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Volumn 147, Issue 3, 2008, Pages 261-266

Molecular biology - Hepcidin - The discovery of a small protein with a pivotal role in iron homeostasis

Author keywords

Ferroportin; Hemochromatosis; Hepcidin; Iron overload; Transferrin

Indexed keywords

ANTIMICROBIAL CATIONIC PEPTIDE; HEPCIDIN; IRON;

EID: 48949098526     PISSN: 00177768     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review
Times cited : (5)

References (37)
  • 1
    • 0035896642 scopus 로고    scopus 로고
    • Hepcidin, A urinary antimicrobial peptide synthesized in the liver
    • Park CH, Valore EV, Waring AJ & Ganz T, Hepcidin, A urinary antimicrobial peptide synthesized in the liver. J Biol Chem, 2001; 276: 7806-10.
    • (2001) J Biol Chem , vol.276 , pp. 7806-7810
    • Park, C.H.1    Valore, E.V.2    Waring, A.J.3    Ganz, T.4
  • 2
    • 0034284595 scopus 로고    scopus 로고
    • LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity
    • Krause A, Neitz S, Magert HJ & al, LEAP-1, a novel highly disulfide-bonded human peptide, exhibits antimicrobial activity. FEBS Lett, 2000; 480: 147-50.
    • (2000) FEBS Lett , vol.480 , pp. 147-150
    • Krause, A.1    Neitz, S.2    HJ, M.3
  • 3
    • 0035902605 scopus 로고    scopus 로고
    • Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice
    • Nicolas G, Bennoun M, Devaux I & al, Lack of hepcidin gene expression and severe tissue iron overload in upstream stimulatory factor 2 (USF2) knockout mice. Proc Natl Acad Sci USA, 2001; 98: 8780-5.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 8780-8785
    • Nicolas, G.1    Bennoun, M.2    Devaux, I.3
  • 4
    • 0035896581 scopus 로고    scopus 로고
    • A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is oevrexpressed during iron overload
    • Pigeon C, Ilyin G, Courselaud B & al, A new mouse liver-specific gene, encoding a protein homologous to human antimicrobial peptide hepcidin, is oevrexpressed during iron overload. J Biol Chem, 2001; 276: 7811-9.
    • (2001) J Biol Chem , vol.276 , pp. 7811-7819
    • Pigeon, C.1    Ilyin, G.2    Courselaud, B.3
  • 5
    • 0037007064 scopus 로고    scopus 로고
    • Severe iron deficiency anemia in transgenic mice expressing liver hepcidin
    • Nicolas G, Bennoun M, Porteu A & al, Severe iron deficiency anemia in transgenic mice expressing liver hepcidin. Proc Natl Acad Sci USA, 2002; 99: 4596-601.
    • (2002) Proc Natl Acad Sci USA , vol.99 , pp. 4596-4601
    • Nicolas, G.1    Bennoun, M.2    Porteu, A.3
  • 6
    • 13544252463 scopus 로고    scopus 로고
    • Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia
    • Rivera S, Liu L, Nemeth E & al, Hepcidin excess induces the sequestration of iron and exacerbates tumor-associated anemia. Blood, 2005; 105: 1797-802.
    • (2005) Blood , vol.105 , pp. 1797-1802
    • Rivera, S.1    Liu, L.2    Nemeth, E.3
  • 7
    • 19544386871 scopus 로고    scopus 로고
    • Hepcidin in iron disorders
    • Papanikolau G, Tzilianos M, Christakis JI & al, Hepcidin in iron disorders. Blood, 2005; 105: 4103-5.
    • (2005) Blood , vol.105 , pp. 4103-4105
    • Papanikolau, G.1    Tzilianos, M.2    JI, C.3
  • 9
    • 0038662619 scopus 로고    scopus 로고
    • Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein
    • Nemeth E, Valore EV, Territo M & al, Hepcidin, a putative mediator of anemia of inflammation, is a type II acute-phase protein. Blood, 2003; 101: 2461-3.
    • (2003) Blood , vol.101 , pp. 2461-2463
