Cross-sections of the reaction 232Th(p,3n)230Pa for production of 230U for targeted alpha therapy

Applied Radiation and Isotopes

Volumn 66, Issue 10, 2008, Pages 1275-1280

  Morgenstern, Alfred ^a   Apostolidis, Christos ^a   Bruchertseifer, Frank ^a   Capote, Roberto ^b   Gouder, Thomas ^a   Simonelli, Federica ^a   Sin, Mihaela ^c   Abbas, Kamel ^a  

^a JOINT RESEARCH CENTRE   (Italy)

^b INTERNATIONAL ATOMIC ENERGY AGENCY   (Austria)

^c UNIVERSITY OF BUCHAREST   (Romania)

Author keywords

Cyclotron; Radioisotope production; Targeted alpha therapy; Thorium 226; Thorium 232; Uranium 230

Indexed keywords

CYCLOTRONS; GAMMA RAY SPECTROMETERS; GAMMA RAYS; PROTON IRRADIATION; RADIOISOTOPES;

ALPHA EMITTERS; EXCITATION FUNCTION; GAMMA RAY SPECTROMETRY; MODEL CALCULATIONS; PROTON ENERGY; RADIOISOTOPE PRODUCTION; STACKED-FOIL TECHNIQUES; TARGETED ALPHA THERAPY;

THORIUM COMPOUNDS;

PROTACTINIUM; PROTACTINIUM 230; THORIUM 232; URANIUM; URANIUM 230;

ALPHA RADIATION; ARTICLE; CYCLOTRON; GAMMA SPECTROMETRY; PRIORITY JOURNAL; PROTON RADIATION; RADIOISOTOPE DECAY;

EID: 48949095817     PISSN: 09698043     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.apradiso.2008.02.066     Document Type: Article

References (32)

