Is deep brain stimulation neuroprotective if applied early in the course of PD?

Nature Clinical Practice Neurology

Volumn 4, Issue 8, 2008, Pages 424-426

  Charles, P David ^a   Gill, Chandler E ^a   Davis, Thomas L ^a   Konrad, Peter E ^a   Benabid, Alim Louis ^b,c  

^a VANDERBILT UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b UNIV GRENOBLE ALPES   (France)

^c MINATEC   (France)

Author keywords

[No Author keywords available]

Indexed keywords

BRAIN DEPTH STIMULATION; CLINICAL RESEARCH; CLINICAL TRIAL; COST BENEFIT ANALYSIS; COST EFFECTIVENESS ANALYSIS; DISEASE COURSE; DISEASE SEVERITY; DOPAMINERGIC NERVE CELL; ELECTROSTIMULATION THERAPY; EXCITOTOXICITY; HUMAN; MOTOR PERFORMANCE; NERVE CELL NECROSIS; NEUROPROTECTION; NONHUMAN; PARKINSON DISEASE; PRIORITY JOURNAL; QUALITY OF LIFE; REVIEW; SUBTHALAMIC NUCLEUS; SYMPTOMATOLOGY; TREATMENT RESPONSE;

ANIMALS; CLINICAL TRIALS AS TOPIC; DEEP BRAIN STIMULATION; HUMANS; PARKINSON DISEASE; SUBTHALAMIC NUCLEUS;

EID: 49249128563     PISSN: 1745834X     EISSN: 17458358     Source Type: Journal    
DOI: 10.1038/ncpneuro0848     Document Type: Review

References (10)

1. Charles PD et al. (2004) Deep brain stimulation of the subthalamic nucleus reduces antiparkinsonian medication costs. Parkinsonism Relat Disord 10: 475-479
2. Krack P et al. (2003) Five-year follow-up of bilateral stimulation of the subthalamic nucleus in advanced Parkinson's disease. N Engl J Med 349: 1925-1934
3. Wallace BA et al. (2007) Survival of midbrain dopaminergic cells altar lesion or deep brain stimulation of the subthalamic nucleus in MPTP-treated monkeys. Brain 130: 2129-2145
4. Temel Y et al. (2006) Protection of nigral cell death by bilateral subthalamic nucleus stimulation. Brain Res 1120: 100-105
5. Schüpbach WM et al. (2007) Neurosurgery at an earlier stage of Parkinson disease: A randomized, controlled trial. Neurology 68 267-271
6. Piallat B et al. (1996) Subthalamic nucleus lesion in rats prevents dopaminergic nigral neuron degeneration after striatal 6-OHDA injection: Behavioural and immunohistochemical studies. Eur J Neurosci 8: 1408-1414
7. Visser-Vandewalle V et al. (2005) Long-term effects of bilateral subthalamic nucleus stimulation in advanced Parkinson disease: A four year follow-up study. Parkinsonism Relat Disord 11: 157-165
8. Hilker R et al. (2005) Disease progression continues in patients with advanced Parkinson's disease and effective subthalamic nucleus stimulation. J Neurol Neurosurg Psychiatry 76: 1217-1221
9. Luquin MR et al. (2006) Does increased excitatory drive from the subthalamic nucleus contribute to dopaminergic neuronal death in Parkinson's disease? Exp Neurol 201: 407-415
10. Ravina B et al. (2005) The role of radiotracer imaging in Parkinson disease. Neurology 64: 208-215