    • Nemeth, E.1    Valore, E.V.2    Territo, M.3
  • 10
    • 24144459870 scopus 로고    scopus 로고
    • Identification of an intestinal heme transporter
    • Shayeghi M, Latunde-Dada GO, Oakhill JS & al, Identification of an intestinal heme transporter. Cell, 2005; 122: 789-801.
    • (2005) Cell , vol.122 , pp. 789-801
    • Shayeghi, M.1    Latunde-Dada, G.O.2    JS, O.3
  • 11
    • 13444252281 scopus 로고    scopus 로고
    • Iron release from macrophages after erythro-phagocytosis is up-regulated by ferroportin 1 over expression and down-regulated by hepcidin
    • Knutson MD, Oukka M, Koss LM & al, Iron release from macrophages after erythro-phagocytosis is up-regulated by ferroportin 1 over expression and down-regulated by hepcidin. Proc Natl Acad Sci USA, 2005; 102: 1324-8.
    • (2005) Proc Natl Acad Sci USA , vol.102 , pp. 1324-1328
    • Knutson, M.D.1    Oukka, M.2    LM, K.3
  • 12
    • 0037131264 scopus 로고    scopus 로고
    • Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation
    • Yang Y, Liu X-b, Quinones M & al, Regulation of reticuloendothelial iron transporter MTP1 (Slc11a3) by inflammation. J Biol Chem, 2002; 277: 39786-91.
    • (2002) J Biol Chem , vol.277 , pp. 39786-39791
    • Yang, Y.1    Liu, X.-B.2    Quinones, M.3
  • 13
    • 0033861745 scopus 로고    scopus 로고
    • A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation
    • McKie AT, Marciani P, Rolfs A & al, A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell, 2000; 5: 299-309.
    • (2000) Mol Cell , vol.5 , pp. 299-309
    • McKie, A.T.1    Marciani, P.2    Rolfs, A.3
  • 14
    • 15044358801 scopus 로고    scopus 로고
    • Hephaestin-a ferroxidase of cellular iron export
    • Petrak J & Vyoral D, Hephaestin-a ferroxidase of cellular iron export. Int J Biochem Cell Biol, 2005; 37: 1173-8.
    • (2005) Int J Biochem Cell Biol , vol.37 , pp. 1173-1178
    • Petrak, J.1    Vyoral, D.2
  • 15
    • 10844258104 scopus 로고    scopus 로고
    • Hepcidin regulates iron efflux by binding to ferroportin and inducing its internalization
    • Nemeth E, Tuttle MS, Powelson J & al, Hepcidin regulates iron efflux by binding to ferroportin and inducing its internalization. Science, 2004; 306: 2090-3.
    • (2004) Science , vol.306 , pp. 2090-2093
    • Nemeth, E.1    Tuttle, M.S.2    Powelson, J.3
  • 16
    • 28444488323 scopus 로고    scopus 로고
    • The presence of the ion exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and downregulated by hepcidin
    • Delaby C, Pilard N, Goncalves AS & al, The presence of the ion exporter ferroportin at the plasma membrane of macrophages is enhanced by iron loading and downregulated by hepcidin. Blood, 2005; 106: 3979-84.
    • (2005) Blood , vol.106 , pp. 3979-3984
    • Delaby, C.1    Pilard, N.2    AS, G.3
  • 17
    • 34548594676 scopus 로고    scopus 로고
    • Hepcidin and its role in regulating systemic ion metabolism
    • Ganz T, Hepcidin and its role in regulating systemic ion metabolism. Hematology, 2006: 29-35.
    • (2006) Hematology , pp. 29-35
    • Ganz, T.1
  • 18
    • 0742272103 scopus 로고    scopus 로고
    • The ferroportin disease
    • Pietrangelo A, The ferroportin disease. Blood cells Mol Dis, 2004; 32: 131-8.
    • (2004) Blood cells Mol Dis , vol.32 , pp. 131-138
    • Pietrangelo, A.1
  • 19
    • 20844462571 scopus 로고    scopus 로고
    • In vitro functional analysis of human ferroportin (FPN) and hemochromatosis- associated FPN mutations
