Anti-human leukocyte antigen antibodies, vascular C4d deposition and increased soluble C4d in broncho-alveolar lavage of lung allografts

Transplantation

Volumn 86, Issue 2, 2008, Pages 342-347

  Girnita, Alin L ^a,c   Lee, Teresa M ^b   McCurry, Kenneth R ^c   Baldwin, William M ^b   Yousem, Samuel A ^a   Detrick, Barbara ^b   Pilewski, Joseph ^d   Toyoda, Yoshiya ^c   Jelinek, Larry ^a   Lomago, Jon ^a   Zaldonis, Diana ^c   Spichty, Kathy J ^a   Zeevi, Adriana ^a  

^a UNIVERSITY OF PITTSBURGH SCHOOL OF MEDICINE   (United States)

^b JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE   (United States)

^c UNIVERSITY OF PITTSBURGH MEDICAL CENTER   (United States)

^d UNIVERSITY OF PITTSBURGH   (United States)

Author keywords

Antibodies; Complement C4d; HLA; Lung transplant; Rejection

Indexed keywords

COMPLEMENT COMPONENT C4D; HLA ANTIBODY; PARAFFIN; STEROID; TACROLIMUS; ALLOANTIBODY; COMPLEMENT C4D; COMPLEMENT COMPONENT C4B; HLA ANTIGEN; PEPTIDE FRAGMENT;

ACUTE GRAFT REJECTION; ADULT; ANTIBODY DETECTION; ANTIBODY SPECIFICITY; ARTICLE; CLINICAL ARTICLE; CLINICAL ASSESSMENT; COMPARATIVE STUDY; COMPLEMENT DEPOSITION; CONTROL GROUP; CONTROLLED STUDY; CROSS-SECTIONAL STUDY; ENZYME LINKED IMMUNOSORBENT ASSAY; EXPIRATORY RESERVE VOLUME; FEMALE; HUMAN; HUMAN TISSUE; IMMUNOSUPPRESSIVE TREATMENT; LOW DRUG DOSE; LUNG FUNCTION; LUNG GRAFT REJECTION; LUNG LAVAGE; LUNG TRANSPLANTATION; MALE; PRIORITY JOURNAL; TISSUE SECTION; TRANSBRONCHIAL BIOPSY; AGED; BIOPSY; CHEMISTRY; GRAFT REJECTION; LUNG; METHODOLOGY; MIDDLE AGED; PATHOLOGY;

ADULT; AGED; BIOPSY; BRONCHOALVEOLAR LAVAGE; BRONCHOALVEOLAR LAVAGE FLUID; COMPLEMENT C4B; FEMALE; GRAFT REJECTION; HLA ANTIGENS; HUMANS; ISOANTIBODIES; LUNG; LUNG TRANSPLANTATION; MALE; MIDDLE AGED; PEPTIDE FRAGMENTS;

EID: 49249116328     PISSN: 00411337     EISSN: None     Source Type: Journal    
DOI: 10.1097/TP.0b013e31817cf2e2     Document Type: Article

References (36)

