Phenotypic analysis of GalR2 knockout mice in anxiety- and depression-related behavioral tests

Neuropeptides

Volumn 42, Issue 4, 2008, Pages 387-397

  Lu, Xiaoying ^a   Ross, Brendon ^a   Sanchez Alavez, Manuel ^a   Zorrilla, Eric P ^a   Bartfai, Tamas ^a  

^a Harrold L Dorris Neurological Research Center   (United States)

Author keywords

Anxiety; Depression; Desipramine; GalR2 knockout

Indexed keywords

ANTIDEPRESSANT AGENT; DESIPRAMINE; G PROTEIN COUPLED RECEPTOR; GALANIN; GALANIN DERIVATIVE; GALANIN RECEPTOR 1; GALANIN RECEPTOR 2; GALANIN RECEPTOR 3; GALANIN[2-11]; NEUROPEPTIDE;

ANIMAL EXPERIMENT; ANXIETY DISORDER; ARTICLE; BEHAVIOR; CENTRAL NERVOUS SYSTEM; CONTROLLED STUDY; DEPRESSION; DORSAL RAPHE NUCLEUS; DRUG INFUSION; GENE DELETION; GENE EXPRESSION; HIPPOCAMPUS; IMMOBILIZATION; KNOCKOUT MOUSE; LEARNED HELPLESSNESS PARADIGM; LIGAND BINDING; LIMBIC SYSTEM; MALE; MAZE TEST; MOUSE; MUTANT; NEUROMODULATION; NONHUMAN; OPEN FIELD BEHAVIOR; PHENOTYPE; PRIORITY JOURNAL; RODENT; SEROTONIN RELEASE; SEROTONINERGIC SYSTEM; SIGNAL TRANSDUCTION; TAIL SUSPENSION TEST; WILD TYPE;

ANIMALS; ANTIDEPRESSIVE AGENTS, TRICYCLIC; BEHAVIOR, ANIMAL; DEPRESSION; DESIPRAMINE; HUMANS; MICE; MICE, INBRED C57BL; MICE, KNOCKOUT; NEUROPSYCHOLOGICAL TESTS; PHENOTYPE; RATS; RECEPTOR, GALANIN, TYPE 2;

MUS; RATTUS; RODENTIA;

EID: 49349114884     PISSN: 01434179     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.npep.2008.04.009     Document Type: Article

References (53)