    • Schimanski LM, Drakesmith H, Merryweather-Clarke AT & al, In vitro functional analysis of human ferroportin (FPN) and hemochromatosis- associated FPN mutations. Blood, 2005; 105: 4096-4102.
    • (2005) Blood , vol.105 , pp. 4096-4102
    • Schimanski, L.M.1    Drakesmith, H.2    AT, M.-C.3
  • 20
    • 28444466958 scopus 로고    scopus 로고
    • Understanding iron homeostasis through genetic analysis of hemochromatosis and related disorders
    • Camaschella C, Understanding iron homeostasis through genetic analysis of hemochromatosis and related disorders. Blood, 2005; 106: 3710-7.
    • (2005) Blood , vol.106 , pp. 3710-3717
    • Camaschella, C.1
  • 21
    • 33750133047 scopus 로고    scopus 로고
    • Regulation of iron metabolism by hepcidin
    • Nemeth E & Ganz T, Regulation of iron metabolism by hepcidin. Ann Rev Nutr, 2006; 26: 323-42.
    • (2006) Ann Rev Nutr , vol.26 , pp. 323-342
    • Nemeth, E.1    Ganz, T.2
  • 22
    • 20244388240 scopus 로고    scopus 로고
    • Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis
    • Roetto A, Papnicolau G, Politou N & al, Mutant antimicrobial peptide hepcidin is associated with severe juvenile hemochromatosis. Nat Genet, 2003; 33: 21-2.
    • (2003) Nat Genet , vol.33 , pp. 21-22
    • Roetto, A.1    Papnicolau, G.2    Politou, N.3
  • 23
    • 27144459908 scopus 로고    scopus 로고
    • Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin
    • Lin L, Goldberg YP & Ganz T, Competitive regulation of hepcidin mRNA by soluble and cell-associated hemojuvelin. Blood, 2005; 106: 2884-9.
    • (2005) Blood , vol.106 , pp. 2884-2889
    • Lin, L.1    Goldberg, Y.P.2    Ganz, T.3
  • 24
    • 33745898241 scopus 로고    scopus 로고
    • Bone morphogenetic proteins 2, 4 and 9 stimulate murine hepcidine 1 expression independently of Hfe, transferring receptor 2 (Tfr2), and IL-6
    • Truksa J, Peng H, Lee P & al, Bone morphogenetic proteins 2, 4 and 9 stimulate murine hepcidine 1 expression independently of Hfe, transferring receptor 2 (Tfr2), and IL-6. Proc Natl Acad Sci USA, 2006; 103: 10289-93.
    • (2006) Proc Natl Acad Sci USA , vol.103 , pp. 10289-10293
    • Truksa, J.1    Peng, H.2    Lee, P.3
  • 25
    • 33646370235 scopus 로고    scopus 로고
    • Bone morphogenetic protein signaling by hemojuvekin regulates hepcidin expression
    • Babitt JL, Huang FW, Wrighting DM & al, Bone morphogenetic protein signaling by hemojuvekin regulates hepcidin expression. Nature Genetics, 2006; 38, 531-9.
    • (2006) Nature Genetics , vol.38 , pp. 531-539
    • Babitt, J.L.1    Huang, F.W.2    DM, W.3
  • 26
    • 8344235994 scopus 로고    scopus 로고
    • Hepcidin: Inflammation's iron curtain
    • McGarth Jr H & Rigby PG, Hepcidin: inflammation's iron curtain. Rheumatology, 2004; 43: 1323-5.
    • (2004) Rheumatology , vol.43 , pp. 1323-1325
    • McGarth Jr, H.1    Rigby, P.G.2
  • 27
    • 1842577545 scopus 로고    scopus 로고
    • Prevalence and outcomes of anemia in cancer: A systematic review of the literature
    • Knight K, Wade S & Balducci L, Prevalence and outcomes of anemia in cancer: a systematic review of the literature. Am J Med, 2004; 116 (Suppl. 7A): 11-16S.
    • (2004) Am J Med , vol.116 , Issue.SUPPL. 7A
    • Knight, K.1    Wade, S.2    Balducci, L.3
  • 28
    • 85047693999 scopus 로고    scopus 로고
    • Anemia of inflammation: The cytokine-hepcidine link
    • Andrews NC, Anemia of inflammation: the cytokine-hepcidine link J Clin Invest, 2004; 113: 1251-3.
