-
1
-
-
0033609388
-
Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein
-
Abdul-Manan N, Aghazadeh B, Liu GA, Majumdar A, Ouerfelli O, Siminovitch KA, Rosen MK (1999) Structure of Cdc42 in complex with the GTPase-binding domain of the 'Wiskott-Aldrich syndrome' protein. Nature 399:379-383
-
(1999)
Nature
, vol.399
, pp. 379-383
-
-
Abdul-Manan, N.1
Aghazadeh, B.2
Liu, G.A.3
Majumdar, A.4
Ouerfelli, O.5
Siminovitch, K.A.6
Rosen, M.K.7
-
2
-
-
0034697303
-
Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1
-
Adam L, Vadlamudi R, Mandal M, Chernoff J, Kumar R (2000) Regulation of microfilament reorganization and invasiveness of breast cancer cells by kinase dead p21-activated kinase-1. J Biol Chem 275:12041-12050
-
(2000)
J Biol Chem
, vol.275
, pp. 12041-12050
-
-
Adam, L.1
Vadlamudi, R.2
Mandal, M.3
Chernoff, J.4
Kumar, R.5
-
3
-
-
0035951824
-
Identification of a carboxyl-terminal diaphanous-related formin homology protein autoregulatory domain
-
Alberts AS (2001) Identification of a carboxyl-terminal diaphanous-related formin homology protein autoregulatory domain. J Biol Chem 276:2824-2830
-
(2001)
J Biol Chem
, vol.276
, pp. 2824-2830
-
-
Alberts, A.S.1
-
4
-
-
0032502680
-
Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7
-
Alberts AS, Bouquin N, Johnston LH, Treisman R (1998) Analysis of RhoA-binding proteins reveals an interaction domain conserved in heterotrimeric G protein beta subunits and the yeast response regulator protein Skn7. J Biol Chem 273:8616-8622
-
(1998)
J Biol Chem
, vol.273
, pp. 8616-8622
-
-
Alberts, A.S.1
Bouquin, N.2
Johnston, L.H.3
Treisman, R.4
-
5
-
-
0032565962
-
Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase
-
Arber S, Barbayannis FA, Hanser H, Schneider C, Stanyon CA, Bernard O, Caroni P (1998) Regulation of actin dynamics through phosphorylation of cofilin by LIM-kinase. Nature 393:805-809
-
(1998)
Nature
, vol.393
, pp. 805-809
-
-
Arber, S.1
Barbayannis, F.A.2
Hanser, H.3
Schneider, C.4
Stanyon, C.A.5
Bernard, O.6
Caroni, P.7
-
6
-
-
0032508636
-
A novel regulator of p21-activated kinases
-
Bagrodia S, Taylor SJ, Jordon KA, Van Aelst L, Cerione RA (1998) A novel regulator of p21-activated kinases. J Biol Chem 273:23633-23636
-
(1998)
J Biol Chem
, vol.273
, pp. 23633-23636
-
-
Bagrodia, S.1
Taylor, S.J.2
Jordon, K.A.3
Van Aelst, L.4
Cerione, R.A.5
-
7
-
-
0346462998
-
P21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells
-
Balasenthil S, Sahin AA, Barnes CJ, Wang RA, Pestell RG, Vadlamudi RK, Kumar R (2004) p21-activated kinase-1 signaling mediates cyclin D1 expression in mammary epithelial and cancer cells. J Biol Chem 279:1422-1428
-
(2004)
J Biol Chem
, vol.279
, pp. 1422-1428
-
-
Balasenthil, S.1
Sahin, A.A.2
Barnes, C.J.3
Wang, R.A.4
Pestell, R.G.5
Vadlamudi, R.K.6
Kumar, R.7
-
8
-
-
0037162288
-
Pak1 phosphorylation on t212 affects microtubules in cells undergoing mitosis
-
Banerjee M, Worth D, Prowse DM, Nikolic M (2002) Pak1 phosphorylation on t212 affects microtubules in cells undergoing mitosis. Curr Biol 12:1233-1239
-
(2002)
Curr Biol
, vol.12
, pp. 1233-1239
-
-
Banerjee, M.1
Worth, D.2
Prowse, D.M.3
Nikolic, M.4
-
9
-
-
33845730371
-
The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity
-
Baumeister MA, Rossman KL, Sondek J, Lemmon MA (2006) The Dbs PH domain contributes independently to membrane targeting and regulation of guanine nucleotide-exchange activity. Biochem J 400:563-572
-
(2006)
Biochem J
, vol.400
, pp. 563-572
-
-
Baumeister, M.A.1
Rossman, K.L.2
Sondek, J.3
Lemmon, M.A.4
-
10
-
-
27744437045
-
Production and use of a cell permeable inhibitor of group A Paks (TAT-PID) to analyze signal transduction
-
Beeser A, Chernoff J (2005) Production and use of a cell permeable inhibitor of group A Paks (TAT-PID) to analyze signal transduction. Methods 37:203-207
-
(2005)
Methods
, vol.37
, pp. 203-207
-
-
Beeser, A.1
Chernoff, J.2
-
11
-
-
17344369363
-
A human homologue of the Drosophila melanogaster diaphanous gene is disrupted in a patient with premature ovarian failure: Evidence for conserved function in oogenesis and implications for human sterility
-
Bione S, Sala C, Manzini C, Arrigo G, Zuffardi O, Banfi S, Borsani G, Jonveaux P, Philippe C, Zuccotti M, Ballabio A, Toniolo D (1998) A human homologue of the Drosophila melanogaster diaphanous gene is disrupted in a patient with premature ovarian failure: evidence for conserved function in oogenesis and implications for human sterility. Am J Hum Genet 62:533-541
-
(1998)
Am J Hum Genet
, vol.62
, pp. 533-541
-
-
Bione, S.1
Sala, C.2
Manzini, C.3
Arrigo, G.4
Zuffardi, O.5
Banfi, S.6
Borsani, G.7
Jonveaux, P.8
Philippe, C.9
Zuccotti, M.10
Ballabio, A.11
Toniolo, D.12
-
12
-
-
0038554077
-
Biology of the p21-activated kinases
-
Bokoch GM (2003) Biology of the p21-activated kinases. Annu Rev Biochem 72:743-781
-
(2003)
Annu Rev Biochem
, vol.72
, pp. 743-781
-
-
Bokoch, G.M.1
-
13
-
-
0029911521
-
Interaction of the Nck adapter protein with p21-activated kinase (PAK1)
-
Bokoch GM, Wang Y, Bohl BP, Sells MA, Quilliam LA, Knaus UG (1996) Interaction of the Nck adapter protein with p21-activated kinase (PAK1). J Biol Chem 271:25746-25749
-
(1996)
J Biol Chem
, vol.271
, pp. 25746-25749
-
-
Bokoch, G.M.1
Wang, Y.2
Bohl, B.P.3
Sells, M.A.4
Quilliam, L.A.5
Knaus, U.G.6
-
14
-
-
34249018367
-
GEFs and GAPs: Critical elements in the control of small G proteins
-
Bos JL, Rehmann H, Wittinghofer A (2007) GEFs and GAPs: critical elements in the control of small G proteins. Cell 129:865-877
-
(2007)
Cell
, vol.129
, pp. 865-877
-
-
Bos, J.L.1
Rehmann, H.2
Wittinghofer, A.3
-
15
-
-
33845868501
-
Evolution of the Rho family of ras-like GTPases in eukaryotes
-
Boureux A, Vignal E, Faure S, Fort P (2007) Evolution of the Rho family of ras-like GTPases in eukaryotes. Mol Biol Evol 24:203-216
-
(2007)
Mol Biol Evol
, vol.24
, pp. 203-216
-
-
Boureux, A.1
Vignal, E.2
Faure, S.3
Fort, P.4
-
16
-
-
0034947838
-
Conformational switch and role of phosphorylation in PAK activation
-
Buchwald G, Hostinova E, Rudolph MG, Kraemer A, Sickmann A, Meyer HE, Scheffzek K, Wittinghofer A (2001) Conformational switch and role of phosphorylation in PAK activation. Mol Cell Biol 21:5179-5189
-
(2001)
Mol Cell Biol
, vol.21
, pp. 5179-5189
-
-
Buchwald, G.1
Hostinova, E.2
Rudolph, M.G.3
Kraemer, A.4
Sickmann, A.5
Meyer, H.E.6
Scheffzek, K.7
Wittinghofer, A.8
