Brain hyperthermia after traumatic brain injury does not reduce brain oxygen

Neurosurgery

Volumn 62, Issue 4, 2008, Pages 864-872

  Spiotta, Alejandro M ^a   Stiefel, Michael F ^a   Heuer, Gregory G ^a   Bloom, Stephanie ^a   Maloney Wilensky, Eileen ^a   Yang, Wei ^a   Grady, M Sean ^a   Le Roux, Peter D ^a,b  

^a UNIVERSITY OF PENNSYLVANIA   (United States)

^b UNIVERSITY OF PENNSYLVANIA   (United States)

Author keywords

Brain oxygen; Hyperthermia; Temperature; Traumatic brain injury

Indexed keywords

FENTANYL; HEMOGLOBIN; MANNITOL; MIDAZOLAM; OXYGEN; PARACETAMOL; PENTOBARBITAL; PHENYLEPHRINE; PHENYTOIN; PROPOFOL;

ADULT; AGE DISTRIBUTION; ARTICLE; BLOOD TRANSFUSION; BODY TEMPERATURE; BRAIN HYPOXIA; BRAIN OXYGEN TENSION; BRAIN PERFUSION; BRAIN TEMPERATURE; BRAIN TISSUE; CORE TEMPERATURE; CORRELATION ANALYSIS; CRYSTALLOID; DIFFUSE AXONAL INJURY; EPIDURAL HEMATOMA; FEMALE; GUNSHOT INJURY; HEAD INJURY; HEMOGLOBIN BLOOD LEVEL; HUMAN; HYPERTHERMIA; HYPOXEMIA; INTENSIVE CARE UNIT; INTRACRANIAL HYPERTENSION; INTRACRANIAL PRESSURE; MAJOR CLINICAL STUDY; MALE; OBSERVATIONAL METHOD; PRIORITY JOURNAL; PROSPECTIVE STUDY; SUBARACHNOID HEMORRHAGE; SUBDURAL HEMATOMA; TISSUE OXYGENATION; TRAUMATIC BRAIN INJURY; BRAIN; BRAIN INJURY; FEVER; METABOLISM; OXYGEN CONSUMPTION;

ADULT; BODY TEMPERATURE; BRAIN; BRAIN INJURIES; FEMALE; FEVER; HUMANS; MALE; OXYGEN CONSUMPTION;

EID: 48949119301     PISSN: 0148396X     EISSN: None     Source Type: Journal    
DOI: 10.1227/01.neu.0000316900.63124.ce     Document Type: Article

References (73)

