Do statins slow the progression of aortic valve stenosis?

Interactive Cardiovascular and Thoracic Surgery

Volumn 7, Issue 4, 2008, Pages 684-689

  Tourmousoglou, Christos E ^a,b   Lalos, Spiros ^a   Psarros, Themistokles ^a  

^a HIPPOKRATION HOSPITAL   (Greece)

^b NONE   (Greece)

Author keywords

Aortic valve stenosis; Statins; Thoracic surgery

Indexed keywords

ATORVASTATIN; EZETIMIBE; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; LIPID; PLACEBO; ROSUVASTATIN; SIMVASTATIN;

AORTA VALVE STENOSIS; ARTICLE; BLOOD VESSEL CALCIFICATION; CLINICAL TRIAL; DISEASE COURSE; DRUG EFFECT; DRUG EFFICACY; HEMODYNAMICS; HUMAN; LIPID BLOOD LEVEL; MEDICAL LITERATURE; MEDLINE; NONHUMAN; PRIORITY JOURNAL; PUBLICATION;

AGED; AGED, 80 AND OVER; ANIMALS; AORTIC VALVE STENOSIS; BENCHMARKING; CALCINOSIS; DISEASE PROGRESSION; EVIDENCE-BASED MEDICINE; HUMANS; HYDROXYMETHYLGLUTARYL-COA REDUCTASE INHIBITORS; MIDDLE AGED; TREATMENT OUTCOME;

EID: 49249128111     PISSN: 15699293     EISSN: None     Source Type: Journal    
DOI: 10.1510/icvts.2008.178038     Document Type: Article

References (15)

1. Dunning J, Prendergast B, Mackway-Jones K. Towards evidence-based medicine in cardiothoracic surgery: best BETS. Interact Cardiovasc Thorac Surg 2003;2:405-409.
2. Aronow WS, Ahn C, Kronzon I, Goldman ME. Association of coronary risk factors and use of statins with progression of mild valvular aortic stenosis in older persons. Am J Cardiol 2001;88:693-695.
3. Novaro GM, Tiong IY, Pearce GL, Lauer MS, Sprecher DL, Griffin BP. Effect of hydroxymethylglutaryl coenzyme A reductase inhibitors on the progression of calcific aortic stenosis. Circulation 2001;104: 2205-2209.
4. Pohle K, Maffert R, Ropers D, Moshage W, Stilianakis N, Daniel W, Achenbach S. Progression of aortic valve calcification. Association with coronary atherosclerosis and cardiovascular risk factors. Circulation 2001;104:1927-1932.
5. Shavelle DM, Takasu J, Budoff MJ, Mao S, Zhao XQ, O'Brien KD. HMG CoA reductase inhibitor (statin) and aortic valve calcium. Lancet 2002;359:1125-1126.
6. Bellamy MF, Pellikka PA, Klarich KW, Tajik AJ, Enriquez-Sarano M. Association of cholesterol levels, hydroxymethylglutaryl coenzyme-A reductase inhibitor treatment, and progression of aortic stenosis in the community. J Am Coll Cardiol 2002;40:1723-1730.
7. Rosenhek R, Rader F, Loho N, Gabriel H, Heger M, Klaar U, Schemper M, Binder T, Maurer G, Baumgartner H. Statins but not angiotensin-converting enzyme inhibitors delay progression of aortic stenosis. Circulation 2004;110:1291-1295.
8. Antonini-Canterin F, Popescu BA, Huang G, Korcova-Miertusova R, Rivaben D, Faggiano P, Pavan D, Piazza R, Bolis A, Ciavattone A, Ruggiero A, Nicolosi GL. Progression of aortic valve sclerosis and aortic valve stenosis: what is the role of statin treatment? Ital Heart J 2005;6:119-124.
9. Rajamannan N, Subramaniam M, Stock S, Stone N, Springett M, Ignatiev K, McConnell J, Singh R, Bonow R, Spelsberg T. Atorvastatin inhibits calcification and enhances nitric oxide synthase production in the hypercholesterolaemic aortic valve. Heart 2005;91:806-810.
10. Rajamannan NM, Subramaniam M, Caira F, Stock SR, Spelsberg TC. Atorvastatin inhibits hypercholesterolemia-induced calcification in the aortic valves via the Lrp5 receptor pathway. Circulation 2005;112: I229-234.
11. Cowell SJ, Newby DE, Prescott RJ, Bloomfield P, Reid J, Northridge DB, Boon NA, Scottish Aortic Stenosis and Lipid lowering Trial, Impact on Regression (SALTIRE) Investigators. A randomized trial of intensive lipid-lowering therapy in calcific aortic stenosis. N Engl J Med 2005;352: 2389-2397.
12. Moura LM, Ramos SF, Zamorano JL, Barros IM, Azevedo LF, Rocha-Goncalves F, Rajamannan NM. Rosuvastatin affecting aortic valve endothelium to slow the progression of aortic stenosis. J Am Coll Cardiol 2007;49:554-561.
13. Mohler ER 3rd, Wang H, Medenilla E, Scott C. Effect of statin treatment on aortic valve and coronary artery calcification. J Heart Valve Dis 2007; 16:378-386.
14. Chan KL, Teo K, Tam J, Dumesnil JG. Astronomer investigators. Rationale, design, and baseline characteristics of a randomized trial to assess the effect of cholesterol lowering on the progression of aortic stenosis: the Aortic Stenosis Progression Observation: Measuring Effects of Rosuvastatin (ASTRONOMER) trial. Am Heart J 2007;153:925-931.
15. Rossebo AB, Pedersen TR, Allen C, Boman K, Chambers J, Egstrup K, Gerdts E, Gohlke-Barwolf C, Holme I, Kesaniemi VA, Malbecq W, Nienaber C, Ray S, Skjaerpe T, Wachtell K, Willenheimer R. Design and baseline characteristics of the simvastatin and ezetimibe in aortic stenosis (SEAS) study. Am J Cardiol 2007;99:970-973.