-
17
-
-
2642553258
-
Target identification in chemical genetics: The (often) missing link
-
Burdine L, Kodadek T (2004) Target identification in chemical genetics: the (often) missing link. Chem Biol 11:593-597
-
(2004)
Chem Biol
, vol.11
, pp. 593-597
-
-
Burdine, L.1
Kodadek, T.2
-
19
-
-
2542452838
-
Pak-1 expression increases with progression of colorectal carcinomas to metastasis
-
Carter JH, Douglass LE, Deddens JA, Colligan BM, Bhatt TR, Pemberton JO, Konicek S, Hom J, Marshall M, Graff JR (2004) Pak-1 expression increases with progression of colorectal carcinomas to metastasis. Clin Cancer Res 10:3448-3456
-
(2004)
Clin Cancer Res
, vol.10
, pp. 3448-3456
-
-
Carter, J.H.1
Douglass, L.E.2
Deddens, J.A.3
Colligan, B.M.4
Bhatt, T.R.5
Pemberton, J.O.6
Konicek, S.7
Hom, J.8
Marshall, M.9
Graff, J.R.10
-
20
-
-
33745482971
-
Ubiquitin-mediated protein degradation in Xenopus egg extracts
-
Castro A, Vigneron S, Bernis C, Labbe JC, Lorca T (2006) Ubiquitin-mediated protein degradation in Xenopus egg extracts. Methods Mol Biol 322:223-234
-
(2006)
Methods Mol Biol
, vol.322
, pp. 223-234
-
-
Castro, A.1
Vigneron, S.2
Bernis, C.3
Labbe, J.C.4
Lorca, T.5
-
21
-
-
33745502220
-
In vitro study of nuclear assembly and nuclear import using Xenopus egg extracts
-
Chan RC, Forbes DI (2006) In vitro study of nuclear assembly and nuclear import using Xenopus egg extracts. Methods Mol Biol 322:289-300
-
(2006)
Methods Mol Biol
, vol.322
, pp. 289-300
-
-
Chan, R.C.1
Forbes, D.I.2
-
22
-
-
0034193426
-
Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338
-
Chaudhary A, King WG, Mattaliano MD, Frost JA, Diaz B, Morrison DK, Cobb MH, Marshall MS, Brugge JS (2000) Phosphatidylinositol 3-kinase regulates Raf1 through Pak phosphorylation of serine 338. Curr Biol 10:551-554
-
(2000)
Curr Biol
, vol.10
, pp. 551-554
-
-
Chaudhary, A.1
King, W.G.2
Mattaliano, M.D.3
Frost, J.A.4
Diaz, B.5
Morrison, D.K.6
Cobb, M.H.7
Marshall, M.S.8
Brugge, J.S.9
-
23
-
-
0030806901
-
Characterization of spindle assembly checkpoint in Xenopus egg extracts
-
Chen RH, Murray A (1997) Characterization of spindle assembly checkpoint in Xenopus egg extracts. Methods Enzymol 283:572-584
-
(1997)
Methods Enzymol
, vol.283
, pp. 572-584
-
-
Chen, R.H.1
Murray, A.2
-
24
-
-
0034644473
-
Signaling to chromatin through histone modifications
-
Cheung P, Allis CD, Sassone-Corsi P (2000) Signaling to chromatin through histone modifications. Cell 103:263-271
-
(2000)
Cell
, vol.103
, pp. 263-271
-
-
Cheung, P.1
Allis, C.D.2
Sassone-Corsi, P.3
-
25
-
-
0035907296
-
The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity
-
Chong C, Tan L, Lim L, Manser E (2001) The mechanism of PAK activation. Autophosphorylation events in both regulatory and kinase domains control activity. J Biol Chem 276:17347-17353
-
(2001)
J Biol Chem
, vol.276
, pp. 17347-17353
-
-
Chong, C.1
Tan, L.2
Lim, L.3
Manser, E.4
-
26
-
-
0020533805
-
Pyrene actin: documentation of the validity of a sensitive assay for actin polymerization
-
Cooper JA, Walker SB, Pollard TD (1983) Pyrene actin: documentation of the validity of a sensitive assay for actin polymerization. J Muscle Res Cell Motil 4:253-262
-
(1983)
J Muscle Res Cell Motil
, vol.4
, pp. 253-262
-
-
Cooper, J.A.1
Walker, S.B.2
Pollard, T.D.3
-
27
-
-
0036854328
-
The diaphanous-related formin mDia1 controls serum response factor activity through its effects on actin polymerization
-
Copeland JW, Treisman R (2002) The diaphanous-related formin mDia1 controls serum response factor activity through its effects on actin polymerization. Mol Biol Cell 13:4088-4099
-
(2002)
Mol Biol Cell
, vol.13
, pp. 4088-4099
-
-
Copeland, J.W.1
Treisman, R.2
-
28
-
-
0041631073
-
P21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD
-
Cotteret S, Jaffer ZM, Beeser A, Chernoff J (2003) p21-Activated kinase 5 (Pak5) localizes to mitochondria and inhibits apoptosis by phosphorylating BAD. Mol Cell Biol 23:5526-5539
-
(2003)
Mol Cell Biol
, vol.23
, pp. 5526-5539
-
-
Cotteret, S.1
Jaffer, Z.M.2
Beeser, A.3
Chernoff, J.4
-
29
-
-
0034306450
-
Specificity and mechanism of action of some commonly used protein kinase inhibitors
-
Davies SP, Reddy H, Caivano M, Cohen P (2000) Specificity and mechanism of action of some commonly used protein kinase inhibitors. Biochem J 351:95-105
-
(2000)
Biochem J
, vol.351
, pp. 95-105
-
-
Davies, S.P.1
Reddy, H.2
Caivano, M.3
Cohen, P.4
-
31
-
-
33745480959
-
Study of apoptosis in vitro using the Xenopus egg extract reconstitution system
-
Deming P, Kornbluth S (2006) Study of apoptosis in vitro using the Xenopus egg extract reconstitution system. Methods Mol Biol 322:379-393
-
(2006)
Methods Mol Biol
, vol.322
, pp. 379-393
-
-
Deming, P.1
Kornbluth, S.2
-
32
-
-
0036333485
-
Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes
-
Eblen ST, Slack JK, Weber MJ, Catling AD (2002) Rac-PAK signaling stimulates extracellular signal-regulated kinase (ERK) activation by regulating formation of MEK1-ERK complexes. Mol Cell Biol 22:6023-6033
-
(2002)
Mol Cell Biol
, vol.22
, pp. 6023-6033
-
-
Eblen, S.T.1
Slack, J.K.2
Weber, M.J.3
Catling, A.D.4
-
33
-
-
0033194037
-
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics
-
Edwards DC, Sanders LC, Bokoch GM, Gill GN (1999) Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat Cell Biol 1:253-259
-
(1999)
Nat Cell Biol
, vol.1
, pp. 253-259
-
-
Edwards, D.C.1
Sanders, L.C.2
Bokoch, G.M.3
Gill, G.N.4
-
34
-
-
19744365702
-
A small molecule-kinase interaction map for clinical kinase inhibitors
-
Fabian MA, Biggs WH 3rd, Treiber DK, Atteridge CE, Azimioara MD, Benedetti MG, Carter TA, Ciceri P, Edeen PT, Floyd M, Ford JM, Galvin M, Gerlach JL, Grotzfeld RM, Herrgard S, Insko DE, Insko MA, Lai AG, Lelias JM, Mehta SA, Milanov ZV, Velasco AM, Wodicka LM, Patel HK, Zarrinkar PP, Lockhart DJ (2005) A small molecule-kinase interaction map for clinical kinase inhibitors. Nat Biotechnol 23:329-336
-
(2005)
Nat Biotechnol
, vol.23
, pp. 329-336
-
-
Fabian, M.A.1
Biggs III, W.H.2
Treiber, D.K.3
Atteridge, C.E.4
Azimioara, M.D.5
Benedetti, M.G.6
Carter, T.A.7
Ciceri, P.8
Edeen, P.T.9
Floyd, M.10
Ford, J.M.11
Galvin, M.12
Gerlach, J.L.13
Grotzfeld, R.M.14
Herrgard, S.15
Insko, D.E.16
Insko, M.A.17
Lai, A.G.18
Lelias, J.M.19
Mehta, S.A.20
Milanov, Z.V.21
Velasco, A.M.22
Wodicka, L.M.23
Patel, H.K.24
Zarrinkar, P.P.25
Lockhart, D.J.26
more..
