The role of anti-cyclic cytrullinate antibodies testing in rheumatoid arthritis

Clinical Reviews in Allergy and Immunology

Volumn 34, Issue 1, 2008, Pages 45-49

  Alessandri, Cristiano ^a   Priori, Roberta ^a   Modesti, Mariagrazia ^a   Mancini, Riccardo ^a   Valesini, Guido ^a  

^a SAPIENZA UNIVERSITY OF ROME   (Italy)

Author keywords

Anti citrullinated protein peptide antibodies; Anti cyclic citrullinate peptide antibodies; Anti TNF agents; Rheumatoid arthritis; Rheumatoid factor

Indexed keywords

ADALIMUMAB; CYCLIC CITRULLINATED PEPTIDE ANTIBODY; ETANERCEPT; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN G ANTIBODY; IMMUNOGLOBULIN M; INFLIXIMAB; RHEUMATOID FACTOR; TUMOR NECROSIS FACTOR ALPHA;

AUTOIMMUNE HEPATITIS; CLINICAL FEATURE; DIAGNOSTIC ACCURACY; DIAGNOSTIC ERROR; DIFFERENTIAL DIAGNOSIS; DISEASE ACTIVITY; DISEASE COURSE; HEPATITIS B; HEPATITIS B VIRUS; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; IMMUNOASSAY; IMMUNOMODULATION; MYOSITIS; PREDICTION; PREDICTOR VARIABLE; PROGNOSIS; PSORIATIC ARTHRITIS; QUALITY OF LIFE; REVIEW; RHEUMATOID ARTHRITIS; SENSITIVITY AND SPECIFICITY; SJOEGREN SYNDROME; SYNOVITIS; SYSTEMIC LUPUS ERYTHEMATOSUS;

ARTHRITIS, RHEUMATOID; AUTOANTIBODIES; BIOLOGICAL MARKERS; EARLY DIAGNOSIS; HUMANS; PEPTIDES, CYCLIC; PROGNOSIS; SENSITIVITY AND SPECIFICITY;

EID: 49349089773     PISSN: 10800549     EISSN: None     Source Type: Journal    
DOI: 10.1007/s12016-007-8023-4     Document Type: Review

References (40)