    • (2004) J Clin Invest , vol.113 , pp. 1251-1253
    • NC, A.1
  • 29
    • 2342510407 scopus 로고    scopus 로고
    • IL-6 mediate hypoferremia of inflammation by inducing regulatory hormone hepcidin
    • Nemeth E, Rivera S, Gabayan V & al, IL-6 mediate hypoferremia of inflammation by inducing regulatory hormone hepcidin. J Clin Invest, 2004; 113: 1271-6.
    • (2004) J Clin Invest , vol.113 , pp. 1271-1276
    • Nemeth, E.1    Rivera, S.2    Gabayan, V.3
  • 30
    • 33751175421 scopus 로고    scopus 로고
    • Interleukin-6 induces hepcidin expression through STAS3
    • Wrighting DM & Andrews NC, Interleukin-6 induces hepcidin expression through STAS3. Blood, 2006; 108: 3204-9.
    • (2006) Blood , vol.108 , pp. 3204-3209
    • Wrighting, D.M.1    Andrews, N.C.2
  • 31
    • 53849090507 scopus 로고    scopus 로고
    • Hepcidin is the principle mediastor of asnemia of inflammation
    • Montreal
    • Rivera S, Hepcidin is the principle mediastor of asnemia of inflammation. Proc Am Coll Chest Physicians Anuual Meeting, 2005, Montreal.
    • (2005) Proc Am Coll Chest Physicians Anuual Meeting
    • Rivera, S.1
  • 32
    • 13844307889 scopus 로고    scopus 로고
    • Regulation of hepcidine transcription by interleukin-1 and interleukin-6
    • Lee P, Peng H, Gelbart T & al, Regulation of hepcidine transcription by interleukin-1 and interleukin-6. Proc. Natl. Acad. Sci. U.S.A., 2005; 102: 1906-10.
    • (2005) Proc. Natl. Acad. Sci. U.S.A , vol.102 , pp. 1906-1910
    • Lee, P.1    Peng, H.2    Gelbart, T.3
  • 33
    • 0027978341 scopus 로고
    • Effects of recombinant human interlueukin-6 in cancer patients: A phase I-II study
    • van Gameren MM, Willemse PH, Mulder NH & al, Effects of recombinant human interlueukin-6 in cancer patients: a phase I-II study. Blood, 1994; 84: 1434-41.
    • (1994) Blood , vol.84 , pp. 1434-1441
    • van Gameren, M.M.1    Willemse, P.H.2    NH, M.3
  • 34
    • 0037111732 scopus 로고    scopus 로고
    • Inappropriate expression of hepcidin is associated with iron refractory anemia: Implications for the anemia of chronic disease
    • Weinstein DA, Roy CN, Fleming M & al, Inappropriate expression of hepcidin is associated with iron refractory anemia: implications for the anemia of chronic disease. Blood, 2002; 100: 3776-81.
    • (2002) Blood , vol.100 , pp. 3776-3781
    • Weinstein, D.A.1    Roy, C.N.2    Fleming, M.3
  • 35
    • 1342263728 scopus 로고    scopus 로고
    • Hepcidin: A molecular link between inflammation and anemia
    • Deicher R & Hörl WH, Hepcidin: a molecular link between inflammation and anemia. Nephrol Dial Transplant, 2004; 19: 521-4.
    • (2004) Nephrol Dial Transplant , vol.19 , pp. 521-524
    • Deicher, R.1    Hörl, W.H.2
  • 36
    • 0347356639 scopus 로고    scopus 로고
    • Hepcidin, the recently identified peptide that appears to regulate iron absorption
    • Leong W-I & Lönnerdal B, Hepcidin, the recently identified peptide that appears to regulate iron absorption. J Nutr, 2004; 134: 1-4.
    • (2004) J Nutr , vol.134 , pp. 1-4
    • Leong, W.-I.1    Lönnerdal, B.2
  • 37
    • 0041672570 scopus 로고    scopus 로고
    • Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation
    • Ganz T, Hepcidin, a key regulator of iron metabolism and mediator of anemia of inflammation. Blood, 2003; 102: 783-8.
    • (2003) Blood , vol.102 , pp. 783-788
    • Ganz, T.1


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