Antidepressant effects of total tertiary alkaloid fraction of Cissampelos sympodialis Eichler in rodents

Revista Brasileira de Farmacognosia

Volumn 18, Issue 2, 2008, Pages 165-169

  Mendonça Netto, Sueli ^a   Varela, Rogério W B ^a   Fechine, Madge F ^a   Queiroga, Marcello N G ^a   Souto Maior, Flávia N ^a   Almeida, Reinaldo N ^a  

^a FEDERAL UNIVERSITY OF PARAÍBA   (Brazil)

Author keywords

Antidepressant activity; Cissampelos sympodialis; Menispermaceae; Total tertiary alkaloids fraction

Indexed keywords

EID: 49049120715     PISSN: 0102695X     EISSN: None     Source Type: Journal    
DOI: 10.1590/S0102-695X2008000200004     Document Type: Article

References (30)

1. Agra MF, Freitas PF, Barbosa-Filho JM 2007. Synopsis of the plants known as medicinal and poisonous in Northeast of Brazil. Rev Bras Farmacogn 17: 114-140.
2. Almeida RN, Navarro DS, Assis TS, Medeiros IA, Thomas G 1998. Antidepressants effect of an ethanolic extract of the leaves of Cissampelos sympodialis in rats and mice. J Ethnophamacol 63: 247-252.
3. Assis TS, Almeida RN, Barbosa-Filho JM, Medeiros IA 2001. CNS pharmacological effects of the total alkaloidal fraction from Albizia inopinata leaves. Fitoterapia 72: 124-130.
4. Barbosa-Filho JM, Agra MF, Thomas G 1997. Botanical, chemical, pharmacology investigation on Cissampelos species from Paraiba (Brazil). Ciência e Cultura, JBraz Assoc Advanc Sci 49: 386-394.
5. Barros HMT, Leite JR 1986. The use of rodents in the animal models of depression. Sci Cult 36: 952-958.
6. Bezerra-Santos CR, Balestieri FMP, Rossi-Bergmann B, Peçanha LMT, Piuvezam MR 2004. Cissampelos sympodialis Eichl. (Menispermaceae): oral treatment decreases IgE levels and induces a Th1-skewed cytokine production in ovalbumin-sensitized mice. J Ethnopharmacol 95: 191-197.
7. Bezerra-Santos CR, Peçanha LMT, Piuvezam MR 2005. Cissampelos sympodialis Eichl. (Menispermaceae) inhibits anaphylactic shock reaction in murine allergic model. Rev Bras Farmacogn 15: 287-291.
8. Bezerra-Santos CR, Vieira-de-Abreu A, Barbosa-Filho JM, Bandeira-Melo C, Piuvezam MR, Bozza PT 2006. Anti-allergic properties of Cissampelos sympodialis and its isolated alkaloid warifteine. Int Immunopharmacol 6: 1152-1160.
9. Butterweck V, Petereit F, Winterhoff H, Nahrstedt A 1998. Solubilized hypericin and pseudohypericin from Hypericim perforatum exert antidepressant activity in the forced swimming test. Planta Med 64: 291-294.
10. Corrêa MP 1984. Dicionário das plantas úteis do Brasil e das exóticas cultivadas. Ministério da Agricultura, IBDF, RJ.
11. Côrtes SF, Alencar JL, Thomas G, Barbosa-Filho JM 1995. Spamolytic actions of wariteine a bisbenzylisoquinoline alkaloid isolated from the root bark of Cissampelos sympodialis Eichl. (Menispermeaceae). Phytother Res 9: 579-583.
12. Costa HF, Bezerra-Santos CR, Barbosa Filho JM, Martins MA, Piuvezam MR 2008. Warifteine, a bisbenzylisoquinoline alkaloid, decreases immediate allergic and thermal hyperalgesic reactions in sensitized animals. Int Immunopharmacol In Press, doi:10.1016/j.intimp.2007.11.009.
13. Cunha EVL, Coraelio ML, Barbosa-Filho JM, Braz-Filho R, Gray AI 1998. Eletefine, a stephaoxocane alkaloid from Cissampelos glaberrima. J Nat Prod 61: 1140-1142.
