S-metoprolol: The 2008 clinical review

Journal of the Indian Medical Association

Volumn 106, Issue 4, 2008, Pages 259-262

  Dasbiswas, Arup ^a   Shinde, Suresh ^b   Dasbiswas, Debasri ^c  

^a INSTITUTE OF POST GRADUATE MEDICAL EDUCATION AND RESEARCH   (India)

^b NRS Medical College ^*

^c NRS MEDICAL COLLEGE   (India)

Author keywords

Beta blocker; Isomer; Metoprolol

Indexed keywords

BETA ADRENERGIC RECEPTOR BLOCKING AGENT; CIMETIDINE; HYDROCHLOROTHIAZIDE; METOPROLOL; METOPROLOL TARTRATE; METPURE; ORAL ANTIDIABETIC AGENT; PAROXETINE; VERAPAMIL;

ANGINA PECTORIS; AUTONOMIC DYSFUNCTION; BRADYCARDIA; CARDIOSELECTIVITY; CHRONIC OBSTRUCTIVE LUNG DISEASE; CLINICAL TRIAL; COLD HANDS AND FEET; CONSTIPATION; DIABETES MELLITUS; DIARRHEA; DIZZINESS; DOSE RESPONSE; DRUG DOSE COMPARISON; DRUG DOSE INCREASE; DRUG DOSE TITRATION; DRUG EFFICACY; DRUG MEGADOSE; DRUG METABOLISM; DRUG SAFETY; DRUG TOLERABILITY; DYSPNEA; ENANTIOMER; FATIGUE; HEADACHE; HEART FAILURE; HEART INFARCTION; HEART PALPITATION; HUMAN; HYPERLIPIDEMIA; HYPERTENSION; LIVER FAILURE; MONOTHERAPY; NAUSEA; POSTMARKETING SURVEILLANCE; PROPHYLAXIS; RACEMIC MIXTURE; RASH; RECOMMENDED DRUG DOSE; REVIEW; RISK ASSESSMENT; SYNCOPE; XEROSTOMIA;

EID: 49149091264     PISSN: 00195847     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (19)

1. Helfand M, Peterson K - Drug class review on beta adrenergic blockers. http://www.ohsu.edu/drugeffectiveness/reports (accessed Jan 22, 2008).
2. Cruickshank JM - Are we misunderstanding beta-blockers. Int J Cardiol 2007; 120: 10-27.
3. Stoschitzky K, Zernigl G, Lindner W - Racemic beta-blockers-fixed combinations of different drugs. J Clin Basic Cardiol 1998; 1: 15-9.
4. Baker JG - The selectivity of β-adrenoceptor antagonists at the human β1, β2 and β3 adrenoceptors. Br J Pharmacol 2005; 144: 317-22.
5. Wahlund G, Nerme V, Abrahamsson T, Sjoquist PO. The beta 1- and beta 2-adrenoceptor affinity and beta 1-blocking potency of S- and R-metoprolol. Br J Pharmacol 1990; 99: 592-6.
6. Nathanson JA - Stereospecificity of beta adrenergic antagonists: R-enantiomers show increased selectivity for beta-2 receptors in ciliary process. J Pharmacol Exp Ther 1988; 245: 94-101.
7. Murthy SS, Shetty U, Nelson WL, Jackson PR, Lennard MS - Enantioselective and diastereoselective aspects of the oxidative metabolism of metoprolol. Biochem Pharmacol 1990; 40: 1637-44.
8. Lennard MS, Silas JH, Freestone S, Ramsay LE, Tucker GT, Woods HF - Oxidation phenotype - a major determinant of metoprolol metabolism and response. N Engl J Med 1982; 307: 1558-60.
9. Dart RA, Gollub S, Lazar J, Nair C, Schroeder D, Woolf SH - Treatment of systemic hypertension in patients with pulmonary disease: COPD and asthma. Chest 2003; 123: 222-43.
10. Kim M, Shen DD, Eddy AC, Nelson WL - Inhibition of the enantioselective oxidative metabolism of metoprolol by verapamil in human liver microsomes. Drug Metab Dispos 1993; 21: 309-17.
11. Hemeryck A, Lefebvre RA, Vriendt CD, Belpaire FM - Paroxetine affects metoprolol pharmacokinetics and pharmacodynamics in healthy volunteers. Clin Pharmacol Ther 2000; 67: 283-91.
12. Toon S, Davidson EM, Garstang FM, Batra H, Bowes RJ, Rowland M - The racemic metoprolol H2-antagonist interaction. Clin Pharmacol Ther 1988; 43: 283-9.
13. The SMART Trial Study Group - The SMART Trial (S-Metoprolol Assessment in Hypertension Trial). Cardiol Today 2005; 9: 222-9.
14. SMART-II Study Group - Results of SMART-II study on efficacy and safety of S-metoprolol extended release tablet. Indian Med Gazette 2006; 140: 72-5.
15. Aneja P, Srinivas A, Janardhan G - Efficacy and safety of S-metoprolol extended release tablets in the management of hypertension - results of multicentric, prospective, clinical study. Indian Med Gazette 2005; 139: 485-7.
16. Singh TSD - Efficacy and safety of a fixed dose combination of S-metoprolol 25 mg and hydrochlorothiazide 12.5 mg tablet in the treatment of mild to moderate hypertension. Indian Med Gazette 2006; 140: 314-7.
17. Mandora VP - Safety and efficacy of S-metoprolol succinate extended release tablet in the treatment of hypertension coexisting with COPD - an open-label, non-comparative, prospective clinical study. Indian Med Gazette 2006; 140: 28-32.
18. Talwalkar PG - Safety and efficacy of S-metoprolol in the treatment of patients with diabetes mellitus and hypertension (SMART-DIMENSION Study). Indian Med Gazette 2007; 141: 139-44.
19. Aneja P, Srinivas A, Das Biswas A - Comparative clinical study of the efficacy and safety of a S-metoprolol ER tablet versus a racemate metoprolol ER tablet in patients with chronic stable angina. Int J Clin Pharmacol Ther 2007; 45: 253-8.