-
35
-
-
33646864565
-
Staying in shape with formins
-
Faix J, Grosse R (2006) Staying in shape with formins. Dev Cell 10:693-706
-
(2006)
Dev Cell
, vol.10
, pp. 693-706
-
-
Faix, J.1
Grosse, R.2
-
36
-
-
0030830220
-
Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins
-
Frost JA, Steen H, Shapiro P, Lewis T, Ahn N, Shaw PE, Cobb MH (1997) Cross-cascade activation of ERKs and ternary complex factors by Rho family proteins. Embo J 16:6426-6438
-
(1997)
Embo J
, vol.16
, pp. 6426-6438
-
-
Frost, J.A.1
Steen, H.2
Shapiro, P.3
Lewis, T.4
Ahn, N.5
Shaw, P.E.6
Cobb, M.H.7
-
37
-
-
0029830139
-
The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1
-
Galisteo ML, Chernoff J, Su YC, Skolnik EY, Schlessinger J (1996) The adaptor protein Nck links receptor tyrosine kinases with the serine-threonine kinase Pak1. J Biol Chem 271:20997-21000
-
(1996)
J Biol Chem
, vol.271
, pp. 20997-21000
-
-
Galisteo, M.L.1
Chernoff, J.2
Su, Y.C.3
Skolnik, E.Y.4
Schlessinger, J.5
-
38
-
-
0033637153
-
Genomic expression programs in the response of yeast cells to environmental changes
-
Gasch AP, Spellman PT, Kao CM, Carmel-Harel O, Eisen MB, Storz G, Botstein D, Brown PO (2000) Genomic expression programs in the response of yeast cells to environmental changes. Mol Biol Cell 11:4241-4257
-
(2000)
Mol Biol Cell
, vol.11
, pp. 4241-4257
-
-
Gasch, A.P.1
Spellman, P.T.2
Kao, C.M.3
Carmel-Harel, O.4
Eisen, M.B.5
Storz, G.6
Botstein, D.7
Brown, P.O.8
-
39
-
-
0037341806
-
RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase
-
Gasman S, Kalaidzidis Y, Zerial M (2003) RhoD regulates endosome dynamics through Diaphanous-related Formin and Src tyrosine kinase. Nat Cell Biol 5:195-204
-
(2003)
Nat Cell Biol
, vol.5
, pp. 195-204
-
-
Gasman, S.1
Kalaidzidis, Y.2
Zerial, M.3
-
40
-
-
33845313646
-
PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane
-
Heo WD, Inoue T, Park WS, Kim ML, Park BO, Wandless TJ, Meyer T (2006) PI(3,4,5)P3 and PI(4,5)P2 lipids target proteins with polybasic clusters to the plasma membrane. Science 314:1458-1461
-
(2006)
Science
, vol.314
, pp. 1458-1461
-
-
Heo, W.D.1
Inoue, T.2
Park, W.S.3
Kim, M.L.4
Park, B.O.5
Wandless, T.J.6
Meyer, T.7
-
41
-
-
1642361261
-
Actin polymerization-driven molecular movement of mDia1 in living cells
-
Higashida C, Miyoshi T, Fujita A, Oceguera-Yanez F, Monypenny J, Andou Y, Narumiya S, Watanabe N (2004) Actin polymerization-driven molecular movement of mDia1 in living cells. Science 303:2007-2010
-
(2004)
Science
, vol.303
, pp. 2007-2010
-
-
Higashida, C.1
Miyoshi, T.2
Fujita, A.3
Oceguera-Yanez, F.4
Monypenny, J.5
Andou, Y.6
Narumiya, S.7
Watanabe, N.8
-
42
-
-
18844438774
-
Formin proteins: A domain-based approach
-
Higgs HN (2005) Formin proteins: a domain-based approach. Trends Biochem Sci 30:342-353
-
(2005)
Trends Biochem Sci
, vol.30
, pp. 342-353
-
-
Higgs, H.N.1
-
43
-
-
11144281883
-
Phylogenetic analysis of the formin homology 2 domain
-
Higgs HN, Peterson KJ (2005) Phylogenetic analysis of the formin homology 2 domain. Mol Biol Cell 16:1-13
-
(2005)
Mol Biol Cell
, vol.16
, pp. 1-13
-
-
Higgs, H.N.1
Peterson, K.J.2
-
44
-
-
3242671847
-
Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex
-
Ho HY, Rohatgi R, Lebensohn AM, Le M, Li J, Gygi SP, Kirschner MW (2004) Toca-1 mediates Cdc42-dependent actin nucleation by activating the N-WASP-WIP complex. Cell 118:203-216
-
(2004)
Cell
, vol.118
, pp. 203-216
-
-
Ho, H.Y.1
Rohatgi, R.2
Lebensohn, A.M.3
Le Li, M.J.4
Gygi, S.P.5
Kirschner, M.W.6
-
45
-
-
32144458888
-
In vitro reconstitution of cdc42-mediated actin assembly using purified components
-
Ho HY, Rohatgi R, Lebensohn AM, Kirschner MW (2006) In vitro reconstitution of cdc42-mediated actin assembly using purified components. Methods Enzymol 406:174-190
-
(2006)
Methods Enzymol
, vol.406
, pp. 174-190
-
-
Ho, H.Y.1
Rohatgi, R.2
Lebensohn, A.M.3
Kirschner, M.W.4
-
47
-
-
27944479854
-
Rho GTPases: Biochemistry and biology
-
Jaffe AB, Hall A (2005) Rho GTPases: biochemistry and biology. Annu Rev Cell Dev Biol 21:247-269
-
(2005)
Annu Rev Cell Dev Biol
, vol.21
, pp. 247-269
-
-
Jaffe, A.B.1
Hall, A.2
-
48
-
-
0036223236
-
P21-activated kinases: Three more join the Pak
-
Jaffer ZM, Chernoff J (2002) p21-activated kinases: three more join the Pak. Int J Biochem Cell Biol 34:713-717
-
(2002)
Int J Biochem Cell Biol
, vol.34
, pp. 713-717
-
-
Jaffer, Z.M.1
Chernoff, J.2
-
50
-
-
0035081810
-
Localization of a mammalian homolog of diaphanous, mDia1, to the mitotic spindle in HeLa cells
-
Kato T, Watanabe N, Morishima Y, Fujita A, Ishizaki T, Narumiya S (2001) Localization of a mammalian homolog of diaphanous, mDia1, to the mitotic spindle in HeLa cells. J Cell Sci 114:775-784
-
(2001)
J Cell Sci
, vol.114
, pp. 775-784
-
-
Kato, T.1
Watanabe, N.2
Morishima, Y.3
Fujita, A.4
Ishizaki, T.5
Narumiya, S.6
-
51
-
-
0034624753
-
Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein
-
Kim AS, Kakalis LT, Abdul-Manan N, Liu GA, Rosen MK (2000) Autoinhibition and activation mechanisms of the Wiskott-Aldrich syndrome protein. Nature 404:151-158
-
(2000)
Nature
, vol.404
, pp. 151-158
-
-
Kim, A.S.1
Kakalis, L.T.2
Abdul-Manan, N.3
Liu, G.A.4
Rosen, M.K.5
-
52
-
-
0032511882
-
The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338
-
King AJ, Sun H, Diaz B, Barnard D, Miao W, Bagrodia S, Marshall MS (1998) The protein kinase Pak3 positively regulates Raf-1 activity through phosphorylation of serine 338. Nature 396:180-183
-
(1998)
Nature
, vol.396
, pp. 180-183
-
-
King, A.J.1
Sun, H.2
Diaz, B.3
Barnard, D.4
Miao, W.5
Bagrodia, S.6
Marshall, M.S.7
-
53
-
-
0037155916
-
Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization
-
Kissil JL, Johnson KC, Eckman MS, Jacks T (2002) Merlin phosphorylation by p21-activated kinase 2 and effects of phosphorylation on merlin localization. J Biol Chem 277:10394-10399
-
(2002)
J Biol Chem
, vol.277
, pp. 10394-10399
-
-
Kissil, J.L.1
Johnson, K.C.2
Eckman, M.S.3
Jacks, T.4
-
54
-
-
0242298576
-
Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1
-
Kissil JL, Wilker EW, Johnson KC, Eckman MS, Yaffe MB, Jacks T (2003) Merlin, the product of the Nf2 tumor suppressor gene, is an inhibitor of the p21-activated kinase, Pak1. Mol Cell 12:841-849
-
(2003)
Mol Cell
, vol.12
, pp. 841-849
-
-
Kissil, J.L.1
Wilker, E.W.2
Johnson, K.C.3
Eckman, M.S.4
Yaffe, M.B.5
Jacks, T.6
-
55
-
-
24944497371
-
Features of selective kinase inhibitors
-
Knight ZA, Shokat KM (2005) Features of selective kinase inhibitors. Chem Biol 12:621-637
-
(2005)
Chem Biol
, vol.12
, pp. 621-637
-
-
Knight, Z.A.1
Shokat, K.M.2
-
56
-
-
33846676987
-
Chemical genetics: Where genetics and pharmacology meet
-
Knight ZA, Shokat KM (2007) Chemical genetics: where genetics and pharmacology meet. Cell 128:425-430
-
(2007)
Cell
, vol.128
, pp. 425-430
-
-
Knight, Z.A.1
Shokat, K.M.2
-
57
-
-
0037133041
-
The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family
-
Koh CG, Tan EJ, Manser E, Lim L (2002) The p21-activated kinase PAK is negatively regulated by POPX1 and POPX2, a pair of serine/threonine phosphatases of the PP2C family. Curr Biol 12:317-321
-
(2002)
Curr Biol
, vol.12
, pp. 317-321
-
-
Koh, C.G.1
Tan, E.J.2
Manser, E.3
Lim, L.4
-
58
-
-
0019427215
-
Fluorimetry study of N-(1-pyrenyl)iodoacetamide-labelled F-actin. Local structural change of actin protomer both on polymerization and on binding of heavy meromyosin
-
Kouyama T, Mihashi K (1981) Fluorimetry study of N-(1-pyrenyl)iodoacetamide-labelled F-actin. Local structural change of actin protomer both on polymerization and on binding of heavy meromyosin. Eur J Biochem 114:33-38
