Enzymatic wound debridement

Journal of Wound, Ostomy and Continence Nursing

Volumn 35, Issue 3, 2008, Pages 273-280

  Ramundo, Janet ^a   Gray, Mikel ^a  

^a UNIVERSITY OF VIRGINIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

COLLAGENASE; PAPAIN; UREA;

AUTOLYSIS; BANDAGE; CHRONIC DISEASE; CLASSIFICATION; CLINICAL NURSING RESEARCH; DEBRIDEMENT; DRUG EFFECT; EVIDENCE BASED MEDICINE; HUMAN; INJURY; INTRADERMAL DRUG ADMINISTRATION; METHODOLOGY; NECROSIS; NURSING; PATHOLOGY; PATIENT SELECTION; PRACTICE GUIDELINE; REVIEW; SKIN CARE; TREATMENT OUTCOME; WOUND HEALING;

ADMINISTRATION, CUTANEOUS; AUTOLYSIS; BANDAGES; CHRONIC DISEASE; CLINICAL NURSING RESEARCH; COLLAGENASES; DEBRIDEMENT; EVIDENCE-BASED MEDICINE; HUMANS; NECROSIS; PAPAIN; PATIENT SELECTION; PRACTICE GUIDELINES AS TOPIC; RESEARCH DESIGN; SKIN CARE; TREATMENT OUTCOME; UREA; WOUND HEALING; WOUNDS AND INJURIES;

EID: 49249104169     PISSN: 10715754     EISSN: None     Source Type: Journal    
DOI: 10.1097/01.WON.0000319125.21854.78     Document Type: Review

References (23)

1. Dorland's Illustrated Medical Dictionary. 31st ed, Philadelphia: Saunders. 2007; 481.
2. Anderson I. Debridement methods in wound care. Nurs Stand. 2006;22(24):65-72.
3. Kirshen C, Woo K, Ayella EA, SIbbald RG. Debridement: a vital component of wound bed preparation. Adv Skin Wound Care. 2006;19(9):506-517.
4. Saap LJ, Falanga V. Debridement performance index and its correlation with complete closure of diabetic foot ulcers. Wound Repair Regen. 2002;10(6):354-359.
5. Vetra H, Whittaker D. Hydrotherapy and topical collagenase for decubitus ulcers. Geriatircs. 1975;30(8):53-58.
6. Loo WT, Sasano H, Chow LW. Pro-inflammatory cytokine, matrix metalloproteinases and TIMP-1 are involved in wound healing after mastectomy in invasive breast cancer patients. Biomed Pharmacother. 2007;61(9):548-552.
7. Lu S, Xiang J, Qing C, Jin S, Liao Z, Shi J. Effect of necrotic tissue on progressive injury in deep partial thickness burn wounds. Chin Med J. 2002;115(3):323-325.
8. Mekkes JR, Le Poole IC, Das PK, Bos JD, Westerhof W. Efficient debridement of necrotic wounds using proteolytic enzymes derived from Antarctic krill: a double-blind, placebo-controlled study in a standardized animal wound model. Wound Repair Regen. 1998;6(1):50-57.
9. Bucalo B, Eaglstein W, Falanga V. Inhibition of cell proliferation by chronic wound fluid. Wound Repair Regen. 1993; 1:181-186.
10. Rogers AA, Burnett S, Moore JC, Shakespeare PG, Chen WYJ. Involvement of proteolytic enzymes, plasminogen activators, and matrix metalloproteinases levels in the pathology of pressure ulcers. Wound Repair Regen. 1995;3:273-283.
11. Schultz G, Mozingo D, Romanelli M, Claxton K. Wound healing and TIME: new concepts and scientific applications. Wound Repair Regen. 2005 13(4)(suppl):S1-S11.
12. Ayello EA, Cuddigan JE. Debridement: controlling the necrotic/cellular burden. Adv Skin Wound Care. 2004 17(20) 66-75.
13. Boxer MA, Gottesman N, Bernstein H, Mandl I. Debridement of dermal ulcers and decubiti with collagenase. Geriatrics. 1969; 24:75-86.
14. Lee LK, Ambrus JL. Collagenase therapy for decubitus ulcers. Geriatrics. 1975;30(5):91-93, 97-98.
15. Varma AO, Bugatch E, German FM. Debridement of dermal ulcers with collagenase. Surg Gynecol Obstet. 1973;136(2):281-282.
16. Palmieri B, Magri M. A new formulation of collagenase ointment (Iruxol Mono) in the treatment of ulcers of the lower extremities: a randomized, placebo-controlled, double-blind study. Clin Drug Invest. 1998;15(5):381-387.
17. Fu X, Wang S, Li L, Zhou L. The clinical evaluation of the effects of a new collagenase ointment (Iruxol mono) on debridement and wound healing in the burn wounds. Chin Med Sci J. 2000;15(4):200.
18. Soroff HS, Sasvary DH. Collagenase and polymyxin B sulfate/bacitracin spray versus silver sulfadiazine in partial thickness burns: a pilot study. J Burn Care Rehabil. 1994;15: 13-17.
19. Konig M, Vanscheidt W, Augustin M, Kapp H. Enzymatic versus autolytic debridement of chronic leg ulcers: a prospective randomized trial. J Wound Care. 2005;14(7):320-323.
20. Alvarez OM, Fernandez-Obregon A, Rogers RS, Bergman L, Black M. A prospective, randomized comparative study of collagenase and papain-urea for pressure ulcer debridement. Wounds. 2002;14(8):293-301.
21. Glyantsev SP, Adamyan AA, Sakharov Y. Crab collagenase in wound debridement. J Wound Care. 1997;6(1):13-16.
22. Ozcan C, Orkan E, Celik A, Corduk N, Ozok G. Enzymatic debridement of burn wound with collagenase in children with partial thickness burns. Burns. 2002;28:791-794.
23. Weir D, Farley KL. Relative efficacy and convenience of spray and ointment formulations of papain-urea-chlorophyllin enzymatic wound therapies. J Wound Ostomy Continence Nurs. 2006;33(5):482-490