AT1 receptor ligands: Virtual-screening-based design with TOPP descriptors, synthesis, and biological evaluation of pyrrolidine derivatives

ChemMedChem

Volumn 2, Issue 9, 2007, Pages 1298-1310

  Lamanna, Claudia ^a,b,f   Catalano, Alessia ^a   Carocci, Alessia ^a   Di Mola, Antonia ^a   Franchini, Carlo ^a   Tortorella, Vincenzo ^a   Vanderheyden, Patrick M L ^c   Sinicropi, Maria S ^d   Watson, Kimberly A ^b   Sciabola, Simone ^e  

^a UNIVERSITY OF BARI   (Italy)

^b The BioCenter   (United Kingdom)

^c VRIJE UNIVERSITEIT BRUSSEL   (Belgium)

^d UNIVERSITY OF CALABRIA   (Italy)

^e UNIVERSITY OF PERUGIA   (Italy)

^f Siena Biotech SpA   (Italy)

Author keywords

Amides; AT1 receptors; Hypertension; Nitrogen heterocycles

Indexed keywords

ANGIOTENSIN RECEPTOR; LIGAND; PYRROLIDINE DERIVATIVE;

ARTICLE; CHEMISTRY; DRUG SCREENING; METABOLISM; STRUCTURE ACTIVITY RELATION; SYNTHESIS;

DRUG EVALUATION, PRECLINICAL; LIGANDS; PYRROLIDINES; RECEPTORS, ANGIOTENSIN; STRUCTURE-ACTIVITY RELATIONSHIP;

EID: 48949090994     PISSN: 18607179     EISSN: 18607187     Source Type: Journal    
DOI: 10.1002/cmdc.200700082     Document Type: Article

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