-
(1981)
Eur J Biochem
, vol.114
, pp. 33-38
-
-
Kouyama, T.1
Mihashi, K.2
-
59
-
-
0036836941
-
Emerging functions of p21-activated kinases in human cancer cells
-
Kumar R, Vadlamudi RK (2002) Emerging functions of p21-activated kinases in human cancer cells. J Cell Physiol 193:133-144
-
(2002)
J Cell Physiol
, vol.193
, pp. 133-144
-
-
Kumar, R.1
Vadlamudi, R.K.2
-
61
-
-
28644442126
-
The regulation of mDia1 by autoinhibition and its release by Rho*GTP
-
Lammers M, Rose R, Scrima A, Wittinghofer A (2005) The regulation of mDia1 by autoinhibition and its release by Rho*GTP. Embo J 24:4176-4187
-
(2005)
Embo J
, vol.24
, pp. 4176-4187
-
-
Lammers, M.1
Rose, R.2
Scrima, A.3
Wittinghofer, A.4
-
62
-
-
32144433330
-
Cdc42 and PI(4,5)P2-induced actin assembly in Xenopus egg extracts
-
Lebensohn AM, Ma L, Ho HY, Kirschner MW (2006) Cdc42 and PI(4,5)P2-induced actin assembly in Xenopus egg extracts. Methods Enzymol 406:156-173
-
(2006)
Methods Enzymol
, vol.406
, pp. 156-173
-
-
Lebensohn, A.M.1
Ma, L.2
Ho, H.Y.3
Kirschner, M.W.4
-
63
-
-
0035889090
-
A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast
-
Lechler T, Jonsdottir GA, Klee SK, Pellman D, Li R (2001) A two-tiered mechanism by which Cdc42 controls the localization and activation of an Arp2/3-activating motor complex in yeast. J Cell Biol 155:261-270
-
(2001)
J Cell Biol
, vol.155
, pp. 261-270
-
-
Lechler, T.1
Jonsdottir, G.A.2
Klee, S.K.3
Pellman, D.4
Li, R.5
-
64
-
-
0034604338
-
Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch
-
Lei M, Lu W, Meng W, Parrini MC, Eck MJ, Mayer BJ, Harrison SC (2000) Structure of PAK1 in an autoinhibited conformation reveals a multistage activation switch. Cell 102:387-397
-
(2000)
Cell
, vol.102
, pp. 387-397
-
-
Lei, M.1
Lu, W.2
Meng, W.3
Parrini, M.C.4
Eck, M.J.5
Mayer, B.J.6
Harrison, S.C.7
-
65
-
-
23744432051
-
Essential role of CIB1 in regulating PAK1 activation and cell migration
-
Leisner TM, Liu M, Jaffer ZM, Chernoff J, Parise LV (2005) Essential role of CIB1 in regulating PAK1 activation and cell migration. J Cell Biol 170:465-476
-
(2005)
J Cell Biol
, vol.170
, pp. 465-476
-
-
Leisner, T.M.1
Liu, M.2
Jaffer, Z.M.3
Chernoff, J.4
Parise, L.V.5
-
66
-
-
0043202969
-
The mouse Formin mDia1 is a potent actin nucleation factor regulated by autoinhibition
-
Li F, Higgs HN (2003) The mouse Formin mDia1 is a potent actin nucleation factor regulated by autoinhibition. Curr Biol 13:1335-1340
-
(2003)
Curr Biol
, vol.13
, pp. 1335-1340
-
-
Li, F.1
Higgs, H.N.2
-
67
-
-
14844288286
-
Dissecting requirements for auto-inhibition of actin nucleation by the formin, mDia1
-
Li F, Higgs HN (2005) Dissecting requirements for auto-inhibition of actin nucleation by the formin, mDia1. J Biol Chem 280:6986-6992
-
(2005)
J Biol Chem
, vol.280
, pp. 6986-6992
-
-
Li, F.1
Higgs, H.N.2
-
68
-
-
0036668638
-
P21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells
-
Li F, Adam L, Vadlamudi RK, Zhou H, Sen S, Chernoff J, Mandal M, Kumar R (2002) p21-activated kinase 1 interacts with and phosphorylates histone H3 in breast cancer cells. EMBO Rep 3:767-773
-
(2002)
EMBO Rep
, vol.3
, pp. 767-773
-
-
Li, F.1
Adam, L.2
Vadlamudi, R.K.3
Zhou, H.4
Sen, S.5
Chernoff, J.6
Mandal, M.7
Kumar, R.8
-
69
-
-
0031080595
-
Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck
-
Lu W, Katz S, Gupta R, Mayer BJ (1997) Activation of Pak by membrane localization mediated by an SH3 domain from the adaptor protein Nck. Curr Biol 7:85-94
-
(1997)
Curr Biol
, vol.7
, pp. 85-94
-
-
Lu, W.1
Katz, S.2
Gupta, R.3
Mayer, B.J.4
-
70
-
-
0030707797
-
Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanous
-
Lynch ED, Lee MK, Morrow JE, Welcsh PL, Leon PE, King MC (1997) Nonsyndromic deafness DFNA1 associated with mutation of a human homolog of the Drosophila gene diaphanous. Science 278:1315-1318
-
(1997)
Science
, vol.278
, pp. 1315-1318
-
-
Lynch, E.D.1
Lee, M.K.2
Morrow, J.E.3
Welcsh, P.L.4
Leon, P.E.5
King, M.C.6
-
71
-
-
0032498854
-
Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts
-
Ma L, Cantley LC, Janmey PA, Kirschner MW (1998a) Corequirement of specific phosphoinositides and small GTP-binding protein Cdc42 in inducing actin assembly in Xenopus egg extracts. J Cell Biol 140:1125-1136
-
(1998)
J Cell Biol
, vol.140
, pp. 1125-1136
-
-
Ma, L.1
Cantley, L.C.2
Janmey, P.A.3
Kirschner, M.W.4
-
72
-
-
0032430263
-
The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42
-
Ma L, Rohatgi R, Kirschner MW (1998b) The Arp2/3 complex mediates actin polymerization induced by the small GTP-binding protein Cdc42. Proc Natl Acad Sci USA 95:15362-15367
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 15362-15367
-
-
Ma, L.1
Rohatgi, R.2
Kirschner, M.W.3
-
73
-
-
0028136434
-
Purification of a cortical complex containing two unconventional actins from Acanthamoeba by affinity chromatography on profilin-agarose
-
Machesky LM, Atkinson SJ, Ampe C, Vandekerckhove J, Pollard TD (1994) Purification of a cortical complex containing two unconventional actins from Acanthamoeba by affinity chromatography on profilin-agarose. J Cell Biol 127:107-115
-
(1994)
J Cell Biol
, vol.127
, pp. 107-115
-
-
Machesky, L.M.1
Atkinson, S.J.2
Ampe, C.3
Vandekerckhove, J.4
Pollard, T.D.5
-
74
-
-
0028078824
-
A brain serine/threonine protein kinase activated by Cdc42 and Rac1
-
Manser E, Leung T, Salihuddin H, Zhao ZS, Lim L (1994) A brain serine/threonine protein kinase activated by Cdc42 and Rac1. Nature 367:40-46
-
(1994)
Nature
, vol.367
, pp. 40-46
-
-
Manser, E.1
Leung, T.2
Salihuddin, H.3
Zhao, Z.S.4
Lim, L.5
-
75
-
-
0031036626
-
Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes
-
Manser E, Huang HY, Loo TH, Chen XQ, Dong JM, Leung T, Lim L (1997) Expression of constitutively active alpha-PAK reveals effects of the kinase on actin and focal complexes. Mol Cell Biol 17:1129-1143
-
(1997)
Mol Cell Biol
, vol.17
, pp. 1129-1143
-
-
Manser, E.1
Huang, H.Y.2
Loo, T.H.3
Chen, X.Q.4
Dong, J.M.5
Leung, T.6
Lim, L.7
-
76
-
-
0031610579
-
PAK kinases are directly coupled to the PIX family of nucleotide exchange factors
-
Manser E, Loo TH, Koh CG, Zhao ZS, Chen XQ, Tan L, Tan I, Leung T, Lim L (1998) PAK kinases are directly coupled to the PIX family of nucleotide exchange factors. Mol Cell 1:183-192
-
(1998)
Mol Cell
, vol.1
, pp. 183-192
-
-
Manser, E.1
Loo, T.H.2
Koh, C.G.3
Zhao, Z.S.4
Chen, X.Q.5
Tan, L.6
Tan, I.7
Leung, T.8
Lim, L.9
-
77
-
-
0035816685
-
Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family
-
Maroney AC, Finn JP, Connors TJ, Durkin JT, Angeles T, Gessner G, Xu Z, Meyer SL, Savage MJ, Greene LA, Scott RW, Vaught JL (2001) Cep-1347 (KT7515), a semisynthetic inhibitor of the mixed lineage kinase family. J Biol Chem 276:25302-25308
-
(2001)
J Biol Chem
, vol.276
, pp. 25302-25308
-
-
Maroney, A.C.1
Finn, J.P.2
Connors, T.J.3
Durkin, J.T.4
Angeles, T.5
Gessner, G.6
Xu, Z.7
Meyer, S.L.8
Savage, M.J.9
Greene, L.A.10
Scott, R.W.11
Vaught, J.L.12
-
78
-
-
33846270032
-
PTENmediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42
-
Martin-Belmonte F, Gassama A, Datta A, Yu W, Rescher U, Gerke V, Mostov K (2007) PTENmediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42. Cell 128:383-397
-
(2007)
Cell
, vol.128
, pp. 383-397
-
-
Martin-Belmonte, F.1
Gassama, A.2
Datta, A.3
Yu, W.4
Rescher, U.5
Gerke, V.6
Mostov, K.7
-
79
-
-
27944445790
-
CZH proteins: A new family of Rho-GEFs
-
Meller N, Merlot S, Guda C (2005) CZH proteins: a new family of Rho-GEFs. J Cell Sci 118:4937-4946.
