Independent transcription of glutamine synthetase (glnA2) and glutamine synthetase adenylyltransferase (glnE) in Mycobacterium bovis and Mycobacterium tuberculosis

Tuberculosis

Volumn 88, Issue 5, 2008, Pages 382-389

  Hotter, Grant S ^a   Mouat, Pania ^a   Collins, Desmond M ^a  

^a AGRESEARCH   (New Zealand)

Author keywords

glnA2; glnE; Glutamine synthetase; Mycobacterium; Tuberculosis

Indexed keywords

BACTERIAL ENZYME; COMPLEMENTARY DNA; GLUTAMATE AMMONIA LIGASE; GLUTAMINE SYTHETASE ADENYLTRANSFERASE; SPACER DNA;

ARTICLE; BACTERIAL CHROMOSOME; BACTERIAL STRAIN; BACTERIAL VIRULENCE; BINDING SITE; DNA SEQUENCE; GENE AMPLIFICATION; GENE LOCUS; GENETIC TRANSCRIPTION; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NORTHERN BLOTTING; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN LOCALIZATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

ANIMALS; CELLS, CULTURED; GLUTAMATE-AMMONIA LIGASE; GUINEA PIGS; MUTAGENESIS, SITE-DIRECTED; MYCOBACTERIUM BOVIS; MYCOBACTERIUM TUBERCULOSIS; NUCLEOTIDYLTRANSFERASES; PROMOTER REGIONS, GENETIC; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; TRANSCRIPTION, GENETIC; UP-REGULATION; VIRULENCE;

EID: 49349095516     PISSN: 14729792     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tube.2008.02.006     Document Type: Article

References (22)

1. Merrick M.J., and Edwards R.A. Nitrogen control in bacteria. Microbiol Rev 59 (1995) 604-622
2. Cosivi O., Grange J.M., Daborn C.J., Raviglione M.C., Fujikura T., Cousins D., et al. Zoonotic tuberculosis due to Mycobacterium bovis in developing countries. Emerg Infect Dis 4 (1998) 59-70
3. Corbett E.L., Watt C.J., Walker N., Maher D., Williams B.G., Raviglione M.C., et al. The growing burden of tuberculosis: global trends and interactions with the HIV epidemic. Arch Intern Med 163 (2003) 1009-1021
4. Cole S.T., Brosch R., Parkhill J., Garnier T., Churcher C., Harris D., et al. Deciphering the biology of Mycobacterium tuberculosis from the complete genome sequence. Nature 393 (1998) 537-544
5. Garnier T., Eiglmeier K., Camus J.-C., Medina N., Mansoor H., Pryor M., et al. The complete genome sequence of Mycobacterium bovis. Proc Natl Acad Sci USA 100 (2003) 7877-7882
6. Harth G., Maslesa-Galic S., Tullius M.V., and Horwitz M.A. All four Mycobacterium tuberculosis glnA genes encode glutamine synthetase activities but only GlnA1 is abundantly expressed and essential for bacterial homeostasis. Mol Microbiol 58 (2005) 1157-1172
7. Collins D.M., Wilson T., Campbell S., Buddle B.M., Wards B.J., Hotter G., et al. Production of avirulent mutants of Mycobacterium bovis with vaccine properties by the use of illegitimate recombination and screening of stationary phase cultures. Microbiology 148 (2002) 3019-3027
8. Tullius M.V., Harth G., and Horwitz M.A. Glutamine synthetase GlnA1 is essential for growth of Mycobacterium tuberculosis in human THP-1 macrophages and guinea pigs. Infect Immun 71 (2003) 3927-3936
9. Lee S., Jeon B.-Y., Bardarov S., Chen M., Morris S.L., and Jacobs Jr. W.R. Protection elicited by two glutamine auxotrophs of Mycobacterium tuberculosis and in vivo growth phenotypes of the four unique glutamine synthetase mutants in a murine model. Infect Immun 74 (2006) 6491-6495
10. Harth G., and Horwitz M.A. An inhibitor of exported Mycobacterium tuberculosis glutamine synthetase selectively blocks the growth of pathogenic mycobacteria in axenic culture and in human monocytes: extracellular proteins as potential novel drug targets. J Exp Med 189 (1999) 1425-1435
11. Harth G., Zamecnik P.C., Tang J.-Y., Tabatadze D., and Horwitz M.A. Treatment of Mycobacterium tuberculosis with antisense oligonucleotides to glutamine synthetase mRNA inhibits glutamine synthetase activity, formation of the poly-L-glutamate/glutamine cell wall structure, and bacterial replication. Proc Natl Acad Sci USA 97 (2000) 418-423
12. Parish T., and Stoker N.G. glnE is an essential gene in Mycobacterium tuberculosis. J Bacteriol 182 (2000) 5715-5720
13. Parish T., Lewis J., and Stoker N.G. Use of the mycobacteriophage L5 excisionase in Mycobacterium tuberculosis to demonstrate gene essentiality. Tuberculosis 81 (2001) 359-364
14. Nolden L., Farwick M., Kramer R., and Burkovski A. Glutamine synthetases of Corynebacterium glutamicum: transcriptional control and regulation of activity. FEMS Microbiol Lett 201 (2001) 91-98
15. Pashley C.A., Brown A.C., Robertson D., and Parish T. Identification of the Mycobacterium tuberculosis GlnE promoter and its response to nitrogen availability. Microbiology 152 (2006) 2727-2734
16. Stewart G.R., Wernisch L., Stabler R., Mangan J.A., Hinds J., Laing K.G., et al. Dissection of the heat-shock response in Mycobacterium tuberculosis using mutants and microarrays. Microbiology 148 (2002) 3129-3138
17. Smith I., Bishai W.R., and Nagaraja V. Control of mycobacterial transcription. In: Cole S.T., Eisenach K.D., McMurray D.N., and Jacobs Jr. W.R. (Eds). Tuberculosis and the tubercle bacillus (2005), ASM Press, Washington, DC 219-231
18. Gomez M., and Smith I. Determinants of mycobacterial gene expression. In: Hatfull G.F., and Jacobs Jr. W.R. (Eds). Molecular genetics of mycobacteria (2000), ASM Press, Washington, DC 111-129
19. Unniraman S., Chatterji M., and Nagaraja V. DNA gyrase genes in Mycobacterium tuberculosis: a single operon driven by multiple promoters. J Bacteriol 184 (2002) 5449-5456
20. Kalate R.N., Tambe S.S., and Kulkarni B.D. Artificial neural networks for prediction of mycobacterial promoter sequences. Comput Biol Chem 27 (2003) 555-564
21. Moll I., Grill S., Gualerzi C.O., and Blasi U. Leaderless mRNAs in bacteria: surprises in ribosomal recruitment and translational control. Mol Microbiol 43 (2002) 239-246
22. Collins D.M., Kawakami R.P., Buddle B.M., Wards B.J., and de Lisle G.W. Different susceptibility of two animal species infected with isogenic mutants of Mycobacterium bovis identifies phoT as having roles in tuberculosis virulence and phosphate transport. Microbiology 149 (2003) 3203-3212