Laforin confers cancer resistance to energy deprivation-induced apoptosis

Cancer Research

Volumn 68, Issue 11, 2008, Pages 4039-4044

  Wang, Yin ^a   Liu, Yan ^a   Wu, Cindy ^b   McNally, Beth ^a   Liu, Yang ^a   Zheng, Pan ^a  

^a UNIVERSITY OF MICHIGAN   (United States)

^b OHIO STATE UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

DEOXYGLUCOSE; HEXOSE KINASE INHIBITOR 2 DEOXYGLUCOSE; LAFORIN; PROTEIN DERIVATIVE; UNCLASSIFIED DRUG; EPM2A PROTEIN, HUMAN; NON RECEPTOR PROTEIN TYROSINE PHOSPHATASE; SMALL INTERFERING RNA;

ANIMAL CELL; ANIMAL MODEL; APOPTOSIS; ARTICLE; CANCER CELL; CANCER RESISTANCE; CANCER THERAPY; CELL KILLING; CONTROLLED STUDY; EMBRYO; ENERGY; EPM2A GENE; GENE; GENETIC DISORDER; HUMAN; HUMAN CELL; LYMPHOMA; MOUSE; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SURVIVAL; AMINO ACID SEQUENCE; ANIMAL; CELL LINE; DRUG EFFECT; ENERGY METABOLISM; GENETICS; PATHOLOGY; PHYSIOLOGY; TUMOR CELL LINE;

AMINO ACID SEQUENCE; ANIMALS; APOPTOSIS; BASE SEQUENCE; CELL LINE; CELL LINE, TUMOR; DEOXYGLUCOSE; ENERGY METABOLISM; HUMANS; LYMPHOMA; MICE; PROTEIN TYROSINE PHOSPHATASES, NON-RECEPTOR; RNA, SMALL INTERFERING;

EID: 49249097453     PISSN: 00085472     EISSN: None     Source Type: Journal    
DOI: 10.1158/0008-5472.CAN-07-6314     Document Type: Article

References (17)

1. Pedersen PL. Tumor mitochondria and the bioenergetics of cancer cells. Prog Exp Tumor Res 1978;22:190-274.
2. Warburg O. On the origin of cancer cells. Science 1956;123:309-14.
3. Hatanaka M. Transport of sugars in tumor cell membranes. Biochim Biophys Acta 1974;355:77-104.
4. Weinhouse S. Glycolysis, respiration, and anomalous gene expression in experimental hepatomas: G.H.A. Clowes memorial lecture. Cancer Res 1972;32:2007-16.
5. Cay O, Radnell M, Jeppsson B, Ahren B, Bengmark S. Inhibitory effect of 2-deoxy-D-glucose on liver tumor growth in rats. Cancer Res 1992;52:5794-6.
6. Kaplan O, Navon G, Lyon RC, Faustino PJ, Straka EJ, Cohen JS. Effects of 2-deoxyglucose on drug-sensitive and drug-resistant human breast cancer cells: toxicity and magnetic resonance spectroscopy studies of metabolism. Cancer Res 1990;50:544-51.
7. Maschek G, Savaraj N, Priebe W, et al. 2-Deoxy-D-glucose increases the efficacy of adriamycin and paclitaxel in human osteosarcoma and non-small cell lung cancers in vivo. Cancer Res 2004;64:31-4.
8. Pan JG, Mak TW. Metabolic targeting as an anticancer strategy: dawn of a new era? Sci STKE 2007;2007:pe14.
9. Inoki K, Ouyang H, Zhu T, et al. TSC2 integrates Wnt and energy signals via a coordinated phosphorylation by AMPK and GSK3 to regulate cell growth. Cell 2006;126:955-68.
10. Inoki K, Zhu T, Guan KL. TSC2 mediates cellular energy response to control cell growth and survival. Cell 2003;115:577-90.
11. Minassian BA, Lee JR, Herbrick JA, et al. Mutations in a gene encoding a novel protein tyrosine phosphatase cause progressive myoclonus epilepsy. Nat Genet 1998;20:171-4.
12. Lohi H, Ianzano L, Zhao XC, et al. Novel glycogen synthase kinase 3 and ubiquitination pathways in progressive myoclonus epilepsy. Hum Mol Genet 2005;14:2727-36.
13. Wang Y, Liu Y, Wu C, et al. Epm2a suppresses tumor growth in an immunocompromised host by inhibiting Wnt signaling. Cancer Cell 2006;10:179-90.
14. Worby CA, Gentry MS, Dixon JE. Laforin: a dual specificity phosphatase that dephosphorylates complex carbohydrates. J Biol Chem 2006;281:30412-8.
15. Gentry MS, Dowen RH III, Worby CA, Mattoo S, Ecker JR, Dixon JE. The phosphatase laforin crosses evolutionary boundaries and links carbohydrate metabolism to neuronal disease. J Cell Biol 2007;178:477-88.
16. Noviello C, Courjal F, Theillet C. Loss of heterozygosity on the long arm of chromosome 6 in breast cancer: possibly four regions of deletion. Clin Cancer Res 1996;2:1601-6.
17. Ganesh S, Delgado-Escueta AV, Sakamoto T, et al. Targeted disruption of the Epm2a gene causes formation of Lafora inclusion bodies, neurodegeneration, ataxia, myoclonus epilepsy, and impaired behavioral response in mice. Hum Mol Genet 2002;11:1251-62.