathologic features of methotrexate-associated lung injury in patients with rheumatoid arthritis: a multicenter study with literature review. Arthritis Rheum 1997: 40: 1829-37.
-
(1997)
Arthritis Rheum.
, vol.40
, pp. 1829-1837
-
-
Kremer, J.M.1
Alarcon, G.S.2
Weinblatt, M.E.3
-
33
-
-
0028792273
-
The effects of nonsteroidal anti-inflammatory drugs on methotrexate pharmacokinetics: Impairment of renal clearance of MTX at weekly maintenance doses but not at 7.5 mg
-
KREMER JM, HAMILTON RA: The effects of nonsteroidal anti-inflammatory drugs on methotrexate pharmacokinetics: impairment of renal clearance of MTX at weekly maintenance doses but not at 7.5 mg. J Rheumatol 1995; 22: 2072-7.
-
(1995)
J. Rheumatol.
, vol.22
, pp. 2072-2077
-
-
Kremer, J.M.1
Hamilton, R.A.2
|