-
(2005)
J Cell Sci
, vol.118
, pp. 4937-4946
-
-
Meller, N.1
Merlot, S.2
Guda, C.3
-
80
-
-
0029815611
-
N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases
-
Miki H, Miura K, Takenawa T (1996) N-WASP, a novel actin-depolymerizing protein, regulates the cortical cytoskeletal rearrangement in a PIP2-dependent manner downstream of tyrosine kinases. EMBO J 15:5326-5335
-
(1996)
EMBO J
, vol.15
, pp. 5326-5335
-
-
Miki, H.1
Miura, K.2
Takenawa, T.3
-
81
-
-
2642579936
-
Signalling to actin assembly via the WASP ( Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex
-
Millard TH, Sharp SJ, Machesky LM (2004) Signalling to actin assembly via the WASP ( Wiskott-Aldrich syndrome protein)-family proteins and the Arp2/3 complex. Biochem J 380:1-17
-
(2004)
Biochem J
, vol.380
, pp. 1-17
-
-
Millard, T.H.1
Sharp, S.J.2
Machesky, L.M.3
-
82
-
-
33745493305
-
Pre-mRNA splicing in the nuclei of Xenopus oocytes
-
Moon KH, Zhao X, Yu YT (2006) Pre-mRNA splicing in the nuclei of Xenopus oocytes. Methods Mol Biol 322:149-163
-
(2006)
Methods Mol Biol
, vol.322
, pp. 149-163
-
-
Moon, K.H.1
Zhao, X.2
Yu, Y.T.3
-
83
-
-
0036635758
-
The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants
-
Nheu TV, He H, Hirokawa Y, Tamaki K, Florin L, Schmitz ML, Suzuki-Takahashi I, Jorissen RN, Burgess AW, Nishimura S, Wood J, Maruta H (2002) The K252a derivatives, inhibitors for the PAK/MLK kinase family selectively block the growth of RAS transformants. Cancer J 8:328-336
-
(2002)
Cancer J
, vol.8
, pp. 328-336
-
-
Nheu, T.V.1
He, H.2
Hirokawa, Y.3
Tamaki, K.4
Florin, L.5
Schmitz, M.L.6
Suzuki-Takahashi, I.7
Jorissen, R.N.8
Burgess, A.W.9
Nishimura, S.10
Wood, J.11
Maruta, H.12
-
84
-
-
0028961293
-
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia
-
Nobes CD, Hall A (1995) Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell 81:53-62
-
(1995)
Cell
, vol.81
, pp. 53-62
-
-
Nobes, C.D.1
Hall, A.2
-
85
-
-
20844439387
-
Structural basis of Rho GTPase-mediated activation of the formin mDia1
-
Otomo T, Otomo C, Tomchick DR, Machius M, Rosen MK (2005) Structural basis of Rho GTPase-mediated activation of the formin mDia1. Mol Cell 18:273-281
-
(2005)
Mol Cell
, vol.18
, pp. 273-281
-
-
Otomo, T.1
Otomo, C.2
Tomchick, D.R.3
Machius, M.4
Rosen, M.K.5
-
86
-
-
0033773937
-
Fluorescence polarization and anisotropy in high throughput screening: Perspectives and primer
-
Owicki JC (2000) Fluorescence polarization and anisotropy in high throughput screening: perspectives and primer. J Biomol Screen 5:297-306
-
(2000)
J Biomol Screen
, vol.5
, pp. 297-306
-
-
Owicki, J.C.1
-
87
-
-
12344337525
-
A polybasic motif allows N-WASP to act as a sensor of PIP(2) density
-
Papayannopoulos V, Co C, Prehoda KE, Snapper S, Taunton J, Lim WA (2005) A polybasic motif allows N-WASP to act as a sensor of PIP(2) density. Mol Cell 17:181-191
-
(2005)
Mol Cell
, vol.17
, pp. 181-191
-
-
Papayannopoulos, V.1
Co, C.2
Prehoda, K.E.3
Snapper, S.4
Taunton, J.5
Lim, W.A.6
-
88
-
-
0036158988
-
Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1
-
Parrini MC, Lei M, Harrison SC, Mayer BJ (2002) Pak1 kinase homodimers are autoinhibited in trans and dissociated upon activation by Cdc42 and Rac1. Mol Cell 9:73-83
-
(2002)
Mol Cell
, vol.9
, pp. 73-83
-
-
Parrini, M.C.1
Lei, M.2
Harrison, S.C.3
Mayer, B.J.4
-
89
-
-
0034809353
-
Use of biomimetic diversityoriented synthesis to discover galanthamine-like molecules with biological properties beyond those of the natural product
-
Pelish HE, Westwood NJ, Feng Y, Kirchhausen T, Shair MD (2001) Use of biomimetic diversityoriented synthesis to discover galanthamine-like molecules with biological properties beyond those of the natural product. J Am Chem Soc 123:6740-6741
-
(2001)
J Am Chem Soc
, vol.123
, pp. 6740-6741
-
-
Pelish, H.E.1
Westwood, N.J.2
Feng, Y.3
Kirchhausen, T.4
Shair, M.D.5
-
90
-
-
33645240619
-
Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro
-
Pelish HE, Peterson JR, Salvarezza SB, Rodriguez-Boulan E, Chen JL, Stamnes M, Macia E, Feng Y, Shair MD, Kirchhausen T (2006) Secramine inhibits Cdc42-dependent functions in cells and Cdc42 activation in vitro. Nat Chem Biol 2:39-46
-
(2006)
Nat Chem Biol
, vol.2
, pp. 39-46
-
-
Pelish, H.E.1
Peterson, J.R.2
Salvarezza, S.B.3
Rodriguez-Boulan, E.4
Chen, J.L.5
Stamnes, M.6
Macia, E.7
Feng, Y.8
Shair, M.D.9
Kirchhausen, T.10
-
91
-
-
0037382160
-
Disruption of the Diaphanousrelated formin Drf1 gene encoding mDia1 reveals a role for Drf3 as an effector for Cdc42
-
Peng J, Wallar BJ, Flanders A, Swiatek PJ, Alberts AS (2003) Disruption of the Diaphanousrelated formin Drf1 gene encoding mDia1 reveals a role for Drf3 as an effector for Cdc42. Curr Biol 13:534-545
-
(2003)
Curr Biol
, vol.13
, pp. 534-545
-
-
Peng, J.1
Wallar, B.J.2
Flanders, A.3
Swiatek, P.J.4
Alberts, A.S.5
-
92
-
-
0032101410
-
FH3, a domain found in formins, targets the fission yeast formin Fus1 to the projection tip during conjugation
-
Petersen J, Nielsen O, Egel R, Hagan IM (1998) FH3, a domain found in formins, targets the fission yeast formin Fus1 to the projection tip during conjugation. J Cell Biol 141:1217-1228
-
(1998)
J Cell Biol
, vol.141
, pp. 1217-1228
-
-
Petersen, J.1
Nielsen, O.2
Egel, R.3
Hagan, I.M.4
-
93
-
-
34247179024
-
Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP
-
Peterson FC, Deng Q, Zettl M, Prehoda KE, Lim WA, Way M, Volkman BF (2007) Multiple WASP-interacting protein recognition motifs are required for a functional interaction with N-WASP. J Biol Chem 282:8446-8453
-
(2007)
J Biol Chem
, vol.282
, pp. 8446-8453
-
-
Peterson, F.C.1
Deng, Q.2
Zettl, M.3
Prehoda, K.E.4
Lim, W.A.5
Way, M.6
Volkman, B.F.7
-
94
-
-
16644399583
-
Autoinhibited proteins as promising drug targets
-
Peterson JR, Golemis EA (2004) Autoinhibited proteins as promising drug targets. J Cell Biochem 93:68-73
-
(2004)
J Cell Biochem
, vol.93
, pp. 68-73
-
-
Peterson, J.R.1
Golemis, E.A.2
-
95
-
-
0036909567
-
Small molecules, big impact: A history of chemical inhibitors and the cytoskeleton
-
Peterson JR, Mitchison TJ (2002) Small molecules, big impact: a history of chemical inhibitors and the cytoskeleton. Chem Biol 9:1275-1285
-
(2002)
Chem Biol
, vol.9
, pp. 1275-1285
-
-
Peterson, J.R.1
Mitchison, T.J.2
-
96
-
-
0035845540
-
A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions
-
Peterson JR, Lokey RS, Mitchison TJ, Kirschner MW (2001) A chemical inhibitor of N-WASP reveals a new mechanism for targeting protein interactions. Proc Natl Acad Sci USA 98:10624-10629
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 10624-10629
-
-
Peterson, J.R.1
Lokey, R.S.2
Mitchison, T.J.3
Kirschner, M.W.4
-
97
-
-
3543015540
-
Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation
-