1. Adelson PD, Ragheb J, Kanev P, Brockmeyer D, Beers SR, Brown SD, Cassidy LD, Chang Y, Levin H: Phase II clinical trial of moderate hypothermia after severe traumatic brain injury in children. Neurosurgery 56:740-754, 2005.
2. Albrecht RF 2nd, Wass CT, Lanier WL: Occurrence of potentially detrimental temperature alterations in hospitalized patients at risk for brain injury. Mayo Clin Proc 73:629-635, 1998.
3. Allan SM, Rothwell NJ: Cytokines and acute neurodegeneration. Nat Rev Neurosci 2:734-744, 2001.
4. Aiyagari V, Diringer MN: Fever control and its impact on outcomes: What is the evidence? J Neurol Sci 261:39-46, 2007.
5. Axelrod YK, Diringer MN: Temperature management in acute neurologic disorders. Crit Care Clin 22:767-785, 2006.
6. Bardt TF, Unterberg AW, Härtl R, Kiening KL, Schneider GH, Lanksch WR: Monitoring of brain tissue PO2 in traumatic brain injury: Effect of cerebral hypoxia on outcome. Acta Neurochir Suppl 71:153-156, 1998.
7. Brain Trauma Foundation: Management and Prognosis of Severe Traumatic Brain Injury. New York, Brain Trauma Foundation, 2000, pp 47-69.
8. Carmona Suazo JA, Maas AI, van den Brink WA, van Santbrink H, Steyerberg EW, Avezaat CJ: CO2 reactivity and brain oxygen pressure monitoring in severe head injury. Crit Care Med 28:3268-3274, 2000.
9. Chatzipanteli K, Alonso OF, Kraydieh S, Dietrich WD: Importance of post-traumatic hypothermia and hyperthermia on the inflammatory response after fluid percussion brain injury: Biochemical and immunocytochemical studies. J Cereb Blood Flow Metab 20:531-542, 2000.
10. Chesnut RM, Marshall LF, Klauber MR, Blunt BA, Baldwin N, Eisenberg HM, Jane JA, Marmarou A, Foulkes MA: The role of secondary brain injury in determining outcome from severe head injury. J Trauma 34:216-222, 1993.
11. Childs C, Vail A, Protheroe R, King AT, Dark PM: Differences between brain and rectal temperatures during routine critical care of patients with severe traumatic brain injury. Anaesthesia 60:759-765, 2005.
12. Clifton GL, Miller ER, Choi SC, Levin HS, McCauley S, Smith KR Jr, Muizelaar JP, Wagner FC Jr, Marion DW, Luerssen TG, Chesnut RM, Schwartz M: Lack of effect of induction of hypothermia after acute brain injury. N Engl J Med 344:556-563, 2001.
13. Clinchot DM, Otis S, Colachis SC: Incidence of fever in the rehabilitation phase following brain injury. Am J Phys Med Rehabil 76:323-327, 1997.
14. Cruz J, Jaggi JL, Hoffstad OJ: Cerebral blood flow, vascular resistance, and oxygen metabolism in acute brain trauma: Redefining the role of cerebral perfusion pressure. Crit Care Med 23:1412-1417, 1995.
15. Dietrich WD: The importance of brain temperature in cerebral injury. J Neurotrauma [Suppl 2]:S475-S485, 1992.
16. Dietrich WD, Alonso O, Halley M, Busto R: Delayed posttraumatic brain hyperthermia worsens outcome after fluid percussion brain injury: A light and electron microscopic study in rats. Neurosurgery 38:533-541, 1996.
17. Dings J, Jäger A, Meixensberger J, Roosen K: Brain tissue pO2 and outcome after severe head injury. Neurol Res 20 [Suppl 1]:S71-75, 1998.
18. Diringer MN, Reaven NL, Funk SE, Uman GC: Elevated body temperature independently contributes to increased length of stay in neurologic intensive care unit patients. Crit Care Med 32:1489-1495, 2004.
19. Geffroy A, Bronchard R, Merckx P, Seince PF, Faillot T, Albaladejo P: Severe traumatic head injury in adults: Which patients are at risk of early hyperthermia? Intensive Care Med 30:785-790, 2004.
20. Gupta AK, Al-Rawi PG, Hutchinson PJ, Kirkpatrick PJ: Effect of hypothermia on brain tissue oxygenation in patients with severe head injury. Br J Anaesth 88:188-192, 2002.
