Epithelial Distribution and Replication of Foot-and-Mouth Disease Virus RNA in Infected Pigs

Journal of Comparative Pathology

Volumn 139, Issue 2-3, 2008, Pages 86-96

  Durand, S ^a   Murphy, C ^a   Zhang, Z ^a   Alexandersen, S ^b  

^a INSTITUTE FOR ANIMAL HEALTH   (United Kingdom)

^b TECHNICAL UNIVERSITY OF DENMARK   (Denmark)

Author keywords

epithelium; foot and mouth disease; in situ hybridization; pig; RNA

Indexed keywords

DIGOXIGENIN; RNA POLYMERASE; VIRUS RNA;

ANIMAL CELL; ANIMAL CELL CULTURE; ANIMAL TISSUE; ARTICLE; BASEMENT MEMBRANE; CONTROLLED STUDY; CYTOPLASM; EPITHELIUM; EPITHELIUM CELL; FOOT AND MOUTH DISEASE; FOOT AND MOUTH DISEASE VIRUS; FROZEN SECTION; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; RNA ANALYSIS; RNA PROBE; SEROTYPE; SIGNAL DETECTION; SWINE DISEASE; TISSUE PRESERVATION; VIRUS REPLICATION;

ANIMALS; EPITHELIAL CELLS; FOOT-AND-MOUTH DISEASE; FOOT-AND-MOUTH DISEASE VIRUS; IMMUNOHISTOCHEMISTRY; IN SITU HYBRIDIZATION; RNA, VIRAL; SWINE; SWINE DISEASES; VIRUS REPLICATION;

FOOT-AND-MOUTH DISEASE VIRUS; SUIDAE;

EID: 48949101585     PISSN: 00219975     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.jcpa.2008.05.004     Document Type: Article

References (22)

1. Alexandersen S., Brotherhood I., and Donaldson A.I. Natural aerosol transmission of foot-and-mouth disease virus to pigs: minimal infectious dose for strain O1 Lausanne. Epidemiology and Infection 128 (2002) 301-312
2. Alexandersen S., and Donaldson A.I. Further studies to quantify the dose of natural aerosols of foot-and-mouth disease virus for pigs. Epidemiology and Infection 128 (2002) 313-323
3. Alexandersen S., and Mowat N. Foot-and-mouth disease: host range and pathogenesis. Current Topics in Microbiology and Immunology 288 (2005) 9-42
4. Alexandersen S., Quan M., Murphy C., Knight J., and Zhang Z. Studies of quantitative parameters of virus excretion and transmission in pigs and cattle experimentally infected with foot-and-mouth disease virus. Journal of Comparative Pathology 129 (2003) 268-282
5. Alexandersen S., Zhang Z., and Donaldson A.I. Aspects of the persistence of foot-and-mouth disease virus in animals - the carrier problem. Microbes and Infection 4 (2002) 1099-1110
6. Alexandersen S., Zhang Z., Donaldson A.I., and Garland A.J. The pathogenesis and diagnosis of foot-and-mouth disease. Journal of Comparative Pathology 129 (2003) 1-36
7. Bedard K.M., and Semler B.L. Regulation of picornavirus gene expression. Microbes and Infection 6 (2004) 702-713
8. Belsham G.J. Distinctive features of foot-and-mouth disease virus, a member of the picornavirus family; aspects of virus protein synthesis, protein processing and structure. Progress in Biophysics and Molecular Biology 60 (1993) 241-260
9. Brown C.C., Meyer R.F., Olander H.J., House C., and Mebus C.A. A pathogenesis study of foot-and-mouth disease in cattle, using in situ hybridization. Canadian Journal of Veterinary Research 56 (1992) 189-193
10. Brown C.C., Olander H.J., and Meyer R.F. Pathogenesis of foot-and-mouth disease in swine, studied by in-situ hybridization. Journal of Comparative Pathology 113 (1995) 51-58
11. Brown F., Martin S.J., and Underwood B. A study of the kinetics of protein and RNA synthesis induced by foot-and-mouth disease virus. Biochimica et Biophysica Acta 129 (1968) 166-177
12. Egger D., Bolten R., Rahner C., and Bienz K. Fluorochrome-labeled RNA as a sensitive, strand-specific probe for direct fluorescence in situ hybridization. Histochemistry and Cell Biology 111 (1999) 319-324
13. Ferris N.P., and Donaldson A.I. Serological response of guinea pigs to inactivated 146s antigens of FMDV after single or repeated inoculations. Revue Scientifique et Technique Office International des Épizooties 3 (1984) 563-574
14. Ferris N.P., Donaldson A.I., Barnett I.T.R., and Osborne R.W. Inactivation, purification and stability of 146s antigens of FMDV for use as reagents in the complement fixation test. Revue Scientifique et Technique Office International des Épizooties 3 (1984) 339-350
15. Monaghan P., Cook H., Jackson T., Ryan M., and Wileman T. The ultrastructure of the developing replication site in foot-and-mouth disease virus-infected BHK-38 cells. Journal of General Virology 85 (2004) 933-946
16. Monaghan P., Simpson J., Murphy C., Durand S., Quan M., and Alexandersen S. Localisation of viral non-structural proteins and potential sites of replication by confocal immuno-fluorescence microscopy in pigs experimentally infected with foot-and-mouth disease virus. Journal of Virology 79 (2005) 6410-6418
17. Mowat G.N., and Chapman W.G. Growth of foot-and-mouth disease virus in a fibroblastic cell line derived from hamster kidneys. Nature 194 (1962) 253-255
18. Murphy M.L., Forsyth M.A., Belsham G.J., and Salt J.S. Localization of foot-and-mouth disease virus RNA by in situ hybridization within bovine tissues. Virus Research 62 (1999) 67-76
19. Parlato R., Rosica A., Cuccurullo V., Mansi L., Macchia P., Owens J.D., Mushinski J.F., De Felice M., Bonner R.F., and Di Lauro R. A preservation method that allows recovery of intact RNA from tissues dissected by laser capture microdissection. Analytical Biochemistry 300 (2002) 139-145
20. Platt H. Renewal times of some squamous epithelia in the guinea pig. Nature 184 (1959) 1654-1655
21. Woodbury E.L., Ilott M.C., Brown C.C., and Salt J.S. Optimization of an in situ hybridization technique for the detection of foot-and-mouth disease virus in bovine tissues using the digoxigenin system. Journal of Virological Methods 51 (1995) 89-93
22. Zhang Z.D., and Kitching R.P. The localization of persistent foot and mouth disease virus in the epithelial cells of the soft palate and pharynx. Journal of Comparative Pathology 124 (2001) 89-94