Peterson JR, Bickford LC, Morgan D, Kim AS, Ouerfelli O, Kirschner MW, Rosen MK (2004) Chemical inhibition of N-WASP by stabilization of a native autoinhibited conformation. Nat Struct Mol Biol 11:747-755
-
(2004)
Nat Struct Mol Biol
, vol.11
, pp. 747-755
-
-
Peterson, J.R.1
Bickford, L.C.2
Morgan, D.3
Kim, A.S.4
Ouerfelli, O.5
Kirschner, M.W.6
Rosen, M.K.7
-
98
-
-
33646073413
-
Biochemical suppression of small-molecule inhibitors: A strategy to identify inhibitor targets and signaling pathway components
-
Peterson JR, Lebensohn AM, Pelish HE, Kirschner MW (2006) Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem Biol 13:443-452
-
(2006)
Chem Biol
, vol.13
, pp. 443-452
-
-
Peterson, J.R.1
Lebensohn, A.M.2
Pelish, H.E.3
Kirschner, M.W.4
-
99
-
-
0034721696
-
Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex
-
Prehoda KE, Scott JA, Mullins RD, Lim WA (2000) Integration of multiple signals through cooperative regulation of the N-WASP-Arp2/3 complex. Science 290:801-806
-
(2000)
Science
, vol.290
, pp. 801-806
-
-
Prehoda, K.E.1
Scott, J.A.2
Mullins, R.D.3
Lim, W.A.4
-
100
-
-
0037178706
-
Role of formins in actin assembly: Nucleation and barbed-end association
-
Pruyne D, Evangelista M, Yang C, Bi E, Zigmond S, Bretscher A, Boone C (2002) Role of formins in actin assembly: nucleation and barbed-end association. Science 297:612-615
-
(2002)
Science
, vol.297
, pp. 612-615
-
-
Pruyne, D.1
Evangelista, M.2
Yang, C.3
Bi, E.4
Zigmond, S.5
Bretscher, A.6
Boone, C.7
-
102
-
-
0026778133
-
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors
-
Ridley AJ, Hall A (1992) The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell 70:389-399
-
(1992)
Cell
, vol.70
, pp. 389-399
-
-
Ridley, A.J.1
Hall, A.2
-
103
-
-
0026654125
-
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling
-
Ridley AJ, Paterson HF, Johnston CL, Diekmann D, Hall A (1992) The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell 70:401-410
-
(1992)
Cell
, vol.70
, pp. 401-410
-
-
Ridley, A.J.1
Paterson, H.F.2
Johnston, C.L.3
Diekmann, D.4
Hall, A.5
-
104
-
-
20444381052
-
A comparative sequence analysis reveals a common GBD/FH3-FH1-FH2-DAD architecture in formins from Dictyostelium, fungi and metazoa
-
Rivero F, Muramoto T, Meyer AK, Urushihara H, Uyeda TQ, Kitayama C (2005) A comparative sequence analysis reveals a common GBD/FH3-FH1-FH2-DAD architecture in formins from Dictyostelium, fungi and metazoa. BMC Genomics 6:28
-
(2005)
BMC Genomics
, vol.6
, pp. 28
-
-
Rivero, F.1
Muramoto, T.2
Meyer, A.K.3
Urushihara, H.4
Uyeda, T.Q.5
Kitayama, C.6
-
105
-
-
0033574722
-
The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly
-
Rohatgi R, Ma L, Miki H, Lopez M, Kirchhausen T, Takenawa T, Kirschner MW (1999) The interaction between N-WASP and the Arp2/3 complex links Cdc42-dependent signals to actin assembly. Cell 97:221-231
-
(1999)
Cell
, vol.97
, pp. 221-231
-
-
Rohatgi, R.1
Ma, L.2
Miki, H.3
Lopez, M.4
Kirchhausen, T.5
Takenawa, T.6
Kirschner, M.W.7
-
106
-
-
0034683746
-
Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate
-
Rohatgi R, Ho HY, Kirschner MW (2000) Mechanism of N-WASP activation by CDC42 and phosphatidylinositol 4, 5-bisphosphate. J Cell Biol 150:1299-1310
-
(2000)
J Cell Biol
, vol.150
, pp. 1299-1310
-
-
Rohatgi, R.1
Ho, H.Y.2
Kirschner, M.W.3
-
107
-
-
0035854732
-
Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway
-
Rohatgi R, Nollau P, Ho HY, Kirschner MW, Mayer BJ (2001) Nck and phosphatidylinositol 4,5-bisphosphate synergistically activate actin polymerization through the N-WASP-Arp2/3 pathway. J Biol Chem 276:26448-26452
-
(2001)
J Biol Chem
, vol.276
, pp. 26448-26452
-
-
Rohatgi, R.1
Nollau, P.2
Ho, H.Y.3
Kirschner, M.W.4
Mayer, B.J.5
-
108
-
-
19544386803
-
Structural and mechanistic insights into the interaction between Rho and mammalian Dia
-
Rose R, Weyand M, Lammers M, Ishizaki T, Ahmadian MR, Wittinghofer A (2005) Structural and mechanistic insights into the interaction between Rho and mammalian Dia. Nature 435:513-518
-
(2005)
Nature
, vol.435
, pp. 513-518
-
-
Rose, R.1
Weyand, M.2
Lammers, M.3
Ishizaki, T.4
Ahmadian, M.R.5
Wittinghofer, A.6
-
109
-
-
13444252631
-
GEF means go: Turning on RHO GTPases with guanine nucleotide-exchange factors
-
Rossman KL, Der CJ, Sondek J (2005) GEF means go: turning on RHO GTPases with guanine nucleotide-exchange factors. Nat Rev Mol Cell Biol 6:167-180
-
(2005)
Nat Rev Mol Cell Biol
, vol.6
, pp. 167-180
-
-
Rossman, K.L.1
Der Sondek, C.J.J.2
-
110
-
-
3142707455
-
PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: Role of mDia1 in PKD2 localization to mitotic spindles
-
Rundle DR, Gorbsky G, Tsiokas L (2004) PKD2 interacts and co-localizes with mDia1 to mitotic spindles of dividing cells: role of mDia1 IN PKD2 localization to mitotic spindles. J Biol Chem 279:29728-29739
-
(2004)
J Biol Chem
, vol.279
, pp. 29728-29739
-
-
Rundle, D.R.1
Gorbsky, G.2
Tsiokas, L.3
-
112
-
-
0033714885
-
Control of beta-catenin stability: Reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts
-
Salic A, Lee E, Mayer L, Kirschner MW (2000) Control of beta-catenin stability: reconstitution of the cytoplasmic steps of the wnt pathway in Xenopus egg extracts. Mol Cell 5:523-532
-
(2000)
Mol Cell
, vol.5
, pp. 523-532
-
-
Salic, A.1
Lee, E.2
Mayer, L.3
Kirschner, M.W.4
-
113
-
-
0029795850
-
Dynamics of capping protein and actin assembly in vitro: Uncapping barbed ends by polyphosphoinositides
-
Schafer DA, Jennings PB, Cooper JA (1996) Dynamics of capping protein and actin assembly in vitro: uncapping barbed ends by polyphosphoinositides. J Cell Biol 135:169-179
-
(1996)
J Cell Biol
, vol.135
, pp. 169-179
-
-
Schafer, D.A.1
Jennings, P.B.2
Cooper, J.A.3
-
114
-
-
0041423391
-
Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma
-
Schraml P, Schwerdtfeger G, Burkhalter F, Raggi A, Schmidt D, Ruffalo T, King W, Wilber K, Mihatsch MJ, Moch H (2003) Combined array comparative genomic hybridization and tissue microarray analysis suggest PAK1 at 11q13.5-q14 as a critical oncogene target in ovarian carcinoma. Am J Pathol 163:985-992
-
(2003)
Am J Pathol
, vol.163
, pp. 985-992
-
-
Schraml, P.1
Schwerdtfeger, G.2
Burkhalter, F.3
Raggi, A.4
Schmidt, D.5
Ruffalo, T.6
King, W.7
Wilber, K.8
Mihatsch, M.J.9
Moch, H.10
-
115
-
-
18044399847
-
The Nf2 tumor suppressor, merlin, functions in Racdependent signaling
-
Shaw RJ, Paez JG, Curto M, Yaktine A, Pruitt WM, Saotome I, O'Bryan JP, Gupta V, Ratner N, Der CJ, Jacks T, McClatchey AI (2001) The Nf2 tumor suppressor, merlin, functions in Racdependent signaling. Dev Cell 1:63-72
-
(2001)
Dev Cell
, vol.1
, pp. 63-72
-
-
Shaw, R.J.1
Paez, J.G.2
Curto, M.3
Yaktine, A.4
Pruitt, W.M.5
Saotome, I.6
O'Bryan, J.P.7
Gupta, V.8
Ratner, N.9
Der Jacks, C.J.T.10
McClatchey, A.I.11