21. Gupta AK, Hutchinson PJ, Al-Rawi PG, Gupta S, Swart M, Kirkpatrick PJ, Menon DK, Datta AK: Measuring brain tissue oxygenation compared with jugular venous oxygen saturation for monitoring cerebral oxygenation after traumatic brain injury. Anesth Analg 88:549-553, 1999.
22. Hägerdal M, Harp J, Nilsson L, Siesjö BK: The effect of induced hypothermia upon oxygen consumption in the rat brain. J Neurochem 24:311-316, 1975.
23. Hemphill JC 3rd, Knudson MM, Derugin N, Morabito D, Manley GT: Carbon dioxide reactivity and pressure autoregulation of brain tissue oxygen. Neurosurgery 48:377-383, 2001.
24. Henker RA, Brown SD, Marion DW: Comparison of brain temperature with bladder and rectal temperatures in adults with severe head injury. Neurosurgery 42:1071-1075, 1998.
25. Huang WT, Tsai S, Lin MT: Involvement of brain glutamate release in pyrogenic fever. Neuropharmacology 41:811-818, 2001.
26. Jia J, Lin YQ, Liu WF, Zhong TA, Zhang J, Ye Y, Xu YQ: Study of the effects of mild hypothermia on cerebral PO2, PCO2 and pH and body temperature in patients with acute severe head injury. Chin J Traumatol 8:138-141, 2005.
27. Jiang JY, Gao GY, Li WP, Yu MK, Zhu C: Early indicators of prognosis in 846 cases of severe traumatic brain injury. J Neurotrauma 19:869-874, 2002.
28. Johnston AJ, Steiner LA, Coles J P, Chatfield DA, Fryer TD, Smielewski P, Hutchinson PJ, O'Connell MT, Al-Rawi PG, Aigbirihio FI, Clark JC, Pickard JD, Gupta AK, Menon DK: Effect of cerebral perfusion pressure augmentation on regional oxygenation and metabolism after head injury. Crit Care Med 33:189-195, 2005.
29. Kiening KL, Härtl R, Unterberg AW, Schneider GH, Bardt T, Lanksch WR: Brain tissue pO2-monitoring in comatose patients: Implications for therapy. Neurol Res 19:233-240, 1997.
30. Kilpatrick MM, Lowry DW, Firlik AD, Yonas H, Marion DW: Hyperthermia in the neurosurgical intensive care unit. Neurosurgery 47:850-856, 2000.
31. Kinoshita K, Hayashi N, Sakurai A, Utagawa A, Moriya T: Changes in cerebrovascular response during brain hypothermia after traumatic brain injury. Acta Neurochir Suppl 86:377-380, 2003.
32. Wilensky EM, Bloom S, Leichter D, Verdiramo AM, Ledwith M, Stiefel M, LeRoux P, Grady MS: Brain tissue oxygen practice guidelines using the LICOX CMP monitoring system. J Neurosci Nurs 37:278-288, 2005.
33. Matthews DS, Bullock RE, Matthews JN, Aynsley-Green A, Eyre JA: Temperature response to severe head injury and the effect on body energy expenditure and cerebral oxygen consumption. Arch Dis Child 72:507-515, 1995.
34. McIntyre LA, Fergusson DA, Hébert PC, Moher D, Hutchison JS: Prolonged therapeutic hypothermia after traumatic brain injury in adults: A systematic review. JAMA 289:2992-2999, 2003.
35. Menon DK, Coles JP, Gupta AK, Fryer TD, Smielewski P, Chatfield DA, Aigbirhio F, Skepper JN, Minhas PS, Hutchinson PJ, Carpenter TA, Clark JC, Pickard JD: Diffusion limited oxygen delivery following head injury. Crit Care Med 32:1384-1390, 2004.
36. Mellergård P, Nordström CH: Intracerebral temperature in neurosurgical patients. Neurosurgery 28:709-713, 1991.
37. Menzel M, Doppenberg EM, Zauner A, Soukup J, Reinert MM, Bullock R: Increased inspired oxygen concentration as a factor in improved brain tissue oxygenation and tissue lactate levels after severe human head injury. J Neurosurg 91:1-10, 1999.
38. Michenfelder JD, Theye RA: Hypothermia: effect on canine brain and whole-body metabolism. Anesthesiology 29:1107-1112, 1968.
39. Morganti-Kossmann MC, Rancan M, Otto VI, Stahel PF, Kossmann T: Role of cerebral inflammation after traumatic brain injury: A revisited concept. Shock 16:165-177, 2001.
