Diagnosis of histoplasmosis in immunosuppressed patients

Current Opinion in Infectious Diseases

Volumn 21, Issue 4, 2008, Pages 421-425

  Kauffman, Carol A ^a  

^a UNIVERSITY OF MICHIGAN MEDICAL SCHOOL   (United States)

Author keywords

Histoplasma antigen; Histoplasmosis; Immunosuppressed patients

Indexed keywords

GALACTOMANNAN; FUNGUS ANTIGEN;

ACQUIRED IMMUNE DEFICIENCY SYNDROME; ANTIGEN DETECTION; ASPERGILLUS; CLINICAL ASSESSMENT; ENZYME IMMUNOASSAY; FALSE POSITIVE RESULT; FUNGUS CULTURE; HISTOPATHOLOGY; HISTOPLASMA CAPSULATUM; HISTOPLASMOSIS; HUMAN; IMMUNE DEFICIENCY; IMMUNOCOMPROMISED PATIENT; IMMUNODIFFUSION; LUNG BIOPSY; LUNG LAVAGE; POLYMERASE CHAIN REACTION; REVIEW; BIOPSY; BLOOD; CYTOLOGY; HISTOPLASMA; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNOLOGY; ISOLATION AND PURIFICATION; LABORATORY DIAGNOSIS; URINE;

ANTIGENS, FUNGAL; BIOPSY; FALSE POSITIVE REACTIONS; HISTOPLASMA; HISTOPLASMOSIS; HIV INFECTIONS; HUMANS; IMMUNOCOMPROMISED HOST;

EID: 49049107208     PISSN: 09517375     EISSN: 14736527     Source Type: Journal    
DOI: 10.1097/QCO.0b013e328306eb8d     Document Type: Review

References (33)