1. Anseloni V.Z., Motta V., Lima G., and Brandao M.L. Behavioral and pharmacological validation of the elevated plus maze constructed with transparent walls. Braz. J. Med. Biol. Res. 28 (1995) 597-601
2. Bailey K.R., Pavlova M.N., Rohde A.D., Hohmann J.G., and Crawley J.N. Galanin receptor subtype 2 (GalR2) null mutant mice display an anxiogenic-like phenotype specific to the elevated plus-maze. Pharmacol. Biochem. Behav. 86 (2007) 8-20
3. Barrera G., Echevarria D.J., Poulin J.F., Laforest S., Drolet G., and Morilak D.A. One for all or one for one: does co-transmission unify the concept of a brain galanin "system" or clarify any consistent role in anxiety?. Neuropeptides 39 (2005) 289-292
4. Bartfai T., Fisone G., and Langel U. Galanin and galanin antagonists: molecular and biochemical perspectives. Trends Pharmacol. Sci. 13 (1992) 312-317
5. Bartfai T., Lu X., Badie-Mahdavi H., Barr A.M., Mazarati A., Hua X.Y., Yaksh T., Haberhauer G., Ceide S.C., Trembleau L., Somogyi L., Krock L., and Rebek Jr. J. Galmic, a nonpeptide galanin receptor agonist, affects behaviors in seizure, pain, and forced-swim tests. Proc. Natl. Acad. Sci. USA 101 (2004) 10470-10475
6. Bing O., Moller C., Engel J.A., Soderpalm B., and Heilig M. Anxiolytic-like action of centrally administered galanin. Neurosci. Lett. 164 (1993) 17-20
7. Branchek T.A., Smith K.E., Gerald C., and Walker M.W. Galanin receptor subtypes. Trends Pharmacol. Sci. 21 (2000) 109-117
8. Caldarone B.J., George T.P., Zachariou V., and Picciotto M.R. Gender differences in learned helplessness behavior are influenced by genetic background. Pharmacol. Biochem. Behav. 66 (2000) 811-817
9. Chourbaji S., Zacher C., Sanchis-Segura C., Dormann C., Vollmayr B., and Gass P. Learned helplessness: validity and reliability of depressive-like states in mice. Brain Res. Protoc. 16 (2005) 70-78
10. Crawley J.N. Biological actions of galanin. Regul. Pept. 59 (1995) 1-16
11. Crawley J., and Goodwin F.K. Preliminary report of a simple animal behavior model for the anxiolytic effects of benzodiazepines. Pharmacol. Biochem. Behav. 13 (1980) 167-170
12. Cryan J.F., and Lucki I. Antidepressant-like behavioral effects mediated by 5-Hydroxytryptamine(2C) receptors. J. Pharmacol. Exp. Ther. 295 (2000) 1120-1126
13. Cryan J.F., O'Leary O.F., Jin S.H., Friedland J.C., Ouyang M., Hirsch B.R., Page M.E., Dalvi A., Thomas S.A., and Lucki I. Norepinephrine-deficient mice lack responses to antidepressant drugs, including selective serotonin reuptake inhibitors. Proc. Natl. Acad. Sci. USA 101 (2004) 8186-8191
14. Detke M.J., and Lucki I. Detection of serotonergic and noradrenergic antidepressants in the rat forced swimming test: the effects of water depth. Behav. Brain Res. 73 (1996) 43-46
15. Detke M.J., Rickels M., and Lucki I. Active behaviors in the rat forced swimming test differentially produced by serotonergic and noradrenergic antidepressants. Psychopharmacology (Berl) 121 (1995) 66-72
16. Gottsch M.L., Zeng H., Hohmann J.G., Weinshenker D., Clifton D.K., and Steiner R.A. Phenotypic analysis of mice deficient in the type 2 galanin receptor (GALR2). Mol. Cell Biol. 25 (2005) 4804-4811
17. Hokfelt T., Broberger C., Diez M., Xu Z.Q., Shi T., Kopp J., Zhang X., Holmberg K., Landry M., and Koistinaho J. Galanin and NPY, two peptides with multiple putative roles in the nervous system. Horm. Metab. Res. 31 (1999) 330-334
18. Holmes A., Yang R.J., and Crawley J.N. Evaluation of an anxiety-related phenotype in galanin overexpressing transgenic mice. J. Mol. Neurosci. 18 (2002) 151-165
19. Holmes A., Yang R.J., Murphy D.L., and Crawley J.N. Evaluation of antidepressant-related behavioral responses in mice lacking the serotonin transporter. Neuropsychopharmacology 27 (2002) 914-923