1. Girnita AL, Duquesnoy R, Yousem SA, et al. HLA-specific antibodies are risk factors for lymphocytic bronchiolitis and chronic lung allograft dysfunction. Am J Transplant2005; 5: 131.
2. Girnita AL, McCurry KR, Iacono AT, et al. HLA-specific antibodies are associated with high-grade and persistent-recurrent lung allograft acute rejection. J Heart Lung Transplant 2004; 23: 1135.
3. Ionescu DN, Girnita AL, ZeeviA,etal. C4d deposition inlung allografts is associated with circulating anti-HLA alloantibody. Transpl Immunol 2005; 15: 63.
4. Jaramillo A, Smith MA, Phelan D, et al. Development of ELISA-detected anti-HLA antibodies precedes the developmentof bronchioli-tis obliterans syndrome and correlates with progressive decline in pulmonary function after lung transplantation. Transplantation1999; 67: 1155.
5. Lau CL, Palmer SM, Posther KE, et al. Influence of panel-reactive antibodies on posttransplant outcomes in lung transplant recipients. Ann Thorac Surg 2000; 69: 1520.
6. Schulman LL, Ho EK, Reed EF, et al. Immunologic monitoring in lung allograft recipients. Transplantation1996; 61: 252.
7. Takemoto SK, Zeevi A, Feng S, et al. National conference to assess antibody-mediated rejection in solid organ transplantation. Am J Transplant2004; 4: 1033.
8. Mauiyyedi S, Crespo M, Collins AB, et al. Acute humoral rejection in kidney transplantation: II. Morphology, immunopathology, and pathologic classification. J Am Soc Nephrol 2002; 13: 779.
9. Mauiyyedi S, Pelle PD, Saidman S, et al. Chronic humoral rejection: Identificationofantibody-mediated chronic renal allograft rejection by C4d deposits in peritubular capillaries. J Am Soc Nephrol 2001; 12: 574.
10. Nickeleit V, Zeiler M, Gudat F, Thiel G, Mihatsch MJ. Detection of the complement degradation product C4d in renal allografts: Diagnostic and therapeutic implications. J Am Soc Nephrol 2002; 13: 242.
11. Regele H, Exner M, Watschinger B, et al. Endothelial C4d deposition is associated with inferior kidney allograft outcome independently of cellular rejection. Nephrol Dial Transplant 2001; 16: 2058.
12. Miller GG, DestaracL,ZeeviA,etal. Acute humoral rejectionofhuman lung allografts and elevation of C4d in bronchoalveolar lavage fluid. Am J Transplant2004; 4: 1323.
13. McCurry KR, Iacono A, Zeevi A, et al. Early outcomes in human lung transplantation with Thymoglobulin or Campath-1H for recipient pre-treatment followed by posttransplant tacrolimus near-monotherapy. J Thorac Cardiovasc Surg 2005; 130: 528.
14. Yousem SA, Berry GJ, Cagle PT, et al. Revision of the 1990 working formulation for the classification of pulmonary allograft rejection: Lung Rejection Study Group. J Heart Lung Transplant 1996; 15(1 pt 1): 1.
15. Estenne M, Maurer JR, Boehler A, et al. Bronchiolitis obliterans syndrome 2001: An update of the diagnostic criteria. J Heart Lung Transplant 2002; 21: 297.
16. StataSoft. STATISTICA for Windows [Computer program manual]. Tulsa, OK, StatSoft Inc. 1995.
17. Stewart KC, Patterson GA. Current trends in lung transplantation. Am J Transplant2001; 1: 204.
18. Jaramillo A, Naziruddin B, Zhang L, et al. Activation of human airway epithelial cells by non-HLA antibodies developed after lung transplantation: A potential etiological factor for bronchiolitis obliterans syndrome. Transplantation2001; 71: 966.
19. McKenna RM, Takemoto SK, Terasaki PI. Anti-HLA antibodies after solid organ transplantation. Transplantation2000; 69: 319.
20. Palmer SM, Davis RD, HadjiliadisD,etal. Development ofan antibody specific to major histocompatibility antigens detectablebyflow cytom-etry after lung transplant is associated with bronchiolitis obliterans syndrome. Transplantation2002; 74: 799.
21. Sundaresan S, Mohanakumar T, Smith MA, et al. HLA-A locus mismatches and development of antibodies to HLA after lung transplantation correlate with the development of bronchiolitis obliterans syndrome. Transplantation1998; 65: 648.
22. FeingoldB, Bowman P, ZeeviA, etal. Survivalinallosensitized children after listing for cardiac transplantation. J Heart Lung Transplant 2007; 26: 565.
23. Girnita AL, Webber SA, Zeevi A. Anti-HLA alloantibodies in pediatric solid organ transplantation. Pediatr Transplant 2006; 10: 146.
24. Behr TM, Feucht HE, RichterK,etal. Detection ofhumoral rejection in human cardiac allografts by assessing the capillary deposition of complement fragment C4d in endomyocardial biopsies. J Heart Lung Transplant 1999; 18: 904.
25. Chantranuwat C, Qiao JH, Kobashigawa J, et al. Immunoperoxidase staining for C4d on paraffin-embedded tissue in cardiac allograft en-domyocardial biopsies: Comparison to frozen tissue immunofluorescence. Appl Immunohistochem Mol Morphol 2004; 12: 166.
26. Collins AB, Schneeberger EE, Pascual MA, et al. Complement activation in acute humoral renal allograft rejection: Diagnostic significance of C4d deposits in peritubular capillaries. J Am Soc Nephrol 1999; 10: 2208.
27. Michaels PJ, Fishbein MC, Colvin RB. Humoral rejection of human organ transplants. Springer Semin Immunopathol 2003; 25: 119.
28. Minami K, Murata K, Lee CY, et al. C4d deposition and clearance in cardiac transplants correlates with alloantibody levels and rejection in rats. Am J Transplant2006; 6(5 pt 1): 923.
29. Rodriguez ER, Skojec DV, Tan CD, et al. Antibody-mediated rejection in human cardiac allografts: Evaluation of immunoglobulins and complement activation products C4d and C3d as markers. Am J Transplant2005; 5: 2778.
30. Racusen LC, Halloran PF, Solez K. Banff 2003 meeting report: New diagnostic insights and standards. Am J Transplant2004; 4: 1562.
31. Bohmig GA, Regele H, Exner M, et al. C4d-positive acute humoral renal allograft rejection: Effective treatment by immunoadsorption. J Am Soc Nephrol 2001; 12: 2482.
32. Haas M, Ratner LE, Montgomery RA. C4d staining of perioperative renal transplant biopsies. Transplantation2002; 74: 711.
33. Nakashima S, Qian Z, Rahimi S, et al. Membrane attack complex contributes to destruction of vascular integrity in acute lung allograft rejection. J Immunol 2002; 169: 4620.
34. Magro CM, Pope HarmanA,KlingerD, etal. UseofC4dasadiagnostic adjunct in lung allograft biopsies. Am J Transplant2003; 3: 1143.
35. Wallace WD, Reed EF, Ross D, et al. C4d staining of pulmonary allo-graft biopsies: An immunoperoxidase study. J Heart Lung Transplant 2005; 24: 1565.
36. Mengel M, Bogers J, Bosmans JL, et al. Incidence of C4d stain in protocol biopsies from renal allografts: Results from a multicenter trial. Am J Transplant2005; 5: 1050.