1. GA Schellekens H Visser BA de Jong FH van den Hoogen JM Hazes FC Breedveld 2000 The diagnostic properties of rheumatoid arthritis antibodies recognizing a cyclic citrullinated peptide Arthritis Rheum 43 155 163
2. EJ Kroot BA de Jong MA van Leeuwen H Swinkels FH van den Hoogen M van't Hof 2000 The prognostic value of anti-cyclic citrullinated peptide antibodies in patients with recent-onset rheumatoid arthritis Arthritis Rheum 43 1831 1835
3. O Meyer C Labarre M Dougados P Goupille A Cantagrel A Dubois 2003 Anticitrullinated protein/peptide antibody assays in early rheumatoid arthritis for predicting five year radiographic damage Ann Rheum Dis 62 120 126
4. VP Nell KP Machold G Eberl TA Stamm M Uffmann JS Smolen 2004 Benefit of very early referral and very early therapy with disease-modifying antirheumatic drugs in patients with early rheumatoid arthritis Rheumatology 43 906 914
5. F van Gaalen A Ioan-Facsinay TW Huizinga RE Toes 2005 The devil in the details: the emerging role of anticitrulline autoimmunity in rheumatoid arthritis J Immunol 175 5575 5580
6. ER Vossenaar TMJ Smeets MC Kraan JM Raats WJ van Venrooij PP Tak 2004 The Presence of Citrullinated Proteins Is Not Specific for Rheumatoid Synovial Tissue Arthritis Rheum 50 3485 3494
7. C Masson-Bessière M Sebbag E Girbal-Neuhauser L Nogueira C Vincent T Senshu 2001 The major synovial targets of the rheumatoid arthritis-specific antifilaggrin autoantibodies are deiminated forms of the a- and b-chains of fibrin J Immunol 166 4177 4184
8. ER Vossenaar WJ Van Venrooij 2004 Citrullinated proteins: the sparks that may ignite the fire in rheumatoid arthritis Arthritis Res Ther 6 107 111
9. J Avouac L Gossec M Dougados 2006 Diagnostic and predictive value of anti-cyclic citrullinated protein antibodies in rheumatoid arthritis: a systematic literature review Ann Rheum Dis 65:845 851
10. MA Quinn AK Gough MJ Green J Devlin EM Hensor A Greenstein 2006 Anti-CCP antibodies measured at disease onset help identify seronegative rheumatoid arthritis and predict radiological and functional outcome Rheumatology 45 478 480
11. T Avcin R Cimaz F Falcini F Zulian G Martini G Simonini 2002 Prevalence and clinical significance of anti-cyclic citrullinated peptide antibodies in juvenile idiopathic arthritis. Ann Rheum Dis 61 608 611
12. M Van Rossum R van Soesbergen S de Kort R Ten Cate AH Zwinderman B de Jong 2003 Anti-cyclic citrullinated peptide (anti-CCP) antibodies in children with juvenile idiopathic arthritis J Rheumatol 30 825 828
13. L Bogliolo C Alpini R Caporali CA Scire R Moratti C Montecucco 2005 Antibodies to cyclic citrullinated peptides in psoriatic arthritis J Rheumatol 32 511 515
14. L Candia J Marquez C Gonzalez AM Santos J Londono R Valle 2006 Low Frequency of Anticyclic Citrullinated Peptide Antibodies in Psoriatic Arthritis But Not in Cutaneous Psoriasis J Clin Rheumatol 12 226 229
15. R Mediwake DA Isenberg GA Schellekens WJ van Venrooij 2001 Use of anti-citrullinated peptide and anti-RA33 antibodies in distinguishing erosive arthritis in patients with systemic lupus erythematosus and rheumatoid arthritis Ann Rheum Dis 60 67 68
16. IE Hoffman I Peene L Cebecauer D Isenberg TW Huizinga A Union 2005 Presence of rheumatoid factor and antibodies to citrullinated peptides in systemic lupus erythematosus Ann Rheum Dis 64 330 332
17. LM Amezcua-Guerra R Springall R Marquez-Velasco L Gómez- García A Vargas R Bojalil 2006 Presence of antibodies against cyclic citrullinated peptides in patients with 'rhupus': a cross-sectional study Arthritis Res Ther 8 R144
18. JE Gottenberg S Mignot P Nicaise-Rolland J Cohen-Solal F Aucouturier J Goetz 2005 Prevalence of anti-cyclic citrullinated peptide and anti-keratin antibodies in patients with primary Sjogren's syndrome Ann Rheum Dis 64 114 117
19. F Ingegnoli V Galbiati S Zeni L Meani L Zahalkova C Lubatti 2007 Use of antibodies recognizing cyclic citrullinated peptide in the differential diagnosis of joint involvement in systemic sclerosis Clin. Rheumatol 26 510 514
20. A Vannini K Cheung M Fusconi J Stammen-Vogelzangs JP Drenth AC Dall'aglio 2007 Anti-CCP2 positivity in non-ra disease samples: citrulline-dependent or not? Ann Rheum Dis 66 511 516
21. M Bombardieri C Alessandri G Labbadia C Iannuccelli F Carlucci V Riccieri 2004 Role of anti-cyclic citrullinated peptide antibodies in discriminating patients with rheumatoid arthritis from patients with chronic hepatitis C infection-associated polyarticular involvement Arthritis Res Ther 6 R137 141