20. Holmes A., Kinney J.W., Wrenn C.C., Li Q., Yang R.J., Ma L., Vishwanath J., Saavedra M.C., Innerfield C.E., Jacoby A.S., Shine J., Iismaa T.P., and Crawley J.N. Galanin GAL-R1 receptor null mutant mice display increased anxiety-like behavior specific to the elevated plus-maze. Neuropsychopharmacology 28 (2003) 1031-1044
21. Holmes A., Li Q., Koenig E.A., Gold E., Stephenson D., Yang R.J., Dreiling J., Sullivan T., and Crawley J.N. Phenotypic assessment of galanin overexpressing and galanin receptor R1 knockout mice in the tail suspension test for depression-related behavior. Psychopharmacology (Berl) 178 (2005) 276-285
22. Hunziker M.H. Opioid nature of learned helplessness and stress induced analgesia observed without re-exposure to shock. Behav. Pharmacol. 3 (1992) 117-121
23. Karlsson R.M., Holmes A., Heilig M., and Crawley J.N. Anxiolytic-like actions of centrally-administered neuropeptide Y, but not galanin, in C57BL/6J mice. Pharmacol. Biochem. Behav. 80 (2005) 427-436
24. Kerekes N., Mennicken F., O'Donnell D., Hokfelt T., and Hill R.H. Galanin increases membrane excitability and enhances Ca(2+) currents in adult, acutely dissociated dorsal root ganglion neurons. Eur. J. Neurosci. 18 (2003) 2957-2966
25. Khoshbouei H., Cecchi M., and Morilak D.A. Modulatory effects of galanin in the lateral bed nucleus of the stria terminalis on behavioral and neuroendocrine responses to acute stress. Neuropsychopharmacology 27 (2002) 25-34
26. Khoshbouei H., Cecchi M., Dove S., Javors M., and Morilak D.A. Behavioral reactivity to stress: amplification of stress-induced noradrenergic activation elicits a galanin-mediated anxiolytic effect in central amygdala. Pharmacol. Biochem. Behav. 71 (2002) 407-417
27. Kuteeva E., Wardi T., Hokfelt T., and Ogren S.O. Galanin enhances and a galanin antagonist attenuates depression-like behaviour in the rat. Eur. Neuropsychopharmacol. 17 (2007) 64-69
28. Lu X., Barr A.M., Kinney J.W., Sanna P., Conti B., Behrens M.M., and Bartfai T. A role for galanin in antidepressant actions with a focus on the dorsal raphe nucleus. Proc. Natl. Acad. Sci. USA 102 (2005) 874-879
29. Lucki I. The forced swimming test as a model for core and component behavioral effects of antidepressant drugs. Behav. Pharmacol. 8 (1997) 523-532
30. Maier S.F., Sherman J.E., Lewis J.W., Terman G.W., and Liebeskind J.C. The opioid/nonopioid nature of stress-induced analgesia and learned helplessness. J. Exp. Psychol. Anim. Behav. Process 9 (1983) 80-90
31. Malberg J.E., and Duman R.S. Cell proliferation in adult hippocampus is decreased by inescapable stress: reversal by fluoxetine treatment. Neuropsychopharmacology 28 (2003) 1562-1571
32. Mazarati A.M., Baldwin R.A., Shinmei S., and Sankar R. In vivo interaction between serotonin and galanin receptors types 1 and 2 in the dorsal raphe: implication for limbic seizures. J. Neurochem. 95 (2005) 1495-1503
33. Melander T., Hokfelt T., Rokaeus A., Cuello A.C., Oertel W.H., Verhofstad A., and Goldstein M. Coexistence of galanin-like immunoreactivity with catecholamines, 5-hydroxytryptamine, GABA and neuropeptides in the rat CNS. J. Neurosci. 6 (1986) 3640-3654
34. Morilak D.A., Cecchi M., and Khoshbouei H. Interactions of norepinephrine and galanin in the central amygdala and lateral bed nucleus of the stria terminalis modulate the behavioral response to acute stress. Life Sci. 73 (2003) 715-726
35. Nishimura H., Tsuda A., Ida Y., and Tanaka M. The modified forced-swim test in rats: influence of rope- or straw-suspension on climbing behavior. Physiol. Behav. 43 (1988) 665-668
36. O'Donnell D., Ahmad S., Wahlestedt C., and Walker P. Expression of the novel galanin receptor subtype GALR2 in the adult rat CNS: distinct distribution from GALR1. J. Comp. Neurol. 409 (1999) 469-481