14. Diniz MFF, Santos RB, Cunha MAL, Duarte JC, Morais MA, Medeiros IA 2002. Subacute toxicology studies on the aqueous fraction of the ethanol extract of the leaves of Cissampelos sympodialis Eichl. (Menispermaceae) in dogs. Rev Bras Farmacogn 12 (Suppl.): 87-89.
15. Freitas MR, Alencar JA, Cunha EVL, Barbosa-Filho JM, Gray AI 1995. Milonine, an 8,14-dihydromorphinandienone alkaloid from leaves of Cissampelos sympodialis. Phytochemistry 40: 1553-1555.
16. Freitas MR, Lemos VS, Queiroga CE, Thomas G, Medeiros IA, Cortês SF 1999. Mechanisms of the contractile effect of the hydroalcoholic extract of Cissampelos sympodialis Eichl. in rat aorta. Phytomedicine 6: 63-67.
17. Hill RT, Tedeshi DH 1971. Animal testing and screening procedures in evaluating psychotic drugs. In: Rech RH, Moore KE (Eds): An intoduction to psychopharmacology. Raven Press, New York, pp. 237-281.
18. Lechin F, Van der Dijs B, Orozco B, Jara H, Rada I, Lechón ME, Lechón AE 1998. Neuropharmachologic treatment of bronchial asthma with antidepressant tianeptine: A double-blind crossover placebo-controlled study. Clin Pharmacol Ther 64: 223-232.
19. Lira GA, Andrade LM, Florêncio KC, Silva MS, Barbosa-Filho JM, Cunha EVL 2002. Roraimine: a bisbenzylisoquinoline alkaloid from Cissampelos sympodialis roots. Fitoterapia 73: 356-358.
20. Mckinney WT 1976. Animal models of depression. In: Gallant DM, Simpson GM (Eds.): Depression: behavioral, biochemical diagnostic and treatment concepts, spectrum, New York, pp. 1-77.
21. Melo PS, Cavalcante HMM, Barbosa-Filho JM, Diniz MFFM, Medeiros IA, Haun M 2003. Warifteine and milonine, alkaloids isolated from Cissampelo ssympodialis Eichl.: cytotoxicity on rat hepatocyte culture and in V79 cells. Toxicol Lett 142: 143-151.
22. Porsolt RD, Anton NB, Jalfre M 1977a. Behavioral despair in rats: a new model sensitive to antidepressant treatments. Eur J Phamacol 47: 379-391.
23. Porsolt RD, Bertin A, Jalfre M 1977b. Behavioral despair in mice: Primary screening-test for antidepressants. Arch Int Phar Ther 229: 327-336.
24. Porsolt RD, Bertin A, Jalfre M 1978. Behavioral despair in rats and mice: strain differences and the effects of Imipramine. Eur J Phamacol. 51: 291-294.
25. Porsolt RD, Mc Arthur RA, Lenègre A 1993. Psychotropic screening procedures. In: Van Haaren F (ed.) Methods in Behavioral Pharmacol. Elsevier, Amsterdam, pp 23-51.
26. Porto NM, Basílio IJLD, Agra MF 2008. Estudo farmacobotânico de folhas de Cissampelos sympodialis Eichl. (Menispermaceae). Rev Bras Farmacogn 18: 102-107.
27. Saccomano NA, Vinick FJ, Koe BK 1991. Calcium-independent phosphodiesterase inhibitors as putative antidepressants: [3-(Bicycloalkyloxy)- 4-methoxyphenyl]-2-imidazolidones. J Med Chem 34: 291-298.
28. Thomas G, Araújo CC, Agra MF, Diniz MFF, Bachelet M, Vagaftig B 1995. Preliminary studies on the hydroalcoholic extract of the root of Cissampelos sympodialis Eichl. in guinea-pig tracheal strips and bronchoalveolar leukocytes. Phytother Res 9: 473-477.
29. Thomas G, Selak M, Henson P 1999. The effects of an aqueous fraction of the ethanolic extract of the leaves of Cissampelos sympodialis Eichl. in human neutrophils. Phytother Res 13: 9-13.
30. Walsh RN, Cummins AB 1976. The open field test: A critical review. Psychol Bull 83: 1-6.