HLA-B27-transgenic rats, amyloid deposits, and spondyloarthropathies

Modern Rheumatology

Volumn 18, Issue 4, 2008, Pages 425-426

  Uchanska Ziegler, Barbara ^a   Ziegler, Andreas ^a  

^a CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PROTEIN; BETA 2 MICROGLOBULIN; COLLAGEN TYPE 2; HLA B27 ANTIGEN;

AMYLOIDOSIS; ANTIGEN EXPRESSION; ARTICLE; CELL SUBPOPULATION; CHRONIC INFLAMMATION; DISEASE ASSOCIATION; DISEASE COURSE; DISEASE DURATION; DISEASE SEVERITY; GENE DUPLICATION; GENE NUMBER; HEMODIALYSIS; HIGH RISK PATIENT; HUMAN; LIGHT CHAIN; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN DETERMINATION; PROTEIN EXPRESSION; RISK ASSESSMENT; RISK FACTOR; SPONDYLOARTHROPATHY; TRANSGENE; TRANSGENIC RAT;

AMYLOIDOSIS; ANIMALS; BETA 2-MICROGLOBULIN; DISEASE MODELS, ANIMAL; HLA-B27 ANTIGEN; RATS; RATS, TRANSGENIC; SPONDYLITIS, ANKYLOSING;

EID: 49149094592     PISSN: 14397595     EISSN: 14397609     Source Type: Journal    
DOI: 10.1007/s10165-008-0066-8     Document Type: Article

References (10)

1. Fukunishi S, Yoh K, Kamae S, Yoshiya S. Beta 2-microglobulin amyloid deposit in HLA-B27 transgenic rats. Mod Rheumatol. 2007;17:380-4.
2. Gejyo F, Yamada T, Odani S, Nakagawa Y, Arakawa M, Kunitomo T, et al. A new form of amyloid protein associated with chronic hemodialysis was identified as beta 2-microglobulin. Biochem Biophys Res Commun. 1985;129:701-6.
3. Cruickshank B. Pathology of ankylosing spondylitis. Bull Rheum Dis. 1960;10:211-4.
4. Lehtinen K. Mortality and causes of death in 398 patients admitted to hospital with ankylosing spondylitis. Ann Rheum Dis. 1993;52:174-6.
5. WTCCC TASC. A genome-wide scan of 14,000 non-synonymous coding SNPs in 5,500 individuals: The Wellcome Trust Case Control Consortium. Nat Genet. 2007;39:1329-37.
6. Hammer RE, Maika SD, Richardson JA, Tang JP, Taurog JD. Spontaneous inflammatory disease in transgenic rats expressing HLA-B27 and human beta 2 m: An animal model of HLA-B27-associated human disorders. Cell. 1990;63:1099-112.
7. Taurog JD, Maika SD, Satumtira N, Dorris ML, McLean IL, Yanagisawa H, et al. Inflammatory disease in HLA-B27 transgenic rats. Immunol Rev. 1999;169:209-23.
8. Tran TM, Dorris ML, Satumtira N, Richardson JA, Hammer RE, Shang J, et al. Additional human beta2 m curbs HLA-B27 misfolding and promotes arthritis and spondylitis without colitis in male HLA-B27 transgenic rats. Arthritis Rheum. 2006;54:1317-27.
9. Ziegler A, Loll B, Misselwitz R, Uchanska-Ziegler B. Implications of structural and thermodynamic studies of HLA-B27 subtypes exhibiting differential association with ankylosing spondylitis. In: López-Larrea C, editor. Molecular mechanisms of spondyloarthropathies. Austin: Landes Bioscience; 2008 (in press).
10. 2m-deposition disease? Trends Immunol. 2003;24:73-6.