-
116
-
-
33745511274
-
Xenopus egg extracts: A model system to study proprotein convertases
-
Shennan KI (2006) Xenopus egg extracts: a model system to study proprotein convertases. Methods Mol Biol 322:199-212
-
(2006)
Methods Mol Biol
, vol.322
, pp. 199-212
-
-
Shennan, K.I.1
-
117
-
-
0042672912
-
PAK1 phosphorylation of MEK1 regulates fibronectinstimulated MAPK activation
-
Slack-Davis JK, Eblen ST, Zecevic M, Boerner SA, Tarcsafalvi A, Diaz HB, Marshall MS, Weber MJ, Parsons JT, Catling AD (2003) PAK1 phosphorylation of MEK1 regulates fibronectinstimulated MAPK activation. J Cell Biol 162:281-291
-
(2003)
J Cell Biol
, vol.162
, pp. 281-291
-
-
Slack-Davis, J.K.1
Eblen, S.T.2
Zecevic, M.3
Boerner, S.A.4
Tarcsafalvi, A.5
Diaz, H.B.6
Marshall, M.S.7
Weber, M.J.8
Parsons, J.T.9
Catling, A.D.10
-
118
-
-
0041989574
-
Cdc42-dependent actin polymerization during compensatory endocytosis in Xenopus eggs
-
Sokac AM, Co C, Taunton J, Bement W (2003) Cdc42-dependent actin polymerization during compensatory endocytosis in Xenopus eggs. Nat Cell Biol 5:727-732
-
(2003)
Nat Cell Biol
, vol.5
, pp. 727-732
-
-
Sokac, A.M.1
Co, C.2
Taunton, J.3
Bement, W.4
-
119
-
-
0034331004
-
Chemical genetics: Ligand-based discovery of gene function
-
Stockwell BR (2000) Chemical genetics: ligand-based discovery of gene function. Nat Rev Genet 1:116-125
-
(2000)
Nat Rev Genet
, vol.1
, pp. 116-125
-
-
Stockwell, B.R.1
-
120
-
-
30844466190
-
Protein complexes regulating Arp2/3-mediated actin assembly
-
Stradal TE, Scita G (2006) Protein complexes regulating Arp2/3-mediated actin assembly. Curr Opin Cell Biol 18:4-10
-
(2006)
Curr Opin Cell Biol
, vol.18
, pp. 4-10
-
-
Stradal, T.E.1
Scita, G.2
-
121
-
-
33845729059
-
The WASP-WAVE protein network: Connecting the membrane to the cytoskeleton
-
Takenawa T, Suetsugu S (2007) The WASP-WAVE protein network: connecting the membrane to the cytoskeleton. Nat Rev Mol Cell Biol 8:37-48
-
(2007)
Nat Rev Mol Cell Biol
, vol.8
, pp. 37-48
-
-
Takenawa, T.1
Suetsugu, S.2
-
122
-
-
33644774386
-
CRIPak, a novel endogenous Pak1 inhibitor
-
Talukder AH, Meng Q, Kumar R (2006) CRIPak, a novel endogenous Pak1 inhibitor. Oncogene 25:1311-1319
-
(2006)
Oncogene
, vol.25
, pp. 1311-1319
-
-
Talukder, A.H.1
Meng, Q.2
Kumar, R.3
-
123
-
-
0030811528
-
Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts
-
Tang Y, Chen Z, Ambrose D, Liu J, Gibbs JB, Chernoff J, Field J (1997) Kinase-deficient Pak1 mutants inhibit Ras transformation of Rat-1 fibroblasts. Mol Cell Biol 17:4454-4464
-
(1997)
Mol Cell Biol
, vol.17
, pp. 4454-4464
-
-
Tang, Y.1
Chen, Z.2
Ambrose, D.3
Liu, J.4
Gibbs, J.B.5
Chernoff, J.6
Field, J.7
-
124
-
-
0032574815
-
A role for Pak protein kinases in Schwann cell transformation
-
Tang Y, Marwaha S, Rutkowski JL, Tennekoon GI, Phillips PC, Field J (1998) A role for Pak protein kinases in Schwann cell transformation. Proc Natl Acad Sci USA 95:5139-5144
-
(1998)
Proc Natl Acad Sci USA
, vol.95
, pp. 5139-5144
-
-
Tang, Y.1
Marwaha, S.2
Rutkowski, J.L.3
Tennekoon, G.I.4
Phillips, P.C.5
Field, J.6
-
125
-
-
21744440559
-
Silencing of p21-activated kinase attenuates vimentin phosphorylation on Ser-56 and reorientation of the vimentin network during stimulation of smooth muscle cells by 5-hydroxytryptamine
-
Tang DD, Bai Y, Gunst SJ (2005) Silencing of p21-activated kinase attenuates vimentin phosphorylation on Ser-56 and reorientation of the vimentin network during stimulation of smooth muscle cells by 5-hydroxytryptamine. Biochem J 388:773-783
-
(2005)
Biochem J
, vol.388
, pp. 773-783
-
-
Tang, D.D.1
Bai, Y.2
Gunst, S.J.3
-
126
-
-
0034614930
-
Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP
-
Taunton J, Rowning BA, Coughlin ML, Wu M, Moon RT, Mitchison TJ, Larabell CA (2000) Actin-dependent propulsion of endosomes and lysosomes by recruitment of N-WASP. J Cell Biol 148:519-530
-
(2000)
J Cell Biol
, vol.148
, pp. 519-530
-
-
Taunton, J.1
Rowning, B.A.2
Coughlin, M.L.3
Wu, M.4
Moon, R.T.5
Mitchison, T.J.6
Larabell, C.A.7
-
128
-
-
0012644537
-
Diaphanousrelated formins bridge Rho GTPase and Src tyrosine kinase signaling
-
Tominaga T, Sahai E, Chardin P, McCormick F, Courtneidge SA, Alberts AS (2000) Diaphanousrelated formins bridge Rho GTPase and Src tyrosine kinase signaling. Mol Cell 5:13-25
-
(2000)
Mol Cell
, vol.5
, pp. 13-25
-
-
Tominaga, T.1
Sahai, E.2
Chardin, P.3
McCormick, F.4
Courtneidge, S.A.5
Alberts, A.S.6
-
129
-
-
0037500256
-
Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition
-
Tran NH, Frost JA (2003) Phosphorylation of Raf-1 by p21-activated kinase 1 and Src regulates Raf-1 autoinhibition. J Biol Chem 278:11221-11226
-
(2003)
J Biol Chem
, vol.278
, pp. 11221-11226
-
-
Tran, N.H.1
Frost, J.A.2
-
130
-
-
0032907949
-
Genetic evidence for Pak1 autoinhibition and its release by Cdc42
-
Tu H, Wigler M (1999) Genetic evidence for Pak1 autoinhibition and its release by Cdc42. Mol Cell Biol 19:602-611
-
(1999)
Mol Cell Biol
, vol.19
, pp. 602-611
-
-
Tu, H.1
Wigler, M.2
-
131
-
-
33745513871
-
Chromosomal DNA replication in a soluble cell-free system derived from Xenopus eggs
-
Tutter AV, Walter JC (2006) Chromosomal DNA replication in a soluble cell-free system derived from Xenopus eggs. Methods Mol Biol 322:121-137
-
(2006)
Methods Mol Biol
, vol.322
, pp. 121-137
-
-
Tutter, A.V.1
Walter, J.C.2
-
132
-
-
0034680834
-
Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells
-
Vadlamudi RK, Adam L, Wang RA, Mandal M, Nguyen D, Sahin A, Chernoff J, Hung MC, Kumar R (2000) Regulatable expression of p21-activated kinase-1 promotes anchorage-independent growth and abnormal organization of mitotic spindles in human epithelial breast cancer cells. J Biol Chem 275:36238-36244
-
(2000)
J Biol Chem
, vol.275
, pp. 36238-36244
-
-
Vadlamudi, R.K.1
Adam, L.2
Wang, R.A.3
Mandal, M.4
Nguyen, D.5
Sahin, A.6
Chernoff, J.7
Hung, M.C.8
Kumar, R.9
-
134
-
-
0037112347
-
Structure of the N-WASP EVH1 domain-WIP complex: Insight into the molecular basis of Wiskott-Aldrich Syndrome
-
Volkman BF, Prehoda KE, Scott JA, Peterson FC, Lim WA (2002) Structure of the N-WASP EVH1 domain-WIP complex: insight into the molecular basis of Wiskott-Aldrich Syndrome. Cell 111:565-576
-
(2002)
Cell
, vol.111
, pp. 565-576
-
-
Volkman, B.F.1
Prehoda, K.E.2
Scott, J.A.3
Peterson, F.C.4
Lim, W.A.5
-
135
-
-
33645235850
-
The basic region of the diaphanous-autoregulatory domain (DAD) is required for autoregulatory interactions with the diaphanous-related formin inhibitory domain
-
Wallar BJ, Stropich BN, Schoenherr JA, Holman HA, Kitchen SM, Alberts AS (2006) The basic region of the diaphanous-autoregulatory domain (DAD) is required for autoregulatory interactions with the diaphanous-related formin inhibitory domain. J Biol Chem 281:4300-4307
