FK506 independently upregulates transforming growth factor β and downregulates inducible nitric oxide synthase in cultured human keratinocytes: Possible mechanisms of how tacrolimus ointment interacts with atopic skin

British Journal of Dermatology

Volumn 151, Issue 3, 2004, Pages 679-684

  Lan, C C E ^a   Kao, Y H ^a   Huang, S M ^a   Yu, H S ^b   Chen, Gwo Shing ^a  

^a KAOHSIUNG MEDICAL UNIVERSITY   (Taiwan)

^b NATIONAL TAIWAN UNIVERSITY   (Taiwan)

Author keywords

Atopic dermatitis; FK506; Inducible nitric oxide synthase; Keratinocyte; Transforming growth factor

Indexed keywords

CELL PROTEIN; NITRIC OXIDE SYNTHASE; RNA; TACROLIMUS; TRANSFORMING GROWTH FACTOR BETA; TUMOR NECROSIS FACTOR ALPHA;

ADULT; ARTICLE; ATOPIC DERMATITIS; CELL CULTURE; CELL PROLIFERATION; CONTROLLED STUDY; DOWN REGULATION; DRUG EFFICACY; ENZYME LINKED IMMUNOSORBENT ASSAY; GENE EXPRESSION; HUMAN; HUMAN CELL; KERATINOCYTE; PRIORITY JOURNAL; PROTEIN EXPRESSION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; UPREGULATION; WESTERN BLOTTING;

ADULT; CELL DIVISION; CELL SURVIVAL; CELLS, CULTURED; DOSE-RESPONSE RELATIONSHIP, DRUG; DOWN-REGULATION; HUMANS; IMMUNOSUPPRESSIVE AGENTS; KERATINOCYTES; MALE; NITRIC OXIDE SYNTHASE; NITRIC OXIDE SYNTHASE TYPE II; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TACROLIMUS; TRANSFORMING GROWTH FACTOR BETA; UP-REGULATION;

EID: 4944219691     PISSN: 00070963     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1365-2133.2004.06109.x     Document Type: Article

References (17)

1. Ruzicka T, Bieber T, Schopf E et al. A short-term trial of tacrolimus ointment for atopic dermatitis. N Engl J Med 1997; 337: 816-21.
2. Boguniewicz M, Fiedler VC, Rainier S et al. A randomized, vehicle-controlled trial of tacrolimus ointment for treatment of atopic dermatitis in children. J Allergy Clin Immunol 1998; 38: 69-76.
3. Hanifin JM, Ling MR, Langley R et al. Tacrolimus ointment for the treatment of atopic dermatitis in adult patients. Part I. efficacy. J Am Acad Dermatol 2001; 44: S28-38.
4. Zhang JG, Walmsley MW, Moy JV et al. Differential effects of cyclosporine A and tacrolimus on the production of TCP-beta: implication for the development of obliterative bronchiolitis after lung transplantation. Transpl Int 1998; 11 (Suppl. 1): S325-7.
5. Conde M, Andrade J, Bedoya FJ et al. Inhibitory effect of cyclosporin A and FK506 on nitric oxide production by cultured macrophages. Evidence of a direct effect on nitric oxide synthase activity. Immunology 1995; 84: 476-81.
6. Rowe A, Farrell AM, Bunker CB. Constitutive endothelial and inducible nitric oxide synthase in inflammatory dermatoses. Br J Dermatol 1997; 136: 18-23.
7. Arkwright PD, Chase JM, Babbage S et al. Atopic dermatitis is associated with a low-producer transforming growth factor-β cytokine genotype. J Allergy Clin Immunol 2001; 108: 281-4.
8. Lee HJ, Lee HP, Ha SJ et al. Spontaneous expression of mRNA for IL-10. GM-CSF, TGF-β, TNF, and IL-6 in peripheral blood mononuclear cells from atopic dermatitis. Ann Allergy Asthma Immunol 2000; 84: 553-8.
9. Yu HS, Kao CH, Yu CL. Coexistence and relationship of anti-keratinocyte and antimelanocyte antibodies in patients with nonsegmental-type vitiligo. J Invest Dermatol 1993; 100: 823-8.
10. Kao YH, Yu CL, Chang LW, Yu HS. Low concentrations of arsenic induce vascular endothelial growth factor and nitric oxide release and stimulate angiogenesis in vitro. Chem Res Toxicol 2003; 16: 460-8.
11. Ackermann L, Harvima IT. Mast cells of psoriatic and atopic dermatitis skin are positive for TNF-α and their degranulation is associated with expression of ICAM-1 in the epidermis. Arch Dermatol Res 1998; 290: 353-9.
12. Taniuchi S, Kojima T, Hara M et al. Increased serum nitrate levels in infants with atopic dermatitis. Allergy 2001; 56: 693-5.
13. Morita H, Semma M, Hori M, Kitano Y. Clinical application of nitric oxide synthase inhibitor for atopic dermatitis. Int J Dermatol 1995; 34: 294-5.
14. Leslie TA, Levell NJ, Bewley AP et al. The role of nitric oxide and cutaneous nerves in the erythema of psoriasis and atopic eczema. J Invest Dermatol 1994; 103: 435 (Abstr.).
15. Liew FY, Yun L, Severn A et al. A possible novel pathway of regulation by murine T helper type-2 (Th2) cells of a Th1 cell activity via the modulation of induction of nitric oxide synthase on macrophages. Eur J Immunol 1991; 21: 2489-94.
16. Vodovotz Y. Control of nitric oxide production of transforming growth factor-β: mechanistic insights and potential relevance to human disease. Nitric Oxide 1997; 1: 3-17.
17. Arany I, Brysk MM, Brysk H, Tyring SK. Regulation of inducible nitric oxide synthase mRNA levels by differentiation and cytokines in human keratinocytes. Biochem Biophys Res Commun 1996; 220: 618-22.