22. D Sene P Ghillani-Dalbin N Limal V Thibault T van Boekel JC Piette 2006 Anti-cyclic citrullinated peptide antibodies in hepatitis C virus associated rheumatological manifestations and Sjogren's syndrome Ann Rheum Dis 65 394 397
23. MH Wener K Hutchinson C Morishima DR Gretch 2004 Absence of antibodies to cyclic citrullinated peptide in sera of patients with hepatitis C virus infection and cryoglobulinemia Arthritis Rheum 50 2305 2308
24. SI Lee WH Yoo HJ Yun DS Kim HS Lee SI Choi 2007 Absence of antibody to cyclic citrullinated peptide in sera of non-arthritic patients with chronic hepatitis B virus infection Clin Rheumatol 26 1079 1082
25. O Elkayam R Segal M Lidgi D Caspi 2006 Positive anti-cyclic citrullinated proteins and rheumatoid factor during active lung tuberculosis Ann Rheum Dis 65 1110 1112
26. A Ates Y Karaaslan S Aksaray 2007 Predictive value of antibodies to cyclic citrullinated peptide in patients with early arthritis Clin Rheumatol 26 499 504
27. T Matsui K Shimada N Ozawa H Hayakawa F Hagiwara H Nakayama 2006 Diagnostic utility of anti-cyclic citrullinated peptide antibodies for very early rheumatoid arthritis J Rheumatol 33 2390 2397
28. AS Russell A Devani WP Maksymowych 2006 The role of anti-cyclic citrullinated peptide antibodies in predicting progression of palindromic rheumatism to rheumatoid arthritis J Rheumatol 33 1240 1242
29. R Panchagnula SR Rajiv J Prakash S Chandrashekara KP Suresh 2006 Role of Anticyclic Citrullinated Peptide in the Diagnosis of Early Rheumatoid Factor-Negative Suspected Rheumatoid Arthritis Is It Worthwhile to Order the Test? J Clin Rheumatol 12 172 175
30. M Johansson L Arlestig G Hallmans S Rantapaa-Dahlqvist 2006 PTPN22 polymorphism and anti-cyclic citrullinated peptide antibodies in combination strongly predicts future onset of rheumatoid arthritis and has a specificity of 100% for the disease Arthritis Res Ther 8 R19
31. O Meyer P Nicaise-Roland MD Santos C Labarre M Dougados P Goupille 2006 Serial determination of cyclic citrullinated peptide autoantibodies predicted five-year radiological outcomes in a prospective cohort of patients with early rheumatoid arthritis Arthritis Res Ther 8 R40
32. SP Linn-Rasker AH Van der Helm-van Mil FC Breedveld TW Huizinga 2007 Arthritis of the large joints, in particular the knee, at first presentation is predictive for a high level of radiological destruction of the small joints in rheumatoid arthritis Ann Rheum Dis 66 646 650
33. KP Machold TA Stamm VP Nell S Pflugbeil D Aletaha G Steiner M Uffmann JS Smolen 2007 Very recent onset rheumatoid arthritis: clinical and serological patient characteristics associated with radiographic progression over the first years of disease Rheumatology 46 342 349
34. AH van der Helm-van Mil KN Verpoort FC Breedveld RE Toes TW Huizinga 2005 Antibodies to citrullinated proteins and differences in clinical progression of rheumatoid arthritis Arthritis Res Ther 7 R949 R958
35. FA van Gaalen J van Aken TW Huizinga GM Schreuder FC Breedveld E Zanelli 2004 Association Between HLA Class II Genes and Autoantibodies to Cyclic Citrullinated Peptides (CCPs) Influences the Severity of Rheumatoid Arthritis Arthritis Rheum 50 2113 2121
36. KN Verpoort CM Jol-van der Zijde EA Papendrecht-van der Voort A Ioan-Facsinay JW Drijfhout MJ van Tol 2006 Isotype distribution of anti-cyclic citrullinated peptide antibodies in undifferentiated arthritis and rheumatoid arthritis reflects an ongoing immune response Arthritis Rheum 54 3799 3808
37. C Alessandri M Bombardieri N Papa M Cinquini L Magrini A Tincani 2004 Decrease of anti-cyclic citrullinated peptide antibodies and rheumatoid factor following anti-TNF alpha therapy (infliximab) in rheumatoid arthritis is associated with clinical improvement Ann Rheum Dis 63 1218 1221
38. L De Rycke X Verhelst E Kruithof F Van den Bosch IE Hoffman EM Veys 2005 Rheumatoid factor, but not anti-citrullinated protein antibodies, is modulated by infliximab treatment in rheumatoid arthritis Ann Rheum Dis 64 299 302
39. HA Chen KC Lin CH Chen HT Liao HP Wang HN Chang 2006 The effect of etanercept on anti-cyclic citrullinated peptide antibodies and rheumatoid factor in patients with rheumatoid arthritis Ann Rheum Dis 65 35 39
40. F Atzeni P Sarzi-Puttini D Dell' Acqua S de Portu G Cecchini C Cruini 2006 Adalimumab clinical efficacy is associated with rheumatoid factor and anti-cyclic citrullinated peptide antibody titer reduction: a one-year prospective study Arthritis Res Ther 8 R3