Safety of long-term tacrolimus therapy for rheumatoid arthritis: An open-label, uncontrolled study in non-elderly patients

Modern Rheumatology

Volumn 18, Issue 4, 2008, Pages 345-353

  Kawai, Shinichi ^a   Tanaka, Kortaro ^b   Ohno, Iwao ^c   Utsunomiya, Kazunori ^c   Seino, Yoshihiko ^d  

^a TOHO UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b TOYAMA UNIVERSITY HOSPITAL   (Japan)

^c JIKEI UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^d NIPPON MEDICAL SCHOOL CHIBA HOKUSOH HOSPITAL   (Japan)

Author keywords

Long term open study; Rheumatoid arthritis; Safety; Tacrolimus

Indexed keywords

DISEASE MODIFYING ANTIRHEUMATIC DRUG; MIZORIBINE; NONSTEROID ANTIINFLAMMATORY AGENT; STEROID; TACROLIMUS;

ABDOMINAL DISCOMFORT; ACUTE KIDNEY FAILURE; ADULT; ALLERGIC CONJUNCTIVITIS; ALLERGIC RHINITIS; ALOPECIA; ANOREXIA; ARTICLE; BLOOD PRESSURE; BODY WEIGHT; BRAIN INFARCTION; BRONCHITIS; BRONCHOPNEUMONIA; CARDIOMEGALY; CARDIOVASCULAR DISEASE; CENTRAL NERVOUS SYSTEM DISEASE; CLINICAL TRIAL; COLON DIVERTICULOSIS; COMMON COLD; COUGHING; DERMATITIS; DIARRHEA; DISEASE ACTIVITY; DIZZINESS; DRUG BLOOD LEVEL; DRUG DOSE REDUCTION; DRUG DOSE REGIMEN; DRUG EFFICACY; DRUG ERUPTION; DRUG FATALITY; DRUG FEVER; DRUG RESPONSE; DRUG SAFETY; DRUG WITHDRAWAL; DUODENUM PERFORATION; DUODENUM ULCER; DYSOSMIA; ERYTHEMA; ERYTHROCYTE COUNT; ESOPHAGITIS; ESOPHAGUS CANDIDIASIS; EVENING DOSAGE; EXTRASYSTOLE; FATIGUE; GASTRITIS; GASTROINTESTINAL DISEASE; GINGIVITIS; GLUCOSE BLOOD LEVEL; GLUCOSE TOLERANCE; GYNECOLOGIC DISEASE; HEART ARRHYTHMIA; HEARTBURN; HEMATOCRIT; HERPES ZOSTER; HOT FLUSH; HUMAN; HYPERTENSION; INFECTION; IRRITABLE COLON; LABORATORY TEST; LEG EDEMA; LEUKOCYTOSIS; LIP PARESTHESIA; LONG TERM CARE; LYMPHOCYTOPENIA; MAJOR CLINICAL STUDY; MENSTRUAL IRREGULARITY; METABOLIC DISORDER; MIGRAINE; MULTICENTER STUDY; NAUSEA; NEUTROPHILIA; NUTRITIONAL DISORDER; OPEN STUDY; PARESTHESIA; PNEUMONIA; POLLAKISURIA; PRIORITY JOURNAL; PROTEINURIA; PRURITUS; PYELONEPHRITIS; RESPIRATORY TRACT DISEASE; RETCHING; RHEUMATOID ARTHRITIS; SIDE EFFECT; SINUSITIS; SKIN DISEASE; SMELLING DISORDER; SORE THROAT; ST SEGMENT DEPRESSION; STOMACH DISCOMFORT; STOMACH HEAVINESS; STOMACH PAIN; STOMACH ULCER; STOMATITIS; SUPPURATION; TINEA; TREATMENT DURATION; TREMOR; UPPER RESPIRATORY TRACT INFECTION; UREA NITROGEN BLOOD LEVEL; URINARY TRACT DISEASE; URTICARIA; VISUAL DISORDER; VOMITING; WEAKNESS;

ADULT; ARTHRITIS, RHEUMATOID; FEMALE; HUMANS; IMMUNOSUPPRESSIVE AGENTS; LONGITUDINAL STUDIES; MALE; MIDDLE AGED; TACROLIMUS; YOUNG ADULT;

EID: 49149106440     PISSN: 14397595     EISSN: 14397609     Source Type: Journal    
DOI: 10.1007/s10165-008-0058-8     Document Type: Article

References (18)