40. Murr R, Schürer L: Correlation of jugular venous oxygen saturation to spontaneous fluctuations of cerebral perfusion pressure in patients with severe head injury. Neurol Res 17:329-333, 1995.
41. Natale JE, Joseph JG, Helfaer MA, Shaffner DH: Early hyperthermia after traumatic brain injury in children: Risk factors, influence on length of stay, and effect on short-term neurologic status. Crit Care Med 28:2608-2615, 2000.
42. Orita T, Izumihara A, Tsurutani T, Kajiwara K: Brain temperature before and after brain death. Neurol Res 17:443-444, 1995.
43. Otawara Y, Ogasawara K, Yukawa H, Tomitsuka N, Kubo Y, Ogawa A, Suzuki M: Brain temperature and cerebral blood flow imaging in patients with severe subarachnoid hemorrhage: Report of two cases. Surg Neurol 60:549-552, 2003.
44. Qiu WS, Liu WG, Shen H, Wang WM, Hang ZL, Zhang Y, Jiang SJ, Yang XF: Therapeutic effect of mild hypothermia on severe traumatic head injury. Chin J Traumatol 8:27-32, 2005.
45. Robertson C: Critical care management of traumatic brain injury, in Winn HR, Youmans JR (eds): Youmans Neurological Surgery. Philadelphia, W.B. Saunders, 2004, ed 5, pp 5103-5144.
46. Rossi S, Zanier ER, Mauri I, Columbo A, Stocchetti N: Brain temperature, body core temperature, and intracranial pressure in acute cerebral damage. J Neurol Neurosurg Psychiatry 71:448-454, 2001.
47. Rovlias A, Kotsou S: The influence of hyperglycemia on neurological outcome in patients with severe head injury. Neurosurgery 46:335-342, 2000.
48. Rumana CS, Gopinath SP, Uzura M, Valadka AB, Robertson CS: Brain temperature exceeds systemic temperature in head-injured patients. Crit Care Med 26:562-567, 1998.
49. Sahuquillo J, Vilalta A: Cooling the injured brain: How does moderate hypothermia influence the pathophysiology of traumatic brain injury. Curr Pharm Des 13:2310-2322, 2007.
50. Sakurai A, Kinoshita K, Atsumi T, Moriya T, Utagawa A, Hayashi N: Relationship between brain oxygen metabolism and temperature gradient between brain and bladder. Acta Neurochir Suppl 86:251-253, 2003.
51. Salci K, Nilsson P, Howells T, Ronne-Engström E, Piper I, Contant CF Jr, Enblad P: Intracerebral microdialysis and intracranial compliance monitoring of patients with traumatic brain injury. J Clin Monit Comput 20:25-31, 2006.
52. Saper CB, Breder CD: The neurologic basis of fever. N Engl J Med 330:1880-1886, 1994.
53. Sazbon L, Groswasser Z: Outcome in 134 patients with prolonged posttraumatic unawareness. Part 1: Parameters determining late recovery of consciousness. J Neurosurg 72:75-80, 1990.
54. Sharma HS, Drieu K, Alm P, Westman J: Role of nitric oxide in blood-brain barrier permeability, brain edema and cell damage following hyperthermic brain injury. An experimental study using EGB-761 and Gingkolide B pretreatment in the rat. Acta Neurochir Suppl 76:81-86, 2000.
55. Shiozaki T, Nakajima Y, Taneda M, Tasaki O, Inoue Y, Ikegawa H, Matsushima A, Tanaka H, Shimazu T, Sugimoto H: Efficacy of moderate hypothermia in patients with severe head injury and intracranial hypertension refractory to mild hypothermia. J Neurosurg 99:47-51, 2003.
56. Soukup J, Zauner A, Doppenberg EM, Menzel M, Gilman C, Bullock R, Young HF: Relationship between brain temperature, brain chemistry and oxygen delivery after severe human head injury: The effect of mild hypothermia. Neurol Res 24:161-168, 2002.
57. Soukup J, Zauner A, Doppenberg EM, Menzel M, Gilman C, Young HF, Bullock R: The importance of brain temperature in patients after severe head injury: Relationship to intracranial pressure, cerebral perfusion pressure, cerebral blood flow, and outcome. J Neurotrauma 19:559-571, 2002.
