Multifocal motor neuropathy: Review of a treatable immune mediated disorder

Postgraduate Medical Journal

Volumn 84, Issue 992, 2008, Pages 287-292

  Rajabally, Y A ^a  

^a UNIVERSITY HOSPITALS OF LEICESTER NHS TRUST   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

AZATHIOPRINE; BETA1A INTERFERON; CYCLOPHOSPHAMIDE; CYCLOSPORIN; IMMUNOGLOBULIN; MYCOPHENOLIC ACID 2 MORPHOLINOETHYL ESTER; RITUXIMAB;

ACUTE KIDNEY FAILURE; ASEPTIC MENINGITIS; CLINICAL TRIAL; CONGESTIVE HEART FAILURE; ECHOGRAPHY; HEADACHE; HUMAN; LABORATORY TEST; MOTOR NEUROPATHY; NAUSEA; NERVE FIBER DEGENERATION; NEUROPHYSIOLOGY; NEUTROPENIA; NUCLEAR MAGNETIC RESONANCE IMAGING; RASH; REVIEW; STROKE;

HUMANS; IMMUNE SYSTEM DISEASES; LABORATORY TECHNIQUES AND PROCEDURES; MAGNETIC RESONANCE IMAGING; MOTOR NEURON DISEASE; NEURAL CONDUCTION;

EID: 49049095054     PISSN: 00325473     EISSN: None     Source Type: Journal    
DOI: 10.1136/pgmj.2007.066209     Document Type: Review

References (68)