-
(2006)
J Biol Chem
, vol.281
, pp. 4300-4307
-
-
Wallar, B.J.1
Stropich, B.N.2
Schoenherr, J.A.3
Holman, H.A.4
Kitchen, S.M.5
Alberts, A.S.6
-
136
-
-
33646682385
-
PAK1 hyperactivation is sufficient for mammary gland tumor formation
-
Wang RA, Zhang H, Balasenthil S, Medina D, Kumar R (2006) PAK1 hyperactivation is sufficient for mammary gland tumor formation. Oncogene 25:2931-2936
-
(2006)
Oncogene
, vol.25
, pp. 2931-2936
-
-
Wang, R.A.1
Zhang, H.2
Balasenthil, S.3
Medina, D.4
Kumar, R.5
-
137
-
-
0030911424
-
P140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin
-
Watanabe N, Madaule P, Reid T, Ishizaki T, Watanabe G, Kakizuka A, Saito Y, Nakao K, Jockusch BM, Narumiya S (1997) p140mDia, a mammalian homolog of Drosophila diaphanous, is a target protein for Rho small GTPase and is a ligand for profilin. EMBO J 16:3044-3056
-
(1997)
EMBO J
, vol.16
, pp. 3044-3056
-
-
Watanabe, N.1
Madaule, P.2
Reid, T.3
Ishizaki, T.4
Watanabe, G.5
Kakizuka, A.6
Saito, Y.7
Nakao, K.8
Jockusch, B.M.9
Narumiya, S.10
-
138
-
-
0033160196
-
Cooperation between mDia1 and ROCK in Rho-induced actin reorganization
-
Watanabe N, Kato T, Fujita A, Ishizaki T, Narumiya S (1999) Cooperation between mDia1 and ROCK in Rho-induced actin reorganization. Nat Cell Biol 1:136-143
-
(1999)
Nat Cell Biol
, vol.1
, pp. 136-143
-
-
Watanabe, N.1
Kato, T.2
Fujita, A.3
Ishizaki, T.4
Narumiya, S.5
-
139
-
-
4444360489
-
EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration
-
Wen Y, Eng CH, Schmoranzer J, Cabrera-Poch N, Morris EJ, Chen M, Wallar BJ, Alberts AS, Gundersen GG (2004) EB1 and APC bind to mDia to stabilize microtubules downstream of Rho and promote cell migration. Nat Cell Biol 6:820-830
-
(2004)
Nat Cell Biol
, vol.6
, pp. 820-830
-
-
Wen, Y.1
Eng, C.H.2
Schmoranzer, J.3
Cabrera-Poch, N.4
Morris, E.J.5
Chen, M.6
Wallar, B.J.7
Alberts, A.S.8
Gundersen, G.G.9
-
140
-
-
33750509850
-
Multiple Rho proteins regulate the subcellular targeting of PAK5
-
Wu X, Frost JA (2006) Multiple Rho proteins regulate the subcellular targeting of PAK5. Biochem Biophys Res Commun 351:328-335
-
(2006)
Biochem Biophys Res Commun
, vol.351
, pp. 328-335
-
-
Wu, X.1
Frost, J.A.2
-
141
-
-
0035932983
-
Regulation of the p21-activated kinase (PAK) by a human Gbeta-like WD-repeat protein, hPIP1
-
Xia C, Ma W, Stafford LJ, Marcus S, Xiong WC, Liu M (2001) Regulation of the p21-activated kinase (PAK) by a human Gbeta-like WD-repeat protein, hPIP1. Proc Natl Acad Sci USA 98:6174-6179
-
(2001)
Proc Natl Acad Sci USA
, vol.98
, pp. 6174-6179
-
-
Xia, C.1
Ma, W.2
Stafford, L.J.3
Marcus, S.4
Xiong, W.C.5
Liu, M.6
-
142
-
-
0037059807
-
P21-activated kinase links Rac/Cdc42 signaling to merlin
-
Xiao GH, Beeser A, Chernoff J, Testa JR (2002) p21-activated kinase links Rac/Cdc42 signaling to merlin. J Biol Chem 277:883-886
-
(2002)
J Biol Chem
, vol.277
, pp. 883-886
-
-
Xiao, G.H.1
Beeser, A.2
Chernoff, J.3
Testa, J.R.4
-
143
-
-
14844355090
-
The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression
-
Xiao GH, Gallagher R, Shetler J, Skele K, Altomare DA, Pestell RG, Jhanwar S, Testa JR (2005) The NF2 tumor suppressor gene product, merlin, inhibits cell proliferation and cell cycle progression by repressing cyclin D1 expression. Mol Cell Biol 25:2384-2394
-
(2005)
Mol Cell Biol
, vol.25
, pp. 2384-2394
-
-
Xiao, G.H.1
Gallagher, R.2
Shetler, J.3
Skele, K.4
Altomare, D.A.5
Pestell, R.G.6
Jhanwar, S.7
Testa, J.R.8
-
144
-
-
0032565769
-
Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization
-
Yang N, Higuchi O, Ohashi K, Nagata K, Wada A, Kangawa K, Nishida E, Mizuno K (1998) Cofilin phosphorylation by LIM-kinase 1 and its role in Rac-mediated actin reorganization. Nature 393:809-812
-
(1998)
Nature
, vol.393
, pp. 809-812
-
-
Yang, N.1
Higuchi, O.2
Ohashi, K.3
Nagata, K.4
Wada, A.5
Kangawa, K.6
Nishida, E.7
Mizuno, K.8
-
145
-
-
1942455757
-
Cdc42 and mDia3 regulate microtubule attachment to kinetochores
-
Yasuda S, Oceguera-Yanez F, Kato T, Okamoto M, Yonemura S, Terada Y, Ishizaki T, Narumiya S (2004) Cdc42 and mDia3 regulate microtubule attachment to kinetochores. Nature 428:767-771
-
(2004)
Nature
, vol.428
, pp. 767-771
-
-
Yasuda, S.1
Oceguera-Yanez, F.2
Kato, T.3
Okamoto, M.4
Yonemura, S.5
Terada, Y.6
Ishizaki, T.7
Narumiya, S.8
-
147
-
-
0037040291
-
Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1
-
Zang M, Hayne C, Luo Z (2002) Interaction between active Pak1 and Raf-1 is necessary for phosphorylation and activation of Raf-1. J Biol Chem 277:4395-4405
-
(2002)
J Biol Chem
, vol.277
, pp. 4395-4405
-
-
Zang, M.1
Hayne, C.2
Luo, Z.3
-
148
-
-
0032748298
-
Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity
-
Zenke FT, King CC, Bohl BP, Bokoch GM (1999) Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity. J Biol Chem 274:32565-32573
-
(1999)
J Biol Chem
, vol.274
, pp. 32565-32573
-
-
Zenke, F.T.1
King, C.C.2
Bohl, B.P.3
Bokoch, G.M.4
-
149
-
-
0141920605
-
P21-activated kinase 2 in neutrophils can be regulated by phosphorylation at multiple sites and by a variety of protein phosphatases
-
Zhan Q, Ge Q, Ohira T, Van Dyke T, Badwey JA (2003) p21-activated kinase 2 in neutrophils can be regulated by phosphorylation at multiple sites and by a variety of protein phosphatases. J Immunol 171:3785-3793
-
(2003)
J Immunol
, vol.171
, pp. 3785-3793
-
-
Zhan, Q.1
Ge, Q.2
Ohira, T.3
Van Dyke, T.4
Badwey, J.A.5
-
150
-
-
0031948850
-
A conserved negative regulatory region in alphaPAK: Inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1
-
Zhao ZS, Manser E, Chen XQ, Chong C, Leung T, Lim L (1998) A conserved negative regulatory region in alphaPAK: inhibition of PAK kinases reveals their morphological roles downstream of Cdc42 and Rac1. Mol Cell Biol 18:2153-2163
-
(1998)
Mol Cell Biol
, vol.18
, pp. 2153-2163
-
-
Zhao, Z.S.1
Manser, E.2
Chen, X.Q.3
Chong, C.4
Leung, T.5
Lim, L.6
-
151
-
-
26944442735
-
The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A
-
Zhao ZS, Lim JP, Ng YW, Lim L, Manser E (2005) The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A. Mol Cell 20:237-249
-
(2005)
Mol Cell
, vol.20
, pp. 237-249
-
-
Zhao, Z.S.1
Lim, J.P.2
Ng, Y.W.3
Lim, L.4
Manser, E.5
-
152
-
-
0029835783
-
Phosphatidylinositol 4,5-bisphosphate provides an alternative to guanine nucleotide exchange factors by stimulating the dissociation of GDP from Cdc42Hs
-
Zheng Y, Glaven JA, Wu WJ, Cerione RA (1996) Phosphatidylinositol 4,5-bisphosphate provides an alternative to guanine nucleotide exchange factors by stimulating the dissociation of GDP from Cdc42Hs. J Biol Chem 271:23815-23819
-
(1996)
J Biol Chem
, vol.271
, pp. 23815-23819
-
-
Zheng, Y.1
Glaven, J.A.2
Wu, W.J.3
Cerione, R.A.4
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