1. Kauffman CA. Histoplasmosis: a clinical and laboratory update. Clin Microbiol Rev 2007; 20:115-132.
2. Dupont B, Crewe Brown HH, et al. Mycoses in AIDS. Med Mycology 2000; 38 (suppl 1):259-268.
3. Kauffman CA. Endemic mycoses after hematopoietic stem cell or solid organ transplantation. In: Bowden RA, Ljungman P, Paya CV, editors. Transplant infections, 2nd edition Philadelphia: Lippincott Williams & Wilkins; 2003. pp. 524-534.
4. Crum NF, Lederman ER, Wallace MR. Infections associated with tumor necrosis factor-alpha antagonists. Medicine (Baltimore) 2005; 84:291-302.
5. Kauffman CA. Endemic mycoses in patients with hematologic malignancies. Sem Respir Infect 2002; 17:106-112.
6. Wheat LJ. Improvements in diagnosis of histoplasmosis. Expert Opin Biol Ther 2006; 6:1207-1221. Comprehensive review of techniques that can be used for the diagnosis of histoplasmosis and update on the experience at Miravista Diagnostics on the performance of the antigen enzyme immunoassay for H. capsulatum.
7. Wheat LJ. Antigen detection, serology, and molecular diagnosis of invasive mycoses in the immunocompromised host. Transpl Infect Dis 2006; 8:128-139.
8. Vail GM, Young RS, Wheat LJ, et al. Incidence of histoplasmosis following allogeneic bone marrow transplant or solid organ transplant in a hyperendemic area. Transpl Infect Dis 2002; 4:148-151.
9. Freifeld A, Kauffman C, Pappas P, et al. Endemic fungal infections among solid organ transplant recipients [abstract 737]. In: 43rd Annual Meeting, Infectious Disease Society of America; 2005; San Francisco. California: Infectious Disease Society of America; 2005.
10. Psarros G, Kaul DL, Kauffman CA. Disseminated histoplasmosis in a heart transplant recipient: an uncommon diagnosis even in the midwest. Infect Dis Clin Pract 2008; 16:49-53.
11. Johnson PC, Wheat LJ, Cloud GA, et al. Safety and efficacy of liposomal amphotericin B compared with conventional amphotericin B for induction therapy of histoplasmosis in patients with AIDS. Ann Intern Med 2002; 137: 105-109.
12. Freifeld AG, Iwen PC, Lesiak BL, et al. Histoplasmosis in solid organ transplant recipients at a large Midwestern university transplant center. Transpl Infect Dis 2005; 7:109-115.
13. Wheat LJ, Conces D, Allen SD, et al. Pulmonary histoplasmosis syndromes: recognition, diagnosis, and management. Sem Respir Crit Care Med 2004; 25:129-144.
14. Couppie P, Sobesky M, Aznar C, et al. Histoplasmosis and acquired immunodeficiency syndrome: a study of prognostic factors. Clin Infect Dis 2004; 38:134-138.
15. Wheat LJ, Hackett E, Durkin M, et al. Histoplasmosis- associated cross-reactivity in the BioRad platelia Aspergillus enzyme immunoassay. Clin Vaccine Immunol 2007; 14:638-640. Important article that establishes the cross-reactivity of circulating H. capsulatum galactomannan antigen with that of Aspergillus galactomannan antigen in the Platelia assay for aspergillosis.
16. Masri K, Mahon N, Rosario A, et al. Reactive hemophagocytic syndrome associated with disseminated histoplasmosis in a heart transplant recipient. J Heart Lung Transplant 2003; 22:487-491.
17. Connolly PA, Durkin MM, LeMonte AM, et al. Improvement in the detection of Histoplasma antigen by a quantitative immunoassay. Clin Vaccine Immunol 2007; 14:1587-1591.
18. LeMonte A, Egan L, Connolly P, et al. Evaluation of the IMMY ALPHA Histoplasma antigen enzyme immunoassay for diagnosis of histoplasmosis marked by antigenuria. Clin Vaccine Immunol 2007; 14:802-803.
19. Cloud JL, Bauman SK, Pelfrey JM, et al. Biased report on the IMMY ALPHA Histoplasma antigen enzyme immunoassay for diagnosis of histoplasmosis. Clin Vaccine Immunol 2007; 14:1389-1391.
20. Wheat LJ, Garringer T, Brizendine E, Connolly P. Diagnosis of histoplasmosis by antigen detection based upon experience at the histoplasmosis reference laboratory. Diagn Microbiol Infect Dis 2002; 43:29-37.
21. Wheat LJ, Connolly-Stringfield P, Williams B, et al. Diagnosis of histoplasmosis in patients with the acquired immunodeficiency syndrome by detection of Histoplasma capsulatum polysaccharide antigen in bronchoalveolar lavage fluid. Am Rev Respir Dis 1992; 145:1421-1424.
22. Wheat LJ, Musial CE, Jenny-Avital E. Diagnosis and management of central nervous system histoplasmosis. Clin Infect Dis 2005; 40:844-852.
23. Durkin M, Witt J, Lemonte A, et al. Antigenassay with the potential to aid in diagnosis of blastomycosis. J Clin Microbiol 2004; 42:4873-4875.
24. Wheat LJ, Connolly P, Durkin M, et al. False-positive Histoplasma antigenemia caused by antithymocyte globulin antibodies. Transpl Infect Dis 2004; 6:23-27
25. Wheat LJ, Hackett E, Durkin M, et al. Histoplasmosis- associated crossreactivity in the BioRad platelia Aspergillus enzyme immunoassay. Clin Vaccine Immunol 2007; 14:638-640. Important article that establishes the cross-reactivity of circulating H. capsulatum galactomannan antigen with that of Aspergillus galactomannan antigen in the Platelia assay for aspergillosis.
26. Wheat LJ, Freifeld AG, Kleiman MB, et al. Clinical practice guidelines for the management of patients with histoplasmosis: 2007 update by the Infectious Diseases Society of America. Clin Infect Dis 2007; 45:807-817. Updated IDSA guidelines for the management of all forms of histoplasmosis. This is the definitive treatment guideline for this disease.
27. Bialek R, Ernst F, Dietz K, et al. Comparison of staining methods and a nested PCR assay to detect Histoplasma capsulatum in tissue sections. Am J Clin Pathol 2002; 117:597-603.
28. Bracca A, Tosello ME, Girardini JE, et al. Molecular detection of Histoplasma capsulatum var. capsulatum in human clinical samples. J Clin Microbiol 2003; 41:1753-1755.
29. Rickets V, Bialek R, Tintlenot K, et al. Rapid PCR-based diagnosis of disseminated histoplasmosis in an AIDS patient. Eur J Clin Microbiol Infect Dis 2002; 21:821-823.
30. Martagon-Villamil J, Shrestha N, Sholtis M, et al. Identification of Histoplasma capsulatum from culture extracts by real-time PCR. J Clin Microbiol 2003; 41:1295-1298.
31. Fuller DD, Davis TE Jr, Denys GA, York MK. Evaluation of BACTEC MYCO/F lytic medium for recovery of mycobacteria, fungi, and bacteria from blood. J Clin Microbiol 2001; 39:2933-2936.
32. Vetter E, Torgerson C, Feuker A, et al. Comparison of the BACTEC MYCO/F lytic bottle to the isolator tube, BACTEC plus aerobic F/bottle and BACTEC anaerobic lytic/10 bottle and comparison of the BACTEC plus aerobic F/bottle to the isolator tube for recovery of bacteria, mycobacteria, and fungi from blood. J Clin Microbiol 2001; 39:4380-4386.
33. Schestatsky P, Chedid MF, Amaral OB, et al. Isolated central nervous system histoplasmosis in immunocompetent hosts: a series of 11 cases. Scand J Infect Dis 2006; 38:43-48. Rouphael NG, Talati NJ, Vaughan C, et al. Infections associated with haemophagocytic syndrome. Lancet Infect Dis 2007; 7:814-822. Although this review only mentions histoplasmosis as a cause of hemophagocytic syndrome, this is a masterful overview of the pathogenesis and clinical aspects of this rare and often lethal syndrome.