1. Talbot K. Motor neuron disease. Postgrad Med J 2002;78:513-19.
2. Chad DA, Hammer K, Sargent J. Slow resolution of multifocal weakness and fasciculation: a reversible motor neuron syndrome. Neurology 1986;36:1260-3.
3. Parry GJ, Clarke S. Multifocal acquired demyelinating neuropathy masquerading as motor neuron disease. Muscle Nerve 1988;11:103-7.
4. Pestronk A, Cornblath DR, Ilyas A, et al. A treatable multifocal motor neuropathy with antibodies to GM1 ganglioside. Ann Neurol 1988;24:73-8.
5. Nobile-Orazio E, Cappelari A, Priori A. Multifocal motor neuropathy: current concepts and controversies. Muscle Nerve 2005;31:663-80.
6. Abhinav K, Stanton B, Johnston C, et al. Amyotrophic lateral sclerosis in South-East England: a population-based study. The South-East England register for amyotrophic lateral sclerosis (SEALS Registry). Neuroepidemiology 2007;29:44-8.
7. Nobile-Orazio E. Multifocal motor neuropathy. J Neuroimmunol 2001;115:4-18.
8. Slee M, Selvan A, Donaghy M. Multifocal motor neuropathy: the diagnostic spectrum and response to treatment. Neurology 2007;69:1680-7.
9. Bulens C, Vermeij FH, van Doom P. Multifocal motor neuropathy with abrupt onset and spontaneous recovery. J Neurol 2007;254:966-7.
10. Olney RK, Lewis RA, Putnam TD, et al. Consensus criteria for the diagnosis of multifocal motor neuropathy. Muscle Nerve 2003;27:117-21.
11. Beydoun SR. Multifocal motor neuropathy with conduction block misdiagnosed as multiple entrapment neuropathies. Muscle Nerve 1998;21:813-15.
12. Chaudhry V, Corse A, Cornblath DR, et al. Multifcal motor neuropathy: electrodiagnostic features. Muscle Nerve 1994;17:198- 205.
13. American Association of Electrodiagnostic Medicine. Consensus criteria for the diagnosis of partial conduction block. Muscle Nerve 1999;8(suppl):S225-9.
14. Ghosh A, Busby M, Kennett R, et al. A practical definition of conduction block in IVIg responsive multifocal motor neuropathy. J Neurol Neurosurg Psychiatry 2005;76:1264-8.
15. Van Asseldonk JT, Van den Bergh LH, Van den Bergh-Vos LM, et al. Demyelination and axonal loss in mutifocal motor neuropathy: distribution and relation to weakness. Brain 2003;126:186-98.
16. Arunachalam R, Osei-Lah A, Mills KR. Transcutaneous cervical root stimulation in the diagnosis of multifocal motor neuropathy with conduction block. J Neurol Neurosurg Psychiatry 2003;74:1329-31.
17. Hitomi T, Kaji R, Murase N, et al. Dynamic change of proximal conduction in demyelinating neuropathies: a cervical magnetic stimulation combined with maximum voluntary contraction. Clin Neurophysiol 2007;118:741-50.
18. Deroide N, Uzenot D, Verschueren A, et al. Triple-stimulation technique in multifocal neuropathy with conduction block. Muscle Nerve 2007;35:632-6.
19. Katz JS, Barohn RJ, Kojan S, et al. Axonal multifocal motor neuropathy without conduction block or other features of demyelination. Neurology 2002;58:615-20.
20. Attarian S, Azulay JP, Verschueren A, et al. Magnetic stimulation using a triple-stimulation technique in patients with multifocal neuropathy without conduction block. Muscle Nerve 2005;32:710-14.
21. . Taylor BV, Wright RA, Harper CM, et al. Natural history of 46 patients with multifocal motor neuropathy with conduction block. Muscle Nerve 2000;23:900-8.
22. Terenghi F, Cappelari A, Bersano A, et al. How long is IVIg effective in multifocal motor neuropathy? Neurology 2004;62:666- 8.
23. Van den Bergh-Vos RM, Franssen H, Wokke JH, et al. Multifocal motor neuropathy: long term clinical and electrophysiological assessment of intravenous immunoglobulin maintenance treatment. Brain 2002;125:1875-86.
24. Delmont E, Azulay JP, Giorgi R, et al. Mutifocal motor neuropathy with and without conduction block. A single entity? Neurology 2006;67:592-6.
25. Ghosh A, Virgincar A, Kennett R, et al. The effect of treatment upon temporal dispersion in IVIg responsive multifocal motor neuropathy. J Neurol Neurosurg Psychiatry 2005;76:1269-72.
26. van Schaik IN, Bossuyt PM, Brand A, et al. Diagnostic value of GM1 antibodies in motor neuron disorders and neuropathies: a meta analysis. Neurology 1995;45:1570-7.
27. Chaudhry V, Corse A, Cornblath DR, et al. Multifocal motor neuropathy: response to human immune globulin. Ann Neurol 1993;33:237-42.
28. Nobile-Orazio E, Meucci N, Carpo M, et al. Multifocal motor neuropathy: clinical and immunological features and response to IVIg in relation to the presence and degree of motor conduction block. J Neurol Neurosurg Psychiatry 2002;72:761-6.
29. Van Es HW, Van den Bergh LH, Franssen H, et al. Magnetic resonance imaging in patients with multifocal motor neuropathy. Neurology 1997;48:1218-24.
30. Beekman R, Van den Bergh LH, Franssen H, et al. Ultrasonography shows extensive nerve enlargements in multifocal motor neuropathy. Neurology 2005;65:305-7.
31. Corse AM, Chaudhry V, Crawford TO, et al. Sensory nerve pathology in multifocal motor neuropathy. Ann Neurol 1996;39:319- 25.
32. Taylor BV, Dyck PJ, Engelstrad J, et al. Multifocal motor neuropathy: pathologic alterations at the site of conduction block. J Neuropathol Exp neurol 2004;63:129-37.
33. Kaji R, Oka N, Tsuji T, et al. Pathological findings at the site of conduction block in multifocal motor neuropathy. Ann Neurol 1993;33:152-8.
34. Feasby TH, Brown WF, Gilbert JJ, et al. The pathological basis of conduction block in human neuropathies. J Neurol Neurosurg Psychiatry 1985;48:239-44.
35. Priori A, Bossi B, Ardolino G, et al. Pathophysiological heterogeneity of conduction blocks in multifocal motor neuropathy. Brain 2005;128:1642-8.
