The association of the PAX4 gene with type 1 diabetes in Han Chinese

Diabetes Research and Clinical Practice

Volumn 81, Issue 3, 2008, Pages 365-369

  Zhang, Yun ^a   Xiao, Xinhua ^a   Liu, Ying ^b   Zhu, Xilin ^b   Wenhui, Li ^a   Li, Naishi ^a   Yuan, Tao ^a   Wang, Heng ^a  

^a PEKING UNION MEDICAL COLLEGE HOSPITAL   (China)

^b INSTITUTE OF BASIC MEDICAL SCIENCES   (China)

Author keywords

Chinese; Genetic association; The paired box gene 4; Type 1 diabetes

Indexed keywords

INSULIN; TRANSCRIPTION FACTOR PAX4;

ADOLESCENT; ADULT; AGED; ALLELE; ARTICLE; CHINESE; CONTROLLED STUDY; DISEASE ASSOCIATION; FEMALE; GENE FREQUENCY; GENOTYPE; HAPLOTYPE; HUMAN; INSULIN BLOOD LEVEL; INSULIN DEPENDENT DIABETES MELLITUS; MAJOR CLINICAL STUDY; MALE; PATHOGENESIS; POLYMERASE CHAIN REACTION; PROTEIN BLOOD LEVEL; SINGLE NUCLEOTIDE POLYMORPHISM;

ADOLESCENT; ADULT; AGED; ASIAN CONTINENTAL ANCESTRY GROUP; BLOOD PRESSURE; CHINA; DIABETES MELLITUS, TYPE 1; DNA PRIMERS; FEMALE; GENE FREQUENCY; GENOTYPE; HOMEODOMAIN PROTEINS; HUMANS; MALE; MIDDLE AGED; PAIRED BOX TRANSCRIPTION FACTORS; POLYMORPHISM, SINGLE NUCLEOTIDE; REFERENCE VALUES;

EID: 49049110021     PISSN: 01688227     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.diabres.2008.05.009     Document Type: Article

References (17)

1. Servitja J.M., and Ferrer J. Transcriptional networks controlling pancreatic development and beta cell function. Diabetologia 47 (2004) 597-613
2. Fajans S.S., Bell G.I., and Polonsky K.S. Molecular mechanisms and clinical pathophysiology of maturity-onset diabetes of the young. N. Engl. J. Med. 345 (2001) 971-980
3. Sosa-Pineda B. The gene Pax4 is an essential regulator of pancreatic beta-cell development. Mol. Cell 18 (2004) 289-294
4. Shimajiri Y., Sanke T., Furuta H., et al. A missense mutation of Pax4 gene (R121W) is associated with type 2 diabetes in Japanese. Diabetes 50 (2001) 2864-2869
5. Mauvais-Jarvis F., Smith S.B., Le May C., et al. PAX4 gene variations predispose to ketosis-prone diabetes. Hum. Mol. Genet. 13 (2004) 3151-3159
6. Mauvais-Jarvis F., Sobngwi E., Porcher R., et al. Ketosis-prone type 2 diabetes in patients of sub-Saharan African origin: clinical pathophysiology and natural history of beta-cell dysfunction and insulin resistance. Diabetes 53 (2004) 645-653
7. Holm P., Rydlander B., Luthman H., et al. Interaction and association analysis of a type 1 diabetes susceptibility locus on chromosome 5q11-q13 and the 7q32 chromosomal region in Scandinavian families. Diabetes 53 (2004) 1584-1591
8. Biason-Lauber A., Boehm B., Lang-Muritano M., et al. Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 48 (2005) 900-905
9. Hermann R., Mantere J., Lipponen K., et al. Lack of association of PAX4 gene with type 1 diabetes in the Finnish and Hungarian populations. Diabetes 54 (2005) 2816-2819
10. Maier L.M., Cooper J.D., Walker N., et al. Comment to: Biason-Lauber A., Boehm B., Lang-Muritano M. et al. (2005) association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 48 (2005) pp. 900-905, 2180-2182
11. Gong C.X., Zhu C., Yan C., et al. Survey of type 1 diabetes incidence in children from 1997 to 2000 in Beijing area. Zhonghua Er Ke Za Zhi. 42 (2004) 113-116
12. WHO Multinational Project for Childhood Diabetes. WHO Diamond Project Group. Diabetes Care. 13, 1990, 1062-1068.
13. Notsu K., Goto Y., Sakurami T., et al. A population survey of pancreatic islet cell antibodies and antithyroid antibodies. Tohoku J. Exp. Med. 141 Suppl. (1983) 261-263
14. Report of a WHO Consultation, Definition, Diagnosis and Classification of Diabetes Mellitus and its Complications, Geneva, 1999.
15. Biason-Lauber A., Boehm B., Lang-Muritano M., et al. Reply to comment on: Biason-Lauber A., Boehm B., Lang-Muritano M. et al. (2005). Association of childhood type 1 diabetes mellitus with a variant of PAX4: possible link to beta cell regenerative capacity. Diabetologia 48 (2005) pp. 900-905, 2185-2186
16. Plengvidhya N., Kooptiwut S., Songtawee N., et al. PAX4 mutations in Thais with maturity-onset diabetes of the young. J. Clin. Endocrinol. Metab. 92 (2007) 2821-2826
17. Ogawa N., List J.F., Habener J.F., and Maki T. Cure of overt diabetes in NOD mice by transient treatment with antilymphocyte serum and exendin-4. Diabetes 53 (2004) 1700-1705