37. Phillips T.J., Hen R., and Crabbe J.C. Complications associated with genetic background effects in research using knockout mice. Psychopharmacology (Berl) 147 (1999) 5-7
38. Rajarao S.J., Platt B., Sukoff S.J., Lin Q., Bender C.N., Nieuwenhuijsen B.W., Ring R.H., Schechter L.E., Rosenzweig-Lipson S., and Beyer C.E. Anxiolytic-like activity of the non-selective galanin receptor agonist, galnon. Neuropeptides 41 (2007) 307-320
39. Rosenthal R., and DiMatteo M.R. Meta-analysis: recent developments in quantitative methods for literature reviews. Annu. Rev. Psychol. 52 (2001) 59-82
40. Shanks N., and Anisman H. Stressor-provoked behavioral changes in six strains of mice. Behav. Neurosci. 102 (1988) 894-905
41. Shanks N., and Anisman H. Escape deficits induced by uncontrollable foot-shock in recombinant inbred strains of mice. Pharmacol. Biochem. Behav. 46 (1993) 511-517
42. Shi T.J., Hua X.Y., Lu X., Malkmus S., Kinney J., Holmberg K., Wirz S., Ceccatelli S., Yaksh T., Bartfai T., and Hokfelt T. Sensory neuronal phenotype in galanin receptor 2 knockout mice: focus on dorsal root ganglion neurone development and pain behaviour. Eur. J. Neurosci. 23 (2006) 627-636
43. Smith K.E., Walker M.W., Artymyshyn R., Bard J., Borowsky B., Tamm J.A., Yao W.J., Vaysse P.J., Branchek T.A., Gerald C., and Jones K.A. Cloned human and rat galanin GALR3 receptors. Pharmacology and activation of G-protein inwardly rectifying K+ channels. J. Biol. Chem. 273 (1998) 23321-23326
44. Snow A.E., Tucker S.M., and Dewey W.L. The role of neurotransmitters in stress-induced antinociception (SIA). Pharmacol. Biochem. Behav. 16 (1982) 47-50
45. Sunal R., Gumusel B., and Kayaalp S.O. Effect of changes in swimming area on results of "behavioral despair test". Pharmacol. Biochem. Behav. 49 (1994) 891-896
46. Swanson C.J., Blackburn T.P., Zhang X., Zheng K., Xu Z.Q., Hokfelt T., Wolinsky T.D., Konkel M.J., Chen H., Zhong H., Walker M.W., Craig D.A., Gerald C.P., and Branchek T.A. Anxiolytic- and antidepressant-like profiles of the galanin-3 receptor (Gal3) antagonists SNAP 37889 and SNAP 398299. Proc. Natl. Acad. Sci. USA 102 (2005) 17489-17494
47. Teixeira N.A., Pereira D.G., and Hermini A.H. Effects of naltrexone and cross-tolerance to morphine in a learned helplessness paradigm. Braz. J. Med. Biol. Res. 30 (1997) 775-782
48. Wang S., Hashemi T., Fried S., Clemmons A.L., and Hawes B.E. Differential intracellular signaling of the GalR1 and GalR2 galanin receptor subtypes. Biochemistry 37 (1998) 6711-6717
49. Weiss J.M., Bonsall R.W., Demetrikopoulos M.K., Emery M.S., and West C.H. Galanin: a significant role in depression?. Ann. N.Y. Acad. Sci. 863 (1998) 364-382
50. Xu Z.Q., and Hokfelt T. Expression of galanin and nitric oxide synthase in subpopulations of serotonin neurons of the rat dorsal raphe nucleus. J. Chem. Neuroanat. 13 (1997) 169-187
51. Xu Z.Q., Shi T.J., and Hokfelt T. Galanin/GMAP- and NPY-like immunoreactivities in locus coeruleus and noradrenergic nerve terminals in the hippocampal formation and cortex with notes on the galanin-R1 and -R2 receptors. J. Comp. Neurol. 392 (1998) 227-251
52. Xu Z.Q., Zhang X., Pieribone V.A., Grillner S., and Hokfelt T. Galanin-5-hydroxytryptamine interactions: electrophysiological, immunohistochemical and in situ hybridization studies on rat dorsal raphe neurons with a note on galanin R1 and R2 receptors. Neuroscience 87 (1998) 79-94
53. Zorrilla E.P., Luborsky L., McKay J.R., Rosenthal R., Houldin A., Tax A., McCorkle R., Seligman D.A., and Schmidt K. The relationship of depression and stressors to immunological assays: a meta-analytic review. Brain Behav. Immun. 15 (2001) 199-226