36. Santoro M, Uncini A, Corbo M, et al. Experimental conduction block induced by serum from a patient with anti-GM1 antibodies. Ann Neurol 1992;31:385-90.
37. Uncini A, Santoro M, Corbo M, et al. Conduction abnormalities induced by sera of patients with multifocal motor neuropathy and anti-GM1 antibodies. Muscle Nerve 1993;16:610-15.
38. Arasaki K, Kusunoki S, Kudo N, et al. Acute conduction block in vitro following exposure to anti-ganglioside sera. Muscle Nerve 1993;16:587-93.
39. Kanda T, Iwasaki T, Yamawaki M, et al. Anti-GM1 antibody facilitates leakage in an in vitro blood-nerve barrier model. Neurology 2000;55:585-7.
40. White JR, Sachs GM, Gilchrist JM. Multifcal motor neuropathy with conduction block and Campylobacter jejuni. Neurology 1996;46:562- 3.
41. Abruzzese M, Reni L, Schenone A, et al. Multifocal motor neuropathy with conduction block after Campylobacter jejuni enteritis. Neurology 1997;48:544.
42. Capasso M, Caporale CM, Pomilio F, et al. Acute motor conduction block neuropathy. Another Guillain-Barré syndrome variant. Neurology 2003;61:617-22.
43. Terenghi F, Allaria S, Scarlato G, et al. Multifocal motor neuropathy and Campylobacter jejuni reactivity. Neurology 2002;59:282-4.
44. Azulay JP, Blin O, Pouget J, et al. Intravenous immunoglobulin treatment in patients with motor neuron syndromes associated with anti-GM1 antibodies. Neurology 1994;44:429-32.
45. Van den Bergh LH, Kerkhoff H, Oey PL, et al. Treatment of multifocal motor neuropathy with high dose intravenous immunoglobulins: a double-blind placebo-controlled study. J Neurol Neurosurg Psychiatry 1995;59:248-52.
46. Federico P, Zochdone DW, Hahn AF, et al. Multifocal motor neuropathy improved by IVIg. Randomized, double-blind, placebo-controlled, study. Neurology 2000;55:1257-62.
47. Léger JM, Chassande B, Musset L, et al. Intravenous immunoglobulin therapy in multifocal motor neuropathy: a double-blind placebo-controlled study. Brain 2001;124:145-53.
48. Bouche P, Moulonguet A, Younes-Chennoufi AB, et al. Multifocal motor neuropathy with conduction block: a study of 24 patients. J Neurol Neurosurg Psychiatry 1995;59:38-44.
49. Nobile-Orazio E, Meucci N, Barbieri S, et al. High dose intravenous immunoglobulin therapy in multifocal motor neuropathy. Neurology 1993;43:537-44.
50. Van den Bergh LH, Franssen H, Wokke JH. The long-term effect of intravenous immunoglobulin treatment in multifocal motor neuropathy. Brain 1998;121:421-8.
51. Léger JM, Viala K, Cancalon F, et al. Intravenous immunoglobulin as short- and long-term therapy of multifocal motor neuropathy: a retrospective study of response to IVIg and its predictive criteria in 40 patients. J Neurol Neurosurg Psychiatry 2008;79:93-6.
52. van Schaik IN, Bouche P, Illa I, et al. European Federation of Neurological Societies: Peripheral Nerve Society, European Federation of Neurological Societies/Peripheral Nerve Society guideline on management of multifocal motor neuropathy. Eur J Neurol 2006;13:802-8.
53. Vucic S, Black KR, Chong PS, et al. Multifocal motor neuropathy: decrease in conduction blocks and reinnervation with long-term IVIg. Neurology 2004;63:1264-9.
54. Lange DJ, Weimer LH, Trojaborg W, et al. Multifocal motor neuropathy with conduction block: slow but not benign. Arch Neurol 2006;63:1778-81.
55. Bertorini TE, Nance AM, Horner LH, et al. Complications of intravenous gammaglobulin in neuromuscular and other diseases. Muscle Nerve 1996;19:388-91.
56. Brannagan TH, Nagle KJ, Lange DJ, et al. Complications of intravenous immunoglobulin in neurologic disease. Neurology 1996;47:674-7.
57. Feldman EL, Bromberg MB, Albers JW, et al. Immunosuppressive treatment in multifocal motor neuropathy. Ann Neurol 1991;30:397-401.
58. Donaghy M, Mills KR, Boniface SJ, et al. Pure motor demyelinating neuropathy: deterioration after steroid treatment and improvement with intravenous immunoglobulin. J Neurol Neurosurg Psychiatry 1994;57:778-83.
59. Carpo M, Cappelari A, Mora G, et al. Deterioration of multifocal motor neuropathy after plasma exchange. Neurology 1998;50:1480-2.
60. Piepers S, Van den Bergh-Vos R, Van der Pol WR, et al. Mycophenolate mofetil as adjunctive therapy for MMN patients: a randomized, controlled trial. Brain 2007;130:2004-2010.
61. . Hausmanova-Petrusewicz I, Rowinska-Marcinska K, Kopec K. Chronic acquired demyelinating motor neuropathy. Acta Neurol Scand 1991;84:40-5.
62. Nemni R, Santuccio G, Calabrese E, et al. Efficacy of cyclosporine in multifocal motor neuropathy. J Neurol 2003;250:1118-20.
63. Martins IS, van Doom PA, Schmitz PI, et al. Chronic motor neuropathies: response to interferon-β 1a after failure of conventional therapies. J Neurol Neurosurg Psychiatry 1999;66:197-201.
64. Van den Bergh-Vos RM, Van den Bergh LH, Franssen H, et al. Treatment of multifocal motor neuropathy with interferon-β 1A. Neurology 2000;54:1518-21.
65. Rüegg SJ, Fuhr P, Steck AJ. Rituximab stabilizes multifocal motor neuropathy increasingly less responsive to IVIg. Neurology 2004;63:2178-9.
66. Gorson KC, Natarajan N, Ropper AH, et al. Rituximab treatment in patients with IVIg-dependent immune polyneuropathy: a prospective pilot trial. Muscle Nerve 2007;35:66-9.
67. Rajabally YA, Seow H, Wilson P. Dose of intravenous immunoglobulins in chronic inflammatory demyelinating polyneuropathy. J Peripher Nerv Syst 2006;11:325-9.
68. Van Asseldonk JT, Van den Bergh LH, Kalmijn S, et al. Axonal loss is an important determinant of weakness in multifocal motor neuropathy. J Neurol Neurosurg Psychiatry 2006;77:743-7.