1. Panayi GS, Lanchbury JS, Kingsley GH. The importance of the T cell in initiating and maintaining the chronic synovitis of rheumatoid arthritis. Arthritis Rheum. 1992;35:729-35.
2. Yocum DE, Pincus T, Choy EHS, Scott DL, Richardson C, Emery P, et al. Cyclosporin in the treatment of severe rheumatoid arthritis and the emerging role of a microemulsion-based formulation (Neoral®). Drugs. 1995;50(Suppl.1).
3. Sakuma S, Kato Y, Nishigaki F, Sasakawa T, Magari K, Miyata S, et al. FK506 potently inhibits T cell activation-induced TNF-α and IL-1β production in vitro by human peripheral blood mononuclear cells. Br J Pharmacol. 2000;130:1655-63.
4. Inamura N, Hasimoto M, Nakahara K, Aoki H, Yamaguchi I, Kohsaka M. Immunosuppressive effect of FK506 on collagen-induced arthritis in rats. Clin Immunol Immunopathol. 1988;46:82-90.
5. Miyahara H, Hotokebushi T, Arita C, Arai K, Sugioka Y, Takagishi K, et al. Comparative studies of the effects of FK506 and cyclosporin A on passively transferred collagen-induced arthritis in rats. Clin Immunol Immunopathol. 1991;60:278-88.
6. Magari K, Miyata S, Nishigaki F, Ohkubo Y, Mutoh S, Goto T. Differential effects of FK506 and methotrexate on inflammatory cytokine levels in rat adjuvant-induced arthritis. J Rheumatol. 2003;30:2193-200.
7. Hara M, Sugawara S, Hirose S, Uchida S, Irimajiri S, Kondo H, et al. Therapeutic effects of FK506 on patients with rheumatoid arthritis (in Japanese). Inflamm Regen. 2002;22:213-26.
8. Kondo H, Abe T, Hashimoto H, Uchida S, Irimajiri S, Hara M, et al. Efficacy and safety of tacrolimus (FK506) in treatment of rheumatoid arthritis: A randomized, double-blind, placebo-controlled dose-finding study. J Rheumatol. 2004;31:243-51.
9. Kawai S, Yamamoto K. Safety of tacrolimus, an immunosuppressive agent, in the treatment of rheumatoid arthritis in elderly patients. Rheumatology. 2006;45:441-4.
10. Kawai S, Hashimoto H, Kondo H, Murasawa T, Kiuchi T, Abe T. Comparison of tacrolimus and mizoribine in a randomized, double-blind controlled study in patients with rheumatoid arthritis. J Rheumatol. 2006;33:2153-61.
11. Yocum DE, Furst DE, Bensen WG, Burch FX, Borton MA, Mengle-Gaw LJ, et al. Safety of tacrolimus in patients with rheumatoid arthritis: long-term experience. Rheumatology. 2004;43:992-9.
12. Arnett FC, Edworthy SM, Bloch DA, McShane DJ, Fries JF, Cooper NS, et al. The American Rheumatism Association 1987 revised criteria for the classification of rheumatoid arthritis. Arthritis Rheum. 1988;31:315-24.
13. Felson DT, Anderson JJ, Boers M, Bombardier C, Chernoff M, Fried B, et al. The American College of Rheumatology preliminary core set of disease activity measures for rheumatoid arthritis clinical trials. Arthritis Rheum. 1993;36:729-40.
14. Felson DT, Anderson JJ, Boers M, Bombardier C, Furst D, Goldsmith C, et al. American College of Rheumatology preliminary definition of improvement in rheumatoid arthritis. Arthritis Rheum. 1995;38:727-35.
15. Maradit-Kremers H, Crowson CS, Nicola PJ, Ballman KV, Roger VL, Jacobsen SJ, et al. Increased unrecognized coronary heart disease and sudden deaths in rheumatoid arthritis: A population-based cohort study. Arthritis Rheum. 2005;52:402-11.
16. Nicola PJ, Maradit-Kremers H, Roger VL, Jacobsen SJ, Crowson CS, Ballman KV, et al. The risk of congestive heart failure in rheumatoid arthritis: a population-based study over 46 years. Arthritis Rheum. 2005;52:412-20.
17. Maradit-Kremers H, Nicola PJ, Crowson CS, Ballman KV, Gabriel SE. Cardiovascular death in rheumatoid arthritis: A population-based study. Arthritis Rheum. 2005;52:722-32.
18. Singh N, Bonham A, Fukui M. Immunosuppressive-associated leukoencephalopathy in organ transplant recipients. Transplantation. 2000;69:467-72.