58. Stiefel MF, Spiotta A, Gracias VH, Garuffe AM, Guillamondegui O, Maloney-Wilensky E, Bloom S, Grady MS, LeRoux PD: Reduced mortality rate in patients with severe traumatic brain injury treated with brain tissue oxygen monitoring. J Neurosurg 103:805-811, 2005.
59. Stiefel MF, Udoetuk JD, Spiotta AM, Gracias VH, Goldberg A, Maloney-Wilensky E, Bloom S, Le Roux PD: Conventional neurocritical care and cerebral oxygenation after traumatic brain injury. J Neurosurg 105:568-575, 2006.
60. Stocchetti N, Protti A, Lattuada M, Magnoni S, Longhi L, Ghisoni L, Egidi M, Zanier ER: Impact of pyrexia on neurochemistry and cerebral oxygenation after acute brain injury. J Neurol Neurosurg Psychiatry 76:1135-1139, 2005.
61. Stocchetti N, Rossi S, Zanier ER, Colombo A, Beretta L, Citerio G: Pyrexia in head-injured patients admitted to intensive care. Intensive Care Med 28: 1555-1562, 2002.
62. Stubbe HD, Greiner C, Van Aken H, Rickert CH, Westphal M, Wassmann H, Akcocuk A, Daudel F, Erren M, Hinder F: Cerebral vascular and metabolic response to sustained systemic inflammation in ovine traumatic brain injury. J Cereb Blood Flow Metab 24:1400-1408, 2004.
63. Thompson HJ, Tkacs NC, Saatman KE, Raghupathi R, McIntosh TK: Hyperthermia following traumatic brain injury: A critical evaluation. Neurobiol Dis 12:163-173, 2003.
64. Thompson HJ, Hoover RC, Tkacs NC, Saatman KE, McIntosh TK: Development of posttraumatic hyperthermia after traumatic brain injury in rats is associated with increased periventricular inflammation. J Cereb Blood Flow Metab 25:163-176, 2005.
65. Tokutomi T, Morimoto K, Miyagi T, Yamaguchi S, Ishikawa K, Shigemori M: Optimal temperature for the management of severe traumatic brain injury: Effect of hypothermia on intracranial pressure, systemic and intracranial hemodynamics, and metabolism. Neurosurgery 52:102-111, 2003.
66. Valadka AB, Gopinath SP, Contant CF, Uzura M, Robertson CS: Relationship of brain tissue PO2 to outcome after severe head injury. Crit Care Med 26:1576-1581, 1998.
67. van den Brink WA, van Santbrink H, Steyerberg EW, Avezaat CJ, Suazo JA, Hogesteeger C, Jansen WJ, Kloos LM, Vermeulen J, Maas AI: Brain oxygen tension in severe head injury. Neurosurgery 46:868-876, 2000.
68. van Santbrink H, vd Brink WA, Steyerberg EW, Carmona Suazo JA, Avezaat CJ, Maas AI: Brain tissue oxygen response in severe traumatic brain injury. Acta Neurochir (Wien) 145:429-438, 2003.
69. Vespa PM, O'Phelan K, McArthur D, Miller C, Eliseo M, Hirt D, Glenn T, Hovda DA: Pericontusional brain tissue exhibits persistent elevation of lactate/pyruvate ratio independent of cerebral perfusion pressure. Crit Care Med 35:1153-1160, 2007.
70. Whalen MJ, Carlos TM, Clark RS, Marion DW, DeKosky MS, Heineman S, Schiding JK, Memarzadeh F, Dixon CE, Kochanek PM: The relationship between brain temperature and neutrophil accumulation after traumatic brain injury in rats. Acta Neurochir Suppl 70:260-261, 1997.
71. Yamaguchi S, Nakahara K, Miyagi T, Tokutomi T, Shigemori M: Neurochemical monitoring in the management of severe head-injured patients with hypothermia. Neurol Res 22:657-664, 2000.
72. Young B, Ott L: Nutritional and metabolic management of the head-injured patient, in Narayan RK, Wilberger JE Jr, Povlishock JT (eds): Neurotrauma. New York, McGraw-Hill, 1996, pp 345-363.
73. Zhang S, Zhi D, Lin X, Shang Y, Niu Y: Effect of mild hypothermia on partial pressure of oxygen in brain tissue and brain temperature in patients with severe head injury. Chin J Traumatol 5:43-45, 2002.