1. Allen B.J., Raja C., Rizvi S., Li Y., Tsui W., Graham P., Thompson J.F., Reisfeld R.A., Kearsley J., Morgenstern A., and Apostolidis C. Intralesional targeted alpha therapy for metastatic melanoma. Cancer Biol. Ther. 4 12 (2005) 1318-1324
2. 229Th for targeted alpha therapy. Anal. Chem. 77 (2005) 6288-6291
3. Belgya T., Bersillon O., Capote R., Fukahori T., Zhigang G., Goriely S., Herman M., Ignatyuk A.V., Kailas S., Koning A., Oblozinsky P., Plujko V., and Young P. Handbook for Calculations of Nuclear Reaction Data, RIPL-2. IAEA-TECDOC-1506 (2006), IAEA, Vienna. http://www-nds.iaea.org/RIPL-2/ Available online at 〈http://www-nds.iaea.org/RIPL-2/〉
4. 223Ra: adjuvant or alternative to conventional modalities?. Clin. Cancer Res. 12 (2006) 6250s-6257s
5. Brun C., and Simonoff G.N. Competition fission-evaporation etude des functions d'excitation dans differents noyaux de protactinium. J. Phys. Radium 23 (1962) 12-16
6. 231Pa nuclei in the fast neutron energy range. Unpublished. See also "Fast neutron range evaluation", Documentation of the Th-232 Evaluation for ENDF/B-VII.0 (MAT=9040 MF=1 MT=451), National Nuclear Data Centre, Brookhaven National Laboratory 〈www.nndc.bnl.gov〉. 15 December 2006.
7. 232Th (p,xn+yn) reactions at energy of protons 6.8-20.2 MeV. Phys. Scripta 24 6 (1981) 930-934
8. 232Th targets irradiated with 200 MeV protons. IEEE Trans. Nucl. Sci. 30 2 (1983) 1153
9. Firestone R.B., Baglin C.M., and Chu F.S.Y. Table of Isotopes. eighth ed (1998), Wiley, New York. 0-471-24699-9 (Update on CD-ROM)
10. Herman M. EMPIRE-II statistical model code for nuclear reaction calculations. In: Paver N., Herman M., and Gandini A. (Eds). Nuclear Reaction Data and Nuclear Reactors. ICTP Lecture Notes vol. 5 (2001), ICTP, Trieste 137-230
11. Herman, M., Oblozinsky, P., Capote, R., Sin, M., Trkov, A., Ventura, A., Zerkin, V., 2004. Recent development of the nuclear reaction model code EMPIRE. In: Proceedings of the International Conference on Nuclear Data for Science and Technology, Santa Fe, New Mexico, USA, September 26-October 1, 2004, vol. 2, pp. 1184-1187.
12. Herman M., Capote R., Carlson B.V., Oblozinsky P., Sin M., Trkov A., Wienke H., and Zerkin V. EMPIRE: nuclear reaction model code system for data evaluation. Nucl. Data Sheets 108 (2007) 2657-2717
13. IAEA, 2007. Charged-particle cross section database for medical radioisotope production, Update March 2007 〈http://www-nds.iaea.org/medical/〉.
14. Jurcic J.G., Larson S.M., Sgouros G., McDevitt M., Finn R.D., Divgi C.R., Ballangrud A.M., Hamacher K.A., Ma D., Humm J.L., Brechbiel M.W., Molinet R., and Scheinberg D.A. Targeted α particle immunotherapy for myeloid leukemia. Blood 100 4 (2002) 1233-1239
15. Jurcic, J.G., McDevitt, M.R., Pandit-Taskar, N., Divgi, C.R., Finn, R.D., Sgouros, G. Apostolidis, C., Chanel, S., Larson, S.M., Scheinberg, D.A., 2007. Alpha-Particle immunotherapy for acute myeloid leukemia (AML) with bismuth-213 and actinium-225. In: Abstracts of the Workshop on Alpha-Emitting Radionuclides in Therapy, Aachen, Germany, April 28-29.
16. Kneifel S., Cordier D., Good S., Ionescu M.C.S., Ghaffari A., Hofer S., Kretzschmar M., Tolnay M., Apostolidis C., Waser B., Arnold M., Mueller-Brand J., Maecke H.R., Reubi J.C., and Merlo A. Local targeting of malignant gliomas by the diffusible peptidic vector 1,4,7,10-tetraazacyclododecane-1-glutaric acid-4,7,10-triacetic acid-substance P. Clin. Cancer Res. 12 (2006) 3843-3850
17. 230U series using continuous radiochemical separations. Radiochim. Acta 68 (1995) 155-160
18. 232Th by protons of energies 8-22 MeV. Phys. Rev. C 25 (1982) 3011
19. Lefort M., Simonoff G.N., and Tarrago X. A spallation nuclear reaction on thorium at 150 and 82 MeV proton energies. Nucl. Phys. 25 (1961) 216
20. Meinke W.W., Wick G.C., and Seaborg G.T. High-energy excitation functions in the heavy region. J. Inorg. Nucl. Chem. 3 (1956) 69
21. Mulford D.A., Scheinberg D.A., and Jurcic J.G. The promise of targeted {alpha}-particle therapy. J. Nucl. Med. 46 1 (2005) 199S-204S
22. Nucleonica-Web driven nuclear science. European Commission, Joint Research Centre, Institute for Transuranium Elements, 2007 〈http://www.nucleonica.net/index.aspx〉.
23. Raja C., Graham P., Rizvi S., Song E., Goldsmith H., Thompson J., Bosserhoff A., Morgenstern A., Apostolidis C., Kearsley J., Reisfeld R., and Allen B.J. Interim analysis of toxicity and response in Phase 1 trial of systemic targeted alpha therapy for metastatic melanoma. Cancer Biol. Ther. 6 6 (2007) 846
24. Raynal J. Optical model and coupled-channels calculations in nuclear physics. In: Aaa A. (Ed). Computing as a Language of Physics, August 2-10, 1971 (IAEA, 1972) (1971), ICTP International Seminar Course, Trieste, Italy 281
25. 232Th by low-energy proton. Phys. Atom Nucl. 60 (1997) 1941
26. Schmidt D., Neumann F., Antke C., Apostolidis C., Martin S., Morgenstern A., Molinet R., Heeger S., Kronenwett R., Müller H.W., and Haas R. Phase I clinical study on alpha-therapy for Non Hodgkin Lymphoma. In: Morgenstern A. (Ed). Proceedings of the Fourth Alpha-Immunotherapy Symposium (2004), Düsseldorf, Germany June 28-29
27. Sin M., Capote R., Ventura A., Herman M., and Oblozinky P. Phys. Rev. C 74 (2006) 014608
28. 232Th up to 200 MeV. Phys. Rev. C 72 (2005) 024604
29. Tewes H.A. Excitation functions for some proton-induced reactions of thorium. Phys. Rev. 98 (1955) 25
30. Tewes H.A., and James R.A. Proton induced reactions of thorium-fission yield curves. Phys. Rev. 88 (1952) 860
31. 211At-labeled chimeric antitenascin monoclonal antibody 81C6. J. Nucl. Med. 49 1 (2008) 30-38
32. Ziegler J.F., Biersack J.P., and Littmark U. SRIM 2003 Code. The Stopping and Range of Ions in Solids (2003), Pergamon, New York